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Gene: Anks6 (ankyrin repeat and sterile alpha motif domain containing 6) Rattus norvegicus

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Symbol:

Anks6

Name:

ankyrin repeat and sterile alpha motif domain containing 6

RGD ID:

3334

Description:

Enables identical protein binding activity. Predicted to be involved in innate immune response. Predicted to act upstream of or within several processes, including determination of left/right symmetry; heart development; and in utero embryonic development. Predicted to be located in ciliary inversin compartment. Predicted to be active in cytoplasm. Used to study polycystic kidney disease; proteinuria; and uremia. Human ortholog(s) of this gene implicated in nephronophthisis 16. Orthologous to human ANKS6 (ankyrin repeat and sterile alpha motif domain containing 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ankyrin repeat and SAM domain-containing protein 6; LOC362515; MGC109646; Pkdr1; Pkdr1_mapped; polycystic kidney disease protein 1; polycystic kidney disease rat 1; polycystic kidney disease rat 1 (mapped); SAM domain-containing protein 6; samcystin; Samd6; sterile alpha motif domain containing 6; sterile alpha motif domain-containing protein 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

Anks6^PKD

Genetic Models:

SPRD-Anks6^PKD/Rrrc ; SPRD-Anks6^PKD/Fsn

Candidate Gene For:

Kidm8

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	66,104,770 - 66,146,186 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	66,104,773 - 66,146,186 (-)	Ensembl				GRCr8
mRatBN7.2	5	61,309,183 - 61,350,596 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	61,309,183 - 61,350,596 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	63,280,885 - 63,322,477 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	65,100,188 - 65,141,780 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	65,069,677 - 65,111,269 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	62,642,974 - 62,684,387 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	62,640,645 - 62,683,964 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	67,163,440 - 67,204,853 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	63,633,540 - 63,674,953 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	59,865,938 - 59,907,349 (-)	NCBI		Celera
RGSC_v3.1	5	63,632,332 - 63,674,981 (-)	NCBI
Cytogenetic Map	5	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant polycystic kidney disease (ISO)

Cardiovascular Abnormalities (ISO)

cystic kidney disease (ISO)

genetic disease (ISO)

liver cirrhosis (ISO)

nephronophthisis 16 (ISO)

polycystic kidney disease (IAGP,IMP)

proteinuria (IAGP)

uremia (IAGP)

visceral heterotaxy (ISS)

visceral heterotaxy 5 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

CGP 52608 (ISO)

choline (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) sulfate (ISO)

dimethyl sulfoxide (ISO)

doxorubicin (ISO)

endosulfan (EXP)

folic acid (ISO)

gentamycin (EXP)

L-methionine (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

menadione (ISO)

methapyrilene (ISO)

N-methyl-4-phenylpyridinium (EXP)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

pravastatin (EXP,ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP)

trichloroethene (EXP)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

zaragozic acid A (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

determination of left/right symmetry (ISO)

heart development (ISO)

in utero embryonic development (ISO)

innate immune response (IBA)

kidney development (ISO)

Cellular Component

ciliary inversin compartment (IEA,ISO)

cilium (IEA)

cytoplasm (IBA,IEA)

Molecular Function

identical protein binding (IPI)

protein binding (IPI,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased hematocrit (IAGP)

enlarged kidney (IAGP)

increased blood urea nitrogen level (IAGP)

increased circulating creatinine level (IAGP)

increased kidney weight (IAGP)

