Scn2a (sodium voltage-gated channel alpha subunit 2) - Rat Genome Database

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Gene: Scn2a (sodium voltage-gated channel alpha subunit 2) Rattus norvegicus
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Symbol: Scn2a
Name: sodium voltage-gated channel alpha subunit 2
RGD ID: 3632
Description: Enables leucine zipper domain binding activity; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; and voltage-gated sodium channel activity. Involved in several processes, including cellular response to hypoxia; nervous system development; and neuronal action potential. Located in axon initial segment; node of Ranvier; and plasma membrane. Part of voltage-gated sodium channel complex. Human ortholog(s) of this gene implicated in benign familial infantile seizures 3; developmental and epileptic encephalopathy 11; and episodic ataxia type 9. Orthologous to human SCN2A (sodium voltage-gated channel alpha subunit 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alternative product; NachII; Nav1.2; RII/RIIA; RIIA sodium channel protein; RNSCPIIR; SCN; Scn2a1; Scn2a2; ScpII; sodium channel protein brain II subunit alpha; sodium channel protein type 2 subunit alpha; sodium channel protein type II subunit alpha; sodium channel protein, brain II subunit alpha; Sodium channel voltage-gated type II alpha polypeptide; sodium channel, voltage-gated, type 2, alpha 1 polypeptide; sodium channel, voltage-gated, type 2, alpha 1 subunit; sodium channel, voltage-gated, type II, alpha 1; Sodium channel, voltage-gated, type II, alpha polypeptide; sodium channel, voltage-gated, type II, alpha subunit; voltage-gated sodium channel subunit alpha Nav1.2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: Scn2aem1Mcwi   Scn2aem2Mcwi  
Genetic Models: LE-Scn2aem2Mcwi LE-Scn2aem1Mcwi
Is Marker For: QTLs:   BpQTLcluster4   Tsu1   Hrtrt17  
Candidate Gene For: Cia11 Hrtrt17
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8370,710,862 - 70,845,569 (+)NCBIGRCr8
mRatBN7.2350,302,781 - 50,437,504 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl350,302,877 - 50,437,214 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx353,646,466 - 53,788,492 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0362,230,075 - 62,372,108 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0360,013,503 - 60,148,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0351,687,910 - 51,822,008 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl351,687,809 - 51,822,250 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0358,322,640 - 58,456,658 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4347,588,413 - 47,722,800 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1347,484,784 - 47,619,172 (+)NCBI
Celera349,896,043 - 50,030,402 (+)NCBICelera
RH 3.4 Map3613.5RGD
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Scn2aRatbenign familial infantile seizures 3  ISOSCN2A (Homo sapiens)13207596DNA: missense mutation: exon 16 : p.N1001KRGD 
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Scn2aRatasphyxiating thoracic dystrophy  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: Jeune thoracic dystrophyClinVarPMID:15133511 more ...
Scn2aRatasphyxiating thoracic dystrophy 1  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: Chondroectodermal dysplasia-like syndromeClinVarPMID:15133511 more ...
Scn2aRatautism spectrum disorder  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:25741868 more ...
Scn2aRatautistic disorder  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:12610651 more ...
Scn2aRatbenign epilepsy with centrotemporal spikes  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: Rolandic epilepsyClinVarPMID:25741868 more ...
Scn2aRatbenign familial infantile epilepsy  ISOSCN2A (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11326335 more ...
Scn2aRatbenign familial infantile seizures 1  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: Seizures more ...ClinVarPMID:37578743
Scn2aRatbenign familial infantile seizures 3  ISOSCN2A (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11326335 more ...
Scn2aRatbenign familial neonatal epilepsy  ISOSCN2A (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15048894 more ...
Scn2aRatbenign familial neonatal epilepsy  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: Familial neonatal seizuresClinVarPMID:15048894 more ...
Scn2aRatbenign neonatal seizures  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: Benign Neonatal EpilepsyClinVarPMID:20371507 more ...
Scn2aRatdevelopmental and epileptic encephalopathy  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:15048894 more ...
Scn2aRatdevelopmental and epileptic encephalopathy 11  ISOSCN2A (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11326335 more ...
