Rock2 (Rho-associated coiled-coil containing protein kinase 2) - Rat Genome Database

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Gene: Rock2 (Rho-associated coiled-coil containing protein kinase 2) Rattus norvegicus
Analyze
Symbol: Rock2
Name: Rho-associated coiled-coil containing protein kinase 2
RGD ID: 3590
Description: Predicted to enable Rho-dependent protein serine/threonine kinase activity; endopeptidase activator activity; and protease binding activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of connective tissue replacement; and positive regulation of cytokine production. Acts upstream of or within Rho protein signal transduction. Predicted to be located in cytoplasmic ribonucleoprotein granule and spindle pole centrosome. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Biomarker of primary biliary cholangitis. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2); PARTICIPATES IN chemokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; Wnt signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: p150 ROK-alpha; p164 ROCK-2; Rho-associated coiled-coil forming kinase 2; rho-associated protein kinase 2; rho-associated, coiled-coil-containing protein kinase 2; rho-associated, coiled-coil-containing protein kinase II; RhoA - binding serine/threosine kinase alpha (ROK - alpha); rhoA-binding kinase 2; ROCK-II; ROK; ROKalpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8645,407,823 - 45,502,773 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl645,407,965 - 45,502,771 (+)EnsemblGRCr8
mRatBN7.2639,679,116 - 39,774,033 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl639,679,082 - 39,774,031 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx640,012,204 - 40,106,584 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0640,326,914 - 40,421,294 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0639,760,198 - 39,854,585 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0642,180,864 - 42,289,910 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl642,180,894 - 42,289,908 (+)Ensemblrn6Rnor6.0
Rnor_5.0651,900,048 - 52,009,234 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4640,581,247 - 40,672,854 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera638,987,591 - 39,082,080 (+)NCBICelera
RGSC_v3.1640,584,199 - 40,675,807 (+)NCBI
Cytogenetic Map6q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
Alkannin  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
BQ 123  (EXP)
Brodifacoum  (EXP)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
emodin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fasudil  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
genistein  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
GSK-J4  (ISO)
guanosine 5'-[gamma-thio]triphosphate  (EXP)
hexadecanoic acid  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
methylmercury(1+)  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
nitrates  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
oroxylin A  (EXP)
ouabain  (ISO)
oxybenzone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
potassium chromate  (ISO)
quercetin  (EXP,ISO)
raloxifene  (EXP)
ramipril  (EXP)
resveratrol  (EXP,ISO)
rhosin  (ISO)
Sanggenon C  (EXP)
sevoflurane  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
Thrombin  (EXP)
tipifarnib  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
Y-27632  (EXP,ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO)
actomyosin structure organization  (IBA)
aortic valve morphogenesis  (ISO)
blood vessel diameter maintenance  (ISO)
cellular response to acetylcholine  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
centrosome duplication  (IEA,ISO)
chromosome condensation  (TAS)
cortical actin cytoskeleton organization  (IBA)
dendrite morphogenesis  (ISO)
embryonic morphogenesis  (IBA)
epithelial to mesenchymal transition  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
host-mediated perturbation of viral process  (IEA)
mitotic cytokinesis  (IBA)
mRNA destabilization  (ISO)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of bicellular tight junction assembly  (IEA,ISO)
negative regulation of biomineral tissue development  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of nitric oxide biosynthetic process  (IEA,ISO)
