Reg1a (regenerating family member 1 alpha) - Rat Genome Database

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Gene: Reg1a (regenerating family member 1 alpha) Rattus norvegicus
Analyze
Symbol: Reg1a
Name: regenerating family member 1 alpha
RGD ID: 3552
Description: Enables growth factor activity; identical protein binding activity; and protein phosphatase binding activity. Involved in several processes, including cellular response to gastrin; liver regeneration; and positive regulation of epithelial cell proliferation. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and zymogen granule. Part of protein-containing complex. Biomarker of colon cancer and myocardial infarction. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including REG1A (regenerating family member 1 alpha); INTERACTS WITH acetylsalicylic acid; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ICRF; islet cells regeneration factor; islet of Langerhans regenerating protein; LITHOST; lithostathine; pancreatic stone protein; pancreatic thread protein; PSP; PTP; rat regenerating islet-derived mouse homolog 1; RATLITHOST; RATRGPI; Reg; Reg1; regenerating islet-derived 1; regenerating islet-derived 1 alpha; regenerating islet-derived mouse homolog 1; regeneration protein lithostatin pancreatic stone protein; regeneration protein, lithostatin, pancreatic stone protein; Rgp1; RGPI
RGD Orthologs
Human
Mouse
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84112,450,466 - 112,453,130 (+)NCBIGRCr8
mRatBN7.24110,892,451 - 110,895,115 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4110,892,453 - 110,895,570 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4116,298,026 - 116,300,690 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04112,073,127 - 112,075,791 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04110,693,322 - 110,695,986 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04109,497,962 - 109,500,626 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4109,497,962 - 109,501,082 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04174,199,389 - 174,202,053 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44112,386,071 - 112,389,205 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14112,630,551 - 112,633,685 (+)NCBI
Celera499,924,400 - 99,927,064 (+)NCBICelera
Cytogenetic Map4q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Regenerating islet-derived 1alpha (Reg-1alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin Tumor-like 3 (EXTL3) receptor. Acquatella-Tran Van Ba I, etal., J Biol Chem. 2012 Feb 10;287(7):4726-39. doi: 10.1074/jbc.M111.260349. Epub 2011 Dec 9.
2. Insights into the mechanisms of gastric adaptation to aspirin-induced injury: a role for regenerating protein but not trefoil peptides. Alderman BM, etal., Lab Invest. 2003 Oct;83(10):1415-25.
3. Reg gene expression is increased in rat gastric enterochromaffin-like cells following water immersion stress. Asahara M, etal., Gastroenterology. 1996 Jul;111(1):45-55.
4. Immunoreactive forms of pancreatic stone protein in six mammalian species. Bernard JP, etal., Pancreas. 1991 Mar;6(2):162-7.
5. Coordinate regulation of PSP/reg and PAP isoforms as a family of secretory stress proteins in an animal model of chronic pancreatitis. Bimmler D, etal., J Surg Res 2004 May 15;118(2):122-35.
6. Pancreatic regenerating protein (reg I) and reg I receptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis. Bluth MH, etal., World J Gastroenterol. 2006 Jul 28;12(28):4511-6.
7. PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha. Bodeker H, etal., Mol Cell Biol Res Commun. 1999 Sep-Dec;2(3):150-4.
8. Age-related changes in peptide-23/pancreatitis-associated protein and pancreatic stone protein/reg gene expression in the rat and regulation by growth hormone-releasing hormone. Chakraborty C, etal., Endocrinology. 1995 May;136(5):1843-9.
9. Bifidobacterium longum supplementation improved high-fat-fed-induced metabolic syndrome and promoted intestinal Reg I gene expression. Chen JJ, etal., Exp Biol Med (Maywood). 2011 Jul;236(7):823-31. doi: 10.1258/ebm.2011.010399. Epub 2011 Jun 17.
10. The human pancreatic stone protein. De Caro A, etal., Biochimie. 1988 Sep;70(9):1209-14.
11. Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain. de la Monte SM, etal., J Clin Invest. 1990 Sep;86(3):1004-13.
12. Rapid PCR cloning and sequence determination of the rat lithostathine gene. Dusetti NJ, etal., Biochim Biophys Acta 1993 Jul 18;1174(1):99-102.
13. Regenerating gene protein may mediate gastric mucosal proliferation induced by hypergastrinemia in rats. Fukui H, etal., Gastroenterology. 1998 Dec;115(6):1483-93.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. A family of 16-kDa pancreatic secretory stress proteins form highly organized fibrillar structures upon tryptic activation. Graf R, etal., J Biol Chem. 2001 Jun 15;276(24):21028-38. Epub 2001 Mar 16.
17. Amelioration of diabetes in nonobese diabetic mice with advanced disease by linomide-induced immunoregulation combined with Reg protein treatment. Gross DJ, etal., Endocrinology. 1998 May;139(5):2369-74.
18. Human REG I gene is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions. Harada K, etal., Hepatology. 2001 May;33(5):1036-42.
