Srsf5 (serine and arginine rich splicing factor 5) - Rat Genome Database

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Gene: Srsf5 (serine and arginine rich splicing factor 5) Rattus norvegicus
Analyze
Symbol: Srsf5
Name: serine and arginine rich splicing factor 5
RGD ID: 3664
Description: Enables RNA binding activity and protein kinase B binding activity. Involved in cellular response to insulin stimulus; liver regeneration; and positive regulation of RNA splicing. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nuclear speck. Orthologous to human SRSF5 (serine and arginine rich splicing factor 5); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: delayed-early protein HRS; HRS; insulin-induced growth response protein CL-4; pre-mRNA-splicing factor SRP40; serine/arginine-rich splicing factor 5; Sfrs5; splicing factor arginine/serine-rich 5 (SRp40 HRS); splicing factor, arginine/serine-rich 5; splicing factor, arginine/serine-rich 5 (SRp40, HRS); SRp40
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: LOC107305674  
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: Due to a potential assembly artifact, Rattus norvegicus Annotation Release 105 annotates the 5' end of this gene on chromosome 6 (NW_007905843.1) and the 3' end on chromosome 17 (NW_007906018.1) on Rnor_6.0. The correct location of this gene is on chromosome 6. [04 Mar 2016]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86106,333,998 - 106,341,467 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6106,336,756 - 106,341,931 (+)EnsemblGRCr8
mRatBN7.26100,605,165 - 100,610,192 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6100,605,456 - 100,610,177 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6100,766,147 - 100,770,857 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06101,065,329 - 101,070,039 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06100,445,515 - 100,450,226 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06104,611,026 - 104,640,033 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6104,611,026 - 104,615,302 (+)Ensemblrn6Rnor6.0
Rnor_5.01721,149,626 - 21,149,932 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.06112,776,230 - 112,805,142 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46104,728,286 - 104,732,982 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera698,461,136 - 98,465,890 (+)NCBICelera
RGSC_v3.16104,731,761 - 104,736,439 (+)NCBI
Cytogenetic Map6q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3',5'-cyclic UMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antimony(0)  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (EXP)
benzatropine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Butylbenzyl phthalate  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dabrafenib  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fipronil  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
FR900359  (ISO)
glyphosate  (EXP)
GSK690693  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
malathion  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrobenzenes  (EXP)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (EXP)
parathion-methyl  (EXP)
phenobarbital  (ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
quercetin  (EXP)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfasalazine  (EXP)
tetraphene  (ISO)
thiabendazole  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nuclear speck  (IBA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2. Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing. Diamond RH, etal., J Biol Chem 1993 Jul 15;268(20):15185-92.
3. Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals. Du K, etal., J Biol Chem. 1998 Dec 25;273(52):35208-15.
4. HRS/SRp40-mediated inclusion of the fibronectin EIIIB exon, a possible cause of increased EIIIB expression in proliferating liver. Du K, etal., Mol Cell Biol. 1997 Jul;17(7):4096-104.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Altered expression of heterogenous nuclear ribonucleoproteins and SR factors in human colon adenocarcinomas. Ghigna C, etal., Cancer Res. 1998 Dec 15;58(24):5818-24.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Cloning of rat Sertoli cell follicle-stimulating hormone primary response complementary deoxyribonucleic acid: regulation of TSC-22 gene expression. Hamil KG and Hall SH, Endocrinology 1994 Mar;134(3):1205-12.
9. Increased expression of SRp40 affecting CD44 splicing is associated with the clinical outcome of lymph node metastasis in human breast cancer. Huang CS, etal., Clin Chim Acta. 2007 Sep;384(1-2):69-74. Epub 2007 Jun 15.
10. Alterations in expression pattern of splicing factors in epithelial ovarian cancer and its clinical impact. Iborra S, etal., Int J Gynecol Cancer. 2013 Jul;23(6):990-6. doi: 10.1097/IGC.0b013e31829783e3.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells. Patel NA, etal., J Biol Chem. 2001 Jun 22;276(25):22648-54. Epub 2001 Mar 30.
13. Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40. Patel NA, etal., J Biol Chem. 2005 Apr 8;280(14):14302-9. Epub 2005 Jan 31.
14. Disturbed expression of splicing factors in renal cancer affects alternative splicing of apoptosis regulators, oncogenes, and tumor suppressors. Piekielko-Witkowska A, etal., PLoS One. 2010 Oct 27;5(10):e13690. doi: 10.1371/journal.pone.0013690.