Scn2aRatdevelopmental and epileptic encephalopathy 12  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 12ClinVarPMID:25741868
Scn2aRatdevelopmental and epileptic encephalopathy 14  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant migrating partial seizures of infancyClinVarPMID:25741868
Scn2aRatdevelopmental and epileptic encephalopathy 30  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 30ClinVarPMID:23935176 more ...
Scn2aRatDevelopmental Disabilities  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVarPMID:28492532 and PMID:32581362
Scn2aRatDevelopmental Disease  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental disorderClinVarPMID:25741868 more ...
Scn2aRatDravet syndrome  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: Severe myoclonic epilepsy in infancyClinVar 
Scn2aRatdystonia 12  ISOSCN2A (Homo sapiens)8554872ClinVar Annotator: match by term: Dystonia 12ClinVarPMID:25741868
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Scn2aRatautistic disorder  ISOSCN2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35982159
Scn2aRatbenign familial infantile seizures 3  ISOSCN2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Scn2aRatbipolar disorder  ISOSCN2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31043756
Scn2aRatepilepsy  ISOSCN2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16464983 more ...
Scn2aRatFebrile Seizures  ISOSCN2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25344690
Scn2aRatNeurodevelopmental Disorders  ISOSCN2A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28191889 and PMID:29942082
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Scn2aRatautism spectrum disorder  ISSScn2a (Mus musculus)13592920 MouseDO 

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Scn2aRat(+)-catechin multiple interactionsISOSCN2A (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SCN2A mRNACTDPMID:24763279
Scn2aRat1,2-dimethylhydrazine decreases expressionISOScn2a (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of SCN2A mRNACTDPMID:22206623
Scn2aRat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of SCN2A mRNACTDPMID:30723492
Scn2aRat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOScn2a (Mus musculus)6480464[2 more ...CTDPMID:25510870
Scn2aRat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionEXP 64804642 more ...CTDPMID:21394737
Scn2aRat2,2',5,5'-tetrachlorobiphenyl decreases expressionEXP 64804642 more ...CTDPMID:23829299
Scn2aRat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOScn2a (Mus musculus)6480464[2 more ...CTDPMID:25510870
Scn2aRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOScn2a (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of SCN2A mRNACTDPMID:21354282
Scn2aRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of SCN2A mRNACTDPMID:33387578
Scn2aRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of SCN2A mRNACTDPMID:32109520
Scn2aRat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Scn2aRat2-methylcholine affects expressionISOSCN2A (Homo sapiens)6480464beta-methylcholine affects the expression of SCN2A mRNACTDPMID:21179406
Scn2aRat3',5'-cyclic AMP multiple interactionsISOSCN2A (Homo sapiens)6480464[BDNF protein co-treated with GDNF protein co-treated with Cyclic AMP co-treated with TGFB3 protein co-treated with Ascorbic Acid] results in increased expression of SCN2A mRNACTDPMID:33713149
Scn2aRat4,5,6,7-TETRABROMOBENZOTRIAZOLE multiple interactionsEXP 64804644 more ...CTDPMID:26917740
Scn2aRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of SCN2A mRNACTDPMID:24780913
Scn2aRataflatoxin B1 decreases methylationISOSCN2A (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of SCN2A geneCTDPMID:27153756
Scn2aRatall-trans-retinoic acid multiple interactionsISOSCN2A (Homo sapiens)6480464[Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3 more ...CTDPMID:23284745 and PMID:26655721
