Rgs5 (regulator of G-protein signaling 5) - Rat Genome Database

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Gene: Rgs5 (regulator of G-protein signaling 5) Rattus norvegicus
Analyze
Symbol: Rgs5
Name: regulator of G-protein signaling 5
RGD ID: 3568
Description: Involved in negative regulation of vascular associated smooth muscle cell proliferation. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Biomarker of hypertension. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma and essential hypertension. Orthologous to human RGS5 (regulator of G protein signaling 5); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; G protein mediated signaling pathway via Galphai family; G protein mediated signaling pathway via Galphaq family; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: regulator of G protein signaling 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81384,381,077 - 84,417,875 (+)NCBIGRCr8
mRatBN7.21381,848,254 - 81,885,053 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1381,836,304 - 81,885,518 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1384,476,082 - 84,512,900 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01385,768,861 - 85,805,669 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01383,001,335 - 83,038,141 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01387,966,820 - 88,002,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1387,966,758 - 88,003,035 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01392,595,346 - 92,631,357 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41385,445,325 - 85,482,294 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11385,459,512 - 85,496,482 (+)NCBI
Celera1381,513,956 - 81,550,630 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
Actein  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
clorgyline  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
deoxynivalenol  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofurans  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
furan  (EXP)
glafenine  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
linalool  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
reserpine  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Impact of Genetic Variation in MicroRNA-binding Site on Susceptibility to Colorectal Cancer. Kang BW, etal., Anticancer Res. 2016 Jul;36(7):3353-61.
3. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Koelle MR and Horvitz HR, Cell 1996 Jan 12;84(1):115-25.
4. Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor. Koh J, etal., Mol Endocrinol. 2011 May;25(5):867-76. doi: 10.1210/me.2010-0277. Epub 2011 Mar 10.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells. Wang Q, etal., J Biol Chem 2002 Jul 12;277(28):24949-58.
12. RGS5, RGS4, and RGS2 expression and aortic contractibility are dynamically co-regulated during aortic banding-induced hypertrophy. Wang X, etal., J Mol Cell Cardiol. 2008 Mar;44(3):539-50. doi: 10.1016/j.yjmcc.2007.11.019. Epub 2007 Dec 8.
13. Antihypertensive effects of peroxisome proliferator-activated receptor-beta activation in spontaneously hypertensive rats. Zarzuelo MJ, etal., Hypertension. 2011 Oct;58(4):733-43. doi: 10.1161/HYPERTENSIONAHA.111.174490. Epub 2011 Aug 8.
Additional References at PubMed
PMID:17939118   PMID:17986358   PMID:21054999   PMID:21593453   PMID:24489801   PMID:25842189   PMID:29061726  