premature death (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Location of the first genetic locus, PKDr1, controlling autosomal dominant polycystic kidney disease in Han:SPRD cy/+ rat.	Bihoreau MT, etal., Hum Mol Genet 1997 Apr;6(4):609-13.
2.	Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in (cy/+) rat.	Brown JH, etal., J Am Soc Nephrol. 2005 Dec;16(12):3517-26. Epub 2005 Oct 5.
3.	ANKS3 Co-Localises with ANKS6 in Mouse Renal Cilia and Is Associated with Vasopressin Signaling and Apoptosis In Vivo in Mice.	Delestre L, etal., PLoS One. 2015 Sep 1;10(9):e0136781. doi: 10.1371/journal.pone.0136781. eCollection 2015.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Transgenic overexpression of Anks6(p.R823W) causes polycystic kidney disease in rats.	Neudecker S, etal., Am J Pathol. 2010 Dec;177(6):3000-9. doi: 10.2353/ajpath.2010.100569.
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	Anks3 alters the sub-cellular localization of the Nek7 kinase.	Ramachandran H, etal., Biochem Biophys Res Commun. 2015 Aug 28;464(3):901-7. doi: 10.1016/j.bbrc.2015.07.063. Epub 2015 Jul 15.
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation
12.	Characterization of the Han:SPRD rat model for hereditary polycystic kidney disease.	Schafer K, etal., Kidney Int 1994 Jul;46(1):134-52.
13.	The Polycystic Kidney Disease-related Proteins Bicc1 and SamCystin Interact.	Stagner EE, etal., Biochem Biophys Res Commun. 2009 Mar 23.
14.	Anks3 interacts with nephronophthisis proteins and is required for normal renal development.	Yakulov TA, etal., Kidney Int. 2015 Jun;87(6):1191-200. doi: 10.1038/ki.2015.17. Epub 2015 Feb 11.

Additional References at PubMed

PMID:12477932	PMID:15057822	PMID:18434273	PMID:20719982	PMID:25807483	PMID:27996060	PMID:29395339

Genomics

Comparative Map Data

Anks6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	66,104,770 - 66,146,186 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	66,104,773 - 66,146,186 (-)	Ensembl				GRCr8
mRatBN7.2	5	61,309,183 - 61,350,596 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	61,309,183 - 61,350,596 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	63,280,885 - 63,322,477 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	65,100,188 - 65,141,780 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	65,069,677 - 65,111,269 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	62,642,974 - 62,684,387 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	62,640,645 - 62,683,964 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	67,163,440 - 67,204,853 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	63,633,540 - 63,674,953 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	59,865,938 - 59,907,349 (-)	NCBI		Celera
RGSC_v3.1	5	63,632,332 - 63,674,981 (-)	NCBI
Cytogenetic Map	5	q22	NCBI

ANKS6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	98,732,009 - 98,796,555 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	98,731,329 - 98,796,965 (-)	Ensembl			hg38	GRCh38
GRCh37	9	101,494,291 - 101,558,837 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	100,534,112 - 100,598,615 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	98,573,856 - 98,638,050	NCBI
Celera	9	72,008,186 - 72,066,777 (-)	NCBI		Celera
Cytogenetic Map	9	q22.33	NCBI
HuRef	9	71,093,661 - 71,157,912 (-)	NCBI		HuRef
CHM1_1	9	101,640,709 - 101,705,196 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	110,903,669 - 110,968,205 (-)	NCBI		T2T-CHM13v2.0

Anks6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	47,015,365 - 47,057,339 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	47,015,669 - 47,057,427 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	47,015,365 - 47,057,327 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	47,015,669 - 47,057,427 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	47,028,561 - 47,070,178 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	47,036,789 - 47,078,406 (-)	NCBI		MGSCv36	mm8
MGSCv36	4	45,863,232 - 45,905,550 (-)	NCBI		MGSCv36	mm8
Celera	4	47,027,647 - 47,069,458 (-)	NCBI		Celera
Cytogenetic Map	4	B1	NCBI
cM Map	4	25.88	NCBI

Anks6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	26,801,925 - 26,851,627 (+)	Ensembl
ChiLan1.0	NW_004955419	26,801,924 - 26,852,116 (+)	NCBI	ChiLan1.0	ChiLan1.0

ANKS6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	40,660,886 - 40,725,561 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	40,663,262 - 40,734,626 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	69,818,669 - 69,886,618 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	97,941,270 - 98,002,933 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	97,941,935 - 98,005,795 (-)	Ensembl			panPan2	panpan1.1

