Symbol:
Slc12a3
Name:
solute carrier family 12 member 3
RGD ID:
3686
Description:
Enables enzyme binding activity and sodium:chloride symporter activity. Involved in chloride transport and sodium ion transmembrane transport. Located in apical plasma membrane and vesicle. Is active in plasma membrane. Human ortholog(s) of this gene implicated in Gitelman syndrome and essential hypertension. Orthologous to human SLC12A3 (solute carrier family 12 member 3); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC102553442; na-Cl symporter; NCC; solute carrier family 12 (sodium/chloride transporter), member 3; solute carrier family 12 (sodium/chloride transporters), member 3; solute carrier family 12 member 3-like; solute carrier family 12, member 3; thiazide-sensitive Na-Cl cotransporter; thiazide-sensitive sodium-chloride cotransporter; TSC
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 19 10,636,594 - 10,690,008 (-) NCBI GRCr8 mRatBN7.2 19 10,630,651 - 10,679,250 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 19 10,631,393 - 10,669,091 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 19 10,594,046 - 10,632,542 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 19 11,360,884 - 11,399,380 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 19 10,647,871 - 10,686,368 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 19 11,106,033 - 11,144,674 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 19 11,106,033 - 11,144,641 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 19 11,084,193 - 11,122,657 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 19 11,070,329 - 11,109,634 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 19 11,075,156 - 11,114,460 (-) NCBI Celera 19 10,518,752 - 10,557,092 (-) NCBI Celera Cytogenetic Map 19 p13-p12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - SMPDB
Biological Process
cell volume homeostasis (IBA) chloride ion homeostasis (IBA) chloride transmembrane transport (IBA,IEA) chloride transport (IMP) monoatomic ion transport (IEA) potassium ion homeostasis (IBA) potassium ion import across plasma membrane (IBA) renal sodium ion absorption (IDA,IEA,ISO) response to aldosterone (IEA,ISO) response to salt (IEA,ISO) sodium ion homeostasis (IBA) sodium ion transmembrane transport (IBA,IDA,IEA,ISO) sodium ion transport (IDA,IEA,IMP,ISO,ISS) transmembrane transport (IEA)
1.
Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney.
Gamba G, etal., J Biol Chem 1994 Jul 1;269(26):17713-22.
2.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.
Rat ISS GO annotations from GOA human gene data--August 2006
GOA data from the GO Consortium
4.
The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.
Matayoshi T, etal., Hypertens Res. 2004 Nov;27(11):821-33.
5.
G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women.
Matsuo A, etal., J Hypertens. 2004 Nov;22(11):2123-7.
6.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
7.
Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction.
Monroy A, etal., Am J Physiol Renal Physiol. 2000 Jul;279(1):F161-9. doi: 10.1152/ajprenal.2000.279.1.F161.
8.
Affinity-defining domains in the Na-Cl cotransporter: a different location for Cl- and thiazide binding.
Moreno E, etal., J Biol Chem. 2006 Jun 23;281(25):17266-75. Epub 2006 Apr 19.
9.
Electronic Transfer of LocusLink and RefSeq Data
NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.
OMIM Disease Annotation Pipeline
OMIM Disease Annotation Pipeline
11.
The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion.
Pacheco-Alvarez D, etal., J Biol Chem. 2006 Sep 29;281(39):28755-63. Epub 2006 Aug 3.
12.
SMPDB Annotation Import Pipeline
Pipeline to import SMPDB annotations from SMPDB into RGD
13.
GOA pipeline
RGD automated data pipeline
14.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
16.
Gitelman syndrome: genetic and expression analysis of the thiazide-sensitive sodium-chloride transporter in blood cells.
Riancho JA, etal., Nephrol Dial Transplant. 2006 Jan;21(1):217-20. Epub 2005 Oct 12.
17.
WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis.
Rinehart J, etal., Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16777-82. Epub 2005 Nov 7.
18.
Redistribution of distal tubule Na+-Cl- cotransporter (NCC) in response to a high-salt diet.
Sandberg MB, etal., Am J Physiol Renal Physiol. 2006 Aug;291(2):F503-8. Epub 2006 Mar 22.
19.
Renal tubule-specific transcription and chromosomal localization of rat thiazide-sensitive na-cl cotransporter gene.
Taniyama Y, etal., J Biol Chem 2001 Jul 13;276(28):26260-8.
