PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) - Rat Genome Database

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Gene: PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) Pan paniscus
Analyze
Symbol: PDHA1
Name: pyruvate dehydrogenase E1 subunit alpha 1
RGD ID: 12002717
Description: ENCODES a protein that exhibits pyruvate dehydrogenase (acetyl-transferring) activity (ortholog); INVOLVED IN acetyl-CoA biosynthetic process from pyruvate (ortholog); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; ASSOCIATED WITH autistic disorder (ortholog); Coffin-Lowry syndrome (ortholog); developmental and epileptic encephalopathy 2 (ortholog); FOUND IN pyruvate dehydrogenase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase alpha 1; pyruvate dehydrogenase E1 alpha 1 subunit; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X21,143,429 - 21,161,379 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X21,146,848 - 21,164,769 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X11,967,944 - 11,985,837 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X19,330,622 - 19,348,443 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX19,330,508 - 19,348,443 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PDHA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X21,143,429 - 21,161,379 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X21,146,848 - 21,164,769 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X11,967,944 - 11,985,837 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X19,330,622 - 19,348,443 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX19,330,508 - 19,348,443 (+)Ensemblpanpan1.1panPan2
PDHA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X19,343,927 - 19,361,718 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX19,343,893 - 19,361,718 (+)EnsemblGRCh38hg38GRCh38
GRCh37X19,362,045 - 19,379,836 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X19,271,972 - 19,287,886 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X19,121,707 - 19,137,622NCBI
CeleraX23,483,337 - 23,501,163 (+)NCBICelera
Cytogenetic MapXp22.12NCBI
HuRefX17,111,170 - 17,129,001 (+)NCBIHuRef
CHM1_1X19,393,050 - 19,410,882 (+)NCBICHM1_1
T2T-CHM13v2.0X18,926,645 - 18,944,454 (+)NCBIT2T-CHM13v2.0
Pdha1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X158,905,215 - 158,921,426 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX158,905,205 - 158,921,409 (-)EnsemblGRCm39 Ensembl
GRCm38X160,122,219 - 160,138,430 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX160,122,209 - 160,138,413 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X156,560,151 - 156,576,268 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X155,466,324 - 155,482,441 (-)NCBIMGSCv36mm8
CeleraX143,366,647 - 143,382,812 (-)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX73.95NCBI
Pdha1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X38,509,158 - 38,522,986 (+)NCBIGRCr8
mRatBN7.2X34,700,481 - 34,714,309 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX34,700,409 - 34,714,311 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX35,837,874 - 35,851,694 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X39,301,516 - 39,315,336 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X34,467,574 - 34,481,394 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X37,329,779 - 37,343,410 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX37,329,779 - 37,343,410 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X37,640,725 - 37,654,356 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X55,899,491 - 55,913,319 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X55,952,967 - 55,966,789 (+)NCBI
CeleraX35,373,056 - 35,386,884 (+)NCBICelera
Cytogenetic MapXq14NCBI
Pdha1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495558697,172 - 114,928 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495558698,492 - 114,927 (-)NCBIChiLan1.0ChiLan1.0
PDHA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X15,338,364 - 15,354,011 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX15,338,202 - 15,387,458 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X15,298,232 - 15,314,012 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX15,298,193 - 15,314,012 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X15,346,993 - 15,362,754 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X15,348,770 - 15,364,534 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X15,416,047 - 15,431,830 (+)NCBIUU_Cfam_GSD_1.0