negative regulation of protein localization to lysosome  (IEA,ISO)
neural tube closure  (ISO)
positive regulation of amyloid precursor protein catabolic process  (IEA,ISO)
positive regulation of amyloid-beta formation  (IEA,ISO)
positive regulation of cardiac muscle hypertrophy  (IEA,IMP,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of centrosome duplication  (IEA,ISO)
positive regulation of connective tissue growth factor production  (IMP)
positive regulation of connective tissue replacement  (IEA,IMP,ISO)
positive regulation of fibroblast growth factor production  (IMP)
positive regulation of gene expression  (IEA,IMP,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of protein localization to early endosome  (IEA,ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of stress fiber assembly  (IEA,ISO)
postsynaptic actin cytoskeleton organization  (ISO)
protein localization to plasma membrane  (IEA,ISO)
protein phosphorylation  (ISO)
regulation of actin cytoskeleton organization  (IBA,IEA)
regulation of angiotensin-activated signaling pathway  (ISO)
regulation of cell junction assembly  (IBA)
regulation of cellular response to hypoxia  (ISO)
regulation of circadian rhythm  (ISO,ISS)
regulation of establishment of endothelial barrier  (IEA,ISO)
regulation of keratinocyte differentiation  (IEA,ISO)
regulation of nervous system process  (ISO)
regulation of synapse maturation  (ISO)
response to angiotensin  (ISO)
response to ischemia  (ISO)
response to transforming growth factor beta  (IEA,IGI,ISO)
Rho protein signal transduction  (IBA,IEA,IMP,ISO)
rhythmic process  (IEA)
signal transduction  (IEA)
smooth muscle contraction  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Re-expression of proteins involved in cytokinesis during cardiac hypertrophy. Ahuja P, etal., Exp Cell Res. 2007 Apr 1;313(6):1270-83. Epub 2007 Jan 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate. Jeon S, etal., J Biol Chem 2002 May 10;277(19):16576-84.
5. A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes. Leung T, etal., J Biol Chem 1995 Dec 8;270(49):29051-4.
6. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Leung T, etal., Mol Cell Biol 1996 Oct;16(10):5313-27.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Ogata T, etal., Mol Cell Biol. 2008 May;28(10):3424-36. doi: 10.1128/MCB.02186-07. Epub 2008 Mar 10.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction. Shimizu T, etal., JCI Insight. 2017 Jul 6;2(13). pii: 93187. doi: 10.1172/jci.insight.93187.
15. ROCK-II-induced membrane blebbing and chromatin condensation require actin cytoskeleton. Song Y, etal., Exp Cell Res 2002 Aug 1;278(1):45-52.
16. Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase. Tan I, etal., FEBS Lett. 2011 May 6;585(9):1260-8. doi: 10.1016/j.febslet.2011.03.054. Epub 2011 Mar 30.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Intrahepatic upregulation of RhoA and Rho-kinase signalling contributes to increased hepatic vascular resistance in rats with secondary biliary cirrhosis. Zhou Q, etal., Gut. 2006 Sep;55(9):1296-305. Epub 2006 Feb 21.
Additional References at PubMed
PMID:8889548   PMID:9353125   PMID:11739394   PMID:12506136   PMID:12902637   PMID:15121898   PMID:15310556   PMID:16141308   PMID:16249236   PMID:16365167   PMID:16396994   PMID:16574662  
PMID:17015463   PMID:17065553   PMID:17220176   PMID:17229766   PMID:17379756   PMID:17468135   PMID:17720771   PMID:18167063   PMID:18524939   PMID:18555800   PMID:18559669   PMID:18621909  
PMID:18640982   PMID:18718479   PMID:19131646   PMID:19181962   PMID:19222995   PMID:19376974   PMID:19391109   PMID:19746421   PMID:19997641   PMID:20232393   PMID:20889845   PMID:20970835  
PMID:21147781   PMID:21411727   PMID:21545816   PMID:22031832   PMID:22136148   PMID:22479572   PMID:22681889   PMID:22727353   PMID:23172836   PMID:23258382   PMID:23365224   PMID:23402758  
PMID:23530857   PMID:23641788   PMID:23826343   PMID:23891689   PMID:24036111   PMID:24065547   PMID:24305806   PMID:24466133   PMID:24699328   PMID:24792035   PMID:24832597   PMID:25243430  
