Rgs6 (regulator of G-protein signaling 6) - Rat Genome Database

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Pathways
Gene: Rgs6 (regulator of G-protein signaling 6) Rattus norvegicus
Analyze
Symbol: Rgs6
Name: regulator of G-protein signaling 6
RGD ID: 3569
Description: Enables protein domain specific binding activity. Involved in positive regulation of neuron differentiation. Part of protein-containing complex. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human RGS6 (regulator of G protein signaling 6); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86107,875,883 - 108,527,472 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6107,876,039 - 108,555,840 (+)EnsemblGRCr8
mRatBN7.26102,264,451 - 102,796,311 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6102,264,447 - 102,824,753 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6102,420,755 - 102,953,980 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06102,719,975 - 103,253,217 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06102,089,444 - 102,622,685 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06106,310,442 - 106,598,668 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6106,496,992 - 106,602,139 (+)Ensemblrn6Rnor6.0
Rnor_5.06114,636,387 - 114,736,790 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46106,470,420 - 106,964,581 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6100,100,895 - 100,625,650 (+)NCBICelera
RGSC_v3.16106,940,142 - 106,967,896 (+)NCBI
Cytogenetic Map6q24-q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO,ISS)
membrane  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)
plasma membrane  (IEA)
protein-containing complex  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. An association study revealed substantial effects of dominance, epistasis and substance dependence co-morbidity on alcohol dependence symptom count. Chen G, etal., Addict Biol. 2017 Nov;22(6):1475-1485. doi: 10.1111/adb.12402. Epub 2016 May 5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain. Gold SJ, etal., J Neurosci 1997 Oct 15;17(20):8024-37.
5. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Koelle MR and Horvitz HR, Cell 1996 Jan 12;84(1):115-25.
6. RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6. Liu Z, etal., J Biol Chem 2002 Oct 4;277(40):37832-9. Epub 2002 Jul 24.
7. Expression of neural RGS-R7 and Gbeta5 Proteins in Response to Acute and Chronic Morphine. López-Fando A, etal., Neuropsychopharmacology. 2005 Jan;30(1):99-110. doi: 10.1038/sj.npp.1300515.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. RGS Proteins in Heart: Brakes on the Vagus. Stewart A, etal., Front Physiol. 2012 Apr 13;3:95. doi: 10.3389/fphys.2012.00095. eCollection 2012.
Additional References at PubMed
PMID:10521509  


Genomics

Comparative Map Data
Rgs6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86107,875,883 - 108,527,472 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6107,876,039 - 108,555,840 (+)EnsemblGRCr8
mRatBN7.26102,264,451 - 102,796,311 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6102,264,447 - 102,824,753 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6102,420,755 - 102,953,980 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06102,719,975 - 103,253,217 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06102,089,444 - 102,622,685 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06106,310,442 - 106,598,668 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6106,496,992 - 106,602,139 (+)Ensemblrn6Rnor6.0
Rnor_5.06114,636,387 - 114,736,790 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46106,470,420 - 106,964,581 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6100,100,895 - 100,625,650 (+)NCBICelera
RGSC_v3.16106,940,142 - 106,967,896 (+)NCBI
Cytogenetic Map6q24-q31NCBI
RGS6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381471,867,335 - 72,630,029 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1471,932,429 - 72,566,530 (+)Ensemblhg38GRCh38
GRCh371472,398,888 - 73,033,238 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361471,469,539 - 72,102,991 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341471,469,585 - 72,100,407NCBI
Celera1452,462,976 - 53,096,417 (+)NCBICelera
Cytogenetic Map14q24.2NCBI
HuRef1452,565,478 - 53,199,765 (+)NCBIHuRef
CHM1_11472,336,952 - 72,971,253 (+)NCBICHM1_1
