Rasa2 (RAS p21 protein activator 2) - Rat Genome Database

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Gene: Rasa2 (RAS p21 protein activator 2) Rattus norvegicus
Analyze
Symbol: Rasa2
Name: RAS p21 protein activator 2
RGD ID: 3538
Description: Enables GTPase activator activity. Predicted to be involved in intracellular signal transduction and negative regulation of Ras protein signal transduction. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human RASA2 (RAS p21 protein activator 2); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GAP1M; ras GTPase-activating protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88105,996,797 - 106,116,285 (-)NCBIGRCr8
mRatBN7.2897,119,983 - 97,236,687 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl897,118,802 - 97,236,671 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8102,786,496 - 102,902,394 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08100,985,753 - 101,101,643 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0898,824,714 - 98,940,606 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08104,417,827 - 104,542,313 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8104,414,567 - 104,542,317 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08103,859,311 - 103,988,460 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48101,616,850 - 101,734,769 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18101,635,908 - 101,754,268 (-)NCBI
Celera896,563,044 - 96,679,053 (-)NCBICelera
RH 3.4 Map81059.99RGD
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Next-generation sequencing identifies rare variants associated with Noonan syndrome. Chen PC, etal., Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11473-8. doi: 10.1073/pnas.1324128111. Epub 2014 Jul 21.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions. Maekawa M, etal., Mol Cell Biol 1994 Oct;14(10):6879-85.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8226805  


Genomics

Comparative Map Data
Rasa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88105,996,797 - 106,116,285 (-)NCBIGRCr8
mRatBN7.2897,119,983 - 97,236,687 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl897,118,802 - 97,236,671 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8102,786,496 - 102,902,394 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08100,985,753 - 101,101,643 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0898,824,714 - 98,940,606 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08104,417,827 - 104,542,313 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8104,414,567 - 104,542,317 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08103,859,311 - 103,988,460 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48101,616,850 - 101,734,769 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18101,635,908 - 101,754,268 (-)NCBI
Celera896,563,044 - 96,679,053 (-)NCBICelera
RH 3.4 Map81059.99RGD
Cytogenetic Map8q31NCBI
RASA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383141,487,027 - 141,615,344 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3141,487,027 - 141,615,344 (+)EnsemblGRCh38hg38GRCh38
GRCh373141,205,869 - 141,334,186 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363142,688,616 - 142,813,887 (+)NCBINCBI36Build 36hg18NCBI36
Build 343142,688,623 - 142,813,895NCBI
Celera3139,629,479 - 139,754,949 (+)NCBICelera
Cytogenetic Map3q23NCBI
HuRef3138,580,937 - 138,706,253 (+)NCBIHuRef
CHM1_13141,169,053 - 141,294,259 (+)NCBICHM1_1
T2T-CHM13v2.03144,234,722 - 144,362,958 (+)NCBIT2T-CHM13v2.0
Rasa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39996,421,353 - 96,513,665 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl996,421,353 - 96,513,670 (-)EnsemblGRCm39 Ensembl
GRCm38996,539,300 - 96,631,612 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl996,539,300 - 96,631,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv37996,439,719 - 96,531,922 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36996,351,797 - 96,440,845 (-)NCBIMGSCv36mm8
Celera996,098,648 - 96,190,756 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map950.66NCBI
Rasa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555084,100,525 - 4,196,753 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555084,097,455 - 4,199,954 (-)NCBIChiLan1.0ChiLan1.0
RASA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22139,396,840 - 139,525,928 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13139,401,573 - 139,530,661 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03138,520,013 - 138,648,798 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13146,108,019 - 146,245,637 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3146,108,019 - 146,245,637 (+)Ensemblpanpan1.1panPan2
RASA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12337,298,422 - 37,509,234 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2337,411,022 - 37,506,844 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2337,348,977 - 37,501,906 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02337,886,431 - 38,039,822 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2337,915,985 - 38,039,813 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12337,569,880 - 37,722,763 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02337,647,104 - 37,800,458 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02337,889,916 - 38,043,155 (+)NCBIUU_Cfam_GSD_1.0
Rasa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560276,581,661 - 76,672,136 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365403,321,479 - 3,408,901 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365403,321,458 - 3,410,715 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RASA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1382,230,178 - 82,352,756 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11382,230,138 - 82,352,759 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21390,125,160 - 90,191,809 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RASA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11548,995,847 - 49,118,895 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1548,995,848 - 49,118,824 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604121,931,589 - 22,054,632 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rasa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473018,119,727 - 18,250,815 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473018,119,663 - 18,253,854 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rasa2
216 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:22
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000016327
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat

Markers in Region
RH132500  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2897,117,349 - 97,117,563 (+)MAPPERmRatBN7.2
Rnor_6.08104,422,959 - 104,423,172NCBIRnor6.0
Rnor_6.08104,414,728 - 104,414,941NCBIRnor6.0
Rnor_5.08103,865,558 - 103,865,771UniSTSRnor5.0
Rnor_5.08103,857,761 - 103,857,974UniSTSRnor5.0
RGSC_v3.48101,613,751 - 101,613,964UniSTSRGSC3.4
Celera896,559,945 - 96,560,158UniSTS
RH 3.4 Map81058.5UniSTS
Cytogenetic Map8q31UniSTS
RH94824  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2897,120,057 - 97,120,305 (+)MAPPERmRatBN7.2
Rnor_6.08104,417,436 - 104,417,683NCBIRnor6.0
Rnor_5.08103,860,469 - 103,860,716UniSTSRnor5.0
RGSC_v3.48101,616,459 - 101,616,706UniSTSRGSC3.4
Celera896,562,653 - 96,562,900UniSTS
RH 3.4 Map81059.99UniSTS
Cytogenetic Map8q31UniSTS
RH143376  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2897,120,104 - 97,120,247 (+)MAPPERmRatBN7.2
Rnor_6.08104,417,483 - 104,417,625NCBIRnor6.0
Rnor_5.08103,860,516 - 103,860,658UniSTSRnor5.0
RGSC_v3.48101,616,506 - 101,616,648UniSTSRGSC3.4
Celera896,562,700 - 96,562,842UniSTS
RH 3.4 Map81051.3UniSTS
Cytogenetic Map8q31UniSTS
BARC0073  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2897,180,284 - 97,180,503 (+)MAPPERmRatBN7.2
mRatBN7.21225,740,516 - 225,740,721 (+)MAPPERmRatBN7.2
Rnor_6.01246,142,301 - 246,142,505NCBIRnor6.0
Rnor_6.08104,484,176 - 104,484,394NCBIRnor6.0
Rnor_5.08103,926,775 - 103,926,993UniSTSRnor5.0
Rnor_5.01253,386,006 - 253,386,210UniSTSRnor5.0
RGSC_v3.41231,632,995 - 231,633,199UniSTSRGSC3.4
RGSC_v3.48101,677,756 - 101,677,974UniSTSRGSC3.4
Celera896,622,999 - 96,623,217UniSTS
Celera1222,907,133 - 222,907,337UniSTS
Cytogenetic Map1q52UniSTS
Cytogenetic Map8q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 4 8 18 70 28 33 9
Low 1 39 49 41 1 41 8 10 4 7 8 2 8
Below cutoff 1

Sequence


RefSeq Acc Id: ENSRNOT00000016327   ⟹   ENSRNOP00000016327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl897,118,802 - 97,236,671 (-)Ensembl
Rnor_6.0 Ensembl8104,414,567 - 104,542,317 (-)Ensembl
RefSeq Acc Id: NM_001105724   ⟹   NP_001099194
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88106,000,002 - 106,116,206 (-)NCBI
mRatBN7.2897,120,449 - 97,236,661 (-)NCBI
Rnor_6.08104,417,827 - 104,542,313 (-)NCBI
Rnor_5.08103,859,311 - 103,988,460 (-)NCBI
RGSC_v3.48101,616,850 - 101,734,769 (-)RGD
Celera896,563,044 - 96,679,053 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080892   ⟹   XP_038936820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88105,996,797 - 106,116,232 (-)NCBI
mRatBN7.2897,119,983 - 97,236,687 (-)NCBI
RefSeq Acc Id: XM_063264951   ⟹   XP_063121021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88106,034,637 - 106,116,285 (-)NCBI
RefSeq Acc Id: XM_063264952   ⟹   XP_063121022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88106,042,285 - 106,116,284 (-)NCBI
RefSeq Acc Id: XR_010053933
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88106,031,143 - 106,116,284 (-)NCBI
RefSeq Acc Id: NP_001099194   ⟸   NM_001105724
- UniProtKB: Q63713 (UniProtKB/Swiss-Prot),   A6I283 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016327   ⟸   ENSRNOT00000016327
RefSeq Acc Id: XP_038936820   ⟸   XM_039080892
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063121021   ⟸   XM_063264951
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063121022   ⟸   XM_063264952
- Peptide Label: isoform X3
Protein Domains
C2   PH   Ras-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63713-F1-model_v2 AlphaFold Q63713 1-847 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696194
Promoter ID:EPDNEW_R6719
Type:initiation region
Name:Rasa2_1
Description:RAS p21 protein activator 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08104,542,357 - 104,542,417EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3538 AgrOrtholog
BioCyc Gene G2FUF-29451 BioCyc
Ensembl Genes ENSRNOG00000011909 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055017543 UniProtKB/Swiss-Prot
  ENSRNOG00060008057 UniProtKB/Swiss-Prot
  ENSRNOG00065007425 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016327 ENTREZGENE
  ENSRNOT00000016327.6 UniProtKB/Swiss-Prot
  ENSRNOT00055029678 UniProtKB/Swiss-Prot
  ENSRNOT00060013289 UniProtKB/Swiss-Prot
  ENSRNOT00065011581 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASA2_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGAP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_Btk_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25597 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25597 ENTREZGENE
PANTHER PTHR10194 UniProtKB/Swiss-Prot
  RAS GTPASE-ACTIVATING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS GTPASE-ACTIVATING PROTEINS UniProtKB/TrEMBL
Pfam BTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rasa2 PhenoGen
PRINTS TECBTKDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_BTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011909 RatGTEx
  ENSRNOG00055017543 RatGTEx
  ENSRNOG00060008057 RatGTEx
  ENSRNOG00065007425 RatGTEx
SMART BTK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP C2 domain (Calcium/lipid-binding domain, CaLB) UniProtKB/TrEMBL
  GTPase activation domain, GAP UniProtKB/TrEMBL
  PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48350 UniProtKB/Swiss-Prot
  SSF49562 UniProtKB/Swiss-Prot
UniProt A6I283 ENTREZGENE, UniProtKB/TrEMBL
  Q63713 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Rasa2  RAS p21 protein activator 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains has domains with similarity to the synaptotagamin phospholipid-binding domain and to a Btk tyrosine kinase domain 729718