ANKS6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	55,845,695 - 55,893,253 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	55,847,808 - 55,893,257 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	54,278,371 - 54,325,978 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	56,955,274 - 57,003,309 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	56,957,377 - 57,003,582 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	55,459,214 - 55,507,459 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	55,483,554 - 55,531,201 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	56,180,571 - 56,231,006 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Anks6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	170,772,429 - 170,816,534 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	7,320,497 - 7,357,350 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	7,320,069 - 7,379,417 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ANKS6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	240,522,837 - 240,584,496 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	240,522,835 - 240,584,354 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	268,768,030 - 268,829,559 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ANKS6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	40,631,235 - 40,695,920 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	40,631,467 - 40,697,393 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	37,666,107 - 37,730,231 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Anks6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624825	2,157,158 - 2,212,971 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624825	2,157,158 - 2,214,115 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Anks6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	100,104,692 - 100,150,889 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Anks6
229 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	241
Count of miRNA genes:	143
Interacting mature miRNAs:	175
Transcripts:	ENSRNOT00000060005
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	38011670	83011670	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	52665372	94894052	Rat
1578776	Stresp18	Stress response QTL 18	2.9		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	5	32751649	77751649	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
6907115	Mcs29	Mammary carcinoma susceptibility QTL 29			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	38004331	83004331	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	23671493	79046465	Rat
61386	Bp49	Blood pressure QTL 49	16.6		cerebrum integrity trait (VT:0010549)	brain infarction volume (CMO:0001013)	5	65089051	103648916	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	48523123	134369373	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	38011670	83011670	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	38011670	83011670	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
1331782	Rf36	Renal function QTL 36	3.296		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	39019942	102105896	Rat
6903292	Stl28	Serum triglyceride level QTL 28	2.6	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	5	33311673	78311673	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1578767	Stresp17	Stress response QTL 17	4.3	0.01	blood aldosterone amount (VT:0005346)	plasma aldosterone level (CMO:0000551)	5	32751649	77751649	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	39985948	84985948	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	6922282	81330203	Rat
6903306	Scl35	Serum cholesterol QTL 35	2.6	0.0073	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33311673	78311673	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	39526924	84526924	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	48523123	91770353	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	60601597	137492949	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	91770353	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	60511627	105511627	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	64589016	109589016	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	7065535	74335773	Rat
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	10019064	87027358	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	26023211	71023211	Rat
2316954	Rf57	Renal function QTL 57	0		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	64589016	93503770	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	56546393	101546393	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	23671493	68671493	Rat
2316957	Pur21	Proteinuria QTL 21	6.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	5	64589016	91762830	Rat

Markers in Region

RH142576

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	61,309,566 - 61,309,723 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	62,643,358 - 62,643,514	NCBI	Rnor6.0
Rnor_5.0	5	67,163,824 - 67,163,980	UniSTS	Rnor5.0
RGSC_v3.4	5	63,633,924 - 63,634,080	UniSTS	RGSC3.4
Celera	5	59,866,322 - 59,866,478	UniSTS
RH 3.4 Map	5	372.6	UniSTS
Cytogenetic Map	5	q22	UniSTS

Genetic Models

This gene Anks6 is modified in the following models/strains:

SPRD-Anks6^PKD/Rrrc SPRD-Anks6^PKD/Fsn

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	87	59	6	351	187	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001015028	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008763699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008763700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066414	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066415	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010066416	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_353968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_592494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_592495	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_592496	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY661303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000060005 ⟹ ENSRNOP00000056754

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	66,104,773 - 66,146,186 (-)	Ensembl
mRatBN7.2 Ensembl	5	61,309,183 - 61,350,596 (-)	Ensembl
Rnor_6.0 Ensembl	5	62,640,645 - 62,683,964 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095092 ⟹ ENSRNOP00000085061

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	66,104,773 - 66,146,186 (-)	Ensembl
mRatBN7.2 Ensembl	5	61,309,183 - 61,350,596 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000146576 ⟹ ENSRNOP00000110315

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	66,113,525 - 66,146,186 (-)	Ensembl

RefSeq Acc Id:

NM_001015028 ⟹ NP_001015028

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	66,104,773 - 66,146,186 (-)	NCBI
mRatBN7.2	5	61,309,183 - 61,350,596 (-)	NCBI
Rnor_6.0	5	62,642,974 - 62,684,387 (-)	NCBI
Rnor_5.0	5	67,163,440 - 67,204,853 (-)	NCBI
RGSC_v3.4	5	63,633,540 - 63,674,953 (-)	RGD
Celera	5	59,865,938 - 59,907,349 (-)	RGD