Scn2aRatall-trans-retinoic acid increases expressionISOSCN2A (Homo sapiens)6480464Tretinoin results in increased expression of SCN2A mRNACTDPMID:26655721
Scn2aRatarsenous acid increases expressionISOSCN2A (Homo sapiens)6480464Arsenic Trioxide results in increased expression of SCN2A mRNACTDPMID:26705709
Scn2aRatatrazine decreases expressionISOSCN2A (Homo sapiens)6480464Atrazine results in decreased expression of SCN2A mRNACTDPMID:22378314

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Biological Process
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Scn2aRataxon development  IEP 10411906 RGD 
Scn2aRatcellular response to hypoxia involved_inIDA 14390052PMID:28029095UniProt 
Scn2aRatcerebral cortex development  IEP 10411906 RGD 
Scn2aRatcorpus callosum development  IEP 10411906 RGD 
Scn2aRatdentate gyrus development acts_upstream_of_or_withinISOScn2a (Mus musculus)1624291MGI:1309503 PMID:16464983RGDPMID:16464983
Scn2aRatdetermination of adult lifespan acts_upstream_of_or_withinISOScn2a (Mus musculus)1624291MGI:1309503 more ...RGDPMID:21156207
Scn2aRatintrinsic apoptotic signaling pathway in response to osmotic stress acts_upstream_of_or_withinISSUniProtKB:B1AWN61600115GO_REF:0000024UniProtGO_REF:0000024
Scn2aRatintrinsic apoptotic signaling pathway in response to osmotic stress acts_upstream_of_or_withinISOScn2a (Mus musculus)1624291MGI:2180186 PMID:10827969RGDPMID:10827969
Scn2aRatmembrane depolarization during action potential involved_inIBAMGI:1345149 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Scn2aRatmemory involved_inISOScn2a (Mus musculus)1624291 PMID:29867081RGDPMID:29867081
Scn2aRatmemory involved_inISSUniProtKB:B1AWN61600115GO_REF:0000024UniProtGO_REF:0000024
Scn2aRatmonoatomic cation transmembrane transport involved_inIEAGO:00052611600115GO_REF:0000108GOCGO_REF:0000108
Scn2aRatmonoatomic ion transmembrane transport involved_inIEAUniProtKB-KW:KW-0407 and UniProtKB-KW:KW-08511600115GO_REF:0000043UniProtGO_REF:0000043
Scn2aRatmonoatomic ion transport involved_inIEAInterPro:IPR0058211600115GO_REF:0000002InterProGO_REF:0000002
Scn2aRatmonoatomic ion transport involved_inIEAUniProtKB-KW:KW-04061600115GO_REF:0000043UniProtGO_REF:0000043
Scn2aRatmyelination involved_inIEP 8553545PMID:16652168BHF-UCL 
Scn2aRatnerve development acts_upstream_of_or_withinISOScn2a (Mus musculus)1624291MGI:1309503 more ...RGDPMID:16464983 and PMID:21156207
Scn2aRatnervous system development acts_upstream_of_or_withinISSUniProtKB:B1AWN61600115GO_REF:0000024UniProtGO_REF:0000024
Scn2aRatnervous system development acts_upstream_of_or_withinISOScn2a (Mus musculus)1624291MGI:2180186 PMID:10827969RGDPMID:10827969
Scn2aRatneuron apoptotic process acts_upstream_of_or_withinISSUniProtKB:B1AWN61600115GO_REF:0000024UniProtGO_REF:0000024
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Cellular Component
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Scn2aRataxon  IDA 10411906MMO:0000686RGD 
Scn2aRataxon located_inISOScn2a (Mus musculus)1624291 PMID:17928448RGDPMID:17928448
Scn2aRataxon is_active_inIBAMGI:103169 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Scn2aRataxon initial segment  IDA 625497 RGD 
Scn2aRatglutamatergic synapse is_active_inISOScn2a (Mus musculus)1624291 PMID:22528969RGDPMID:22528969
Scn2aRatintercalated disc located_inISOScn2a (Mus musculus)1624291 PMID:15746173RGDPMID:15746173
Scn2aRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Scn2aRatmembrane located_inISOScn2a (Mus musculus)1624291 PMID:10827969 and PMID:17537961RGDPMID:10827969 and PMID:17537961
Scn2aRatmembrane located_inIEAInterPro:IPR0058211600115GO_REF:0000002InterProGO_REF:0000002
Scn2aRatmonoatomic ion channel complex part_ofIEAUniProtKB-KW:KW-08511600115GO_REF:0000043UniProtGO_REF:0000043
Scn2aRatnode of Ranvier located_inIDA 8553545PMID:16652168BHF-UCL 
Scn2aRatparanode region of axon located_inISOScn2a (Mus musculus)1624291 PMID:16723544RGDPMID:16723544
Scn2aRatplasma membrane is_active_inISOSCN2A (Homo sapiens)1624291 PMID:1325650 more ...RGDPMID:1325650 more ...