Pdha1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X8,400,113 - 8,416,930 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936844889,635 - 909,586 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936844889,720 - 906,631 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDHA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX15,700,050 - 15,718,903 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X15,699,924 - 15,718,908 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X16,947,200 - 16,966,053 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PDHA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X17,804,123 - 17,820,087 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605619,671,536 - 19,689,681 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdha1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248294,154,066 - 4,169,670 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248294,154,143 - 4,170,726 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003819553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000042796   ⟹   ENSPPAP00000020013
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX19,330,508 - 19,348,443 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000042807   ⟹   ENSPPAP00000020024
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX19,330,727 - 19,346,292 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000042812   ⟹   ENSPPAP00000020029
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX19,330,727 - 19,346,292 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000042816   ⟹   ENSPPAP00000020032
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX19,333,049 - 19,346,292 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000042821   ⟹   ENSPPAP00000020037
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX19,334,113 - 19,346,292 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000042832   ⟹   ENSPPAP00000020047
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX19,335,376 - 19,346,292 (+)Ensembl
RefSeq Acc Id: XM_003819553   ⟹   XP_003819601
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X21,143,429 - 21,161,379 (+)NCBI
NHGRI_mPanPan1X21,146,848 - 21,164,769 (+)NCBI
Mhudiblu_PPA_v0X11,967,944 - 11,985,837 (+)NCBI
PanPan1.1X19,330,622 - 19,348,443 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003819601 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000020013
  ENSPPAP00000020013.1
  ENSPPAP00000020024.1
  ENSPPAP00000020029.1
  ENSPPAP00000020032.1
  ENSPPAP00000020037.1
  ENSPPAP00000020047.1
Reference Protein Sequences
RefSeq Acc Id: XP_003819601   ⟸   XM_003819553
- UniProtKB: A0A2R9ARQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000020013   ⟸   ENSPPAT00000042796
RefSeq Acc Id: ENSPPAP00000020024   ⟸   ENSPPAT00000042807
RefSeq Acc Id: ENSPPAP00000020029   ⟸   ENSPPAT00000042812
RefSeq Acc Id: ENSPPAP00000020032   ⟸   ENSPPAT00000042816
RefSeq Acc Id: ENSPPAP00000020037   ⟸   ENSPPAT00000042821
RefSeq Acc Id: ENSPPAP00000020047   ⟸   ENSPPAT00000042832
Protein Domains
Dehydrogenase E1 component


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000032993 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000042796.1 UniProtKB/TrEMBL
  ENSPPAT00000042807.1 UniProtKB/TrEMBL
  ENSPPAT00000042812.1 UniProtKB/TrEMBL
  ENSPPAT00000042816.1 UniProtKB/TrEMBL
  ENSPPAT00000042821.1 UniProtKB/TrEMBL
  ENSPPAT00000042832.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.970 UniProtKB/TrEMBL
InterPro DH_E1 UniProtKB/TrEMBL
  Pyrv_DH_E1_asu_subgrp-y UniProtKB/TrEMBL
  THDP-binding UniProtKB/TrEMBL
NCBI Gene PDHA1 ENTREZGENE
PANTHER PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA UniProtKB/TrEMBL
  PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, SOMATIC FORM, MITOCHONDRIAL UniProtKB/TrEMBL
  PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR UniProtKB/TrEMBL
Pfam E1_dh UniProtKB/TrEMBL
Superfamily-SCOP SSF52518 UniProtKB/TrEMBL
UniProt A0A2R9ARQ1_PANPA UniProtKB/TrEMBL
  A0A2R9ARQ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ARR3_PANPA UniProtKB/TrEMBL
  A0A2R9AS55_PANPA UniProtKB/TrEMBL
  A0A2R9AYA2_PANPA UniProtKB/TrEMBL
  A0A2R9AYA7_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-07-01 PDHA1  pyruvate dehydrogenase E1 subunit alpha 1  PDHA1  pyruvate dehydrogenase E1 alpha 1 subunit  Symbol and/or name change 5135510 APPROVED
2017-08-15 PDHA1  pyruvate dehydrogenase E1 alpha 1 subunit    pyruvate dehydrogenase alpha 1  Symbol and/or name change 5135510 APPROVED
2017-05-30 PDHA1  pyruvate dehydrogenase alpha 1    pyruvate dehydrogenase (lipoamide) alpha 1  Symbol and/or name change 5135510 APPROVED