Sag (S-antigen visual arrestin) - Rat Genome Database

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Gene: Sag (S-antigen visual arrestin) Rattus norvegicus
Analyze
Symbol: Sag
Name: S-antigen visual arrestin
RGD ID: 3619
Description: Enables spectrin binding activity. Predicted to be involved in G protein-coupled receptor internalization and sensory perception. Located in photoreceptor inner segment and photoreceptor outer segment. Human ortholog(s) of this gene implicated in Oguchi disease-1; hereditary night blindness; retinitis pigmentosa 47; and retinitis pigmentosa 96. Orthologous to human SAG (S-antigen visual arrestin); PARTICIPATES IN altered visual phototransduction pathway; retinitis pigmentosa pathway; visual phototransduction pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 48 kDa protein; retina and pineal gland (arrestin); retinal S-antigen; rod photoreceptor arrestin; S-AG; S-antigen; S-antigen; retina and pineal gland (arrestin); S-arrestin; SAGMR; SANTI
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8995,915,640 - 95,956,641 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl995,917,197 - 95,956,507 (+)EnsemblGRCr8
mRatBN7.2988,467,797 - 88,508,821 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,469,376 - 88,508,820 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx996,893,929 - 96,933,394 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09102,030,109 - 102,069,572 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,397,588 - 100,437,033 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0994,926,901 - 94,972,162 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl994,928,489 - 94,972,027 (+)Ensemblrn6Rnor6.0
Rnor_5.0994,646,333 - 94,691,522 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4986,759,933 - 86,799,902 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera254,322,671 - 54,345,084 (-)NCBICelera
Celera985,877,786 - 85,890,904 (+)NCBICelera
RGSC_v3.1986,944,774 - 86,983,310 (+)NCBI
Cytogenetic Map9q35NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
photoreceptor inner segment  (IBA,IDA,IEA,ISO)
photoreceptor outer segment  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rat pineal S-antigen: sequence analysis reveals presence of alpha-transducin homologous sequence. Abe T, etal., FEBS Lett 1989 Apr 24;247(2):307-11.
2. Photoreceptor signaling: supporting vision across a wide range of light intensities. Arshavsky VY and Burns ME, J Biol Chem. 2012 Jan 13;287(3):1620-6. Epub 2011 Nov 10.
3. Differential expression of mRNA and protein encoding retinal and pineal S-antigen during the light/dark cycle. Craft CM, etal., J Neurochem 1990 Nov;55(5):1461-73.
4. Genes and mutations causing retinitis pigmentosa. Daiger SP, etal., Clin Genet. 2013 Aug;84(2):132-41. doi: 10.1111/cge.12203. Epub 2013 Jun 19.
5. A homozygous 1-base pair deletion in the arrestin gene is a frequent cause of Oguchi disease in Japanese. Fuchs S, etal., Nat Genet 1995 Jul;10(3):360-2.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. The functional cycle of visual arrestins in photoreceptor cells. Gurevich VV, etal., Prog Retin Eye Res. 2011 Nov;30(6):405-30. Epub 2011 Jul 29.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. The giant spectrin betaV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Papal S, etal., Hum Mol Genet. 2013 Sep 15;22(18):3773-88. doi: 10.1093/hmg/ddt228. Epub 2013 May 23.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Photoreceptor function of retinal transplants implicated by light-dark shift of S-antigen and rod transducin. Seiler MJ, etal., Vision Res. 1999 Jul;39(15):2589-96.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Wright AF, etal., Nat Rev Genet. 2010 Apr;11(4):273-84. doi: 10.1038/nrg2717.