19. Mutations of RegIalpha are associated with enterochromaffin-like cell tumor development in patients with hypergastrinemia. Higham AD, etal., Gastroenterology. 1999 Jun;116(6):1310-8.
20. Reg protein is overexpressed in gastric cancer cells, where it activates a signal transduction pathway that converges on ERK1/2 to stimulate growth. Kadowaki Y, etal., FEBS Lett 2002 Oct 23;530(1-3):59-64.
21. Neutrophil chemoattractant 2 beta regulates expression of the Reg gene in injured gastric mucosa in rats. Kazumori H, etal., Gastroenterology. 2000 Dec;119(6):1610-22.
22. Activation of regenerating gene Reg in rat and human hearts in response to acute stress. Kiji T, etal., Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H277-84. Epub 2005 Mar 18.
23. Involvement of REG Ialpha protein in the regeneration of ductal epithelial cells in the minor salivary glands of patients with Sjogren's syndrome. Kimura T, etal., Clin Exp Immunol. 2009 Jan;155(1):16-20. doi: 10.1111/j.1365-2249.2008.03806.x. Epub 2008 Nov 6.
24. Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor. Kobayashi S, etal., J Biol Chem 2000 Apr 14;275(15):10723-6.
25. Secretory apparatus assessed by analysis of pancreatic secretory stress protein expression in a rat model of chronic pancreatitis. Meili S, etal., Cell Tissue Res. 2003 Jun;312(3):291-9. Epub 2003 May 23.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Characterization of the 5'-regulatory region of rat Reg I gene. Miyashita H, etal., Biochim Biophys Acta 1994 Sep 13;1219(1):241-3.
28. Pancreatic reg I binds MKP-1 and regulates cyclin D in pancreatic-derived cells. Mueller CM, etal., J Surg Res. 2008 Nov;150(1):137-43. doi: 10.1016/j.jss.2008.03.047. Epub 2008 Apr 28.
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. Increased expression of a regenerating (reg) gene protein in neonatal rat pancreas treated with streptozotocin. Ohno T, etal., Endocr J. 1995 Oct;42(5):649-53.
31. The Reg gene family and Reg proteins: with special attention to the regeneration of pancreatic beta-cells. Okamoto H J Hepatobiliary Pancreat Surg. 1999;6(3):254-62.
32. Pancreatic beta cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene. Ota H, etal., Life Sci. 2013 Nov 4;93(18-19):664-72. doi: 10.1016/j.lfs.2013.09.001. Epub 2013 Sep 17.
33. GOA pipeline RGD automated data pipeline
34. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
35. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
36. Rat pancreatic stone protein messenger RNA. Abundant expression in mature exocrine cells, regulation by food content, and sequence identity with the endocrine reg transcript. Rouquier S, etal., J Biol Chem 1991 Jan 15;266(2):786-91.
37. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
38. A novel gene activated in regenerating islets. Terazono K, etal., J Biol Chem 1988 Feb 15;263(5):2111-4.
39. Administration of anti-Reg I and anti-PAPII antibodies worsens pancreatitis. Viterbo D, etal., JOP. 2009 Jan 8;10(1):15-23.
40. Expression and localization of regenerating gene I in a rat liver regeneration model. Wang J, etal., Biochem Biophys Res Commun. 2009 Mar 13;380(3):472-7. doi: 10.1016/j.bbrc.2009.01.126. Epub 2009 Jan 27.
41. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. Watanabe T, etal., J Biol Chem. 1990 May 5;265(13):7432-9.
42. Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein. Watanabe T, etal., Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3589-92.
