Rgn (regucalcin) - Rat Genome Database

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Gene: Rgn (regucalcin) Rattus norvegicus
Analyze
Symbol: Rgn
Name: regucalcin
RGD ID: 3560
Description: Enables calcium ion binding activity and gluconolactonase activity. Involved in several processes, including liver regeneration; negative regulation of bone development; and regulation of primary metabolic process. Predicted to be located in cytoplasm and nucleus. Used to study familial hyperlipidemia. Biomarker of hepatocellular carcinoma. Orthologous to human RGN (regucalcin); PARTICIPATES IN ascorbate and aldarate metabolic pathway; pentose phosphate pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: gluconolactonase; GNL; Rc; Reguc; regucalcin (senescence marker protein-30); senescence marker protein 30; SMP-30
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD-Tg(CAG-Rgn)Slc
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X4,172,537 - 4,190,112 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX4,172,537 - 4,190,251 (-)EnsemblGRCr8
mRatBN7.2X1,619,030 - 1,634,456 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,619,032 - 1,634,450 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX1,653,062 - 1,668,461 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X5,128,761 - 5,144,164 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,444,046 - 1,459,469 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,833,484 - 1,848,904 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,833,492 - 1,848,904 (-)Ensemblrn6Rnor6.0
Rnor_5.0X2,626,525 - 2,641,949 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X13,037,171 - 13,052,846NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX2,182,952 - 2,198,371 (-)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-aminobenzotriazole  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5-Hydroxythalidomide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
bacitracin  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chromium trinitrate  (ISO)
cisplatin  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clotrimazole  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (EXP)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
diallyl disulfide  (ISO)
Diallyl sulfide  (EXP)
diclofenac  (EXP)
dicrotophos  (ISO)
diisopropyl fluorophosphate  (ISO)
dioscin  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
eugenol  (EXP)
flavonoids  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hexadecanoic acid  (ISO)
hydrazine  (EXP)
hydrogen peroxide  (ISO)
indoxyl sulfate  (ISO)
inulin  (ISO)
melatonin  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pent-4-enoic acid  (EXP)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
polaprezinc  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
Propiverine  (EXP)
quercetin  (ISO)
rac-1,2-dichloropropane  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
sarin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
Soman  (ISO)
tacrolimus hydrate  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thallium atom  (EXP)
thallium sulfate  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
intracellular calcium ion homeostasis  (IDA)
kidney development  (IEP)
L-ascorbic acid biosynthetic process  (IBA,IEA,ISO,ISS)
liver development  (IEP)
liver regeneration  (IEP)
negative regulation of apoptotic process  (IDA)
negative regulation of bone development  (IDA,IMP)
negative regulation of calcium-dependent ATPase activity  (IMP)
negative regulation of cyclic-nucleotide phosphodiesterase activity  (IDA)
negative regulation of DNA biosynthetic process  (IMP)
negative regulation of DNA catabolic process  (IDA)
negative regulation of epithelial cell proliferation  (IDA)
negative regulation of flagellated sperm motility  (IDA)
negative regulation of GTPase activity  (IMP)
negative regulation of nitric oxide biosynthetic process  (IMP)
negative regulation of protein kinase activity  (IMP)
negative regulation of protein phosphorylation  (IMP)
negative regulation of RNA biosynthetic process  (IMP)
negative regulation of translation  (IDA)
positive regulation of ATP-dependent activity  (IDA)
positive regulation of ATPase-coupled calcium transmembrane transporter activity  (IDA)
positive regulation of fatty acid biosynthetic process  (IDA)
positive regulation of glucose metabolic process  (IDA)
positive regulation of GTPase activity  (IDA)
positive regulation of phosphatase activity  (IMP)
positive regulation of proteolysis involved in protein catabolic process  (IDA)
positive regulation of superoxide dismutase activity  (IDA)
positive regulation of triglyceride biosynthetic process  (IDA)
regulation of calcium-mediated signaling  (IDA)
spermatogenesis  (IDA)

Cellular Component
cytoplasm  (IEA,ISO,ISS)
nucleus  (ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regucalcin increases Ca2+-ATPase activity in the heart mitochondria of normal and regucalcin transgenic rats. Akhter T, etal., Int J Mol Med. 2006 Jul;18(1):171-6.
2. Gel-based proteomics of liver cancer progression in rat. Albrethsen J, etal., Biochim Biophys Acta. 2011 Oct;1814(10):1367-76. Epub 2011 Jun 6.