T2T-CHM13v2.01466,072,765 - 66,835,660 (+)NCBIT2T-CHM13v2.0
Rgs6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391282,663,325 - 83,208,835 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1282,635,066 - 83,208,830 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381282,616,551 - 83,162,061 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1282,588,292 - 83,162,056 (+)Ensemblmm10GRCm38
MGSCv371283,718,025 - 84,259,799 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361283,535,886 - 84,077,669 (+)NCBIMGSCv36mm8
Celera1284,069,722 - 84,604,177 (+)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1238.14NCBI
Rgs6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555232,762,987 - 3,335,474 (-)Ensembl
ChiLan1.0NW_0049555232,763,143 - 3,366,851 (-)NCBIChiLan1.0ChiLan1.0
RGS6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21573,042,379 - 73,677,406 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11472,258,892 - 72,893,920 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01452,511,846 - 53,146,872 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11471,377,567 - 72,012,766 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1471,409,701 - 72,008,988 (+)EnsemblpanPan2panpan1.1
RGS6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1845,392,246 - 45,975,073 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl845,438,239 - 46,009,049 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha845,077,684 - 45,656,669 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0845,630,187 - 46,197,033 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl845,654,256 - 46,194,458 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1845,301,232 - 45,866,115 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0845,329,999 - 45,882,332 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0845,692,998 - 46,272,644 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rgs6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864030,144,323 - 30,732,878 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364881,361,310 - 1,921,353 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364881,336,075 - 1,924,635 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl795,365,939 - 95,930,034 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1795,365,212 - 95,930,040 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RGS6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12449,161,466 - 49,803,209 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2449,591,815 - 49,775,653 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605337,367,918 - 37,991,218 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473428,829,698 - 29,411,779 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473428,830,254 - 29,436,945 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rgs6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1796,756,587 - 97,266,112 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rgs6
3816 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:56
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000058181
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat

Markers in Region
RH140792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26102,792,686 - 102,792,927 (+)MAPPERmRatBN7.2
Rnor_6.06106,598,200 - 106,598,440NCBIRnor6.0
Rnor_5.06114,736,322 - 114,736,562UniSTSRnor5.0
RGSC_v3.46106,987,770 - 106,988,010UniSTSRGSC3.4
Celera6100,625,182 - 100,625,422UniSTS
RH 3.4 Map6732.5UniSTS
Cytogenetic Map6q24UniSTS
RH143195  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26102,792,822 - 102,793,075 (+)MAPPERmRatBN7.2
Rnor_6.06106,598,336 - 106,598,588NCBIRnor6.0
Rnor_5.06114,736,458 - 114,736,710UniSTSRnor5.0
RGSC_v3.46106,987,906 - 106,988,158UniSTSRGSC3.4
Celera6100,625,318 - 100,625,570UniSTS
RH 3.4 Map6738.0UniSTS
Cytogenetic Map6q24UniSTS
RH143409  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86108,423,622 - 108,423,874 (+)Marker Load Pipeline
mRatBN7.26102,692,460 - 102,692,712 (+)MAPPERmRatBN7.2
Rnor_6.06106,499,816 - 106,500,067NCBIRnor6.0
Rnor_5.06114,639,079 - 114,639,330UniSTSRnor5.0
RGSC_v3.46106,876,517 - 106,876,768UniSTSRGSC3.4
Celera6100,526,473 - 100,526,724UniSTS
RH 3.4 Map6738.0UniSTS
Cytogenetic Map6q24UniSTS
BF398997  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26102,773,210 - 102,773,402 (+)MAPPERmRatBN7.2
Rnor_6.06106,578,724 - 106,578,915NCBIRnor6.0
Rnor_5.06114,716,846 - 114,717,037UniSTSRnor5.0
RGSC_v3.46106,968,294 - 106,968,485UniSTSRGSC3.4
Celera6100,605,596 - 100,605,787UniSTS
RH 3.4 Map6738.0UniSTS
Cytogenetic Map6q24UniSTS
fc10a03.x1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26102,616,986 - 102,618,290 (+)MAPPERmRatBN7.2
Rnor_6.06107,944,860 - 107,946,163NCBIRnor6.0
Rnor_5.06117,600,272 - 117,601,576NCBIRnor5.0
RGSC_v3.46106,800,999 - 106,802,302UniSTSRGSC3.4
Celera6100,451,085 - 100,452,388UniSTS
Cytogenetic Map6q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 12 67 160 91 90 59 92 59 6 353 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000058181   ⟹   ENSRNOP00000054984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6107,995,999 - 108,524,602 (+)Ensembl
mRatBN7.2 Ensembl6102,264,447 - 102,793,155 (+)Ensembl
Rnor_6.0 Ensembl6106,497,125 - 106,598,668 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086136   ⟹   ENSRNOP00000069089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6107,996,208 - 108,527,480 (+)Ensembl
mRatBN7.2 Ensembl6102,693,478 - 102,773,706 (+)Ensembl
Rnor_6.0 Ensembl6106,496,992 - 106,602,139 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095987   ⟹   ENSRNOP00000082201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6107,996,208 - 108,555,840 (+)Ensembl
mRatBN7.2 Ensembl6102,264,631 - 102,824,753 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100420   ⟹   ENSRNOP00000077898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6107,968,977 - 108,464,382 (+)Ensembl
mRatBN7.2 Ensembl6102,264,447 - 102,733,221 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103061   ⟹   ENSRNOP00000079796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6107,968,977 - 108,504,465 (+)Ensembl
mRatBN7.2 Ensembl6102,689,770 - 102,770,177 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107970   ⟹   ENSRNOP00000091378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6107,996,004 - 108,505,466 (+)Ensembl
mRatBN7.2 Ensembl6102,264,447 - 102,773,304 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109319   ⟹   ENSRNOP00000079945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6107,996,626 - 108,527,480 (+)Ensembl
mRatBN7.2 Ensembl6102,264,447 - 102,793,132 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112595   ⟹   ENSRNOP00000092991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6107,876,039 - 108,524,483 (+)Ensembl
mRatBN7.2 Ensembl6102,264,447 - 102,793,132 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113156   ⟹   ENSRNOP00000091512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6107,876,039 - 108,524,483 (+)Ensembl
mRatBN7.2 Ensembl6102,264,447 - 102,793,132 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114544   ⟹   ENSRNOP00000085795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6107,995,996 - 108,489,192 (+)Ensembl
mRatBN7.2 Ensembl6102,264,447 - 102,824,753 (+)Ensembl
RefSeq Acc Id: NM_019342   ⟹   NP_062215
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,996,495 - 108,524,316 (+)NCBI
mRatBN7.26102,265,295 - 102,793,155 (+)NCBI
Rnor_6.06106,310,442 - 106,598,668 (+)NCBI
Rnor_5.06114,636,387 - 114,736,790 (+)NCBI
Celera6100,100,895 - 100,625,650 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112783   ⟹   XP_038968711
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,996,666 - 108,527,472 (+)NCBI
mRatBN7.26102,265,483 - 102,796,311 (+)NCBI
RefSeq Acc Id: XM_039112784   ⟹   XP_038968712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,996,881 - 108,527,472 (+)NCBI
mRatBN7.26102,265,679 - 102,796,311 (+)NCBI
RefSeq Acc Id: XM_039112785   ⟹   XP_038968713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,996,460 - 108,527,472 (+)NCBI
mRatBN7.26102,265,264 - 102,796,311 (+)NCBI
RefSeq Acc Id: XM_039112787   ⟹   XP_038968715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,875,883 - 108,504,530 (+)NCBI
mRatBN7.26102,293,910 - 102,777,665 (+)NCBI
RefSeq Acc Id: XM_039112789   ⟹   XP_038968717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,875,883 - 108,523,530 (+)NCBI
mRatBN7.26102,293,910 - 102,792,406 (+)NCBI
RefSeq Acc Id: XM_039112790   ⟹   XP_038968718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,875,883 - 108,488,421 (+)NCBI
mRatBN7.26102,293,910 - 102,759,765 (+)NCBI
RefSeq Acc Id: XM_063262367   ⟹   XP_063118437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,875,883 - 108,527,472 (+)NCBI
RefSeq Acc Id: XM_063262368   ⟹   XP_063118438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,875,883 - 108,527,472 (+)NCBI
RefSeq Acc Id: XM_063262369   ⟹   XP_063118439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,875,883 - 108,527,472 (+)NCBI
RefSeq Acc Id: XM_063262370   ⟹   XP_063118440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,996,608 - 108,527,472 (+)NCBI
RefSeq Acc Id: XR_005505572
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86107,875,883 - 108,523,504 (+)NCBI
mRatBN7.26102,293,910 - 102,792,343 (+)NCBI
RefSeq Acc Id: NP_062215   ⟸   NM_019342
- UniProtKB: F1LS67 (UniProtKB/TrEMBL),   A0A8I6GJP9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054984   ⟸   ENSRNOT00000058181
Ensembl Acc Id: ENSRNOP00000069089   ⟸   ENSRNOT00000086136
RefSeq Acc Id: XP_038968713   ⟸   XM_039112785
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G3X7 (UniProtKB/TrEMBL),   A0A8I6GJP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968711   ⟸   XM_039112783
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G3X7 (UniProtKB/TrEMBL),   A0A8I6GJP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968712   ⟸   XM_039112784
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G3X7 (UniProtKB/TrEMBL),   A0A8I6GJP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968717   ⟸   XM_039112789
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GJP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968715   ⟸   XM_039112787
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GJK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968718   ⟸   XM_039112790
- Peptide Label: isoform X7
- UniProtKB: A0A8I6GJP9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079796   ⟸   ENSRNOT00000103061
Ensembl Acc Id: ENSRNOP00000079945   ⟸   ENSRNOT00000109319
Ensembl Acc Id: ENSRNOP00000091512   ⟸   ENSRNOT00000113156
Ensembl Acc Id: ENSRNOP00000092991   ⟸   ENSRNOT00000112595
Ensembl Acc Id: ENSRNOP00000091378   ⟸   ENSRNOT00000107970
Ensembl Acc Id: ENSRNOP00000085795   ⟸   ENSRNOT00000114544
Ensembl Acc Id: ENSRNOP00000077898   ⟸   ENSRNOT00000100420
Ensembl Acc Id: ENSRNOP00000082201   ⟸   ENSRNOT00000095987
RefSeq Acc Id: XP_063118437   ⟸   XM_063262367
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GJP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118438   ⟸   XM_063262368
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GJP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118439   ⟸   XM_063262369
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GJP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118440   ⟸   XM_063262370
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G3X7 (UniProtKB/TrEMBL),   A0A8I6GJP9 (UniProtKB/TrEMBL)
Protein Domains
DEP   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49801-F1-model_v2 AlphaFold P49801 1-66 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3569 AgrOrtholog
BioCyc Gene G2FUF-36866 BioCyc
Ensembl Genes ENSRNOG00000008082 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000058181 ENTREZGENE
  ENSRNOT00000086136 ENTREZGENE
  ENSRNOT00000107970 ENTREZGENE
  ENSRNOT00000109319 ENTREZGENE
  ENSRNOT00000113156 ENTREZGENE
  ENSRNOT00000114544 ENTREZGENE
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot
InterPro RGS UniProtKB/Swiss-Prot
  RGS6/7/9/11 UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot
  RGS_subdomain_2 UniProtKB/Swiss-Prot
NCBI Gene 54295 ENTREZGENE
PANTHER LP21163P UniProtKB/Swiss-Prot
  REGULATOR OF G-PROTEIN SIGNALING 6 UniProtKB/Swiss-Prot
Pfam RGS UniProtKB/Swiss-Prot
PhenoGen Rgs6 PhenoGen
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot
PROSITE RGS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008082 RatGTEx
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot
UniProt A0A0G2JUG4_RAT UniProtKB/TrEMBL
  A0A8I5YC31_RAT UniProtKB/TrEMBL
  A0A8I5ZPB7_RAT UniProtKB/TrEMBL
  A0A8I5ZTQ5_RAT UniProtKB/TrEMBL
  A0A8I6A357_RAT UniProtKB/TrEMBL
  A0A8I6AIT2_RAT UniProtKB/TrEMBL
  A0A8I6G3X7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GJK3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GJP9 ENTREZGENE, UniProtKB/TrEMBL
  F1LS67 ENTREZGENE, UniProtKB/TrEMBL
  P49801 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Rgs6  regulator of G-protein signaling 6      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction human homolog binds neuronal growth associated protein SCG10 737642