Sequence:

show sequence

CCACAAGCCCGGAGGCGGGTCCTGCGCGCGCGTACTCAGCAGGCGCGGCCCCGGAGGCGCGCGC
GCACCCAGGGGGCGGGCCTGCGGAAGGCGGCGGGCACGCGCGGACTCGGGGTGGGAGCGGGCGG
CGGCGCGGAGCGAGCGGCGGGCGATGGGCGAGGGCGCGCTGGCCCCGGGCCTGCAGCTGCTGCT
CCGCGCCTGCGAGCAGGGTGACACGGACACGGCGCGGCGCCTGCTGGAGCCAGGAGGGGAGCCG
GTCGCGGGGTCCGAGGCGGGAGCGGAGCCGGCAGGGCCCGAGGCGGCCCGGGCAGTGGAGGCCG
GGACGCCGGTGCCGGTGGACTGCTCGGATGAGGCGGGCAACTCGGCGCTGCAGCTGGCGGCGGC
CGGTGGTCACGAGCCACTCGTGAGGTTCCTGCTGCGCCGCGGAGCCTCGGTCAACAGCCGCAAC
CACTACGGCTGGAGCGCGCTCATGCAGGCGGCCAGGTGTGGGCATGCGAGCGTGGCACACCTCC
TTTTGGATCATGGAGCTGATGTCAACGCTCAGAATCGGCTGGGTGCCAGTGTGCTCACTGTGGC
TTCCCGAGGGGGCCACCTGGGTGTGGTGAAACTGCTGCTCGAGGCAGGCGCCACTGTGGACCAT
CGTAACCCTTCTGGAGAGTCAACAGCATCGGGAGGCAGCAGGGACGAACTGCTGGGCATCACAG
CCCTGATGGCTGCCGTCCAGCATGGGCATGAGGCCGTCGTACGCCTGCTGATGGAGTGGGGTGC
GGACCCCAACCACACAGCCCGGACTGTGGGCTGGAGCCCTCTGATGCTGGCAGCCCTCCTCGGG
AAGCTCAGTGTGGTGCAGCAGCTGGTCGAGAAGGGAGCCAACCCCGACCACCTCGGCGTGCTGG
AGAAGACAGCCTTCGAGGTTGCCCTTGACCGAAAACACAGGGATCTAGCTGATTACCTGGACCC
ACTGACCACTGTCAGGCCGAAAACAGATGAGGAGAAGAGGCGACCTGATATTTTCCACGCCCTG
AAGATGGGAAACTTCCAGCTGGTCAAGGAGATTGCTGACGAAGACCCCAACCACGTGAACCTGG
TCAACGGGGACGGGGCGACCCCACTGATGCTGGCTGCTGTCACGGGACAGTTGCCCCTGGTACA
GCTGCTGGTAGAGAAGCATGCAGACATGAACAAGCAGGACAGCGTGCATGGCTGGACGGCCCTC
ATGCAGGCCACCTACCATGGAAATAAAGAAATTGTAAAGTATCTGCTAAATCAAGGGGCTGATG
TTACTCTTCGAGCCAAAAACGGATACACGGCCTTCGACCTGGTAATGCTGCTGAATGATCCTGA
CACTGAACTTGTTCGACTGCTAGCGTCTGTGTGCATGCAGGTGAATAAGGACCGAGGTGGTCGG
CCCAGCCACCGTCCACCCCTGCCCCACTCGAAGGCCAGGCAACCCTGGAGCATCCCCATGCTGC
CCGACGACAAGGGAGGCCTGAAGTCCTGGTGGAGCCGGATGTCCAACAGGTTCCGAAAACTCAA
ACTTATGCAGACACTGCCACGCGGGCTGGCTGCCAACCAACCTTTGCCTTTCTCTGACGAGCCT
GAGCTGGCACTGGACTCCACCATGCGGGCACCCCCCCAGGACAGGACTAACCACCTTGGGCCAC
CTGAAGCAGCCCATGCAGCCAAAGACAGTGGCCCTGGGAACCCGAGAAGGGAGAAGGACGATGT
GTTACTGACGACCATGCTGCGCAATGGAGCCCCCTTCCCCCGGCTCCCCAGTGACAAGCTGAAG
GCCGTCATCCCACCCTTCCTGCCCCCGTCCAGCTTCGAACTGTGGAGCTCCGACAGGTCCCGCA
CGTGTCCCAATGGGAAGGCGGACCCCATGAAGACTGTGCTGCCCCCAAGAGCCAGCAGGGCCCA
CCCTGTGGGCTGCGTGGGCACAGACGGTGCTGCTGGCAGGCCAGTCAAATTCCCCAGCATCTCC
AGGAGCCCCACGTCCCCTGCCAGCTCCGGGAACTTTAACCACTCGCCTCATTCTTCAGGGGGTG
CCAGTGGCGTGGGCAGCATGAGCAGGCTGGGGGGAGAGCTGCATAACCGCTCAGGTGGCAGCGT
AGACAGTGTCCTCTCCCAGATCGCTGCTCAGAGGAAAAAAGCGGCTGGCCTGTGTGAGCAGAAG