PMID:25260465   PMID:25761652   PMID:25816133   PMID:25959411   PMID:26169356   PMID:26191148   PMID:26194354   PMID:26391686   PMID:26634652   PMID:27288754   PMID:27333569   PMID:28469189  
PMID:28657365   PMID:28820400   PMID:29219181   PMID:29353861   PMID:29791873   PMID:30053369   PMID:30363018   PMID:30747210   PMID:31825931   PMID:32308124   PMID:32386193   PMID:32485129  
PMID:32813542   PMID:37096660  


Genomics

Comparative Map Data
Rock2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8645,407,823 - 45,502,773 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl645,407,965 - 45,502,771 (+)EnsemblGRCr8
mRatBN7.2639,679,116 - 39,774,033 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl639,679,082 - 39,774,031 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx640,012,204 - 40,106,584 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0640,326,914 - 40,421,294 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0639,760,198 - 39,854,585 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0642,180,864 - 42,289,910 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl642,180,894 - 42,289,908 (+)Ensemblrn6Rnor6.0
Rnor_5.0651,900,048 - 52,009,234 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4640,581,247 - 40,672,854 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera638,987,591 - 39,082,080 (+)NCBICelera
RGSC_v3.1640,584,199 - 40,675,807 (+)NCBI
Cytogenetic Map6q16NCBI
ROCK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38211,179,759 - 11,345,437 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl211,179,759 - 11,348,330 (-)Ensemblhg38GRCh38
GRCh37211,319,885 - 11,485,563 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36211,239,229 - 11,402,162 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34211,272,375 - 11,435,309NCBI
Celera211,237,615 - 11,400,586 (-)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef211,171,519 - 11,335,102 (-)NCBIHuRef
CHM1_1211,251,294 - 11,414,170 (-)NCBICHM1_1
T2T-CHM13v2.0211,212,159 - 11,378,745 (-)NCBIT2T-CHM13v2.0
Rock2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391216,944,808 - 17,038,275 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1216,944,896 - 17,037,824 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381216,894,978 - 16,988,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1216,894,895 - 16,987,823 (+)Ensemblmm10GRCm38
MGSCv371216,901,784 - 16,995,080 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361216,920,670 - 17,003,586 (+)NCBIMGSCv36mm8
Celera1217,218,328 - 17,311,507 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map128.04NCBI
Rock2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554875,859,204 - 5,972,401 (-)Ensembl
ChiLan1.0NW_0049554875,856,190 - 5,972,408 (-)NCBIChiLan1.0ChiLan1.0
ROCK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212115,184,603 - 115,347,775 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A115,188,575 - 115,351,748 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A11,167,353 - 11,331,339 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A11,316,755 - 11,478,986 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A11,318,370 - 11,478,986 (-)EnsemblpanPan2panpan1.1
ROCK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1177,931,786 - 8,012,484 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl177,934,739 - 8,178,707 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha177,863,769 - 8,005,135 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0178,035,035 - 8,176,737 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl178,037,253 - 8,177,067 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1177,920,092 - 8,061,813 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0177,923,254 - 8,065,610 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0177,943,547 - 8,085,045 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rock2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629252,387,532 - 52,529,676 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365327,145,882 - 7,286,244 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365327,142,580 - 7,284,722 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ROCK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3125,352,920 - 125,493,362 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13125,353,063 - 125,493,368 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23134,221,182 - 134,297,878 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ROCK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11496,275,889 - 96,443,048 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1496,276,023 - 96,432,790 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604515,835,723 - 16,002,638 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rock2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248654,461,215 - 4,588,836 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248654,461,200 - 4,591,309 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rock2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1736,704,377 - 36,798,321 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rock2
445 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:103
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000006403
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)64005241156848866Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63902865963457441Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)63332884178328841Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)63332884178328841Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat

Markers in Region
D6Rat34  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8645,443,294 - 45,443,466 (+)Marker Load Pipeline
mRatBN7.2639,714,550 - 39,714,722 (+)MAPPERmRatBN7.2
Rnor_6.0642,230,436 - 42,230,607NCBIRnor6.0
Rnor_5.0651,949,590 - 51,949,761UniSTSRnor5.0
RGSC_v3.4640,616,049 - 40,616,221RGDRGSC3.4
RGSC_v3.4640,616,050 - 40,616,221UniSTSRGSC3.4
Celera639,022,855 - 39,023,026UniSTS
RGSC_v3.1640,619,003 - 40,619,174RGD
RH 3.4 Map6179.0UniSTS
RH 3.4 Map6179.0RGD
RH 2.0 Map6341.7RGD
SHRSP x BN Map633.0298RGD
Cytogenetic Map6q15-q16UniSTS
AW823633  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8645,502,441 - 45,502,574 (+)Marker Load Pipeline
mRatBN7.2639,773,701 - 39,773,833 (+)MAPPERmRatBN7.2
Rnor_6.0642,289,579 - 42,289,710NCBIRnor6.0
Rnor_5.0652,008,903 - 52,009,034UniSTSRnor5.0
RGSC_v3.4640,675,463 - 40,675,594UniSTSRGSC3.4
Celera639,081,749 - 39,081,880UniSTS
Cytogenetic Map6q15-q16UniSTS
AW531154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2639,766,688 - 39,766,898 (+)MAPPERmRatBN7.2
Rnor_6.0642,282,566 - 42,282,775NCBIRnor6.0
Rnor_5.0652,001,890 - 52,002,099UniSTSRnor5.0
RGSC_v3.4640,668,450 - 40,668,659UniSTSRGSC3.4
Celera639,074,736 - 39,074,945UniSTS
RH 3.4 Map6181.0UniSTS
Cytogenetic Map6q15-q16UniSTS
RH143143  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2639,733,600 - 39,733,864 (+)MAPPERmRatBN7.2
Rnor_6.0642,249,477 - 42,249,740NCBIRnor6.0
Rnor_5.0651,968,801 - 51,969,064UniSTSRnor5.0
RGSC_v3.4640,635,361 - 40,635,624UniSTSRGSC3.4
Celera639,041,920 - 39,042,183UniSTS
RH 3.4 Map6178.9UniSTS
Cytogenetic Map6q15-q16UniSTS
BI279627  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2639,773,561 - 39,773,775 (+)MAPPERmRatBN7.2
Rnor_6.0642,289,439 - 42,289,652NCBIRnor6.0
Rnor_5.0652,008,763 - 52,008,976UniSTSRnor5.0
RGSC_v3.4640,675,323 - 40,675,536UniSTSRGSC3.4
Celera639,081,609 - 39,081,822UniSTS
RH 3.4 Map6181.1UniSTS
Cytogenetic Map6q15-q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000006403   ⟹   ENSRNOP00000006403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl645,408,116 - 45,494,213 (+)Ensembl
mRatBN7.2 Ensembl639,679,371 - 39,766,576 (+)Ensembl
Rnor_6.0 Ensembl642,180,894 - 42,286,970 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090816   ⟹   ENSRNOP00000073496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl645,408,116 - 45,502,771 (+)Ensembl
mRatBN7.2 Ensembl639,679,371 - 39,774,031 (+)Ensembl
Rnor_6.0 Ensembl642,180,894 - 42,289,908 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109820   ⟹   ENSRNOP00000091227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl645,407,965 - 45,502,771 (+)Ensembl
mRatBN7.2 Ensembl639,679,082 - 39,774,031 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119147   ⟹   ENSRNOP00000088194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl645,408,116 - 45,497,656 (+)Ensembl
mRatBN7.2 Ensembl639,679,371 - 39,772,743 (+)Ensembl
RefSeq Acc Id: NM_013022   ⟹   NP_037154