Scn2aRatplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Scn2aRatplasma membrane located_inIEAInterPro:IPR0432031600115GO_REF:0000002InterProGO_REF:0000002
Scn2aRatplasma membrane located_inISOScn2a (Mus musculus)1624291 PMID:10827969RGDPMID:10827969
Scn2aRatplasma membrane located_inIDA 8554774PMID:24297919UniProt 
Scn2aRatplasma membrane located_inIDA 14390052PMID:28029095UniProt 
Scn2aRatplasma membrane is_active_inIEAUniProtKB:Q99250 and ensembl:ENSP000003645861600115GO_REF:0000107EnsemblGO_REF:0000107
Scn2aRatplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
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Scn2aRatcalmodulin binding enablesIEAUniProtKB:Q99250 and ensembl:ENSP000003645861600115GO_REF:0000107EnsemblGO_REF:0000107
Scn2aRatcalmodulin binding enablesISOSCN2A (Homo sapiens)1624291 PMID:25232683RGDPMID:25232683
Scn2aRatleucine zipper domain binding  IPIAkap7 (Rattus norvegicus)2317301 RGD 
Scn2aRatmonoatomic cation channel activity enablesIEAInterPro:IPR0432031600115GO_REF:0000002InterProGO_REF:0000002
Scn2aRatmonoatomic ion channel activity enablesIEAInterPro:IPR0058211600115GO_REF:0000002InterProGO_REF:0000002
Scn2aRatprotein binding enablesIPIUniProtKB:P217078553647PMID:10737807IntAct 
Scn2aRatprotein binding enablesISOSCN2A (Homo sapiens)1624291UniProtKB:Q14576 and PMID:36950384RGDPMID:36950384
Scn2aRatprotein binding enablesIPIUniProtKB:P0746313432231PMID:21439835IntAct 
Scn2aRatsodium channel activity enablesIEAUniProtKB-KW:KW-08941600115GO_REF:0000043UniProtGO_REF:0000043
Scn2aRatvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential enablesIMP 13702364PMID:25615535SynGO 
Scn2aRatvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential enablesNAS 13702364PMID:25615535SynGO 
Scn2aRatvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential enablesIDA 13702364PMID:25615535SynGO 
Scn2aRatvoltage-gated sodium channel activity  ICGO:00192282289019 RGD 
Scn2aRatvoltage-gated sodium channel activity  IDA 1299025 RGD 
Scn2aRatvoltage-gated sodium channel activity enablesISOScn2a (Mus musculus)1624291 PMID:10827969RGDPMID:10827969
Scn2aRatvoltage-gated sodium channel activity enablesIEAUniProtKB:Q99250 and ensembl:ENSP000003645861600115GO_REF:0000107EnsemblGO_REF:0000107
Scn2aRatvoltage-gated sodium channel activity enablesIBAFB:FBgn0285944 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Scn2aRatvoltage-gated sodium channel activity enablesIEAInterPro:IPR001696 and InterPro:IPR0105261600115GO_REF:0000002InterProGO_REF:0000002
Scn2aRatvoltage-gated sodium channel activity enablesIDA 8554774PMID:24297919UniProt 
Scn2aRatvoltage-gated sodium channel activity enablesIDA 14390052PMID:28029095UniProt 
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Reference Title
Reference Citation
1. Interaction of the Nav1.2a subunit of the voltage-dependent sodium channel with nodal ankyrinG. In vitro mapping of the interacting domains and association in synaptosomes. Bouzidi M, etal., J Biol Chem 2002 Aug 9;277(32):28996-9004.
2. Structural and energetic determinants of apo calmodulin binding to the IQ motif of the Na(V)1.2 voltage-dependent sodium channel. Feldkamp MD, etal., Structure. 2011 May 11;19(5):733-47. doi: 10.1016/j.str.2011.02.009.
3. Dopamine modulation of neuronal Na(+) channels requires binding of A kinase-anchoring protein 15 and PKA by a modified leucine zipper motif. Few WP, etal., Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5187-92. Epub 2007 Mar 14.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Crystallographic insights into sodium-channel modulation by the beta4 subunit. Gilchrist J, etal., Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E5016-24. doi: 10.1073/pnas.1314557110. Epub 2013 Dec 2.
6. Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
7. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
8. Autosomal dominant epilepsy with febrile seizures plus with missense mutations of the (Na+)-channel alpha 1 subunit gene, SCN1A. Ito M, etal., Epilepsy Res 2002 Jan;48(1-2):15-23.
9. The Nav1.2 channel is regulated by GSK3. James TF, etal., Biochim Biophys Acta. 2015 Apr;1850(4):832-44. doi: 10.1016/j.bbagen.2015.01.011. Epub 2015 Jan 20.
10. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. Helix-stabilizing effects of the pentapeptide KIFMK and its related peptides on the sodium channel inactivation gate peptides. Maeda Y, etal., J Pept Res 2001 Nov;58(5):413-23.
12. Molecular diversity of voltage-gated sodium channel alpha subunits expressed in neuronal and non-neuronal excitable cells. Mechaly I, etal., Neuroscience. 2005;130(2):389-96.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Structure and function of sodium channel. Noda M and Numa S, J Recept Res 1987;7(1-4):467-97.
16. Structure and function of sodium channel. Noda M and Numa S, J Recept Res 1987;7(1-4):467-97.
17. Existence of distinct sodium channel messenger RNAs in rat brain. Noda M, etal., Nature 1986 Mar 13-19;320(6058):188-92.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons. Plant LD, etal., Elife. 2016 Dec 28;5. doi: 10.7554/eLife.20054.
20. Sodium currents in medullary neurons isolated from the pre-Botzinger complex region. Ptak K, etal., J Neurosci. 2005 May 25;25(21):5159-70.
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PMID:1299025   PMID:10827969   PMID:12829783   PMID:12930796   PMID:12967988   PMID:15548568   PMID:15746173   PMID:16596442   PMID:16723544   PMID:16815341   PMID:17021166   PMID:17537961  
PMID:17928448   PMID:19221510   PMID:19465131   PMID:19692609   PMID:19809503   PMID:20459109   PMID:21795675   PMID:22123950   PMID:22528969   PMID:22871113   PMID:23219908   PMID:23364266  
PMID:24737319   PMID:25724910   PMID:26039939   PMID:26259688   PMID:28256214   PMID:28343066   PMID:28758202   PMID:28916793   PMID:29867081   PMID:29956586   PMID:33051988  



Scn2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8370,710,862 - 70,845,569 (+)NCBIGRCr8
mRatBN7.2350,302,781 - 50,437,504 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl350,302,877 - 50,437,214 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx353,646,466 - 53,788,492 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0362,230,075 - 62,372,108 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0360,013,503 - 60,148,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0351,687,910 - 51,822,008 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl351,687,809 - 51,822,250 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0358,322,640 - 58,456,658 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4347,588,413 - 47,722,800 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1347,484,784 - 47,619,172 (+)NCBI
Celera349,896,043 - 50,030,402 (+)NCBICelera
RH 3.4 Map3613.5RGD
Cytogenetic Map3q21NCBI
SCN2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382165,239,414 - 165,392,304 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2165,194,993 - 165,392,310 (+)EnsemblGRCh38hg38GRCh38
GRCh372166,095,924 - 166,248,814 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362165,804,158 - 165,957,066 (+)NCBINCBI36Build 36hg18NCBI36
Build 342165,976,098 - 166,072,046NCBI
Celera2159,706,512 - 159,859,384 (+)NCBICelera
Cytogenetic Map2q24.3NCBI
HuRef2157,978,323 - 158,131,089 (+)NCBIHuRef
CHM1_12166,101,845 - 166,254,789 (+)NCBICHM1_1
T2T-CHM13v2.02165,696,714 - 165,849,575 (+)NCBIT2T-CHM13v2.0
Scn2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39265,451,108 - 65,597,791 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl265,451,115 - 65,597,791 (+)EnsemblGRCm39 Ensembl
GRCm38265,620,764 - 65,767,447 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl265,620,771 - 65,767,447 (+)EnsemblGRCm38mm10GRCm38
MGSCv37265,508,502 - 65,605,504 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36265,471,335 - 65,568,290 (+)NCBIMGSCv36mm8
Celera267,347,826 - 67,445,379 (+)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map238.61NCBI
Scn2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554498,721,784 - 8,846,200 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554498,722,043 - 8,846,165 (-)NCBIChiLan1.0ChiLan1.0
SCN2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21367,900,817 - 68,052,848 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B67,915,794 - 68,067,823 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B52,514,918 - 52,667,225 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B169,873,992 - 170,026,392 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B169,928,323 - 170,027,509 (+)Ensemblpanpan1.1panPan2
SCN2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13610,472,496 - 10,605,055 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3610,472,361 - 10,602,685 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3610,615,273 - 10,749,736 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03610,604,046 - 10,738,882 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3610,604,041 - 10,738,874 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13610,686,329 - 10,820,763 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03610,658,084 - 10,792,902 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03610,770,872 - 10,905,712 (+)NCBIUU_Cfam_GSD_1.0
Scn2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303127,536,296 - 127,745,013 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646913,872,701 - 13,971,005 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646913,872,701 - 14,019,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCN2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1571,864,784 - 71,999,211 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11571,864,753 - 71,999,219 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21580,349,224 - 80,429,339 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCN2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11050,717,264 - 50,886,079 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1050,717,271 - 50,888,145 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040148,625,514 - 148,788,747 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.