CCCCCCTGCCAGCAGTCCAGTCCTGTGGGGCCAGCGACCGGCTCCAGCCCACCTGAGCTGCCAG
CCTCCCTCCTGGGCAGTGGTAGTGGCTCTTCCAATGTTACTTCCAGCAGCAAGAAACTGGACCC
TGGCAAACGGCCTCCCTCTGGAACTTCTGCTACCTCTAAAAGCACCTCTCCCACCCTCACGCCT
TCCCCCTCTCCCAAAGGCCACACTGCGGAGTCCTCAGTGTCTTCCTCCTCGTCCCACCGGCAAT
CTAAGAGCAGTGGGGGCTCTAGCAGTGGCACCATCACCGATGAGGATGAGCTGACTGGAATCCT
TAAGAAGTTATCACTTGAGAAATACCAGCCCATCTTCGAGGAGCAAGAGGTGGACATGGAAGCT
TTCCTCACACTCACCGACGGTGACCTGCAGGAGCTGGGGATTAAGACGGATGGTTCCCGGCAGC
AGATTCTGGCGGCCATCTCTGAGCTGAATGCGGGCAAGGGGCGTGAGAGGCAGATTCTACAGGA
AACCATTCACAACTTCCACTCTTCCTTTGAGAGCAGCGCCAGCAACACCAGAGCCCCTGGCAAC
AGTCCCTCCATGGCCGGATGGGTAAGGCCAGAAGAAACAGTGTCGAGCAGGAGGTAGCCACAGC
TTGGGCGGCTCCGCTGGCCTCGGAGCCCTGAGGTGGTGAGGACTGAGCAGTGAACCCCCGCCCT
TCCTCTGTGTCTGCTCCTGGGTTATTTCTTCCCTGGGACTCACAGCAAGTGGACAGAGAGAAGG
CTGGCTAGCCAGATCCTCAGGGCTGATGCAGTGGGCAGAGCCTGAGAAGCCACCTTTGCAGAGG
CCTGAGAATATGCAGGCCGTGCTGGATGCCGCACGGCTGCAGGTACAAACCCGAACCTGCATGT
GCAAGGACGTGCTGCCCTCCAGGCCTAGGACCCTTCCAGAAAAGATGCTATACCCAGTGAACCC
CTGCAGAAGGTGTGGTGAAGCACCCACTGTGAACCCCTGCAGAAGGTGTGGTGAAGCACCCGCA
GTGAACCCCTGCAGAAGGTGTGGTGAAGCACCCGCAGTGAACCTCTGCAGAAGGTGTGGTGAAG
CACCCACTGTGAACCCCTGCAGAAGGTGTGGTGAAGCACCCACTGTAACTGCTGTTGCTTGTTT
TACGCAGTCACCAACAGGTCCTCTTCAGCATGTGAGGAAGCTCAATGCTGTCCCTAATGAAGCT
GGTGCCCGAGTCTGCAGACTGCCCAGGAGAGGGGCCCGAGACCCTGGGAGTTTCCTGCTTATTC
ACGTGAGGCCTCCAGAGAACAGGCCAGGCTCCCCCCTGCTCTTGAGACGCTACAAGCCTGGTCA
CAGCCATGGTTGTAGTACAGCTGTGCACAAATGGACAGTGAGGGGAGGGTGCAGGAGGGAGCTG
TTGATGAAGAGCCACGTTGGAAGAGCGCGCCAAGCCTGCCCACTTCACTTGTCTTCAGCTCCTT
CCACCCCACTGGGCTTCCTTCCTGTGGCCAAAACCATGCTTGCTGCTGGCCAAAGCCCTGCCGC
TGAGTGGAGCCGACTCAGCTCAGAGCAACCTCCTGTGTCCCGTGTGAGCCTTCCCTCTAAGACC
AGCAGACAGGGTCATCTTCATCAGGATACCCCAGTGGCAGGACTAGAATGACCTTGTCCCAGCT
CACACTGGAGTACCCTGAATGGTCAGAAGCCACGGCGCCATCTTGCTTCAGCTCTGCAGCTGGT
TCATTTTTCTCTCATCAGTCACAGCATCATTTCTACACAGGGACTCAGTCCTTGGAAAGATTTT
TGCTTGCCAGACCACGTCTATTAAAAATGGGGAGTCTGCCCCCTGTCTCTGTGCTCTCGAGGGC
ATCACATGCCGCCCAGGGTTCCTATCAAATAGCTAACATGCAGGGTGTTCCCCTGCACTCCCTT
ACCCCATCTCCACAGCAAGTGCTGAGGCAGCTGGAACCTTTTATTCCGGTCAGTTTGGTGACTG
TGACACACGATGGTAACCCAGCTAAGGAGGGACACTGGTTTGGATGCAGGTCTCACCTCAGAGT
CGTCTTCCTGATGTCAGCAACGAGTAACCCAGCCAGCAACCAAACACAAACAAATGACACTTTG
TCATTTCCTCTTTGAGGTTCATTTACAGTGGGGAGGGGGTGCAAAGTGCTATAAATGGCTTGGA
GATTCTTGTTTCTGG

