Rasgrp1 Rat Gene (RAS guanyl releasing protein 1 (calcium and DAG-regulated))

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Keyword

Gene:
Rasgrp1 ( Rattus norvegicus )
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
Description: putative guanine nucleotide exchange factor with Ca2+ and diacylglycerol binding domains; may activate Rap protein mediated inhibition of Ras signaling pathways
Synonyms: RAS guanyl releasing protein 1; CalDAG-GEF1; Rasgrp; calcium and DAG-regulated guanine nucleotide exchange factor II; RAS guanyl releasing protein;
ArrayIDs: 5779645; 1369129_at; 6223600; 1369130_at; 5810704; 6190009; GE20587; 6721071; 6650396; 6129937; 6272890; AF081196_at; 6618375; AF060819_s_at; 6124315; 1383542_at; 6569193; 6094851; 5763569; 6020373; A_43_P11980; 6353551; 6500412; 6396860; 6204238; 5761525; GE1137371; 6397519; 6621006; 5765131; 6545727; 5867544; 6024801; 6688149; 6140833;  (details...)
Gene Type: protein-coding

Additional Data

Homologs
Homo sapiens: RASGRP1     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Rasgrp1     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Rasgrp1 genome assembly 3.1 3 103268306 - 103329438
Rat Celera Assembly 3 103097991 - 103157871
RGSC genome assembly v3.4 3 103371879 - 103433010
Cytogenetic 3 q34-q35
Mus musculus Rasgrp1 Mouse genome assembly build 36.1 2 117105729 - 117168613
Cytogenetic 2 2 E5
Homo sapiens RASGRP1 human genome assembly 15 36567597 - 36644224
Human genome assembly build 36.2 15 36567596 - 36644224
Cytogenetic 15 q14

View comparative maps:      NCBI MapViewer

Genome
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Annotation
Molecular Function

Gene Ontology

protein binding,  zinc ion binding,  guanyl-nucleotide exchange factor activity ... (details...)
Biological Process

Gene Ontology

regulation of small GTPase mediated signal transduction,  cell differentiation (details...)
Cellular Component

Gene Ontology

cytoplasm,  plasma membrane,  Golgi apparatus ... (details...)

External Links
Databases
DATABASE ID SOURCE
SMART: RasGEFN IPI
SMART: RasGEF IPI
SMART: C1 IPI
PROSITE: ZF_DAG_PE_2 IPI
PROSITE: ZF_DAG_PE_1 IPI
PROSITE: RASGEF_CAT IPI
PROSITE: EF_HAND_2 IPI
PROSITE: EF_HAND_1 IPI
PROSITE: RASGEF_NTER IPI
UNIPARC: UPI0000182502 IPI
UNIPARC: UPI00000E6B13 IPI
KEGG Report: rno:29434 ENTREZGENE
HomoloGene Group ID: 4195 ENTREZGENE
Germonline: 3539
Pfam: efhand IPI
Pfam: RasGEF_N IPI
Pfam: RasGEF IPI
Pfam: C1_1 IPI
KEGG Pathway: 04010 ENTREZGENE
KEGG Pathway: 04660 ENTREZGENE
InterPro: Ras_GEF. IPI
InterPro: RasGRF_CDC25. IPI
InterPro: Ras-like_Gua-exchang_fac_N. IPI
InterPro: DAG/PE_bd. IPI
InterPro: EF-Hand_type. IPI
InterPro: EF_Hand_1_Ca_BS. IPI
InterPro: EF_HAND_2. IPI
InterPro: Prot_Kinase_C-like_PE/DAG_bd. IPI
InterPro: EF_Hand_dom. IPI
Ensembl Protein: ENSRNOP00000059214 IPI
Ensembl Protein: ENSRNOP00000007687 IPI
IPI: IPI00951224 IPI
IPI: IPI00214389 IPI
Gene3D-CATH: EF-Hand_type IPI
Gene3D-CATH: RasGRF_CDC25 IPI
Entrez Gene: Rasgrp1 ENTREZGENE
TIGR: TC234472
UniProt: GRP1_RAT IPI
Ensembl Genes: ENSRNOG00000005404 IPI
Superfamily-SCOP: Ras_GEF IPI
PANTHER: Ras_GEF IPI
PRINTS: DAGPEDOMAIN. IPI
Sequences
Nucleotide: NM_019211 Get FASTA Search GEO Profiles
Nucleotide: CH473949 Get FASTA Search GEO Profiles
Nucleotide: AF060819 Get FASTA Search GEO Profiles
Nucleotide: AF081196 Get FASTA Search GEO Profiles
(View all 4 Nucleotide Accessions)
Protein: Q9R1K8 Get FASTA
Protein: AAC79700 Get FASTA
Protein: EDL79846 Get FASTA
Protein: NP_062084 Get FASTA
Protein: AAC40137 Get FASTA
(View all 5 Protein Accessions)
Clusters
UniGene: 162685

References
Curated References
8 references in RGD related to Rasgrp1

Other References
5 other references at PubMed related to Rasgrp1

Database Information
RGD ID 3539
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

24-SEP-08: Rasgrp1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) Rasgrp1 RAS guanyl releasing protein 1 APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863

10-JUN-02: Rasgrp1 RAS guanyl releasing protein 1 APPROVED Name updated 70584

06-DEC-01: Rasgrp1 RAS guanyl releasing protein 1 APPROVED Symbol updated to reflect Human and Mouse nomenclature 69665