3. Sperm parameters and epididymis function in transgenic rats overexpressing the Ca2+-binding protein regucalcin: a hidden role for Ca2+ in sperm maturation? Correia S, etal., Mol Hum Reprod. 2013 Sep;19(9):581-9. doi: 10.1093/molehr/gat030. Epub 2013 Apr 23.
4. Isolation of cDNA clone encoding rat senescence marker protein-30 (SMP30) and its tissue distribution. Fujita T, etal., Biochim Biophys Acta 1992 Oct 20;1132(3):297-305.
5. Gene regulation of senescence marker protein-30 (SMP30): coordinated up-regulation with tissue maturation and gradual down-regulation with aging. Fujita T, etal., Mech Ageing Dev. 1996 Jun 25;87(3):219-29.
6. Overexpression of regucalcin suppresses apoptotic cell death in the cloned rat hepatoma H4-II-E cells induced by a naturally occurring isothiocyanate sulforaphane. Fukaya Y and Yamaguchi M, Int J Mol Med. 2005 May;15(5):853-7.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Stimulatory effect of calcium-binding protein regucalcin on phosphatase activity in the brain cytosol of rats with different ages. Hanahisa Y and Yamaguchi M, Brain Res Bull. 1998 Jul 1;46(4):347-51.
9. Identification of a prognostic 5-Gene expression signature for gastric cancer. Hou JY, etal., J Cancer Res Clin Oncol. 2017 Apr;143(4):619-629. doi: 10.1007/s00432-016-2324-z. Epub 2016 Dec 29.
10. Regucalcin increases superoxide dismutase activity in the heart cytosol of normal and regucalcin transgenic rats. Ichikawa E and Yamaguchi M, Int J Mol Med. 2004 Oct;14(4):691-5.
11. Suppressive role of endogenous regucalcin in the enhancement of protein kinase activity with proliferation of cloned rat hepatoma cells (H4-II-E). Inagaki S and Yamaguchi M, J Cell Biochem Suppl. 2001;Suppl 36:12-8.
12. Regulatory role of endogenous regucalcin in the enhancement of nuclear deoxyribonuleic acid synthesis with proliferation of cloned rat hepatoma cells (H4-II-E). Inagaki S and Yamaguchi M, J Cell Biochem. 2001;82(4):704-11.
13. Role of endogenous regucalcin in protein tyrosine phosphatase regulation in the cloned rat hepatoma cells (H4-II-E). Inagaki S, etal., Mol Cell Biochem. 2000 Oct;213(1-2):43-50.
14. Hepatic calcium-binding protein regucalcin concentration is decreased by streptozotocin-diabetic state and ethanol ingestion in rats. Isogai M, etal., Mol Cell Biochem. 1997 Mar;168(1-2):67-72.
15. Inhibitory effect of calcium-binding protein regucalcin on protein kinase activity in the nuclei of regenerating rat liver. Katsumata T and Yamaguchi M, J Cell Biochem. 1998 Dec 15;71(4):569-76.
16. Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy. Kondo Y, etal., Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5723-8. Epub 2006 Apr 3.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Nuclear localization of regucalcin is enhanced in culture with protein kinase C activation in cloned normal rat kidney proximal tubular epithelial NRK52E cells. Nakagawa T and Yamaguchi M, Int J Mol Med. 2008 May;21(5):605-10.
19. Overexpression of regucalcin suppresses apoptotic cell death in cloned normal rat kidney proximal tubular epithelial NRK52E cells: change in apoptosis-related gene expression. Nakagawa T and Yamaguchi M, J Cell Biochem. 2005 Dec 15;96(6):1274-85.
20. Overexpression of regucalcin suppresses cell proliferation of cloned normal rat kidney proximal tubular epithelial NRK52E cells. Nakagawa T, etal., Int J Mol Med. 2005 Oct;16(4):637-43.
21. Overexpression of regucalcin enhances glucose utilization and lipid production in cloned rat hepatoma H4-II-E cells: Involvement of insulin resistance. Nakashima C and Yamaguchi M, J Cell Biochem. 2006 Dec 15;99(6):1582-92.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Regulation of protein phosphatase activity by regucalcin localization in rat liver nuclei. Omura M and Yamaguchi M, J Cell Biochem. 1999 Dec 1;75(3):437-45.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. GOA pipeline RGD automated data pipeline
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Molecular cloning and sequencing of the cDNA coding for a calcium-binding protein regucalcin from rat liver. Shimokawa N and Yamaguchi M, FEBS Lett 1993 Aug 2;327(3):251-5.
28. Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis. Son TG, etal., J Neurosci Res. 2009 Oct;87(13):2890-7. doi: 10.1002/jnr.22122.
29. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
30. Stimulatory effect of regucalcin on ATP-dependent Ca(2+) uptake activity in rat liver mitochondria. Takahashi H and Yamaguchi M, J Cell Biochem. 2000 Apr;78(1):121-30.
31. Activatory effect of regucalcin on GTPase activity in rat liver plasma membranes. Takahashi H and Yamaguchi M, Mol Cell Biochem. 2001 Aug;224(1-2):117-22.
32. Inhibitory role of regucalcin in the regulation of nitric oxide synthase activity in rat brain cytosol: involvement of aging. Tobisawa M and Yamaguchi M, J Neurol Sci. 2003 May 15;209(1-2):47-54.
33. Suppressive effect of endogenous regucalcin on guanosine triphosphatase activity in rat liver nucleus. Tsurusaki Y and Yamaguchi M, Biol Pharm Bull. 2001 Aug;24(8):958-61.
34. Role of endogenous regucalcin in the regulation of Ca(2+)-ATPase activity in rat liver nuclei. Tsurusaki Y and Yamaguchi M, J Cell Biochem. 2000 Jun 12;78(4):541-9.
35. Role of endogenous regucalcin in nuclear regulation of regenerating rat liver: suppression of the enhanced ribonucleic acid synthesis activity. Tsurusaki Y and Yamaguchi M, J Cell Biochem. 2002;87(4):450-7.
36. Enhanced expression of calcium-binding protein regucalcin mRNA in regenerating rat liver. Yamaguchi M and Kanayama Y, J Cell Biochem. 1995 Feb;57(2):185-90.
37. Effect of calcium-binding protein regucalcin on hepatic protein synthesis: inhibition of aminoacyl-tRNA synthetase activity. Yamaguchi M and Mori S, Mol Cell Biochem. 1990 Dec 3;99(1):25-32.
38. Role of regucalcin as an activator of sarcoplasmic reticulum Ca2+-ATPase activity in rat heart muscle. Yamaguchi M and Nakajima R, J Cell Biochem 2002;86(1):184-93.
39. Inhibitory effect of calcium-binding protein regucalcin on Ca2(+)-activated DNA fragmentation in rat liver nuclei. Yamaguchi M and Sakurai T, FEBS Lett. 1991 Feb 25;279(2):281-4.
40. Reversible effect of calcium-binding protein regucalcin on the Ca(2+)-induced inhibition of deoxyuridine 5'-triphosphatase activity in rat liver cytosol. Yamaguchi M and Sakurai T, Mol Cell Biochem. 1992 Mar 4;110(1):25-9.
41. Inhibitory effect of calcium-binding protein regucalcin on Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase activity in rat liver cytosol. Yamaguchi M and Tai H, Mol Cell Biochem. 1991 Jul 24;106(1):25-30.
42. Calcium-binding protein regucalcin increases calcium-independent proteolytic activity in rat liver cytosol. Yamaguchi M and Tai H, Mol Cell Biochem. 1992 May 13;112(1):89-95.
43. Expression of calcium-binding protein regucalcin mRNA in fetal rat liver is stimulated by calcium administration. Yamaguchi M and Ueoka S, Mol Cell Biochem. 1998 Jan;178(1-2):283-7.
44. Purification of calcium binding substance from soluble fraction of normal rat liver. Yamaguchi M and Yamamoto T, Chem Pharm Bull (Tokyo). 1978 Jun;26(6):1915-8.
45. Expression of Ca(2+)-binding protein regucalcin in rat brain neurons: inhibitory effect on protein phosphatase activity. Yamaguchi M, etal., Brain Res Bull. 2000 Jul 15;52(5):343-8.
46. Role of endogenous regucalcin in bone metabolism: bone loss is induced in regucalcin transgenic rats. Yamaguchi M, etal., Int J Mol Med. 2002 Oct;10(4):377-83.
47. Hyperlipidemia is induced in regucalcin transgenic rats with increasing age. Yamaguchi M, etal., Int J Mol Med. 2004 Oct;14(4):647-51.
48. Role of endogenous regucalcin in transgenic rats: suppression of kidney cortex cytosolic protein phosphatase activity and enhancement of heart muscle microsomal Ca2+-ATPase activity. Yamaguchi M, etal., J Cell Biochem 2002;86(3):520-9.
49. Novel protein RGPR-p117: the gene expression in physiologic state and the binding activity to regucalcin gene promoter region in rat liver. Yamaguchi M, etal., J Cell Biochem 2003 Apr 15;88(6):1092-100.