.
Variants in Scn2a
951 total Variants

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:70
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000007069
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 57 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat

1 to 10 of 57 rows
D3Mit8  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8370,710,756 - 70,710,963 (+)Marker Load Pipeline
mRatBN7.2350,302,679 - 50,302,886 (+)MAPPERmRatBN7.2
Rnor_6.0351,687,711 - 51,687,917NCBIRnor6.0
Rnor_5.0358,322,441 - 58,322,647UniSTSRnor5.0
RGSC_v3.4347,588,214 - 47,588,420UniSTSRGSC3.4
RGSC_v3.1347,484,585 - 47,484,792RGD
Celera349,895,844 - 49,896,050UniSTS
RH 3.4 Map3615.3UniSTS
RH 3.4 Map3615.3RGD
SHRSP x BN Map335.0198UniSTS
SHRSP x BN Map335.0198RGD
FHH x ACI Map336.02RGD
Cytogenetic Map3q24UniSTS
D3Wox9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2350,436,913 - 50,437,042 (+)MAPPERmRatBN7.2
Rnor_6.0351,821,710 - 51,821,836NCBIRnor6.0
Rnor_5.0358,456,360 - 58,456,486UniSTSRnor5.0
RGSC_v3.4347,722,501 - 47,722,628RGDRGSC3.4
RGSC_v3.4347,722,502 - 47,722,628UniSTSRGSC3.4
Celera350,030,104 - 50,030,230UniSTS
Cytogenetic Map3q24UniSTS
D3Wox10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2350,436,913 - 50,437,041 (+)MAPPERmRatBN7.2
Rnor_6.0351,821,710 - 51,821,835NCBIRnor6.0
Rnor_5.0358,456,360 - 58,456,485UniSTSRnor5.0
RGSC_v3.4347,722,501 - 47,722,627RGDRGSC3.4
RGSC_v3.4347,722,502 - 47,722,627UniSTSRGSC3.4
Celera350,030,104 - 50,030,229UniSTS
Cytogenetic Map3q24UniSTS
D3Wox14  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2350,436,785 - 50,437,053 (+)MAPPERmRatBN7.2
Rnor_6.0351,821,582 - 51,821,847NCBIRnor6.0
Rnor_5.0358,456,232 - 58,456,497UniSTSRnor5.0
RGSC_v3.4347,722,374 - 47,722,639UniSTSRGSC3.4
Celera350,029,976 - 50,030,241UniSTS
Cytogenetic Map3q24UniSTS
D3Arb7  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8370,844,979 - 70,845,227 (+)Marker Load Pipeline
mRatBN7.2350,436,912 - 50,437,162 (+)MAPPERmRatBN7.2
Rnor_6.0351,821,709 - 51,821,956NCBIRnor6.0
Rnor_5.0358,456,359 - 58,456,606UniSTSRnor5.0
RGSC_v3.4347,722,501 - 47,722,748UniSTSRGSC3.4
RGSC_v3.4347,722,500 - 47,722,748RGDRGSC3.4
RGSC_v3.1347,618,872 - 47,619,120RGD
Celera350,030,103 - 50,030,350UniSTS
RH 3.4 Map3614.1RGD
RH 3.4 Map3614.1UniSTS
RH 2.0 Map3405.1RGD
SHRSP x BN Map335.0198RGD
FHH x ACI Map334.98RGD
Cytogenetic Map3q24UniSTS
D3Rat240  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8370,752,912 - 70,753,137 (+)Marker Load Pipeline
mRatBN7.2350,344,842 - 50,345,069 (+)MAPPERmRatBN7.2
Rnor_6.0351,729,860 - 51,730,084NCBIRnor6.0
Rnor_5.0358,364,510 - 58,364,734UniSTSRnor5.0
RGSC_v3.4347,630,437 - 47,630,661UniSTSRGSC3.4
RGSC_v3.4347,630,436 - 47,630,661RGDRGSC3.4
RGSC_v3.1347,526,593 - 47,527,132RGD
Celera349,938,073 - 49,938,297UniSTS
FHH x ACI Map336.02UniSTS
FHH x ACI Map336.02RGD
Cytogenetic Map3q24UniSTS
RH94610  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2350,435,631 - 50,435,801 (+)MAPPERmRatBN7.2
Rnor_6.0351,820,428 - 51,820,597NCBIRnor6.0
Rnor_5.0358,455,078 - 58,455,247UniSTSRnor5.0
RGSC_v3.4347,721,220 - 47,721,389UniSTSRGSC3.4
Celera350,028,822 - 50,028,991UniSTS