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
17. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, etal., PLoS Genet. 2016 May 18;12(5):e1006074. doi: 10.1371/journal.pgen.1006074. eCollection 2016 May.
18. The spliceosome: design principles of a dynamic RNP machine. Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
19. Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver. Walsh CM, etal., J Biol Chem. 2013 Jan 25;288(4):2816-28. doi: 10.1074/jbc.M112.410803. Epub 2012 Dec 11.
Additional References at PubMed
PMID:8889548   PMID:9434190   PMID:15057822   PMID:15489334   PMID:15798186   PMID:18758164   PMID:22658674   PMID:22681889   PMID:25931508   PMID:30053369  


Genomics

Comparative Map Data
Srsf5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86106,333,998 - 106,341,467 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6106,336,756 - 106,341,931 (+)EnsemblGRCr8
mRatBN7.26100,605,165 - 100,610,192 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6100,605,456 - 100,610,177 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6100,766,147 - 100,770,857 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06101,065,329 - 101,070,039 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06100,445,515 - 100,450,226 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06104,611,026 - 104,640,033 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6104,611,026 - 104,615,302 (+)Ensemblrn6Rnor6.0
Rnor_5.01721,149,626 - 21,149,932 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.06112,776,230 - 112,805,142 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46104,728,286 - 104,732,982 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera698,461,136 - 98,465,890 (+)NCBICelera
RGSC_v3.16104,731,761 - 104,736,439 (+)NCBI
Cytogenetic Map6q24NCBI
SRSF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381469,767,142 - 69,772,005 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1469,726,893 - 69,773,904 (+)Ensemblhg38GRCh38
GRCh371470,233,859 - 70,238,722 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361469,303,582 - 69,308,475 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341469,303,562 - 69,308,474NCBI
Celera1450,297,941 - 50,302,834 (+)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1450,402,386 - 50,407,279 (+)NCBIHuRef
CHM1_11470,171,971 - 70,176,864 (+)NCBICHM1_1
T2T-CHM13v2.01463,934,566 - 63,979,677 (+)NCBIT2T-CHM13v2.0
Srsf5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391280,992,308 - 80,997,277 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1280,992,278 - 80,997,281 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381280,945,495 - 80,950,507 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1280,945,504 - 80,950,507 (+)Ensemblmm10GRCm38
MGSCv371282,046,491 - 82,051,494 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361281,865,424 - 81,869,347 (+)NCBIMGSCv36mm8
Celera1282,411,025 - 82,416,029 (+)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1237.2NCBI
Srsf5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955466612,221 - 617,753 (-)Ensembl
ChiLan1.0NW_004955466612,221 - 617,087 (-)NCBIChiLan1.0ChiLan1.0
SRSF5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21570,851,134 - 70,896,038 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11470,067,686 - 70,112,551 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01450,320,820 - 50,365,650 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11469,230,730 - 69,236,596 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1469,230,730 - 69,236,596 (+)EnsemblpanPan2panpan1.1
SRSF5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1843,514,048 - 43,519,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl843,514,076 - 43,518,481 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha843,202,998 - 43,207,951 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0843,742,032 - 43,746,990 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl843,742,032 - 43,746,989 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1843,356,400 - 43,361,355 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0843,430,128 - 43,435,082 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0843,790,108 - 43,795,064 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Srsf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864061,234,058 - 61,239,077 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649512,952,646 - 12,960,681 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649512,952,610 - 12,957,640 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRSF5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl793,393,426 - 93,403,011 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1793,393,379 - 93,398,510 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2799,667,698 - 99,676,353 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRSF5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12447,009,211 - 47,014,108 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2447,009,122 - 47,013,644 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605335,235,478 - 35,241,387 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srsf5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473431,309,656 - 31,314,891 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473431,309,647 - 31,314,923 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Srsf5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1795,166,954 - 95,171,666 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Srsf5
