Pdha1 (pyruvate dehydrogenase E1 subunit alpha 1) - Rat Genome Database

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Gene: Pdha1 (pyruvate dehydrogenase E1 subunit alpha 1) Rattus norvegicus
Analyze
Symbol: Pdha1
Name: pyruvate dehydrogenase E1 subunit alpha 1
RGD ID: 3286
Description: Contributes to pyruvate dehydrogenase (acetyl-transferring) activity. Involved in pyruvate decarboxylation to acetyl-CoA. Located in mitochondrial matrix. Part of pyruvate dehydrogenase complex. Used to study pyruvate decarboxylase deficiency. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC114215; MGC94854; PDHE1-A type I; pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase alpha 1; pyruvate dehydrogenase E1 alpha 1; pyruvate dehydrogenase E1 alpha 1 subunit; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; pyruvate dehydrogenase E1alpha subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Pdha1l1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X38,509,158 - 38,522,986 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX38,509,084 - 38,522,536 (+)EnsemblGRCr8
mRatBN7.2X34,700,481 - 34,714,309 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX34,700,409 - 34,714,311 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX35,837,874 - 35,851,694 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X39,301,516 - 39,315,336 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X34,467,574 - 34,481,394 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X37,329,779 - 37,343,410 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX37,329,779 - 37,343,410 (+)Ensemblrn6Rnor6.0
Rnor_5.0X37,640,725 - 37,654,356 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X55,899,491 - 55,913,319 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX35,373,056 - 35,386,884 (+)NCBICelera
RGSC_v3.1X55,952,967 - 55,966,789 (+)NCBI
Cytogenetic MapXq14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dimethoxyphenol  (ISO)
2-methoxyethanol  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
angiotensin II  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
brequinar  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
celastrol  (ISO)
ciguatoxin CTX1B  (ISO)
cobalt dichloride  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
dinophysistoxin 1  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
duvoglustat  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
Fusaric acid  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
hydrogen peroxide  (ISO)
Ile(5)-angiotensin II  (EXP)
isoniazide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kojic acid  (ISO)
maneb  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mitoxantrone  (ISO)
N-acetyl-L-cysteine  (ISO)
nefazodone  (EXP)
nitrates  (ISO)
nobiletin  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (EXP)
perfluorooctanoic acid  (EXP,ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quinoline  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
superoxide  (ISO)
temozolomide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
triclosan  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The pyruvate dehydrogenase complex: cloning of the rat somatic E1 alpha subunit and its coordinate expression with the mRNAs for the E1 beta, E2, and E3 catalytic subunits in developing rat brain. Cullingford TE, etal., J Neurochem 1994 May;62(5):1682-90.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops. Kato M, etal., Structure. 2008 Dec 10;16(12):1849-59. doi: 10.1016/j.str.2008.10.010.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Mutations in the X-linked pyruvate dehydrogenase (E1) alpha subunit gene (PDHA1) in patients with a pyruvate dehydrogenase complex deficiency. Lissens W, etal., Hum Mutat 2000;15(3):209-19.
7. Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat. Maury J, etal., Biochem J. 1995 Oct 15;311 ( Pt 2):531-5.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. An animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1a. Ojano-Dirain C, etal., Mol Genet Metab. 2010 Oct-Nov;101(2-3):183-91. doi: 10.1016/j.ymgme.2010.07.008. Epub 2010 Jul 15.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases. Patel MS and Korotchkina LG, Exp Mol Med. 2001 Dec 31;33(4):191-7.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. Mutational study in the PDHA1 gene of 40 patients suspected of pyruvate dehydrogenase complex deficiency. Quintana E, etal., Clin Genet. 2010 May;77(5):474-82. doi: 10.1111/j.1399-0004.2009.01313.x. Epub 2009 Dec 10.
16. Monitoring phosphorylation of the pyruvate dehydrogenase complex. Rardin MJ, etal., Anal Biochem. 2009 Jun 15;389(2):157-64. doi: 10.1016/j.ab.2009.03.040. Epub 2009 Mar 31.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:2025639   PMID:11708858   PMID:14651853   PMID:16641100   PMID:17634366   PMID:18586888   PMID:18614015   PMID:19429050   PMID:20833797   PMID:21630459   PMID:22809973   PMID:26503465  
PMID:27871875   PMID:28376086   PMID:29476059   PMID:35352799  


Genomics

Comparative Map Data
Pdha1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X38,509,158 - 38,522,986 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX38,509,084 - 38,522,536 (+)EnsemblGRCr8
mRatBN7.2X34,700,481 - 34,714,309 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX34,700,409 - 34,714,311 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX35,837,874 - 35,851,694 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X39,301,516 - 39,315,336 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X34,467,574 - 34,481,394 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X37,329,779 - 37,343,410 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX37,329,779 - 37,343,410 (+)Ensemblrn6Rnor6.0
Rnor_5.0X37,640,725 - 37,654,356 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X55,899,491 - 55,913,319 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX35,373,056 - 35,386,884 (+)NCBICelera
RGSC_v3.1X55,952,967 - 55,966,789 (+)NCBI
Cytogenetic MapXq14NCBI
PDHA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X19,343,927 - 19,361,718 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX19,343,893 - 19,361,718 (+)Ensemblhg38GRCh38
GRCh37X19,362,045 - 19,379,836 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X19,271,972 - 19,287,886 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X19,121,707 - 19,137,622NCBI
CeleraX23,483,337 - 23,501,163 (+)NCBICelera
Cytogenetic MapXp22.12NCBI
HuRefX17,111,170 - 17,129,001 (+)NCBIHuRef
CHM1_1X19,393,050 - 19,410,882 (+)NCBICHM1_1
T2T-CHM13v2.0X18,926,645 - 18,944,454 (+)NCBIT2T-CHM13v2.0
Pdha1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X158,905,215 - 158,921,426 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX158,905,205 - 158,921,409 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X160,122,219 - 160,138,430 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX160,122,209 - 160,138,413 (-)Ensemblmm10GRCm38
MGSCv37X156,560,151 - 156,576,268 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X155,466,324 - 155,482,441 (-)NCBIMGSCv36mm8
CeleraX143,366,647 - 143,382,812 (-)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX73.95NCBI
Pdha1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495558697,172 - 114,928 (-)Ensembl
ChiLan1.0NW_00495558698,492 - 114,927 (-)NCBIChiLan1.0ChiLan1.0
PDHA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X21,143,429 - 21,161,379 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X21,146,848 - 21,164,769 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X11,967,944 - 11,985,837 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X19,330,622 - 19,348,443 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX19,330,508 - 19,348,443 (+)EnsemblpanPan2panpan1.1
PDHA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X15,338,364 - 15,354,011 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX15,338,202 - 15,387,458 (+)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.0X15,298,232 - 15,314,012 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX15,298,193 - 15,314,012 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X15,346,993 - 15,362,754 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X15,348,770 - 15,364,534 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X15,416,047 - 15,431,830 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pdha1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X8,400,113 - 8,416,930 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936844889,635 - 909,586 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936844889,720 - 906,631 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDHA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX15,700,050 - 15,718,903 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X15,699,924 - 15,718,908 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X16,947,200 - 16,966,053 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDHA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X17,804,123 - 17,820,087 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605619,671,536 - 19,689,681 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdha1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248294,154,066 - 4,169,670 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248294,154,143 - 4,170,726 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pdha1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X32,679,840 - 32,693,839 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pdha1
54 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:339
Count of miRNA genes:219
Interacting mature miRNAs:257
Transcripts:ENSRNOT00000038352
Prediction methods:Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2447036044931007Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2447036045082063Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat

Markers in Region
AI170398  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X34,714,460 - 34,714,644 (+)MAPPERmRatBN7.2
Rnor_6.0X37,343,562 - 37,343,745NCBIRnor6.0
Rnor_5.0X37,654,508 - 37,654,691UniSTSRnor5.0
RGSC_v3.4X55,913,471 - 55,913,654UniSTSRGSC3.4
CeleraX35,387,036 - 35,387,219UniSTS
RH 3.4 MapX500.8UniSTS
Cytogenetic MapXq21UniSTS
RH144218  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X34,712,636 - 34,712,737 (+)MAPPERmRatBN7.2
Rnor_6.0X37,341,738 - 37,341,838NCBIRnor6.0
Rnor_5.0X37,652,684 - 37,652,784UniSTSRnor5.0
RGSC_v3.4X55,911,647 - 55,911,747UniSTSRGSC3.4
CeleraX35,385,212 - 35,385,312UniSTS
Cytogenetic MapXq21UniSTS
AA819807  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X34,713,892 - 34,714,106 (+)MAPPERmRatBN7.2
mRatBN7.21682,511,694 - 82,511,908 (-)MAPPERmRatBN7.2
mRatBN7.2X34,713,892 - 34,714,106 (-)MAPPERmRatBN7.2
mRatBN7.21682,511,694 - 82,511,908 (+)MAPPERmRatBN7.2
Rnor_6.0X37,342,994 - 37,343,207NCBIRnor6.0
Rnor_6.01688,344,652 - 88,344,865NCBIRnor6.0
Rnor_5.01687,741,383 - 87,741,596UniSTSRnor5.0
Rnor_5.0X37,653,940 - 37,654,153UniSTSRnor5.0
RGSC_v3.4X55,912,903 - 55,913,116UniSTSRGSC3.4
RGSC_v3.41687,958,417 - 87,958,630UniSTSRGSC3.4
Celera1680,231,365 - 80,231,578UniSTS
CeleraX35,386,468 - 35,386,681UniSTS
Cytogenetic MapXq21UniSTS
RH141520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21682,512,559 - 82,512,740 (-)MAPPERmRatBN7.2
mRatBN7.21682,512,559 - 82,512,740 (+)MAPPERmRatBN7.2
mRatBN7.2X34,713,049 - 34,713,230 (-)MAPPERmRatBN7.2
mRatBN7.2X34,713,049 - 34,713,230 (+)MAPPERmRatBN7.2
Rnor_6.0X37,342,151 - 37,342,331NCBIRnor6.0
Rnor_6.01688,345,517 - 88,345,697NCBIRnor6.0
Rnor_5.0X37,653,097 - 37,653,277UniSTSRnor5.0
Rnor_5.01687,742,248 - 87,742,428UniSTSRnor5.0
RGSC_v3.4X55,912,060 - 55,912,240UniSTSRGSC3.4
RGSC_v3.41687,959,282 - 87,959,462UniSTSRGSC3.4
Celera1680,232,230 - 80,232,410UniSTS
CeleraX35,385,625 - 35,385,805UniSTS
RH 3.4 MapX503.51UniSTS
Cytogenetic Map16q12.5UniSTS
Cytogenetic MapXq21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000038352   ⟹   ENSRNOP00000030279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX38,509,084 - 38,522,536 (+)Ensembl
mRatBN7.2 EnsemblX34,700,409 - 34,714,311 (+)Ensembl
Rnor_6.0 EnsemblX37,329,779 - 37,343,410 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088802   ⟹   ENSRNOP00000069789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX38,513,058 - 38,522,536 (+)Ensembl
mRatBN7.2 EnsemblX34,704,381 - 34,714,299 (+)Ensembl
Rnor_6.0 EnsemblX37,329,817 - 37,341,807 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110948   ⟹   ENSRNOP00000094690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX38,513,540 - 38,522,536 (+)Ensembl
mRatBN7.2 EnsemblX34,704,570 - 34,714,299 (+)Ensembl
RefSeq Acc Id: NM_001004072   ⟹   NP_001004072
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X38,509,158 - 38,522,986 (+)NCBI
mRatBN7.2X34,700,481 - 34,714,309 (+)NCBI
Rnor_6.0X37,329,779 - 37,343,410 (+)NCBI
Rnor_5.0X37,640,725 - 37,654,356 (+)NCBI
RGSC_v3.4X55,899,491 - 55,913,319 (+)RGD
CeleraX35,373,056 - 35,386,884 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001004072 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98897 (Get FASTA)   NCBI Sequence Viewer  
  EDL96148 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030279
GenBank Protein P26284 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001004072   ⟸   NM_001004072
- Peptide Label: precursor
- UniProtKB: P26284 (UniProtKB/Swiss-Prot),   Q4FZZ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000030279   ⟸   ENSRNOT00000038352
Ensembl Acc Id: ENSRNOP00000069789   ⟸   ENSRNOT00000088802
Ensembl Acc Id: ENSRNOP00000094690   ⟸   ENSRNOT00000110948
Protein Domains
Dehydrogenase E1 component

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26284-F1-model_v2 AlphaFold P26284 1-390 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701816
Promoter ID:EPDNEW_R12333
Type:initiation region
Name:Pdha1_1
Description:pyruvate dehydrogenase E1 alpha 1 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X37,329,767 - 37,329,827EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3286 AgrOrtholog
BioCyc Gene G2FUF-2492 BioCyc
Ensembl Genes ENSRNOG00000025383 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000038352 ENTREZGENE
Gene3D-CATH 3.40.50.970 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7103543 IMAGE-MGC_LOAD
  IMAGE:7109678 IMAGE-MGC_LOAD
InterPro DH_E1 UniProtKB/Swiss-Prot
  PDH_E1_Alpha_Subunit UniProtKB/Swiss-Prot
  Pyrv_DH_E1_asu_subgrp-y UniProtKB/Swiss-Prot
  THDP-binding UniProtKB/Swiss-Prot
MGC_CLONE MGC:114215 IMAGE-MGC_LOAD
  MGC:94854 IMAGE-MGC_LOAD
NCBI Gene 29554 ENTREZGENE
PANTHER PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, SOMATIC FORM, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR UniProtKB/Swiss-Prot
Pfam E1_dh UniProtKB/Swiss-Prot
PhenoGen Pdha1 PhenoGen
RatGTEx ENSRNOG00000025383 RatGTEx
Superfamily-SCOP SSF52518 UniProtKB/Swiss-Prot
UniProt A0A0G2JW90_RAT UniProtKB/TrEMBL
  A0A8I6GKV6_RAT UniProtKB/TrEMBL
  F7FKI5_RAT UniProtKB/TrEMBL
  ODPA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4FZZ4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Pdha1  pyruvate dehydrogenase E1 subunit alpha 1  Pdha1  pyruvate dehydrogenase E1 alpha 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-08-23 Pdha1  pyruvate dehydrogenase E1 alpha 1 subunit  Pdha1  pyruvate dehydrogenase alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-06-20 Pdha1  pyruvate dehydrogenase alpha 1  Pdha1  pyruvate dehydrogenase (lipoamide) alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Pdha1  pyruvate dehydrogenase (lipoamide) alpha 1  Pdha1  pyruvate dehydrogenase E1 alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pdha1  Pyruvate dehydrogenase (lipoamide) alpha 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog is detected in patients with pyruvate dehydrogenase complex deficiency disease 731230