Rock2 Rat Gene (Rho-associated coiled-coil containing protein kinase 2)

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Keyword

Gene:
Rock2 ( Rattus norvegicus )
Rho-associated coiled-coil containing protein kinase 2
Description: a Rho kinase that is involved in inducing membrane blebbing and chromatin condensation
Synonyms: ROK; Rho-associated coiled-coil forming kinase 2; RhoA - binding serine/threosine kinase alpha (ROK - alpha);
ArrayIDs: 6283787; 6041957; 6346261; 6708000; 1387379_at; 6144064; 6320977; 6181398; 6383458; 5908330; 6410129; U38481_at; 5821112; 6524206; rc_AA891595_at; 5632863; A_43_P15257; 5777235; 6233356; 6633215; A_44_P101644; 1393045_at; GE20122; 6075229; 6076227; 6207663; 6723269; 5952000; 6570780; 6440563; 6610145; 6303602; 5782356; 5945581; 6210287; 5855055; 6202671; 6271565; 6188707; A_44_P163519; 6643956; 5678114; 5820296;  (details...)
Gene Type: protein-coding

Additional Data

Homologs
Homo sapiens: ROCK2     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Rock2     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Rock2 genome assembly 3.1 6 40584199 - 40675807
Rat Celera Assembly 6 38987591 - 39079140
RGSC genome assembly v3.4 6 40581248 - 40672854
Cytogenetic 6 q15-q16
Mus musculus Rock2 Mouse genome assembly build 36.1 12 16901784 - 16995080
Cytogenetic 12 12 A3
Homo sapiens ROCK2 human genome assembly 2 11272375 - 11435309
Human genome assembly build 36.2 2 11239229 - 11402162
Cytogenetic 2 p24

View comparative maps:      NCBI MapViewer

Genome
View:

Browsers:

Annotation
Molecular Function

Gene Ontology

zinc ion binding,  nucleotide binding,  kinase activity ... (details...)
Biological Process

Gene Ontology

chromosome condensation,  actin cytoskeleton organization,  protein amino acid phosphorylation ... (details...)
Cellular Component

Gene Ontology

cytoplasm,  plasma membrane,  spindle pole centrosome ... (details...)
Disease

Ontology

Hypertrophy, Left Ventricular (details...)
Physical interaction

Note Reference

binds RhoA, RhoB, and RhoC but not Rac1 and Cdc42 633784

External Links
Databases
DATABASE ID SOURCE
UNIPARC: UPI0001B7AE03 IPI
UNIPARC: UPI0001B7ADE8 IPI
KEGG Report: rno:25537 ENTREZGENE
HomoloGene Group ID: 21010 ENTREZGENE
Germonline: 3590
KEGG Pathway: 04810 ENTREZGENE
KEGG Pathway: 04360 ENTREZGENE
KEGG Pathway: 04062 ENTREZGENE
KEGG Pathway: 04510 ENTREZGENE
KEGG Pathway: 04670 ENTREZGENE
KEGG Pathway: 04350 ENTREZGENE
KEGG Pathway: 04270 ENTREZGENE
KEGG Pathway: 04310 ENTREZGENE
IPI: IPI00950467 IPI
IPI: IPI00565862 IPI
Ensembl Protein: ENSRNOP00000063773 IPI
Ensembl Protein: ENSRNOP00000006403 IPI
Entrez Gene: Rock2 ENTREZGENE
TIGR: TC205230
UniProt: ROCK2_RAT IPI
Ensembl Genes: ENSRNOG00000004496 IPI
RatMap: 41422 ENTREZGENE
Sequences
Nucleotide: U38481 Get FASTA Search GEO Profiles
Nucleotide: NM_013022 Get FASTA Search GEO Profiles
Nucleotide: CH473947 Get FASTA Search GEO Profiles
(View all 3 Nucleotide Accessions)
Protein: NP_037154 Get FASTA
Protein: Q62868 Get FASTA
Protein: AAB37540 Get FASTA
Protein: EDM03141 Get FASTA
(View all 4 Protein Accessions)
Clusters
UniGene: 88642

References
Curated References
10 references in RGD related to Rock2

Other References
22 other references at PubMed related to Rock2

Database Information
RGD ID 3590
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

15-FEB-08: Rock2 Rho-associated coiled-coil containing protein kinase 2 Rock2 Rho-associated coiled-coil forming kinase 2 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863

10-JUN-02: Rock2 RhoA - binding serine/threosine kinase alpha (ROK - alpha) APPROVED Symbol and Name status set to approved 70586