80 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:72
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000007583
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat

Markers in Region
A001W22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26100,609,900 - 100,610,044 (-)MAPPERmRatBN7.2
Rnor_6.01719,124,441 - 19,124,584NCBIRnor6.0
Rnor_5.01721,149,774 - 21,149,917UniSTSRnor5.0
RGSC_v3.46104,732,696 - 104,732,839UniSTSRGSC3.4
Celera698,465,599 - 98,465,742UniSTS
Cytogenetic Map6q24UniSTS
G19714  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26100,609,900 - 100,610,044 (-)MAPPERmRatBN7.2
Rnor_6.01719,124,441 - 19,124,584NCBIRnor6.0
Rnor_5.01721,149,774 - 21,149,917UniSTSRnor5.0
RGSC_v3.46104,732,696 - 104,732,839UniSTSRGSC3.4
Celera698,465,599 - 98,465,742UniSTS
Cytogenetic Map6q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001195505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001195506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAHX01045449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01045450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF020683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE115959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM049719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM059586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM081441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L13635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L33267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW395873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000007583   ⟹   ENSRNOP00000007583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6100,605,456 - 100,609,659 (+)Ensembl
Rnor_6.0 Ensembl6104,611,026 - 104,615,302 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107441   ⟹   ENSRNOP00000087250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6106,336,756 - 106,341,931 (+)Ensembl
mRatBN7.2 Ensembl6100,605,456 - 100,610,177 (+)Ensembl
RefSeq Acc Id: NM_001195505   ⟹   NP_001182434
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,336,756 - 106,341,467 (+)NCBI
mRatBN7.26100,605,481 - 100,610,192 (+)NCBI
Rnor_6.06104,611,026 - 104,640,033 (+)NCBI
Rnor_5.01721,149,626 - 21,149,932 (-)NCBI
Rnor_5.06112,776,230 - 112,805,142 (+)NCBI
Celera698,461,136 - 98,465,890 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001195506   ⟹   NP_001182435
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,336,756 - 106,341,467 (+)NCBI
mRatBN7.26100,605,481 - 100,610,192 (+)NCBI
Rnor_6.06104,611,026 - 104,640,033 (+)NCBI
Rnor_5.01721,149,626 - 21,149,932 (-)NCBI
Rnor_5.06112,776,230 - 112,805,142 (+)NCBI
Celera698,461,136 - 98,465,890 (+)NCBI
Sequence:
RefSeq Acc Id: NM_019257   ⟹   NP_062130
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,336,756 - 106,341,467 (+)NCBI
mRatBN7.26100,605,481 - 100,610,192 (+)NCBI
Rnor_6.06104,611,026 - 104,640,033 (+)NCBI
Rnor_5.01721,149,626 - 21,149,932 (-)NCBI
Rnor_5.06112,776,230 - 112,805,142 (+)NCBI
RGSC_v3.46104,728,286 - 104,732,982 (+)RGD
Celera698,461,136 - 98,465,890 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039111856   ⟹   XP_038967784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,333,998 - 106,341,467 (+)NCBI
mRatBN7.26100,605,165 - 100,610,192 (+)NCBI
RefSeq Acc Id: XM_039111857   ⟹   XP_038967785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,333,998 - 106,341,467 (+)NCBI
mRatBN7.26100,605,165 - 100,610,192 (+)NCBI
RefSeq Acc Id: XM_039111858   ⟹   XP_038967786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,333,998 - 106,341,467 (+)NCBI
mRatBN7.26100,605,165 - 100,610,192 (+)NCBI
RefSeq Acc Id: XM_039111859   ⟹   XP_038967787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,333,998 - 106,341,467 (+)NCBI
mRatBN7.26100,605,753 - 100,610,192 (+)NCBI
RefSeq Acc Id: XM_039111860   ⟹   XP_038967788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,338,824 - 106,341,467 (+)NCBI
mRatBN7.26100,607,548 - 100,610,192 (+)NCBI
RefSeq Acc Id: XM_063261587   ⟹   XP_063117657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,333,998 - 106,341,467 (+)NCBI
RefSeq Acc Id: XM_063261588   ⟹   XP_063117658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,338,824 - 106,341,467 (+)NCBI
RefSeq Acc Id: XM_063261589   ⟹   XP_063117659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,333,998 - 106,339,925 (+)NCBI
RefSeq Acc Id: XM_063261590   ⟹   XP_063117660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,333,998 - 106,339,925 (+)NCBI
RefSeq Acc Id: XM_063261591   ⟹   XP_063117661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,333,998 - 106,339,925 (+)NCBI
RefSeq Acc Id: XR_010052053
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86106,333,998 - 106,340,509 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001182434 (Get FASTA)   NCBI Sequence Viewer  
  NP_001182435 (Get FASTA)   NCBI Sequence Viewer  