43. Effect of reg protein on rat pancreatic ductal cells. Zenilman ME, etal., Pancreas. 1998 Oct;17(3):256-61.
Additional References at PubMed
PMID:18953250   PMID:19557902   PMID:23370676   PMID:23376485   PMID:23533145   PMID:23544109   PMID:23954444   PMID:24465846   PMID:28415799   PMID:29537200  


Genomics

Comparative Map Data
Reg1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84112,450,466 - 112,453,130 (+)NCBIGRCr8
mRatBN7.24110,892,451 - 110,895,115 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4110,892,453 - 110,895,570 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4116,298,026 - 116,300,690 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04112,073,127 - 112,075,791 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04110,693,322 - 110,695,986 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04109,497,962 - 109,500,626 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4109,497,962 - 109,501,082 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04174,199,389 - 174,202,053 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44112,386,071 - 112,389,205 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14112,630,551 - 112,633,685 (+)NCBI
Celera499,924,400 - 99,927,064 (+)NCBICelera
Cytogenetic Map4q33NCBI
REG1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38279,120,488 - 79,123,409 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl279,120,362 - 79,123,409 (+)EnsemblGRCh38hg38GRCh38
GRCh37279,347,614 - 79,350,535 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36279,201,092 - 79,204,053 (+)NCBINCBI36Build 36hg18NCBI36
Build 34279,259,238 - 79,262,200NCBI
Celera279,176,313 - 79,179,273 (+)NCBICelera
Cytogenetic Map2p12NCBI
HuRef279,082,895 - 79,085,855 (+)NCBIHuRef
CHM1_1279,277,113 - 79,280,074 (+)NCBICHM1_1
T2T-CHM13v2.0279,120,807 - 79,123,727 (+)NCBIT2T-CHM13v2.0
Reg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39678,402,966 - 78,405,651 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl678,399,694 - 78,405,650 (+)EnsemblGRCm39 Ensembl
GRCm38678,425,983 - 78,428,668 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl678,422,711 - 78,428,667 (+)EnsemblGRCm38mm10GRCm38
MGSCv37678,375,977 - 78,378,660 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36678,355,492 - 78,358,175 (+)NCBIMGSCv36mm8
Celera680,448,960 - 80,451,643 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map634.77NCBI
Reg1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062925,855,625 - 5,864,718 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365564,873,331 - 4,875,608 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365564,873,331 - 4,875,608 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Reg1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474923,993,755 - 23,995,923 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Reg1a
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:342
Count of miRNA genes:217
Interacting mature miRNAs:249
Transcripts:ENSRNOT00000057869
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4103194805112478794Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat

Markers in Region
D4Wox28  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24110,891,355 - 110,891,492 (+)MAPPERmRatBN7.2
Rnor_6.04109,496,867 - 109,497,003NCBIRnor6.0
Rnor_5.04174,198,294 - 174,198,430UniSTSRnor5.0
RGSC_v3.44112,384,976 - 112,385,112UniSTSRGSC3.4
Celera499,923,305 - 99,923,441UniSTS
Cytogenetic Map4q33-q34UniSTS
RH128913  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24110,894,873 - 110,895,059 (+)MAPPERmRatBN7.2
Rnor_6.04109,500,385 - 109,500,570NCBIRnor6.0
Rnor_5.04174,201,812 - 174,201,997UniSTSRnor5.0
RGSC_v3.44112,388,964 - 112,389,149UniSTSRGSC3.4
Celera499,926,823 - 99,927,008UniSTS
RH 3.4 Map9868.3UniSTS
Cytogenetic Map4q33-q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 4 5 4
Low 1 2 4 2 5 2 3 1
Below cutoff 15 9 6 4 5 8 1 8 4 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000057869   ⟹   ENSRNOP00000054678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4110,892,453 - 110,895,570 (+)Ensembl
Rnor_6.0 Ensembl4109,497,962 - 109,501,082 (+)Ensembl
RefSeq Acc Id: NM_012641   ⟹   NP_036773
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84112,450,466 - 112,453,130 (+)NCBI
mRatBN7.24110,892,451 - 110,895,115 (+)NCBI
Rnor_6.04109,497,962 - 109,500,626 (+)NCBI
Rnor_5.04174,199,389 - 174,202,053 (+)NCBI
RGSC_v3.44112,386,071 - 112,389,205 (+)RGD
Celera499,924,400 - 99,927,064 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036773   ⟸   NM_012641
- Peptide Label: precursor
- UniProtKB: P10758 (UniProtKB/Swiss-Prot),   A6IAG3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054678   ⟸   ENSRNOT00000057869
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10758-F1-model_v2 AlphaFold P10758 1-165 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693155
Promoter ID:EPDNEW_R3679
Type:multiple initiation site
Name:Reg1a_1
Description:regenerating family member 1 alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04109,497,963 - 109,498,023EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3552 AgrOrtholog
BioCyc Gene G2FUF-44084 BioCyc
Ensembl Genes ENSRNOG00000006486 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055020553 UniProtKB/Swiss-Prot
  ENSRNOG00060002099 UniProtKB/Swiss-Prot
  ENSRNOG00065005420 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000057869 ENTREZGENE
  ENSRNOT00000057869.6 UniProtKB/Swiss-Prot
  ENSRNOT00055035083 UniProtKB/Swiss-Prot
  ENSRNOT00060003289 UniProtKB/Swiss-Prot
  ENSRNOT00065008033 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24714 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24714 ENTREZGENE
PANTHER LITHOSTATHINE-1-ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Reg1a PhenoGen
PRINTS PNCREATITSAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006486 RatGTEx
  ENSRNOG00055020553 RatGTEx
  ENSRNOG00060002099 RatGTEx
  ENSRNOG00065005420 RatGTEx
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP C-type lectin-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC232312
UniProt A6IAG3 ENTREZGENE, UniProtKB/TrEMBL
  LITH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Reg1a  regenerating family member 1 alpha  Reg1a  regenerating islet-derived 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Reg1a  regenerating islet-derived 1 alpha  Reg1  regenerating islet-derived 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Reg1  regeneration protein, lithostatin, pancreatic stone protein      Symbol and Name status set to approved 70586 APPROVED
2001-06-20 Reg  Regeneration protein, lithostatin, pancreatic stone protein      Symbol withdrawn, duplicate of Reg1 (RGD:3552) 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference