Psap (prosaposin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Psap (prosaposin) Rattus norvegicus
Analyze
Symbol: Psap
Name: prosaposin
RGD ID: 3423
Description: Predicted to enable several functions, including ganglioside binding activity; protein homodimerization activity; and scaffold protein binding activity. Predicted to be involved in several processes, including cellular response to reactive oxygen species; ganglioside GM1 transport to membrane; and prostate gland development. Predicted to act upstream of or within with a negative effect on gene expression. Predicted to act upstream of or within several processes, including glycosylceramide metabolic process; nervous system development; and protein transport. Predicted to be located in aggresome; extracellular region; and late endosome. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in atypical Gaucher's disease due to saposin c deficiency; combined saposin deficiency; and late onset Parkinson's disease. Orthologous to human PSAP (prosaposin); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Prosaposin (sulfated glycoprotein sphingolipid hydrolase activator); Prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator); SGP-1; SGP1A; sulfated glycoprotein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82028,756,951 - 28,783,422 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2028,757,181 - 28,783,421 (+)EnsemblGRCr8
mRatBN7.22028,214,229 - 28,240,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2028,214,271 - 28,240,498 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2029,228,797 - 29,255,391 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02028,615,101 - 28,641,697 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02029,357,562 - 29,384,161 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02029,831,302 - 29,856,876 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2029,831,314 - 29,856,875 (+)Ensemblrn6Rnor6.0
Rnor_5.02031,629,564 - 31,668,605 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42027,595,048 - 27,621,574 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2029,653,298 - 29,678,819 (+)NCBICelera
RGSC_v3.12027,608,847 - 27,635,374 (+)NCBI
Cytogenetic Map20q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcidiol  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (ISO)
diquat  (ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
glycidyl methacrylate  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
Monobutylphthalate  (ISO)
oxaliplatin  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenylpropanolamine  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
propiconazole  (ISO)
raloxifene  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
aggresome  (ISO)
cytoplasm  (IEA,ISO)
extracellular region  (IEA,ISO,ISS)
extracellular space  (IBA,ISO)
late endosome  (ISO,ISS)
lysosome  (IBA,IEA,ISO,ISS)
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Biosynthesis and molecular cloning of sulfated glycoprotein 1 secreted by rat Sertoli cells: sequence similarity with the 70-kilodalton precursor to sulfatide/GM1 activator. Collard MW, etal., Biochemistry 1988 Jun 14;27(12):4557-64.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The evolutionary history of prosaposin: two successive tandem-duplication events gave rise to the four saposin domains in vertebrates. Hazkani-Covo E, etal., J Mol Evol 2002 Jan;54(1):30-4.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Molecular role of sulfated glycoprotein-1 (SGP-1/prosaposin) in Sertoli cells. Morales CR, etal., Histol Histopathol 1995 Oct;10(4):1023-34.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1454804   PMID:8601692   PMID:9678511   PMID:11105903   PMID:11371512   PMID:12810822   PMID:12813057   PMID:12867159   PMID:12965054   PMID:14651853   PMID:14674747   PMID:14684827  
PMID:15111580   PMID:15132426   PMID:15345707   PMID:16502470   PMID:17156877   PMID:17167097   PMID:17353235   PMID:17763872   PMID:18022721   PMID:18462685   PMID:18480170   PMID:18706485  
PMID:19056867   PMID:19471889   PMID:19732768   PMID:20498017   PMID:20551380   PMID:21684311   PMID:22326583   PMID:22431521   PMID:23376485   PMID:23420452   PMID:23533145   PMID:23690594  
PMID:24006456   PMID:24414178   PMID:24871372   PMID:24872419   PMID:25002582   PMID:25461957   PMID:26370502   PMID:27068509   PMID:27356620   PMID:27559042   PMID:28541286   PMID:28835281  