RH 3.4 Map3613.5UniSTS
Cytogenetic Map3q24UniSTS
RH138915  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2350,413,356 - 50,413,550 (+)MAPPERmRatBN7.2
Rnor_6.0351,798,334 - 51,798,527NCBIRnor6.0
Rnor_5.0358,432,984 - 58,433,177UniSTSRnor5.0
RGSC_v3.4347,698,945 - 47,699,138UniSTSRGSC3.4
Celera350,006,547 - 50,006,740UniSTS
RH 3.4 Map3619.4UniSTS
Cytogenetic Map3q24UniSTS
Scn1a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2350,432,608 - 50,433,910 (+)MAPPERmRatBN7.2
Rnor_6.0351,817,586 - 51,818,887NCBIRnor6.0
Rnor_5.0358,452,236 - 58,453,537UniSTSRnor5.0
RGSC_v3.4347,718,197 - 47,719,498UniSTSRGSC3.4
Celera350,025,799 - 50,027,100UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map3q24UniSTS
Scn3a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2350,432,608 - 50,433,887 (+)MAPPERmRatBN7.2
Rnor_6.0351,817,586 - 51,818,864NCBIRnor6.0
Rnor_5.0358,452,236 - 58,453,514UniSTSRnor5.0
RGSC_v3.4347,718,197 - 47,719,475UniSTSRGSC3.4
Celera350,025,799 - 50,027,077UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map8q32UniSTS
Cytogenetic Map3q24UniSTS


This gene Scn2a is modified in the following models/strains:
LE-Scn2aem2Mcwi     LE-Scn2aem1Mcwi    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 67 66 35 25 35 6 192 96 93 44 60 31



Ensembl Acc Id: ENSRNOT00000007069   ⟹   ENSRNOP00000007069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl350,302,877 - 50,434,883 (+)Ensembl
Rnor_6.0 Ensembl351,737,904 - 51,819,679 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087242   ⟹   ENSRNOP00000072059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl350,302,877 - 50,437,214 (+)Ensembl
Rnor_6.0 Ensembl351,687,809 - 51,822,250 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098856   ⟹   ENSRNOP00000076431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl350,302,877 - 50,437,214 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108259   ⟹   ENSRNOP00000095098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl350,302,877 - 50,437,214 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118742   ⟹   ENSRNOP00000087779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl350,302,877 - 50,435,212 (+)Ensembl
RefSeq Acc Id: NM_012647   ⟹   NP_036779
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8370,710,956 - 70,845,279 (+)NCBI
mRatBN7.2350,302,879 - 50,437,214 (+)NCBI
Rnor_6.0351,687,910 - 51,822,008 (+)NCBI
Rnor_5.0358,322,640 - 58,456,658 (+)NCBI
RGSC_v3.4347,588,413 - 47,722,800 (+)RGD
Celera349,896,043 - 50,030,402 (+)RGD
Sequence:
RefSeq Acc Id: XM_063283105   ⟹   XP_063139175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8370,710,875 - 70,845,569 (+)NCBI
RefSeq Acc Id: XM_063283106   ⟹   XP_063139176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8370,710,862 - 70,845,569 (+)NCBI
RefSeq Acc Id: XM_063283107   ⟹   XP_063139177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8370,759,048 - 70,845,569 (+)NCBI
RefSeq Acc Id: NP_036779   ⟸   NM_012647
- UniProtKB: A0A8I5YBA6 (UniProtKB/TrEMBL),   A6HLX5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072059   ⟸   ENSRNOT00000087242
Ensembl Acc Id: ENSRNOP00000007069   ⟸   ENSRNOT00000007069