20.
Tentative Sequence Identification Numbers
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21.
Interaction with grp58 increases activity of the thiazide-sensitive Na-Cl cotransporter.
Wyse B, etal., Am J Physiol Renal Physiol 2002 Mar;282(3):F424-30.
22.
Sodium retention in rats with liver cirrhosis is associated with increased renal abundance of NaCl cotransporter (NCC).
Yu Z, etal., Nephrol Dial Transplant. 2005 Sep;20(9):1833-41. Epub 2005 Jun 14.
Slc12a3 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 19 10,636,594 - 10,690,008 (-) NCBI GRCr8 mRatBN7.2 19 10,630,651 - 10,679,250 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 19 10,631,393 - 10,669,091 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 19 10,594,046 - 10,632,542 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 19 11,360,884 - 11,399,380 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 19 10,647,871 - 10,686,368 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 19 11,106,033 - 11,144,674 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 19 11,106,033 - 11,144,641 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 19 11,084,193 - 11,122,657 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 19 11,070,329 - 11,109,634 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 19 11,075,156 - 11,114,460 (-) NCBI Celera 19 10,518,752 - 10,557,092 (-) NCBI Celera Cytogenetic Map 19 p13-p12 NCBI
SLC12A3 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 16 56,865,207 - 56,915,850 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 16 56,865,207 - 56,915,850 (+) Ensembl GRCh38 hg38 GRCh38 GRCh37 16 56,899,119 - 56,949,762 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 16 55,456,643 - 55,504,850 (+) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 16 55,456,642 - 55,504,850 NCBI Celera 16 41,398,377 - 41,450,052 (+) NCBI Celera Cytogenetic Map 16 q13 NCBI HuRef 16 42,768,662 - 42,819,218 (+) NCBI HuRef CHM1_1 16 58,307,135 - 58,357,791 (+) NCBI CHM1_1 T2T-CHM13v2.0 16 62,661,526 - 62,712,168 (+) NCBI T2T-CHM13v2.0
Slc12a3 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 8 95,055,737 - 95,092,850 (+) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 8 95,055,829 - 95,092,842 (+) Ensembl GRCm39 Ensembl GRCm38 8 94,329,109 - 94,366,222 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 8 94,329,201 - 94,366,214 (+) Ensembl GRCm38 mm10 GRCm38 MGSCv37 8 96,853,108 - 96,890,122 (+) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 8 97,218,355 - 97,255,092 (+) NCBI MGSCv36 mm8 Celera 8 98,660,930 - 98,697,944 (+) NCBI Celera Cytogenetic Map 8 C5 NCBI cM Map 8 46.46 NCBI
Slc12a3 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955433 14,553,758 - 14,587,602 (+) Ensembl ChiLan1.0 ChiLan1.0 NW_004955433 14,553,752 - 14,588,317 (+) NCBI ChiLan1.0 ChiLan1.0
SLC12A3 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 18 66,316,962 - 66,386,655 (+) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 16 72,237,646 - 72,307,205 (+) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 16 37,142,797 - 37,193,713 (+) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 16 56,276,026 - 56,326,973 (+) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 16 56,276,049 - 56,324,528 (+) Ensembl panpan1.1 panPan2
SLC12A3 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 2 59,413,737 - 59,449,129 (-) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 2 59,413,828 - 59,449,081 (-) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 2 56,042,573 - 56,077,948 (-) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 2 59,952,797 - 59,988,344 (-) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 2 59,952,888 - 59,988,297 (-) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 2 56,783,974 - 56,819,378 (-) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 2 57,791,053 - 57,826,469 (-) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 2 58,685,512 - 58,720,937 (-) NCBI UU_Cfam_GSD_1.0
Slc12a3 Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024409349 50,512,705 - 50,545,228 (-) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936475 9,044,106 - 9,076,307 (+) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936475 9,044,099 - 9,076,301 (+) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
SLC12A3
SLC12A3 Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 5 42,808,773 - 42,877,714 (+) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 5 42,811,597 - 42,862,002 (+) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666047 33,488,318 - 33,536,531 (-) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Slc12a3
.