PMID:29514215   PMID:29656342   PMID:31215019   PMID:33259479   PMID:33914781   PMID:37208379  


Genomics

Comparative Map Data
Psap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82028,756,951 - 28,783,422 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2028,757,181 - 28,783,421 (+)EnsemblGRCr8
mRatBN7.22028,214,229 - 28,240,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2028,214,271 - 28,240,498 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2029,228,797 - 29,255,391 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02028,615,101 - 28,641,697 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02029,357,562 - 29,384,161 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02029,831,302 - 29,856,876 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2029,831,314 - 29,856,875 (+)Ensemblrn6Rnor6.0
Rnor_5.02031,629,564 - 31,668,605 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42027,595,048 - 27,621,574 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2029,653,298 - 29,678,819 (+)NCBICelera
RGSC_v3.12027,608,847 - 27,635,374 (+)NCBI
Cytogenetic Map20q11NCBI
PSAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381071,816,298 - 71,851,251 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1071,816,289 - 71,851,330 (-)Ensemblhg38GRCh38
GRCh371073,576,055 - 73,611,008 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361073,246,061 - 73,281,088 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341073,246,063 - 73,281,015NCBI
Celera1066,858,625 - 66,893,657 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1067,569,822 - 67,604,837 (-)NCBIHuRef
CHM1_11073,858,033 - 73,893,009 (-)NCBICHM1_1
T2T-CHM13v2.01072,687,031 - 72,721,975 (-)NCBIT2T-CHM13v2.0
Psap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391060,113,436 - 60,138,379 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1060,113,449 - 60,138,376 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381060,277,628 - 60,302,600 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1060,277,627 - 60,302,597 (+)Ensemblmm10GRCm38
MGSCv371059,740,376 - 59,765,348 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361059,673,095 - 59,697,957 (+)NCBIMGSCv36mm8
Celera1061,374,486 - 61,399,457 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1030.02NCBI
Psap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543719,667,252 - 19,680,796 (+)Ensembl
ChiLan1.0NW_00495543719,667,252 - 19,683,669 (+)NCBIChiLan1.0ChiLan1.0
PSAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2883,966,632 - 84,001,690 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11083,971,953 - 84,007,011 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01068,286,359 - 68,321,349 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11070,810,591 - 70,845,593 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1070,810,881 - 70,828,781 (-)EnsemblpanPan2panpan1.1
PSAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1422,571,095 - 22,603,880 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl422,572,153 - 22,603,848 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha422,708,767 - 22,741,495 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0422,847,636 - 22,880,854 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl422,847,638 - 22,880,795 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1422,753,725 - 22,786,399 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0422,952,336 - 22,985,298 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0423,306,841 - 23,339,591 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Psap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721358,483,085 - 58,516,521 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365216,975,770 - 7,009,136 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365216,975,844 - 7,009,460 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1474,734,189 - 74,887,763 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11474,734,185 - 74,820,645 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21480,625,273 - 80,660,726 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1959,440,327 - 59,474,773 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl959,440,311 - 59,474,986 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604820,084,030 - 20,118,523 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247545,726,681 - 5,753,575 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247545,725,697 - 5,753,575 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Psap