Ensembl Acc Id: ENSRNOP00000095098   ⟸   ENSRNOT00000108259
Ensembl Acc Id: ENSRNOP00000087779   ⟸   ENSRNOT00000118742
Ion transport   IQ   Sodium ion transport-associated   Voltage-gated Na+ ion channel cytoplasmic

Name Modeler Protein Id AA Range Protein Structure
AF-P04775-F1-model_v2 AlphaFold P04775 1-2005 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692106
Promoter ID:EPDNEW_R2629
Type:single initiation site
Name:Scn2a_1
Description:sodium voltage-gated channel alpha subunit 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0351,687,836 - 51,687,896EPDNEW


1 to 40 of 40 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-49554 BioCyc
Ensembl Genes ENSRNOG00000005018 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000087242 ENTREZGENE
  ENSRNOT00000098856 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.120.350 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
  iswi atpase UniProtKB/Swiss-Prot
InterPro Ion_trans_dom UniProtKB/Swiss-Prot
  IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot
  Na_channel_asu UniProtKB/Swiss-Prot
  Na_chnl_inactivation_gate UniProtKB/Swiss-Prot
  Na_trans_assoc UniProtKB/Swiss-Prot
  Na_trans_cytopl UniProtKB/Swiss-Prot
  VGCC_Ca_Na UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:24766 UniProtKB/Swiss-Prot
NCBI Gene 24766 ENTREZGENE
PANTHER PTHR10037 UniProtKB/Swiss-Prot
  SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA UniProtKB/Swiss-Prot
Pfam Ion_trans UniProtKB/Swiss-Prot
  Na_trans_assoc UniProtKB/Swiss-Prot
  Na_trans_cytopl UniProtKB/Swiss-Prot
PharmGKB SCN2A RGD
PhenoGen Scn2a PhenoGen
PRINTS NACHANNEL UniProtKB/Swiss-Prot
PROSITE PS50096 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005018 RatGTEx
SMART SM00015 UniProtKB/Swiss-Prot
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A0G2K207 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5YBA6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GFG6_RAT UniProtKB/TrEMBL
  A0A8I6GL05_RAT UniProtKB/TrEMBL
  A6HLX5 ENTREZGENE, UniProtKB/TrEMBL
  A9JQD7_RAT UniProtKB/TrEMBL
  F1M9G9_RAT UniProtKB/TrEMBL
  P04775 ENTREZGENE
  Q9ESV9_RAT UniProtKB/TrEMBL
  SCN2A_RAT UniProtKB/Swiss-Prot
1 to 40 of 40 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Scn2a  sodium voltage-gated channel alpha subunit 2  Scn2a  sodium channel, voltage-gated, type II, alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-13 Scn2a  sodium channel, voltage-gated, type II, alpha subunit  Scn2a1  sodium channel, voltage-gated, type II, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-31 Scn2a1  sodium channel, voltage-gated, type II, alpha 1  Scn2a1  sodium channel, voltage-gated, type 2, alpha 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-20 Scn2a1  sodium channel, voltage-gated, type 2, alpha 1 subunit  Scn2a1  sodium channel, voltage-gated, type 2, alpha 1 polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Scn2a1  sodium channel, voltage-gated, type 2, alpha 1 polypeptide      Name updated 70585 PROVISIONAL

Note Type Note Reference
gene_process responsible for generation and propagation of action potentials, chiefly in nerve and muscle 68844