Slc10a2 (solute carrier family 10 member 2) - Rat Genome Database

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Gene: Slc10a2 (solute carrier family 10 member 2) Rattus norvegicus
Analyze
Symbol: Slc10a2
Name: solute carrier family 10 member 2
RGD ID: 3682
Description: Enables bile acid:sodium symporter activity. Involved in bile acid and bile salt transport. Located in apical plasma membrane. Part of proteasome complex. Human ortholog(s) of this gene implicated in intestinal disease. Orthologous to human SLC10A2 (solute carrier family 10 member 2); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17alpha-ethynylestradiol; 3,3',5-triiodo-L-thyronine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: apical sodium-dependent bile acid transporter; ASBT; IBAT; ileal Na(+)/bile acid cotransporter; ileal sodium-dependent bile acid transporter; ileal sodium/bile acid cotransporter; ISBAT; ISBT; Na(+)-dependent ileal bile acid transporter; sodium/taurocholate-cotransporting polypeptide, ileal; solute carrier family 10 (sodium/bile acid cotransporter family), member 2; solute carrier family 10 (sodium/bile acid cotransporter), member 2; solute carrier family 10, member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81691,088,089 - 91,111,025 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1691,076,423 - 91,111,025 (+)EnsemblGRCr8
mRatBN7.21684,386,528 - 84,409,475 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1684,374,862 - 84,409,475 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1689,642,557 - 89,665,103 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01693,095,100 - 93,117,661 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01688,368,950 - 88,391,491 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01690,324,420 - 90,350,254 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1690,324,361 - 90,345,865 (+)Ensemblrn6Rnor6.0
Rnor_5.01689,709,462 - 89,732,970 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41689,939,295 - 89,961,444 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1682,094,445 - 82,108,935 (+)NCBICelera
RGSC_v3.11689,925,334 - 90,169,172 (+)NCBI
Cytogenetic Map16q12.5NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
alfacalcidol  (ISO)
allocholic acid  (ISO)
ammonium chloride  (EXP)
atorvastatin calcium  (ISO)
Azoxymethane  (ISO)
aztreonam  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-hexachlorocyclohexane  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
bromosulfophthalein  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
cholic acid  (EXP,ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
diquat  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
erythrosin B  (ISO)
ethanol  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (ISO)
genistein  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycoursodeoxycholic acid  (ISO)
graphite  (EXP)
GW 4064  (ISO)
ibuprofen  (ISO)
indocyanine green  (ISO)
inulin  (ISO)
L-methionine  (ISO)
lactacystin  (ISO)
leflunomide  (EXP)
lithocholic acid  (ISO)
metformin  (ISO)
Muraglitazar  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
oxycodone  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procymidone  (ISO)
propiconazole  (ISO)
Prothioconazole-desthio  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 203580  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
streptozocin  (ISO)
tauro-beta-muricholic acid  (EXP)
taurochenodeoxycholic acid  (EXP,ISO)
taurocholic acid  (EXP,ISO)
taurodeoxycholic acid  (ISO)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (EXP,ISO)
ursodeoxycholic acid  (EXP,ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
apical plasma membrane  (IBA,IDA,IEA,ISO)
membrane  (IEA)
microvillus  (IEA,ISO)
proteasome complex  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The role of AP-1 in the transcriptional regulation of the rat apical sodium-dependent bile acid transporter. Chen F, etal., J Biol Chem 2001 Oct 19;276(42):38703-14.
2. Comparative analysis of the ontogeny of a sodium-dependent bile acid transporter in rat kidney and ileum. Christie DM, etal., Am J Physiol 1996 Aug;271(2 Pt 1):G377-85.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). Oelkers P, etal., J Clin Invest. 1997 Apr 15;99(8):1880-7.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter. Shneider BL, etal., J Clin Invest 1995 Feb;95(2):745-54.
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes. Xia X, etal., J Biol Chem. 2004 Oct 22;279(43):44931-7. Epub 2004 Aug 10.
Additional References at PubMed
PMID:15133850   PMID:15834929   PMID:16481392   PMID:16934605   PMID:20616306   PMID:21526375   PMID:23012479   PMID:23200860   PMID:23747249   PMID:28299817  