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11826,100,380 - 26,125,645 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Psap
203 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:327
Count of miRNA genes:201
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000000696
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat

Markers in Region
RH128021  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22028,240,158 - 28,240,358 (+)MAPPERmRatBN7.2
Rnor_6.02029,856,534 - 29,856,733NCBIRnor6.0
Rnor_5.02031,668,263 - 31,668,462UniSTSRnor5.0
RGSC_v3.42027,621,565 - 27,621,764UniSTSRGSC3.4
Celera2029,678,477 - 29,678,676UniSTS
RH 3.4 Map21521.6UniSTS
Cytogenetic Map20q11UniSTS
RH138734  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22028,234,549 - 28,234,713 (+)MAPPERmRatBN7.2
Rnor_6.02029,850,926 - 29,851,089NCBIRnor6.0
Rnor_5.02031,662,655 - 31,662,818UniSTSRnor5.0
RGSC_v3.42027,615,957 - 27,616,120UniSTSRGSC3.4
Celera2029,672,869 - 29,673,032UniSTS
Cytogenetic Map20q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001190236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001190237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001190238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB717025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK365248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO403947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO558861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY313840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S81353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000000696   ⟹   ENSRNOP00000000696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2028,757,193 - 28,783,419 (+)Ensembl
mRatBN7.2 Ensembl2028,214,271 - 28,240,498 (+)Ensembl
Rnor_6.0 Ensembl2029,831,314 - 29,856,875 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093802   ⟹   ENSRNOP00000086321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2028,771,197 - 28,783,421 (+)Ensembl
mRatBN7.2 Ensembl2028,228,275 - 28,240,498 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104593   ⟹   ENSRNOP00000096557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2028,757,181 - 28,783,419 (+)Ensembl
mRatBN7.2 Ensembl2028,214,271 - 28,240,498 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128039   ⟹   ENSRNOP00000111640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2028,757,241 - 28,783,419 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000135879   ⟹   ENSRNOP00000108599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2028,757,187 - 28,783,419 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000163815   ⟹   ENSRNOP00000106490
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2028,760,440 - 28,783,421 (+)Ensembl
RefSeq Acc Id: NM_001190236   ⟹   NP_001177165
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,757,193 - 28,783,422 (+)NCBI
mRatBN7.22028,214,271 - 28,240,501 (+)NCBI
Rnor_6.02029,831,314 - 29,856,876 (+)NCBI
Rnor_5.02031,629,564 - 31,668,605 (+)NCBI
Celera2029,653,298 - 29,678,819 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001190237   ⟹   NP_001177166
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,757,193 - 28,783,422 (+)NCBI
mRatBN7.22028,214,271 - 28,240,501 (+)NCBI
Rnor_6.02029,831,314 - 29,856,876 (+)NCBI
Rnor_5.02031,629,564 - 31,668,605 (+)NCBI
Celera2029,653,298 - 29,678,819 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001190238   ⟹   NP_001177167
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,757,193 - 28,783,422 (+)NCBI
mRatBN7.22028,214,271 - 28,240,501 (+)NCBI
Rnor_6.02029,831,314 - 29,856,876 (+)NCBI
Rnor_5.02031,629,564 - 31,668,605 (+)NCBI
Celera2029,653,298 - 29,678,819 (+)NCBI
Sequence:
RefSeq Acc Id: NM_013013   ⟹   NP_037145
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,757,193 - 28,783,422 (+)NCBI
mRatBN7.22028,214,271 - 28,240,501 (+)NCBI
Rnor_6.02029,831,314 - 29,856,876 (+)NCBI
Rnor_5.02031,629,564 - 31,668,605 (+)NCBI
RGSC_v3.42027,595,048 - 27,621,574 (+)RGD
Celera2029,653,298 - 29,678,819 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063278980   ⟹   XP_063135050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,756,951 - 28,783,422 (+)NCBI