Assembly: RGSC_v3.4 Assembly: Rnor_5.0 Assembly: Rnor_6.0
Predicted Target Of
Count of predictions: 303 Count of miRNA genes: 183 Interacting mature miRNAs: 207 Transcripts: ENSRNOT00000025377 Prediction methods: Microtar, Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
1549847 Bss8 Bone structure and strength QTL 8 4 lumbar vertebra strength trait (VT:0010574) vertebra ultimate force (CMO:0001678) 19 1 31963836 Rat 8552935 Pigfal10 Plasma insulin-like growth factor 1 level QTL 10 5.7 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 19 1 36824771 Rat 61447 Tcas1 Tongue tumor susceptibility QTL 1 6.08 tongue integrity trait (VT:0010553) squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875) 19 2316121 47316121 Rat 631681 Cm12 Cardiac mass QTL 12 3.33 0.00053 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 19 1 28982497 Rat 9590298 Uminl5 Urine mineral level QTL 5 3.59 0.001 urine mineral amount (VT:0015086) urine electrolyte level (CMO:0000593) 19 1 36824771 Rat 631840 Niddm38 Non-insulin dependent diabetes mellitus QTL 38 3.86 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 19 10323180 23069265 Rat 10054132 Srcrt9 Stress Responsive Cort QTL 9 2.87 0.0017 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 19 1 27355345 Rat 1331737 Uae29 Urinary albumin excretion QTL 29 5.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 19 4096155 55283277 Rat 724518 Uae19 Urinary albumin excretion QTL 19 5.5 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 19 7457249 42983518 Rat 8694186 Bw152 Body weight QTL 152 3.34 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 19 569374 45569374 Rat 7411590 Foco7 Food consumption QTL 7 6.8 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 19 1 24688055 Rat 631678 Cm9 Cardiac mass QTL 9 4.27 0.0001 aorta mass (VT:0002845) aorta weight (CMO:0000076) 19 1 28982497 Rat 9590250 Scort11 Serum corticosterone level QTL 11 23.45 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 19 1 36824771 Rat 9590090 Insglur8 Insulin/glucose ratio QTL 8 10.81 0.001 blood insulin amount (VT:0001560) calculated plasma insulin level (CMO:0002170) 19 1 36824771 Rat 2317848 Alcrsp21 Alcohol response QTL 21 1.899999976158142 0.05 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 19 3204777 48204777 Rat 9589102 Slep13 Serum leptin concentration QTL 13 4.63 0.001 blood leptin amount (VT:0005667) plasma leptin level (CMO:0000781) 19 569374 45569374 Rat 7247442 Uae39 Urinary albumin excretion QTL 39 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 19 2187927 46708701 Rat 724566 Uae12 Urinary albumin excretion QTL 12 5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 19 2187927 56457239 Rat 724565 Tcas5 Tongue tumor susceptibility QTL 5 10.04 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) 19 9977753 39654489 Rat
BF391454
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 19 10,670,522 - 10,670,696 (+) MAPPER mRatBN7.2 Rnor_6.0 19 11,146,073 - 11,146,246 NCBI Rnor6.0 Rnor_5.0 19 11,124,089 - 11,124,262 UniSTS Rnor5.0 RGSC_v3.4 19 11,111,066 - 11,111,239 UniSTS RGSC3.4 Celera 19 10,558,524 - 10,558,697 UniSTS RH 3.4 Map 19 97.5 UniSTS Cytogenetic Map 19 p14-p12 UniSTS
DXS1162
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 19 10,667,970 - 10,668,444 (+) MAPPER mRatBN7.2 Rnor_6.0 19 11,143,521 - 11,143,994 NCBI Rnor6.0 Rnor_5.0 19 11,121,537 - 11,122,010 UniSTS Rnor5.0 RGSC_v3.4 19 11,108,514 - 11,108,987 UniSTS RGSC3.4 Celera 19 10,555,972 - 10,556,445 UniSTS Cytogenetic Map 19 p14-p12 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
10
49
113
83
82
51
25
51
6
209
96
93
45
60
31
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000081246 ⟹ ENSRNOP00000070064