Genomics

Comparative Map Data
Slc10a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81691,088,089 - 91,111,025 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1691,076,423 - 91,111,025 (+)EnsemblGRCr8
mRatBN7.21684,386,528 - 84,409,475 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1684,374,862 - 84,409,475 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1689,642,557 - 89,665,103 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01693,095,100 - 93,117,661 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01688,368,950 - 88,391,491 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01690,324,420 - 90,350,254 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1690,324,361 - 90,345,865 (+)Ensemblrn6Rnor6.0
Rnor_5.01689,709,462 - 89,732,970 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41689,939,295 - 89,961,444 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1682,094,445 - 82,108,935 (+)NCBICelera
RGSC_v3.11689,925,334 - 90,169,172 (+)NCBI
Cytogenetic Map16q12.5NCBI
SLC10A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813103,043,998 - 103,066,417 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13103,043,998 - 103,066,417 (-)Ensemblhg38GRCh38
GRCh3713103,696,348 - 103,718,767 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613102,494,351 - 102,517,197 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3413102,494,350 - 102,517,197NCBI
Celera1384,540,839 - 84,563,679 (-)NCBICelera
Cytogenetic Map13q33.1NCBI
HuRef1384,288,627 - 84,311,468 (-)NCBIHuRef
CHM1_113103,665,790 - 103,688,632 (-)NCBICHM1_1
T2T-CHM13v2.013102,262,214 - 102,284,623 (-)NCBIT2T-CHM13v2.0
Slc10a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3985,133,219 - 5,155,287 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl85,133,219 - 5,155,351 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3885,083,219 - 5,105,287 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl85,083,219 - 5,105,351 (-)Ensemblmm10GRCm38
MGSCv3785,085,623 - 5,105,232 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3685,085,595 - 5,105,204 (-)NCBIMGSCv36mm8
Celera85,284,430 - 5,304,029 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map82.16NCBI
Slc10a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554048,122,119 - 8,137,236 (+)Ensembl
ChiLan1.0NW_0049554048,122,119 - 8,137,236 (+)NCBIChiLan1.0ChiLan1.0
SLC10A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214104,557,172 - 104,579,612 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113103,226,769 - 103,249,184 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01384,200,209 - 84,224,164 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113103,336,510 - 103,359,359 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13103,336,073 - 103,359,359 (-)EnsemblpanPan2panpan1.1
SLC10A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12252,523,679 - 52,541,976 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2252,523,568 - 52,541,976 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2252,303,382 - 52,321,688 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02252,971,496 - 52,989,910 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2252,971,385 - 52,989,910 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12252,623,655 - 52,642,062 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02252,641,492 - 52,659,869 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02252,682,501 - 52,700,845 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc10a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945187,883,292 - 187,899,366 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364728,052,789 - 8,068,863 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364728,052,789 - 8,069,085 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC10A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1171,327,017 - 71,348,757 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11171,328,801 - 71,348,779 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21178,617,382 - 78,629,178 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC10A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1381,608,394 - 81,630,170 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl381,607,276 - 81,629,719 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604638,148,726 - 38,170,077 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc10a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247938,452,727 - 8,468,661 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247938,452,536 - 8,468,835 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc10a2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11378,272,879 - 78,291,925 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:88
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000057310
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat