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,408,116 - 45,502,773 (+)NCBI
mRatBN7.2639,679,371 - 39,774,033 (+)NCBI
Rnor_6.0642,180,894 - 42,289,910 (+)NCBI
Rnor_5.0651,900,048 - 52,009,234 (+)NCBI
RGSC_v3.4640,581,247 - 40,672,854 (+)RGD
Celera638,987,591 - 39,082,080 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239909   ⟹   XP_006239971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,407,823 - 45,502,755 (+)NCBI
mRatBN7.2639,679,419 - 39,774,020 (+)NCBI
Rnor_6.0642,180,942 - 42,289,896 (+)NCBI
Rnor_5.0651,900,048 - 52,009,234 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039111810   ⟹   XP_038967738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8645,473,437 - 45,502,755 (+)NCBI
mRatBN7.2639,715,390 - 39,774,020 (+)NCBI
Protein Sequences
Protein RefSeqs NP_037154 (Get FASTA)   NCBI Sequence Viewer  
  XP_006239971 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967738 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB37540 (Get FASTA)   NCBI Sequence Viewer  
  EDM03141 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073496
  ENSRNOP00000088194
GenBank Protein Q62868 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037154   ⟸   NM_013022
- UniProtKB: Q62868 (UniProtKB/Swiss-Prot),   A0A0G2K5N6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239971   ⟸   XM_006239909
- Peptide Label: isoform X2
- UniProtKB: F1LQT3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006403   ⟸   ENSRNOT00000006403
Ensembl Acc Id: ENSRNOP00000073496   ⟸   ENSRNOT00000090816
RefSeq Acc Id: XP_038967738   ⟸   XM_039111810
- Peptide Label: isoform X1
- UniProtKB: A6HAT7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091227   ⟸   ENSRNOT00000109820
Ensembl Acc Id: ENSRNOP00000088194   ⟸   ENSRNOT00000119147
Protein Domains
AGC-kinase C-terminal   PH   Phorbol-ester/DAG-type   Protein kinase   REM-1   RhoBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62868-F1-model_v2 AlphaFold Q62868 1-1388 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694504
Promoter ID:EPDNEW_R5029
Type:single initiation site
Name:Rock2_1
Description:Rho-associated coiled-coil containing protein kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0642,180,876 - 42,180,936EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3590 AgrOrtholog
BioCyc Gene G2FUF-38062 BioCyc
Ensembl Genes ENSRNOG00000004496 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000090816 ENTREZGENE
  ENSRNOT00000119147 ENTREZGENE
Gene3D-CATH 1.20.5.340 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  3.30.60.20 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  C1-like_sf UniProtKB/Swiss-Prot
  HR1_rho-bd UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Rho-assoc_Ser/Thr_Kinase UniProtKB/Swiss-Prot
  Rho-bd_dom UniProtKB/Swiss-Prot
  ROCK1/ROCK2 UniProtKB/Swiss-Prot
  ROCK2_cat UniProtKB/Swiss-Prot
  ROCK2_HR1 UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:25537 UniProtKB/Swiss-Prot
NCBI Gene 25537 ENTREZGENE
PANTHER MYOTONIC DYSTROPHY S/T KINASE-RELATED UniProtKB/Swiss-Prot
  RHO-ASSOCIATED PROTEIN KINASE 2 UniProtKB/Swiss-Prot
Pfam PH_MRCK UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Rho_Binding UniProtKB/Swiss-Prot
PhenoGen Rock2 PhenoGen
PIRSF Rho_kinase UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  REM_1 UniProtKB/Swiss-Prot
  RHO_BD UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004496 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP G protein-binding domain UniProtKB/Swiss-Prot
  PH domain-like UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
  SSF57889 UniProtKB/Swiss-Prot
TIGR TC205230
UniProt A0A0G2K5N6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7C5_RAT UniProtKB/TrEMBL
  A0A8I6AEW1_RAT UniProtKB/TrEMBL
  A6HAT7 ENTREZGENE, UniProtKB/TrEMBL
  F1LQT3 ENTREZGENE, UniProtKB/TrEMBL
  Q62868 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Rock2  Rho-associated coiled-coil containing protein kinase 2  Rock2  Rho-associated coiled-coil forming kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Rock2  RhoA - binding serine/threosine kinase alpha (ROK - alpha)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds RhoA, RhoB, and RhoC but not Rac1 and Cdc42 633784