Additional References at PubMed
PMID:2373176   PMID:3720866   PMID:12486395   PMID:19332500   PMID:22869374  


Genomics

Comparative Map Data
Sag
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8995,915,640 - 95,956,641 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl995,917,197 - 95,956,507 (+)EnsemblGRCr8
mRatBN7.2988,467,797 - 88,508,821 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,469,376 - 88,508,820 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx996,893,929 - 96,933,394 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09102,030,109 - 102,069,572 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,397,588 - 100,437,033 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0994,926,901 - 94,972,162 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl994,928,489 - 94,972,027 (+)Ensemblrn6Rnor6.0
Rnor_5.0994,646,333 - 94,691,522 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4986,759,933 - 86,799,902 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera254,322,671 - 54,345,084 (-)NCBICelera
Celera985,877,786 - 85,890,904 (+)NCBICelera
RGSC_v3.1986,944,774 - 86,983,310 (+)NCBI
Cytogenetic Map9q35NCBI
SAG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382233,307,816 - 233,347,055 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2233,307,816 - 233,347,055 (+)Ensemblhg38GRCh38
GRCh372234,216,462 - 234,255,701 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362233,881,207 - 233,920,440 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342233,998,492 - 234,037,701NCBI
Celera2227,937,838 - 227,977,217 (+)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2226,017,093 - 226,056,496 (+)NCBIHuRef
CHM1_12234,222,389 - 234,261,775 (+)NCBICHM1_1
T2T-CHM13v2.02233,795,900 - 233,835,144 (+)NCBIT2T-CHM13v2.0
Sag
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39187,731,402 - 87,772,880 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl187,731,402 - 87,772,880 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38187,798,143 - 87,845,158 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl187,803,680 - 87,845,158 (+)Ensemblmm10GRCm38
MGSCv37189,700,255 - 89,741,732 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36189,634,851 - 89,676,328 (+)NCBIMGSCv36mm8
Celera190,761,584 - 90,803,003 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map144.44NCBI
Sag
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554532,844,925 - 2,878,846 (-)Ensembl
ChiLan1.0NW_0049554532,845,561 - 2,878,342 (-)NCBIChiLan1.0ChiLan1.0
SAG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213135,910,867 - 135,948,833 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B135,925,831 - 135,963,742 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B120,532,049 - 120,574,914 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B239,449,910 - 239,487,626 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B239,449,910 - 239,487,537 (+)EnsemblpanPan2panpan1.1
SAG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12544,800,141 - 44,843,580 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2544,812,362 - 44,843,579 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2545,307,685 - 45,338,815 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02545,060,350 - 45,103,430 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2545,072,284 - 45,103,429 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12544,996,643 - 45,027,722 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02544,842,616 - 44,873,724 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02544,997,874 - 45,029,086 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sag
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303186,974,069 - 187,007,603 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365253,931,933 - 3,964,834 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365253,932,118 - 3,965,651 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SAG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15133,705,008 - 133,741,798 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115133,704,975 - 133,741,844 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215147,580,489 - 147,592,533 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.215147,812,862 - 147,835,188 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SAG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110119,343,562 - 119,383,119 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10119,344,090 - 119,382,983 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604080,120,831 - 80,162,410 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sag
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248435,844,823 - 5,870,300 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248435,837,105 - 5,870,417 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sag
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14159,919,549 - 159,957,850 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sag
336 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:22
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000024733