Additional References at PubMed
PMID:8569761   PMID:8979263   PMID:11936841   PMID:11967991   PMID:12368201   PMID:12647304   PMID:12851718   PMID:12851719   PMID:12964038   PMID:14767576   PMID:15108356   PMID:15251439  
PMID:15254778   PMID:15289895   PMID:15289899   PMID:15340235   PMID:15489334   PMID:15578574   PMID:16052480   PMID:16273285   PMID:16676356   PMID:16677110   PMID:16767692   PMID:17334641  
PMID:17671736   PMID:17912465   PMID:18157649   PMID:18181158   PMID:18442420   PMID:20329768   PMID:21347421   PMID:21431902   PMID:21680783   PMID:22652898   PMID:23349732   PMID:24519986  
PMID:26171977   PMID:26553531   PMID:27553527   PMID:29602294   PMID:33137709   PMID:35041836   PMID:38171814  


Genomics

Comparative Map Data
Rgn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X4,172,537 - 4,190,112 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX4,172,537 - 4,190,251 (-)EnsemblGRCr8
mRatBN7.2X1,619,030 - 1,634,456 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,619,032 - 1,634,450 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX1,653,062 - 1,668,461 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X5,128,761 - 5,144,164 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,444,046 - 1,459,469 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,833,484 - 1,848,904 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,833,492 - 1,848,904 (-)Ensemblrn6Rnor6.0
Rnor_5.0X2,626,525 - 2,641,949 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X13,037,171 - 13,052,846NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX2,182,952 - 2,198,371 (-)NCBICelera
Cytogenetic MapXq11NCBI
RGN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,078,443 - 47,093,313 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,078,190 - 47,094,419 (+)Ensemblhg38GRCh38
GRCh37X46,937,842 - 46,952,712 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X46,822,719 - 46,837,656 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X46,696,510 - 46,708,966NCBI
CeleraX51,129,720 - 51,148,035 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX44,651,176 - 44,667,384 (+)NCBIHuRef
CHM1_1X46,969,564 - 46,984,507 (+)NCBICHM1_1
T2T-CHM13v2.0X46,485,437 - 46,503,065 (+)NCBIT2T-CHM13v2.0
Rgn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,413,980 - 20,428,328 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,416,026 - 20,428,328 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X20,549,766 - 20,562,089 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,549,787 - 20,562,089 (+)Ensemblmm10GRCm38
MGSCv37X20,126,944 - 20,139,213 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X19,706,777 - 19,719,046 (+)NCBIMGSCv36mm8
CeleraX18,681,357 - 18,693,626 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.04NCBI
Rgn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516955,680 - 978,910 (-)Ensembl
ChiLan1.0NW_004955516958,416 - 978,829 (-)NCBIChiLan1.0ChiLan1.0
RGN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X48,703,675 - 48,720,753 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X48,707,048 - 48,724,130 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X39,513,135 - 39,530,188 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,371,225 - 47,388,881 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,371,226 - 47,388,881 (+)EnsemblpanPan2panpan1.1
RGN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X40,697,292 - 40,715,491 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX40,698,768 - 40,715,490 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX15,074,578 - 15,090,960 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X40,818,343 - 40,849,916 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX40,833,166 - 40,849,918 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X40,806,174 - 40,837,694 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X40,793,810 - 40,825,378 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X40,886,864 - 40,918,439 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rgn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,032,122 - 33,050,817 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650212,872,824 - 12,891,506 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650212,872,938 - 12,891,270 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX41,726,526 - 41,749,381 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X41,725,660 - 41,749,736 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X46,902,494 - 46,926,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,282,825 - 44,299,027 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,285,601 - 44,299,258 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660769,539,184 - 9,555,388 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248873,883,213 - 3,899,277 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248873,881,624 - 3,900,144 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rgn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X3,269,260 - 3,286,712 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rgn