  NP_062130 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967784 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967785 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967786 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967787 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967788 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117657 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117658 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117659 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117660 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117661 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42316 (Get FASTA)   NCBI Sequence Viewer  
  AAA62266 (Get FASTA)   NCBI Sequence Viewer  
  AAB71864 (Get FASTA)   NCBI Sequence Viewer  
  AAH58479 (Get FASTA)   NCBI Sequence Viewer  
  EDL81400 (Get FASTA)   NCBI Sequence Viewer  
  EDL81401 (Get FASTA)   NCBI Sequence Viewer  
  EDL81402 (Get FASTA)   NCBI Sequence Viewer  
  EDL81403 (Get FASTA)   NCBI Sequence Viewer  
  EDL81404 (Get FASTA)   NCBI Sequence Viewer  
  EDL81405 (Get FASTA)   NCBI Sequence Viewer  
  EDL81406 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000087250
  ENSRNOP00000087250.1
GenBank Protein Q09167 (Get FASTA)   NCBI Sequence Viewer  
  QST77903 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062130   ⟸   NM_019257
- UniProtKB: O35335 (UniProtKB/Swiss-Prot),   Q09167 (UniProtKB/Swiss-Prot),   A6JDK6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001182434   ⟸   NM_001195505
- UniProtKB: O35335 (UniProtKB/Swiss-Prot),   Q09167 (UniProtKB/Swiss-Prot),   A6JDK6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001182435   ⟸   NM_001195506
- UniProtKB: O35335 (UniProtKB/Swiss-Prot),   Q09167 (UniProtKB/Swiss-Prot),   A6JDK6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007583   ⟸   ENSRNOT00000007583
RefSeq Acc Id: XP_038967784   ⟸   XM_039111856
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967785   ⟸   XM_039111857
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967786   ⟸   XM_039111858
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967787   ⟸   XM_039111859
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q2R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967788   ⟸   XM_039111860
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000087250   ⟸   ENSRNOT00000107441
RefSeq Acc Id: XP_063117657   ⟸   XM_063261587
- Peptide Label: isoform X2
- UniProtKB: Q09167 (UniProtKB/Swiss-Prot),   O35335 (UniProtKB/Swiss-Prot),   A6JDK6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117661   ⟸   XM_063261591
- Peptide Label: isoform X5
- UniProtKB: A6JDK8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117659   ⟸   XM_063261589
- Peptide Label: isoform X5
- UniProtKB: A6JDK8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117660   ⟸   XM_063261590
- Peptide Label: isoform X5
- UniProtKB: A6JDK8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117658   ⟸   XM_063261588
- Peptide Label: isoform X4
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q09167-F1-model_v2 AlphaFold Q09167 1-269 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694710
Promoter ID:EPDNEW_R5226
Type:multiple initiation site
Name:Srsf5_1
Description:serine and arginine rich splicing factor 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06104,611,036 - 104,611,096EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3664 AgrOrtholog
BioCyc Gene G2FUF-36903 BioCyc
Ensembl Genes ENSRNOG00000005513 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000107441 ENTREZGENE
  ENSRNOT00000107441.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6920786 IMAGE-MGC_LOAD
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
  RRT5_SRSF_SR UniProtKB/Swiss-Prot
KEGG Report rno:29667 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72853 IMAGE-MGC_LOAD
NCBI Gene 29667 ENTREZGENE
PANTHER RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot
  SERINE AND ARGININE RICH SPLICING FACTOR 5 UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Srsf5 PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005513 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A8L2Q2R9 ENTREZGENE
  A6JDK6 ENTREZGENE, UniProtKB/TrEMBL
  A6JDK8 ENTREZGENE, UniProtKB/TrEMBL
  O35335 ENTREZGENE
  Q09167 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O35335 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Srsf5  serine and arginine rich splicing factor 5  Srsf5  serine/arginine-rich splicing factor 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Srsf5  serine/arginine-rich splicing factor 5  Sfrs5  splicing factor, arginine/serine-rich 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-22 Sfrs5  splicing factor, arginine/serine-rich 5  Srsf5  serine/arginine-rich splicing factor 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-13 Srsf5  serine/arginine-rich splicing factor 5  Sfrs5  splicing factor, arginine/serine-rich 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-20 Sfrs5  splicing factor, arginine/serine-rich 5  Srsf5  serine/arginine-rich splicing factor 5   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-14 Srsf5  serine/arginine-rich splicing factor 5   Sfrs5  splicing factor, arginine/serine-rich 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression is highly induced by insulin 729792