Resp18 (regulated endocrine-specific protein 18) - Rat Genome Database

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Gene: Resp18 (regulated endocrine-specific protein 18) Rattus norvegicus
Analyze
Symbol: Resp18
Name: regulated endocrine-specific protein 18
RGD ID: 3555
Description: Predicted to act upstream of or within in utero embryonic development. Located in perikaryon; rough endoplasmic reticulum lumen; and secretory granule. Used to study hypertension and renal fibrosis. Orthologous to human RESP18 (regulated endocrine specific protein 18); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Resp18em2Mcwi   Resp18em3Mcwi  
Genetic Models: SS-Resp18em2Mcwi SS-Resp18em3Mcwi
Is Marker For: Strains:   SS.SR-(D9Rat89-Resp18)/Mco   SS.SR-(D9Mco95-Resp18)/Mco   SS.SR-(D9Mco98-Resp18)/1Mco   SS.SR-(D9Mco98-Resp18)/2Mco   SS.SR-(D9Mco101-Resp18)/Mco   SS.SR-(D9Mco72-Resp18)/Mco   SS.SR-(D9Mco14-Resp18)/1Mco   SS.SR-(D9Mco14-Resp18)/2Mco   SS.SR-(D9Mco14-Resp18)/3Mco  
QTLs:   Bp284  
Candidate Gene For: Bp284
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,213,844 - 84,220,186 (-)NCBIGRCr8
mRatBN7.2976,765,179 - 76,771,824 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,764,590 - 76,778,722 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx985,209,715 - 85,216,056 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,338,603 - 90,344,944 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,724,817 - 88,731,158 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,470,794 - 82,477,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,470,759 - 82,477,181 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,240,055 - 82,246,695 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,551,809 - 74,558,151 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,698,790 - 74,705,133 (-)NCBI
Celera974,335,568 - 74,341,910 (-)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. RESP18, a novel endocrine secretory protein transcript, and four other transcripts are regulated in parallel with pro-opiomelanocortin in melanotropes. Bloomquist BT, etal., J Biol Chem 1994 Mar 25;269(12):9113-22.
2. The expression of regulated endocrine-specific protein of 18 kDa in peptidergic cells of rat peripheral endocrine tissues and in blood. Darlington DN, etal., J Endocrinol. 1997 Nov;155(2):329-41.
3. Expression of RESP18 in peptidergic and catecholaminergic neurons. Darlington DN, etal., J Histochem Cytochem. 1997 Sep;45(9):1265-77.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Targeted disruption of regulated endocrine-specific protein ( Resp18) in Dahl SS/Mcw rats aggravates salt-induced hypertension and renal injury. Kumarasamy S, etal., Physiol Genomics. 2018 May 1;50(5):369-375. doi: 10.1152/physiolgenomics.00008.2018. Epub 2018 Mar 23.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7988462   PMID:15489334   PMID:21104147   PMID:22561140   PMID:34340197  


Genomics

Comparative Map Data
Resp18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,213,844 - 84,220,186 (-)NCBIGRCr8
mRatBN7.2976,765,179 - 76,771,824 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,764,590 - 76,778,722 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx985,209,715 - 85,216,056 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,338,603 - 90,344,944 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,724,817 - 88,731,158 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,470,794 - 82,477,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,470,759 - 82,477,181 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,240,055 - 82,246,695 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4974,551,809 - 74,558,151 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1974,698,790 - 74,705,133 (-)NCBI
Celera974,335,568 - 74,341,910 (-)NCBICelera
Cytogenetic Map9q33NCBI
RESP18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,327,407 - 219,336,656 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,327,407 - 219,333,177 (-)EnsemblGRCh38hg38GRCh38
GRCh372220,192,129 - 220,197,899 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,900,375 - 219,906,143 (-)NCBINCBI36Build 36hg18NCBI36
Celera2213,962,131 - 213,967,896 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2212,045,173 - 212,050,937 (-)NCBIHuRef
CHM1_12220,197,974 - 220,203,727 (-)NCBICHM1_1
T2T-CHM13v2.02219,812,175 - 219,821,424 (-)NCBIT2T-CHM13v2.0
Resp18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39175,248,841 - 75,255,059 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl175,248,843 - 75,255,059 (-)EnsemblGRCm39 Ensembl
GRCm38175,272,197 - 75,278,415 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl175,272,199 - 75,278,415 (-)EnsemblGRCm38mm10GRCm38
MGSCv37175,268,777 - 75,274,955 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36175,155,350 - 75,161,528 (-)NCBIMGSCv36mm8
Celera175,763,036 - 75,769,217 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.65NCBI
Resp18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545314,106,430 - 14,111,920 (+)NCBIChiLan1.0ChiLan1.0
RESP18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,957,498 - 121,964,196 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,972,446 - 121,983,317 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,584,632 - 106,590,704 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B225,175,198 - 225,180,916 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B225,175,221 - 225,180,916 (-)Ensemblpanpan1.1panPan2
Resp18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,388,977 - 175,394,900 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365691,731,756 - 1,737,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RESP18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.115121,364,165 - 121,371,430 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,397,624 - 134,404,845 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RESP18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110105,230,482 - 105,235,907 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10105,230,560 - 105,235,766 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604094,162,499 - 94,167,915 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Resp18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248235,688,508 - 5,693,522 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Resp18
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:39
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000026753
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97665062976771824Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)95584784177026453Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
2303180Bp333Blood pressure QTL 3330.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)95662771378595166Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat

Markers in Region
D9Mco42  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,772,836 - 76,773,039 (+)MAPPERmRatBN7.2
Rnor_6.0982,478,446 - 82,478,648NCBIRnor6.0
Rnor_5.0982,247,707 - 82,247,909UniSTSRnor5.0
RGSC_v3.4974,559,461 - 74,559,663UniSTSRGSC3.4
Celera974,343,220 - 74,343,422UniSTS
Cytogenetic Map9q33UniSTS




Genetic Models
This gene Resp18 is modified in the following models/strains:


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 214 95 93 43 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026753   ⟹   ENSRNOP00000026753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,765,184 - 76,778,722 (-)Ensembl
Rnor_6.0 Ensembl982,470,794 - 82,477,136 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089555   ⟹   ENSRNOP00000071007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,764,590 - 76,771,526 (-)Ensembl
Rnor_6.0 Ensembl982,470,759 - 82,477,181 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116091   ⟹   ENSRNOP00000086022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl976,765,184 - 76,770,612 (-)Ensembl
RefSeq Acc Id: NM_019278   ⟹   NP_062151
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,213,844 - 84,220,186 (-)NCBI
mRatBN7.2976,765,184 - 76,771,526 (-)NCBI
Rnor_6.0982,470,794 - 82,477,136 (-)NCBI
Rnor_5.0982,240,055 - 82,246,695 (-)NCBI
RGSC_v3.4974,551,809 - 74,558,151 (-)RGD
Celera974,335,568 - 74,341,910 (-)RGD
Sequence:
RefSeq Acc Id: NP_062151   ⟸   NM_019278
- Peptide Label: precursor
- UniProtKB: P47940 (UniProtKB/Swiss-Prot),   A6JW14 (UniProtKB/TrEMBL),   A0A0G2JZD6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026753   ⟸   ENSRNOT00000026753
Ensembl Acc Id: ENSRNOP00000071007   ⟸   ENSRNOT00000089555
Ensembl Acc Id: ENSRNOP00000086022   ⟸   ENSRNOT00000116091
Protein Domains
RESP18

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47940-F1-model_v2 AlphaFold P47940 1-175 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696779
Promoter ID:EPDNEW_R7302
Type:initiation region
Name:Resp18_1
Description:regulated endocrine-specific protein 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0982,477,112 - 82,477,172EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3555 AgrOrtholog
BioCyc Gene G2FUF-27080 BioCyc
Ensembl Genes ENSRNOG00000019704 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026753.3 UniProtKB/TrEMBL
  ENSRNOT00000089555.2 UniProtKB/TrEMBL
  ENSRNOT00000116091.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6922403 IMAGE-MGC_LOAD
InterPro RESP18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RESP18_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50561 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72855 IMAGE-MGC_LOAD
NCBI Gene 50561 ENTREZGENE
PANTHER PTHR17314 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REGULATED ENDOCRINE-SPECIFIC PROTEIN 18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RESP18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Resp18 PhenoGen
RatGTEx ENSRNOG00000019704 RatGTEx
SMART RESP18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217837
UniProt A0A0G2JZD6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A1F3_RAT UniProtKB/TrEMBL
  A0A8L2QE97_RAT UniProtKB/TrEMBL
  A6JW13_RAT UniProtKB/TrEMBL
  A6JW14 ENTREZGENE, UniProtKB/TrEMBL
  A6JW15_RAT UniProtKB/TrEMBL
  P47940 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Resp18  regulated endocrine-specific protein 18      Name updated 70584 APPROVED