Markers in Region
D16Wox20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21684,406,888 - 84,406,996 (+)MAPPERmRatBN7.2
Rnor_6.01690,347,662 - 90,347,769NCBIRnor6.0
Rnor_5.01689,729,609 - 89,729,716UniSTSRnor5.0
RGSC_v3.41689,960,052 - 89,960,159UniSTSRGSC3.4
Celera1682,106,349 - 82,106,456UniSTS
Cytogenetic Map16q12.5UniSTS
D16Wox19  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81691,108,063 - 91,108,199 (+)Marker Load Pipeline
mRatBN7.21684,406,513 - 84,406,649 (+)MAPPERmRatBN7.2
Rnor_6.01690,347,287 - 90,347,422NCBIRnor6.0
Rnor_5.01689,729,234 - 89,729,369UniSTSRnor5.0
RGSC_v3.41689,959,677 - 89,959,812UniSTSRGSC3.4
Celera1682,105,974 - 82,106,109UniSTS
Cytogenetic Map16q12.5UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 2 21 32 30 28 1 28 1 117 6 18 74 38 2 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000057310   ⟹   ENSRNOP00000054127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1690,325,304 - 90,345,865 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081359   ⟹   ENSRNOP00000072918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1690,324,361 - 90,341,797 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100219   ⟹   ENSRNOP00000095418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1691,076,423 - 91,111,025 (+)Ensembl
mRatBN7.2 Ensembl1684,374,862 - 84,409,475 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113335   ⟹   ENSRNOP00000088268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1691,088,196 - 91,111,025 (+)Ensembl
mRatBN7.2 Ensembl1684,386,635 - 84,409,475 (+)Ensembl
RefSeq Acc Id: NM_017222   ⟹   NP_058918
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81691,088,089 - 91,111,025 (+)NCBI
mRatBN7.21684,386,528 - 84,409,475 (+)NCBI
Rnor_6.01690,325,197 - 90,350,254 (+)NCBI
Rnor_5.01689,709,462 - 89,732,970 (+)NCBI
RGSC_v3.41689,939,295 - 89,961,444 (+)RGD
Celera1682,094,445 - 82,108,935 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058918 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB84300 (Get FASTA)   NCBI Sequence Viewer  
  AAC53101 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000088268
  ENSRNOP00000088268.1
  ENSRNOP00000095418.1
GenBank Protein Q62633 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058918   ⟸   NM_017222
- UniProtKB: Q62633 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054127   ⟸   ENSRNOT00000057310
Ensembl Acc Id: ENSRNOP00000072918   ⟸   ENSRNOT00000081359
Ensembl Acc Id: ENSRNOP00000095418   ⟸   ENSRNOT00000100219
Ensembl Acc Id: ENSRNOP00000088268   ⟸   ENSRNOT00000113335

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62633-F1-model_v2 AlphaFold Q62633 1-348 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700253
Promoter ID:EPDNEW_R10777
Type:single initiation site
Name:Slc10a2_1
Description:solute carrier family 10 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01690,325,228 - 90,325,288EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3682 AgrOrtholog
BioCyc Gene G2FUF-10571 BioCyc
Ensembl Genes ENSRNOG00000037753 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000100219.1 UniProtKB/Swiss-Prot
  ENSRNOT00000113335 ENTREZGENE
  ENSRNOT00000113335.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1530.20 UniProtKB/Swiss-Prot
InterPro BilAc:Na_symport/Acr3 UniProtKB/Swiss-Prot
  Bilac:Na_transpt UniProtKB/Swiss-Prot
  Na+/solute_symporter_sf UniProtKB/Swiss-Prot
KEGG Report rno:29500 UniProtKB/Swiss-Prot
NCBI Gene 29500 ENTREZGENE
PANTHER PTHR10361 UniProtKB/Swiss-Prot
  PTHR10361:SF19 UniProtKB/Swiss-Prot
Pfam SBF UniProtKB/Swiss-Prot
PhenoGen Slc10a2 PhenoGen
RatGTEx ENSRNOG00000037753 RatGTEx
TIGR TC204104
UniProt NTCP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc10a2  solute carrier family 10 member 2  Slc10a2  solute carrier family 10 (sodium/bile acid cotransporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc10a2  solute carrier family 10 (sodium/bile acid cotransporter), member 2  Slc10a2  solute carrier family 10 (sodium/bile acid cotransporter family), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc10a2  solute carrier family 10 (sodium/bile acid cotransporter family), member 2  Slc10a2  solute carrier family 10, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Slc10a2  solute carrier family 10, member 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression found in the renal and bile duct epithelial cells 628456
gene_process involved in the intestinal reclamation of bile salts which are secreted by the liver 628456
gene_regulation transcription regulated by specific AP-1 element; down regulated by intestinal inflammation and upregulated by gluco-corticoid administration 628456
gene_transcript contains 6 exons and 5 introns, has two potential sites of transcription initiation 628456