hide sequence

RefSeq Acc Id:

XM_039110236 ⟹ XP_038966164

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	66,112,726 - 66,146,083 (-)	NCBI
mRatBN7.2	5	61,317,136 - 61,350,493 (-)	NCBI

RefSeq Acc Id:

XM_063287917 ⟹ XP_063143987

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	66,104,770 - 66,146,083 (-)	NCBI

RefSeq Acc Id:

XR_010066413

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	66,107,163 - 66,146,083 (-)	NCBI

RefSeq Acc Id:

XR_010066414

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	66,107,088 - 66,146,083 (-)	NCBI

RefSeq Acc Id:

XR_010066415

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	66,113,603 - 66,146,083 (-)	NCBI

RefSeq Acc Id:

XR_010066416

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	66,112,824 - 66,146,083 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001015028	(Get FASTA)	NCBI Sequence Viewer
	XP_038966164	(Get FASTA)	NCBI Sequence Viewer
	XP_063143987	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91436	(Get FASTA)	NCBI Sequence Viewer
	AAT76432	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000056754
	ENSRNOP00000110315
GenBank Protein	P0C0T2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001015028 ⟸ NM_001015028

- UniProtKB:

Q5BJL2 (UniProtKB/Swiss-Prot), Q2VWC0 (UniProtKB/Swiss-Prot), P0C0T2 (UniProtKB/Swiss-Prot), A0A0G2JSX8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGEGALAPGLQLLLRACEQGDTDTARRLLEPGGEPVAGSEAGAEPAGPEAARAVEAGTPVPVDC
SDEAGNSALQLAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARCGHASVAHLLLDHGADV
NAQNRLGASVLTVASRGGHLGVVKLLLEAGATVDHRNPSGESTASGGSRDELLGITALMAAVQH
GHEAVVRLLMEWGADPNHTARTVGWSPLMLAALLGKLSVVQQLVEKGANPDHLGVLEKTAFEVA
LDRKHRDLADYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPNHVNLVNGDGATP
LMLAAVTGQLPLVQLLVEKHADMNKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNG
YTAFDLVMLLNDPDTELVRLLASVCMQVNKDRGGRPSHRPPLPHSKARQPWSIPMLPDDKGGLK
SWWSRMSNRFRKLKLMQTLPRGLAANQPLPFSDEPELALDSTMRAPPQDRTNHLGPPEAAHAAK
DSGPGNPRREKDDVLLTTMLRNGAPFPRLPSDKLKAVIPPFLPPSSFELWSSDRSRTCPNGKAD
PMKTVLPPRASRAHPVGCVGTDGAAGRPVKFPSISRSPTSPASSGNFNHSPHSSGGASGVGSMS
RLGGELHNRSGGSVDSVLSQIAAQRKKAAGLCEQKPPCQQSSPVGPATGSSPPELPASLLGSGS
GSSNVTSSSKKLDPGKRPPSGTSATSKSTSPTLTPSPSPKGHTAESSVSSSSSHRQSKSSGGSS
SGTITDEDELTGILKKLSLEKYQPIFEEQEVDMEAFLTLTDGDLQELGIKTDGSRQQILAAISE
LNAGKGRERQILQETIHNFHSSFESSASNTRAPGNSPSMAGWVRPEETVSSRR

hide sequence

Ensembl Acc Id:

ENSRNOP00000056754 ⟸ ENSRNOT00000060005

RefSeq Acc Id:	XP_038966164 ⟸ XM_039110236
- Peptide Label:	isoform X2
- UniProtKB:	Q5BJL2 (UniProtKB/Swiss-Prot), Q2VWC0 (UniProtKB/Swiss-Prot), P0C0T2 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSRNOP00000085061 ⟸ ENSRNOT00000095092

RefSeq Acc Id:	XP_063143987 ⟸ XM_063287917
- Peptide Label:	isoform X1
- UniProtKB:	Q5BJL2 (UniProtKB/Swiss-Prot), Q2VWC0 (UniProtKB/Swiss-Prot), P0C0T2 (UniProtKB/Swiss-Prot)

Ensembl Acc Id:

ENSRNOP00000110315 ⟸ ENSRNOT00000146576

Protein Domains

SAM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P0C0T2-F1-model_v2	AlphaFold	P0C0T2	1-885	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3334	AgrOrtholog
BioCyc Gene	G2FUF-41392	BioCyc
Ensembl Genes	ENSRNOG00000023309	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000060005	ENTREZGENE
	ENSRNOT00000146576	ENTREZGENE
Gene3D-CATH	1.10.150.50	UniProtKB/Swiss-Prot
	1.25.40.20	UniProtKB/Swiss-Prot
InterPro	Ankyrin-KH/SAM_domain	UniProtKB/Swiss-Prot
	Ankyrin_rpt	UniProtKB/Swiss-Prot
	Ankyrin_rpt-contain_sf	UniProtKB/Swiss-Prot
	SAM	UniProtKB/Swiss-Prot
	SAM/pointed_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:362515	UniProtKB/Swiss-Prot
NCBI Gene	Anks6	ENTREZGENE
PANTHER	MASK PROTEIN	UniProtKB/Swiss-Prot
	PROTEIN KINASE DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot
Pfam	Ank	UniProtKB/Swiss-Prot
	Ank_2	UniProtKB/Swiss-Prot
	SAM_1	UniProtKB/Swiss-Prot
PhenoGen	Anks6	PhenoGen
PRINTS	ANKYRIN	UniProtKB/Swiss-Prot
PROSITE	ANK_REP_REGION	UniProtKB/Swiss-Prot
	ANK_REPEAT	UniProtKB/Swiss-Prot
	SAM_DOMAIN	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000023309	RatGTEx
SMART	ANK	UniProtKB/Swiss-Prot
	SAM	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47769	UniProtKB/Swiss-Prot
	SSF48403	UniProtKB/Swiss-Prot
UniProt	A0A0G2JSX8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZZA2_RAT	UniProtKB/TrEMBL
	A0ABK0LVC9_RAT	UniProtKB/TrEMBL
	ANKS6_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q2VWC0	ENTREZGENE
	Q5BJL2	ENTREZGENE
UniProt Secondary	Q2VWC0	UniProtKB/Swiss-Prot
	Q5BJL2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2007-09-17	Anks6	ankyrin repeat and sterile alpha motif domain containing 6	Pkdr1_mapped	polycystic kidney disease rat 1 (mapped)	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2007-09-17	Pkdr1_mapped	polycystic kidney disease rat 1 (mapped)	Samd6	sterile alpha motif domain containing 6	Data merged from RGD:1309352	737654	APPROVED
2005-12-06	Samd6	sterile alpha motif domain containing 6	Samd6_predicted	sterile alpha motif domain containing 6 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-11-17	Pkdr1_mapped	polycystic kidney disease rat 1 (mapped)	Pkdr1	polycystic kidney disease rat 1	Symbol and Name updated	1556543	APPROVED
2005-01-12	Samd6_predicted	sterile alpha motif domain containing 6 (predicted)			Symbol and Name status set to approved	70820	APPROVED
2002-06-10	Pkdr1	Polycystic kidney disease rat 1			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_mapping	associated with a QTL controlling kidney mass, plasma urea concentration, and polycystic kidney disease	629573

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Mammalian Phenotype

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Imported Disease Annotations - OMIM

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