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 19 10,631,393 - 10,669,091 (-) Ensembl Rnor_6.0 Ensembl 19 11,106,033 - 11,144,641 (-) Ensembl
RefSeq Acc Id:
NM_019345 ⟹ NP_062218
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 19 10,636,596 - 10,675,050 (-) NCBI mRatBN7.2 19 10,630,651 - 10,669,108 (-) NCBI Rnor_6.0 19 11,106,033 - 11,144,641 (-) NCBI Rnor_5.0 19 11,084,193 - 11,122,657 (-) NCBI RGSC_v3.4 19 11,070,329 - 11,109,634 (-) RGD Celera 19 10,518,752 - 10,557,092 (-) RGD
Sequence:
CCCGGAGCCATAATGGCAGAGCTACCCGTGACAGAGATGCCAGGCGATGCTCTGTGCAGTGGGCGCTTCACCATCAGCACGCTGCTGGGGGGTGACGAGCCCCCACCAGCTGCCTGTGACAATAGCCA
hide sequence
RefSeq Acc Id:
XM_063278264 ⟹ XP_063134334
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 19 10,636,594 - 10,690,008 (-) NCBI
RefSeq Acc Id:
XM_063278265 ⟹ XP_063134335
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 19 10,636,594 - 10,690,008 (-) NCBI
RefSeq Acc Id:
XM_063278266 ⟹ XP_063134336
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 19 10,636,594 - 10,690,008 (-) NCBI
RefSeq Acc Id:
NP_062218 ⟸ NM_019345
- UniProtKB:
P55018 (UniProtKB/Swiss-Prot), G3V8G0 (UniProtKB/TrEMBL), A6JY68 (UniProtKB/TrEMBL)
- Sequence:
MAELPVTEMPGDALCSGRFTISTLLGGDEPPPAACDNSQPSHLTHGSTLYLRTFGYNTIDVVPAYEHYANSALPGEPRKVRPTLADLHSFLKQEGSHLHALAFDGRPGHELTDGLVEDETGANSEKSP
hide sequence
Ensembl Acc Id:
ENSRNOP00000070064 ⟸ ENSRNOT00000081246
RefSeq Acc Id:
XP_063134334 ⟸ XM_063278264
- Peptide Label:
isoform X1
- UniProtKB:
P55018 (UniProtKB/Swiss-Prot)
RefSeq Acc Id:
XP_063134336 ⟸ XM_063278266
- Peptide Label:
isoform X3
- UniProtKB:
P55018 (UniProtKB/Swiss-Prot)
RefSeq Acc Id:
XP_063134335 ⟸ XM_063278265
- Peptide Label:
isoform X2
- UniProtKB:
P55018 (UniProtKB/Swiss-Prot)
RGD ID: 13700947 Promoter ID: EPDNEW_R11471 Type: single initiation site Name: Slc12a3_1 Description: solute carrier family 12 member 3 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 19 11,144,657 - 11,144,717 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2021-03-09
Slc12a3
solute carrier family 12 member 3
LOC102553442
solute carrier family 12 member 3-like
Data merged from RGD:7680931
737654 PROVISIONAL
2016-02-25
Slc12a3
solute carrier family 12 member 3
Slc12a3
solute carrier family 12 (sodium/chloride transporter), member 3
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2013-12-18
LOC102553442
solute carrier family 12 member 3-like
Symbol and Name status set to provisional
70820 PROVISIONAL
2013-08-02
Slc12a3
solute carrier family 12 (sodium/chloride transporter), member 3
Slc12a3
solute carrier family 12 (sodium/chloride transporters), member 3
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2008-09-19
Slc12a3
solute carrier family 12 (sodium/chloride transporters), member 3
Slc12a3
solute carrier family 12, member 3
Nomenclature updated to reflect human and mouse nomenclature
1299863 APPROVED
2002-06-10
Slc12a3
solute carrier family 12, member 3
Symbol and Name status set to approved
70586 APPROVED
2002-02-27
Slc12a3
solute carrier family 12, member 3
Name updated to reflect Human and Mouse nomenclature
70292 APPROVED
2001-12-12
Slc12a3
Thiazide-sensitive Na-Cl cotransporter
Name updated to reflect Human and Mouse nomenclature
68673 APPROVED
Note Type
Note
Reference
gene_disease
mutation of the human homolog causes Gitelman's syndrome
68673
gene_drugs
is a target of thiazide diuretics
68673
gene_expression
expressed specifically in the kidney
68673
gene_function
acts as a sodium/chloride cotransporter
68673
gene_function
acts as a sodium/chloride cotransporter
69999
gene_process
may be involved in reabsorption of NaCl in the kidney
68673
gene_process
may be involved in reabsorption of NaCl in the kidney
69999
gene_process
may play a role in acid-base balance
68673
gene_process
may play a role in acid-base balance
69999
