RGD Reference Report - Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain. - Rat Genome Database

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Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain.

Authors: De la Monte, SM  Ozturk, M  Wands, JR 
Citation: de la Monte SM, etal., J Clin Invest. 1990 Sep;86(3):1004-13.
RGD ID: 9850119
Pubmed: PMID:2394826   (View Abstract at PubMed)
PMCID: PMC296822   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI114762   (Journal Full-text)

Pancreatic thread protein (PTP) is a major exocrine secretory protein that in vitro forms filamentous bundles reminiscent of the paired helical filaments of Alzheimer's disease (AD). We previously described increased PTP immunoreactivity in AD brains and now report high levels in the developing human brain. Using a full-length cloned bovine PTP cDNA and synthetic oligonucleotides corresponding to human PTP cDNA, which is identical to human islet cell regeneration factor, we analyzed the expression of PTP in pancreas and brain. A major 0.9-kb as well as several minor transcripts were identified in human pancreas. In AD brain, the same size transcripts were detected by Northern analysis, primer extension assay, or polymerase chain reaction amplification of cDNAs generated by reverse transcriptase assay. There were significantly higher levels of PTP mRNA in brains with AD compared with aged controls, with increased amounts of 1.2-, 0.6-, and 0.4-kb transcripts by Northern analysis. In situ hybridization localized expression to pyramidal neurons in the cerebral cortex, the same population that contains neurofibrillary tangles and high levels of immunoreactive PTP. These findings suggest that AD is associated with enhanced expression of PTP-related transcripts with intraneuronal accumulation of PTP-like proteins.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IEP 9850119mRNA:increased expression:brain (human)RGD 
Alzheimer's disease  ISOREG1A (Homo sapiens)9850119; 9850119mRNA:increased expression:brain (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Reg1a  (regenerating family member 1 alpha)

Genes (Mus musculus)
Reg1  (regenerating islet-derived 1)

Genes (Homo sapiens)
REG1A  (regenerating family member 1 alpha)


Additional Information