Genomics

Comparative Map Data
Rgs5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81384,381,077 - 84,417,875 (+)NCBIGRCr8
mRatBN7.21381,848,254 - 81,885,053 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1381,836,304 - 81,885,518 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1384,476,082 - 84,512,900 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01385,768,861 - 85,805,669 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01383,001,335 - 83,038,141 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01387,966,820 - 88,002,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1387,966,758 - 88,003,035 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01392,595,346 - 92,631,357 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41385,445,325 - 85,482,294 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11385,459,512 - 85,496,482 (+)NCBI
Celera1381,513,956 - 81,550,630 (+)NCBICelera
Cytogenetic Map13q24NCBI
RGS5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381163,142,299 - 163,321,735 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1163,111,121 - 163,321,791 (-)EnsemblGRCh38hg38GRCh38
GRCh371163,112,089 - 163,291,525 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,378,716 - 161,439,496 (-)NCBINCBI36Build 36hg18NCBI36
Build 341159,843,754 - 159,904,530NCBI
Celera1136,216,406 - 136,277,298 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1134,357,419 - 134,536,920 (-)NCBIHuRef
CHM1_11164,534,977 - 164,714,483 (-)NCBICHM1_1
T2T-CHM13v2.01162,487,178 - 162,666,666 (-)NCBIT2T-CHM13v2.0
Rgs5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,483,070 - 169,523,367 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,483,070 - 169,523,382 (+)EnsemblGRCm39 Ensembl
GRCm381169,655,501 - 169,695,813 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,655,501 - 169,695,813 (+)EnsemblGRCm38mm10GRCm38
MGSCv371171,585,632 - 171,623,657 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361171,492,176 - 171,530,201 (+)NCBIMGSCv36mm8
Celera1172,079,009 - 172,116,960 (+)NCBICelera
Cytogenetic Map1H2.3NCBI
cM Map176.84NCBI
Rgs5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546213,228,002 - 13,283,034 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546213,228,110 - 13,288,063 (+)NCBIChiLan1.0ChiLan1.0
RGS5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2186,454,433 - 86,636,039 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1186,243,733 - 86,304,615 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01138,561,940 - 138,622,698 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11142,357,626 - 142,418,583 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1142,362,663 - 142,387,291 (-)Ensemblpanpan1.1panPan2
RGS5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13819,683,396 - 19,730,514 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3819,683,485 - 19,725,778 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3819,739,840 - 19,786,792 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03819,767,480 - 19,814,881 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3819,767,312 - 19,812,214 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13819,742,970 - 19,790,108 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03820,094,362 - 20,141,746 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03820,385,842 - 20,433,074 (+)NCBIUU_Cfam_GSD_1.0
Rgs5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344103,574,526 - 103,636,359 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648121,421,277 - 21,483,132 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648121,421,319 - 21,483,108 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl487,286,953 - 87,342,088 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1487,286,953 - 87,340,816 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2494,999,826 - 95,053,683 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RGS5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12565,608,384 - 65,667,811 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2565,608,303 - 65,662,772 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605567,398,522 - 67,458,157 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248261,648,891 - 1,699,353 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248261,644,874 - 1,698,855 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rgs5
170 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:74
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000003705
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
AA817884  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21381,884,990 - 81,885,208 (+)MAPPERmRatBN7.2
Rnor_6.01388,002,769 - 88,002,986NCBIRnor6.0
Rnor_5.01392,631,295 - 92,631,512UniSTSRnor5.0
RGSC_v3.41385,482,232 - 85,482,449UniSTSRGSC3.4
Celera1381,550,568 - 81,550,785UniSTS
RH 3.4 Map13514.8UniSTS
Cytogenetic Map13q24UniSTS
UniSTS:495957  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21381,883,212 - 81,883,305 (+)MAPPERmRatBN7.2
Rnor_6.01388,000,991 - 88,001,083NCBIRnor6.0
Rnor_5.01392,629,517 - 92,629,609UniSTSRnor5.0
RGSC_v3.41385,480,455 - 85,480,545UniSTSRGSC3.4
Celera1381,548,790 - 81,548,882UniSTS
Cytogenetic Map13q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 27 11 19 11 8 11 68 35 35 11 8
Low 30 30 30 6 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003705   ⟹   ENSRNOP00000003705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1381,836,304 - 81,885,518 (+)Ensembl
Rnor_6.0 Ensembl1387,986,240 - 88,002,831 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079593   ⟹   ENSRNOP00000069463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1381,848,137 - 81,885,518 (+)Ensembl
Rnor_6.0 Ensembl1387,966,758 - 88,003,035 (+)Ensembl
RefSeq Acc Id: NM_019341   ⟹   NP_062214
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81384,381,077 - 84,417,875 (+)NCBI
mRatBN7.21381,848,254 - 81,885,053 (+)NCBI
Rnor_6.01387,966,820 - 88,002,831 (+)NCBI
Rnor_5.01392,595,346 - 92,631,357 (+)NCBI
RGSC_v3.41385,445,325 - 85,482,294 (+)RGD
Celera1381,513,956 - 81,550,630 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_062214   ⟸   NM_019341
- UniProtKB: Q9JKD7 (UniProtKB/Swiss-Prot),   P49800 (UniProtKB/Swiss-Prot),   A5YN34 (UniProtKB/TrEMBL),   A0A0G2JVF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069463   ⟸   ENSRNOT00000079593
RefSeq Acc Id: ENSRNOP00000003705   ⟸   ENSRNOT00000003705
Protein Domains
RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49800-F1-model_v2 AlphaFold P49800 1-181 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698979
Promoter ID:EPDNEW_R9504
Type:multiple initiation site
Name:Rgs5_1
Description:regulator of G-protein signaling 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01387,966,734 - 87,966,794EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3568 AgrOrtholog
BioCyc Gene G2FUF-17492 BioCyc
Ensembl Genes ENSRNOG00000002730 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055023162 UniProtKB/Swiss-Prot
  ENSRNOG00060021605 UniProtKB/Swiss-Prot
  ENSRNOG00065020128 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003705.7 UniProtKB/TrEMBL
  ENSRNOT00000079593 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000079593.2 UniProtKB/Swiss-Prot
  ENSRNOT00055039794 UniProtKB/Swiss-Prot
  ENSRNOT00060037480 UniProtKB/Swiss-Prot
  ENSRNOT00065033951 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.196.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_RGS5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54294 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 54294 ENTREZGENE
PANTHER PTHR10845:SF42 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REGULATOR OF G PROTEIN SIGNALING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rgs5 PhenoGen
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002730 RatGTEx
  ENSRNOG00055023162 RatGTEx
  ENSRNOG00060021605 RatGTEx
  ENSRNOG00065020128 RatGTEx
SMART RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JVF3 ENTREZGENE, UniProtKB/TrEMBL
  A5YN34 ENTREZGENE, UniProtKB/TrEMBL
  A6IDM7_RAT UniProtKB/TrEMBL
  A6IDM8_RAT UniProtKB/TrEMBL
  F1LP00_RAT UniProtKB/TrEMBL
  P49800 ENTREZGENE
  Q9JKD7 ENTREZGENE
  RGS5_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9JKD7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Rgs5  regulator of G-protein signaling 5      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds directly to the activated Ga subunits and promotes GTP hydrolysis 625585
gene_process serves as a GTPase-activating protein (GAP) and inhibits G protein signaling; inhibits angiotensin AT1a receptor signaling through Gq/11 625585