RefSeq Acc Id: XM_063278981   ⟹   XP_063135051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,756,951 - 28,783,422 (+)NCBI
RefSeq Acc Id: NP_037145   ⟸   NM_013013
- Peptide Label: isoform A preproprotein
- UniProtKB: Q64190 (UniProtKB/Swiss-Prot),   Q62841 (UniProtKB/Swiss-Prot),   P10960 (UniProtKB/Swiss-Prot),   A6K3X0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177165   ⟸   NM_001190236
- Peptide Label: isoform B preproprotein
- UniProtKB: Q64190 (UniProtKB/Swiss-Prot),   Q62841 (UniProtKB/Swiss-Prot),   P10960 (UniProtKB/Swiss-Prot),   A6K3W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177166   ⟸   NM_001190237
- Peptide Label: isoform C preproprotein
- UniProtKB: Q64190 (UniProtKB/Swiss-Prot),   Q62841 (UniProtKB/Swiss-Prot),   P10960 (UniProtKB/Swiss-Prot),   A0A8I6ASQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177167   ⟸   NM_001190238
- Peptide Label: isoform D preproprotein
- UniProtKB: Q64190 (UniProtKB/Swiss-Prot),   Q62841 (UniProtKB/Swiss-Prot),   P10960 (UniProtKB/Swiss-Prot),   Q6P7A4 (UniProtKB/TrEMBL),   F7EPE0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000696   ⟸   ENSRNOT00000000696
Ensembl Acc Id: ENSRNOP00000086321   ⟸   ENSRNOT00000093802
Ensembl Acc Id: ENSRNOP00000096557   ⟸   ENSRNOT00000104593
RefSeq Acc Id: XP_063135050   ⟸   XM_063278980
- Peptide Label: isoform X1
- UniProtKB: Q64190 (UniProtKB/Swiss-Prot),   Q62841 (UniProtKB/Swiss-Prot),   P10960 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063135051   ⟸   XM_063278981
- Peptide Label: isoform X2
- UniProtKB: Q64190 (UniProtKB/Swiss-Prot),   Q62841 (UniProtKB/Swiss-Prot),   P10960 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000108599   ⟸   ENSRNOT00000135879
Ensembl Acc Id: ENSRNOP00000106490   ⟸   ENSRNOT00000163815
Ensembl Acc Id: ENSRNOP00000111640   ⟸   ENSRNOT00000128039
Protein Domains
Saposin A-type   Saposin B-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10960-F1-model_v2 AlphaFold P10960 1-554 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701596
Promoter ID:EPDNEW_R12119
Type:initiation region
Name:Psap_1
Description:prosaposin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02029,831,361 - 29,831,421EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3423 AgrOrtholog
BioCyc Gene G2FUF-3743 BioCyc
Ensembl Genes ENSRNOG00000000571 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000000696 ENTREZGENE
  ENSRNOT00000104593 ENTREZGENE
  ENSRNOT00000128039 ENTREZGENE
Gene3D-CATH Saposin-like UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5600088 IMAGE-MGC_LOAD
InterPro SAP_A UniProtKB/Swiss-Prot
  SapB_1 UniProtKB/Swiss-Prot
  SapB_2 UniProtKB/Swiss-Prot
  Saposin UniProtKB/Swiss-Prot
  Saposin-like UniProtKB/Swiss-Prot
  Saposin_chordata UniProtKB/Swiss-Prot
  SaposinB_dom UniProtKB/Swiss-Prot
  Sphingo_Act-Surfact_Prot UniProtKB/Swiss-Prot
KEGG Report rno:25524 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72521 IMAGE-MGC_LOAD
NCBI Gene 25524 ENTREZGENE
PANTHER PROSAPOSIN UniProtKB/Swiss-Prot
  SAPOSIN-RELATED UniProtKB/Swiss-Prot
Pfam SapA UniProtKB/Swiss-Prot
  SapB_1 UniProtKB/Swiss-Prot
  SapB_2 UniProtKB/Swiss-Prot
PhenoGen Psap PhenoGen
PIRSF Saposin UniProtKB/Swiss-Prot
PRINTS SAPOSIN UniProtKB/Swiss-Prot
PROSITE SAP_A UniProtKB/Swiss-Prot
  SAP_B UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000571 RatGTEx
SMART SAPA UniProtKB/Swiss-Prot
  SapB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47862 UniProtKB/Swiss-Prot
TIGR TC228544
UniProt A0A8I6A1Z1_RAT UniProtKB/TrEMBL
  A0A8I6ASQ4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LL30_RAT UniProtKB/TrEMBL
  A0ABK0LLI7_RAT UniProtKB/TrEMBL
  A0ABK0M2D3_RAT UniProtKB/TrEMBL
  A0ABZ3NN69_RAT UniProtKB/TrEMBL
  A6K3W9 ENTREZGENE, UniProtKB/TrEMBL
  A6K3X0 ENTREZGENE, UniProtKB/TrEMBL
  A6K3X1_RAT UniProtKB/TrEMBL
  A6K3X2_RAT UniProtKB/TrEMBL
  F7EPE0 ENTREZGENE
  P10960 ENTREZGENE
  Q62841 ENTREZGENE
  Q64190 ENTREZGENE
  Q6P7A4 ENTREZGENE, UniProtKB/TrEMBL
  SAP_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q62841 UniProtKB/Swiss-Prot
  Q64190 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Psap  prosaposin    Prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator)  Name updated 629478 APPROVED
2002-06-10 Psap  Prosaposin (sulfated glycoprotein, sphingolipid hydrolase activator)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization secreted into the extracellular space 633775