27 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:588
Count of miRNA genes:268
Interacting mature miRNAs:337
Transcripts:ENSRNOT00000010984
Prediction methods:Microtar, Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149314046933Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X400149324470521Rat

Markers in Region
DXWox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,623,715 - 1,623,851 (+)MAPPERmRatBN7.2
Rnor_6.0X1,838,166 - 1,838,301NCBIRnor6.0
Rnor_5.0X2,631,211 - 2,631,346UniSTSRnor5.0
RGSC_v3.4X13,041,853 - 13,041,988UniSTSRGSC3.4
CeleraX2,187,634 - 2,187,769UniSTS
Cytogenetic MapXq11-q12UniSTS
RH142290  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X4,174,136 - 4,174,755 (+)Marker Load Pipeline
mRatBN7.2X1,620,629 - 1,621,248 (+)MAPPERmRatBN7.2
Rnor_6.0X1,835,084 - 1,835,702NCBIRnor6.0
Rnor_5.0X2,628,129 - 2,628,747UniSTSRnor5.0
RGSC_v3.4X13,038,771 - 13,039,389UniSTSRGSC3.4
CeleraX2,184,552 - 2,185,170UniSTS
Cytogenetic MapXq11-q12UniSTS


Related Rat Strains
The following Strains have been annotated to Rgn
SD-Tg(CAG-Rgn)Slc    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 64 141 91 90 59 40 59 6 303 137 11 117 83 90 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000010984   ⟹   ENSRNOP00000010984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX4,172,537 - 4,187,957 (-)Ensembl
mRatBN7.2 EnsemblX1,619,032 - 1,634,450 (-)Ensembl
Rnor_6.0 EnsemblX1,833,492 - 1,848,904 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123249   ⟹   ENSRNOP00000103000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX4,172,537 - 4,190,251 (-)Ensembl
RefSeq Acc Id: NM_031546   ⟹   NP_113734
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X4,172,537 - 4,187,957 (-)NCBI
mRatBN7.2X1,619,030 - 1,634,456 (-)NCBI
Rnor_6.0X1,833,484 - 1,848,904 (-)NCBI
Rnor_5.0X2,626,525 - 2,641,949 (-)NCBI
RGSC_v3.4X13,037,171 - 13,052,846 (-)RGD
CeleraX2,182,952 - 2,198,371 (-)RGD
Sequence:
RefSeq Acc Id: XM_063279817   ⟹   XP_063135887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X4,172,537 - 4,190,112 (-)NCBI
RefSeq Acc Id: NP_113734   ⟸   NM_031546
- UniProtKB: Q925W3 (UniProtKB/Swiss-Prot),   Q63496 (UniProtKB/Swiss-Prot),   Q9QWP2 (UniProtKB/Swiss-Prot),   Q03336 (UniProtKB/Swiss-Prot),   A6JZT8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010984   ⟸   ENSRNOT00000010984
RefSeq Acc Id: XP_063135887   ⟸   XM_063279817
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000103000   ⟸   ENSRNOT00000123249
Protein Domains
SMP-30/Gluconolactonase/LRE-like region

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03336-F1-model_v2 AlphaFold Q03336 1-299 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701698
Promoter ID:EPDNEW_R12222
Type:multiple initiation site
Name:Rgn_1
Description:regucalcin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X1,848,910 - 1,848,970EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3560 AgrOrtholog
BioCyc Gene G2FUF-3182 BioCyc
BioCyc Pathway PWY3DJ-35471 [L-ascorbate biosynthesis IV (animals, D-glucuronate pathway)] BioCyc
BioCyc Pathway Image PWY3DJ-35471 BioCyc
Ensembl Genes ENSRNOG00000007949 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010984 ENTREZGENE
  ENSRNOT00000010984.6 UniProtKB/Swiss-Prot
  ENSRNOT00000123249 ENTREZGENE
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7126233 IMAGE-MGC_LOAD
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot
  Regucalcin UniProtKB/Swiss-Prot
  SGL UniProtKB/Swiss-Prot
  SMP-30 UniProtKB/Swiss-Prot
KEGG Report rno:25106 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93360 IMAGE-MGC_LOAD
NCBI Gene 25106 ENTREZGENE
PANTHER REGUCALCIN UniProtKB/Swiss-Prot
  REGUCALCIN UniProtKB/Swiss-Prot
Pfam SGL UniProtKB/Swiss-Prot
PhenoGen Rgn PhenoGen
PRINTS REGUCALCIN UniProtKB/Swiss-Prot
  SMP30FAMILY UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007949 RatGTEx
Superfamily-SCOP Calcium-dependent phosphotriesterase UniProtKB/Swiss-Prot
UniProt A0ABK0LNM0_RAT UniProtKB/TrEMBL
  A6JZT8 ENTREZGENE, UniProtKB/TrEMBL
  Q03336 ENTREZGENE
  Q63496 ENTREZGENE
  Q925W3 ENTREZGENE
  Q9QWP2 ENTREZGENE
  RGN_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q63496 UniProtKB/Swiss-Prot
  Q925W3 UniProtKB/Swiss-Prot
  Q9QWP2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-07 Rgn  regucalcin  Rgn  regucalcin (senescence marker protein-30)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Rgn  regucalcin (senescence marker protein-30)  Rgn  regucalcin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Rgn  Regucalcin      Symbol and Name status set to approved 70586 APPROVED