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
D9Rat6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,507,055 - 88,507,212 (+)MAPPERmRatBN7.2
Rnor_6.0994,970,397 - 94,970,553NCBIRnor6.0
Rnor_5.0994,689,758 - 94,689,914UniSTSRnor5.0
RGSC_v3.4986,798,138 - 86,798,294UniSTSRGSC3.4
RGSC_v3.4986,797,847 - 86,798,339RGDRGSC3.4
Celera254,324,279 - 54,324,435UniSTS
RGSC_v3.1986,981,557 - 86,981,713RGD
RH 3.4 Map2363.51RGD
RH 3.4 Map2363.51UniSTS
RH 2.0 Map9866.0RGD
SHRSP x BN Map956.8299RGD
FHH x ACI Map959.98RGD
Cytogenetic Map9q35UniSTS
D9Wox29  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8995,949,385 - 95,949,506 (+)Marker Load Pipeline
mRatBN7.2988,501,564 - 88,501,966 (+)MAPPERmRatBN7.2
mRatBN7.2988,501,653 - 88,501,685 (+)MAPPERmRatBN7.2
mRatBN7.2988,501,564 - 88,501,685 (+)MAPPERmRatBN7.2
Rnor_6.0994,964,593 - 94,964,713NCBIRnor6.0
Rnor_6.0994,964,593 - 94,965,026NCBIRnor6.0
Rnor_5.0994,683,954 - 94,684,387UniSTSRnor5.0
Rnor_5.0994,683,954 - 94,684,074UniSTSRnor5.0
RGSC_v3.4986,792,647 - 86,792,767UniSTSRGSC3.4
Celera254,329,806 - 54,329,914UniSTS
Cytogenetic Map9q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 3 47 86 44 54 27 71 27 5 208 130 6 79 35 66 27 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000024733   ⟹   ENSRNOP00000024733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl988,469,376 - 88,508,820 (+)Ensembl
Rnor_6.0 Ensembl994,928,516 - 94,972,027 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085770   ⟹   ENSRNOP00000071579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl995,917,197 - 95,956,507 (+)Ensembl
mRatBN7.2 Ensembl988,469,376 - 88,508,686 (+)Ensembl
Rnor_6.0 Ensembl994,928,516 - 94,972,027 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087366   ⟹   ENSRNOP00000072320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl994,928,489 - 94,969,040 (+)Ensembl
RefSeq Acc Id: NM_013023   ⟹   NP_037155
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8995,917,197 - 95,956,641 (+)NCBI
mRatBN7.2988,469,376 - 88,508,820 (+)NCBI
Rnor_6.0994,927,066 - 94,972,161 (+)NCBI
Rnor_5.0994,646,333 - 94,691,522 (+)NCBI
RGSC_v3.4986,759,933 - 86,799,902 (+)RGD
Celera254,322,671 - 54,345,084 (-)NCBI
Celera985,877,786 - 85,890,904 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083069   ⟹   XP_038938997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8995,915,640 - 95,956,507 (+)NCBI
mRatBN7.2988,467,797 - 88,508,821 (+)NCBI
Protein Sequences
Protein RefSeqs NP_037155 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938997 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42107 (Get FASTA)   NCBI Sequence Viewer  
  CAA33412 (Get FASTA)   NCBI Sequence Viewer  
  CAA36076 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071579
  ENSRNOP00000071579.1
GenBank Protein P15887 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037155   ⟸   NM_013023
- UniProtKB: P15887 (UniProtKB/Swiss-Prot),   R4GNK4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024733   ⟸   ENSRNOT00000024733
Ensembl Acc Id: ENSRNOP00000072320   ⟸   ENSRNOT00000087366
Ensembl Acc Id: ENSRNOP00000071579   ⟸   ENSRNOT00000085770
RefSeq Acc Id: XP_038938997   ⟸   XM_039083069
- Peptide Label: isoform X1
- UniProtKB: P15887 (UniProtKB/Swiss-Prot),   R4GNK4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15887-F1-model_v2 AlphaFold P15887 1-403 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3619 AgrOrtholog
BioCyc Gene G2FUF-26832 BioCyc
Ensembl Genes ENSRNOG00000018185 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000085770 ENTREZGENE
  ENSRNOT00000085770.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.640 UniProtKB/Swiss-Prot
  2.60.40.840 UniProtKB/Swiss-Prot
InterPro Arrestin UniProtKB/Swiss-Prot
  Arrestin-like_N UniProtKB/Swiss-Prot
  Arrestin_C UniProtKB/Swiss-Prot
  Arrestin_C-like UniProtKB/Swiss-Prot
  Arrestin_CS UniProtKB/Swiss-Prot
  Arrestin_N UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
KEGG Report rno:25539 UniProtKB/Swiss-Prot
NCBI Gene 25539 ENTREZGENE
PANTHER PTHR11792 UniProtKB/Swiss-Prot
  S-ARRESTIN UniProtKB/Swiss-Prot
Pfam Arrestin_C UniProtKB/Swiss-Prot
  Arrestin_N UniProtKB/Swiss-Prot
PhenoGen Sag PhenoGen
PRINTS ARRESTIN UniProtKB/Swiss-Prot
PROSITE ARRESTINS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018185 RatGTEx
SMART Arrestin_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot
TIGR TC218978
UniProt ARRS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  R4GNK4 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-09-26 Sag  S-antigen visual arrestin  Sag  S-antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-09-22 Sag  S-antigen  Sag  S-antigen; retina and pineal gland (arrestin)  Name changed 629549 APPROVED
2008-09-18 Sag  S-antigen; retina and pineal gland (arrestin)  Sag  retinal S-antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sag  S-antigen      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutations of the human homolog are detected in Oguchi disease, a rare autosomal recessive form of congenital stationary night blindness 734491