Pcsk2 (proprotein convertase subtilisin/kexin type 2) - Rat Genome Database

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Gene: Pcsk2 (proprotein convertase subtilisin/kexin type 2) Rattus norvegicus
Analyze
Symbol: Pcsk2
Name: proprotein convertase subtilisin/kexin type 2
RGD ID: 3273
Description: Enables serine-type endopeptidase activity. Involved in islet amyloid polypeptide processing. Located in dendrite and perikaryon. Colocalizes with secretory granule. Used to study chronic kidney disease. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: KEX2-like endoprotease 2; NEC 2; neuroendocrine convertase 2; PC2; prohormone convertase 2; proprotein convertase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83151,333,938 - 151,636,628 (+)NCBIGRCr8
mRatBN7.23130,880,422 - 131,183,127 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3130,880,422 - 131,183,127 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3134,802,865 - 135,106,847 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03143,386,914 - 143,690,922 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03141,090,099 - 141,394,130 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03137,618,891 - 137,923,385 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3137,618,898 - 137,925,605 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03144,059,121 - 144,362,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43131,925,648 - 132,256,178 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13131,831,220 - 132,161,751 (+)NCBI
Celera3129,792,699 - 130,080,973 (+)NCBICelera
RH 3.4 Map31176.7RGD
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway   (ISO)
melanocortin system pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing. Arias AE, etal., J Cell Sci. 2000 Jun;113 ( Pt 11):2075-83.
2. Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain. Billova S, etal., Neuroscience. 2007 Jun 29;147(2):403-18. Epub 2007 Jun 1.
3. Prohormone-converting enzymes: regulation and evaluation of function using antisense RNA. Bloomquist BT, etal., Mol Endocrinol 1991 Dec;5(12):2014-24.
4. Distribution and colocalization of cholecystokinin with the prohormone convertase enzymes PC1, PC2, and PC5 in rat brain. Cain BM, etal., J Comp Neurol 2003 Dec 15;467(3):307-25.
5. Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases. Davidson HW, etal., Nature. 1988 May 5;333(6168):93-6. doi: 10.1038/333093a0.
6. Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile. Deboer MD, etal., Endocrinology. 2008 Feb;149(2):827-35. Epub 2007 Nov 26.
7. Association of genetic variants in SEMA3F, CLEC16A, LAMA3, and PCSK2 with myocardial infarction in Japanese individuals. Fujimaki T, etal., Atherosclerosis. 2010 Jun;210(2):468-73. Epub 2009 Dec 5.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Isolation of two complementary deoxyribonucleic acid clones from a rat insulinoma cell line based on similarities to Kex2 and furin sequences and the specific localization of each transcript to endocrine and neuroendocrine tissues in rats. Hakes DJ, etal., Endocrinology 1991 Dec;129(6):3053-63.
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Lipopolysaccharide mediated regulation of neuroendocrine associated proprotein convertases and neuropeptide precursor processing in the rat spleen. Lansac G, etal., J Neuroimmunol. 2006 Feb;171(1-2):57-71. Epub 2005 Dec 5.
13. Neuroendocrine protein 7B2 can be inactivated by phosphorylation within the secretory pathway. Lee SN, etal., J Biol Chem. 2006 Feb 10;281(6):3312-20. Epub 2005 Nov 14.
14. Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells. Malide D, etal., J Histochem Cytochem. 1995 Jan;43(1):11-9.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Subcellular pathways of beta-endorphin synthesis, processing, and release from immunocytes in inflammatory pain. Mousa SA, etal., Endocrinology. 2004 Mar;145(3):1331-41. Epub 2003 Nov 20.
17. Up-regulation of splenic prohormone convertases PC1 and PC2 in diabetic rats. Nakashima M, etal., Regul Pept. 2001 Dec 15;102(2-3):135-45.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Extracellular matrix proteins increase the expression of pro-TRH and pro-protein convertase PC1 in fetal hypothalamic neurons in vitro. Niquet J, etal., Brain Res Dev Brain Res. 2000 Mar 15;120(1):49-56.
20. Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation. Paulsson JF and Westermark GT, Diabetes. 2005 Jul;54(7):2117-25.
21. Thyroid hormones selectively regulate the posttranslational processing of prothyrotropin-releasing hormone in the paraventricular nucleus of the hypothalamus. Perello M, etal., Endocrinology. 2006 Jun;147(6):2705-16. Epub 2006 Feb 23.
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity. Pritchard LE, etal., J Endocrinol 2002 Mar;172(3):411-21.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing. Rhodes CJ, etal., J Biol Chem. 1992 Nov 15;267(32):22719-27.
28. Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone. Sanchez VC, etal., J Clin Invest. 2004 Aug;114(3):357-69.
29. Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter. Shen X, etal., Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E236-45.
30. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
31. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
32. Association of the prohormone convertase 2 gene (PCSK2) on chromosome 20 with NIDDM in Japanese subjects. Yoshida H, etal., Diabetes. 1995 Apr;44(4):389-93.
33. Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains. Zhan S, etal., J Cereb Blood Flow Metab. 2009 Apr;29(4):698-706. Epub 2009 Jan 14.
34. The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity. Zheng M, etal., J Neurosci. 1994 Aug;14(8):4656-73.
Additional References at PubMed
PMID:7626024   PMID:8034613   PMID:8262946   PMID:8397508   PMID:9020868   PMID:9242664   PMID:12859669   PMID:16893422   PMID:17531155   PMID:17556096   PMID:19428990   PMID:19628676  
PMID:24625528   PMID:26755731   PMID:28719828  


Genomics

Comparative Map Data
Pcsk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83151,333,938 - 151,636,628 (+)NCBIGRCr8
mRatBN7.23130,880,422 - 131,183,127 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3130,880,422 - 131,183,127 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3134,802,865 - 135,106,847 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03143,386,914 - 143,690,922 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03141,090,099 - 141,394,130 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03137,618,891 - 137,923,385 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3137,618,898 - 137,925,605 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03144,059,121 - 144,362,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43131,925,648 - 132,256,178 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13131,831,220 - 132,161,751 (+)NCBI
Celera3129,792,699 - 130,080,973 (+)NCBICelera
RH 3.4 Map31176.7RGD
Cytogenetic Map3q41NCBI
PCSK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382017,226,107 - 17,484,578 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2017,226,107 - 17,484,578 (+)EnsemblGRCh38hg38GRCh38
GRCh372017,206,752 - 17,465,223 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362017,155,631 - 17,413,223 (+)NCBINCBI36Build 36hg18NCBI36
Build 342017,155,630 - 17,413,223NCBI
Celera2017,282,082 - 17,539,671 (+)NCBICelera
Cytogenetic Map20p12.1NCBI
HuRef2017,169,857 - 17,428,162 (+)NCBIHuRef
CHM1_12017,206,780 - 17,465,251 (+)NCBICHM1_1
T2T-CHM13v2.02017,276,847 - 17,535,278 (+)NCBIT2T-CHM13v2.0
Pcsk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392143,388,053 - 143,658,204 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2143,388,076 - 143,658,205 (+)EnsemblGRCm39 Ensembl
GRCm382143,546,133 - 143,816,284 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2143,546,156 - 143,816,285 (+)EnsemblGRCm38mm10GRCm38
MGSCv372143,371,869 - 143,642,020 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362143,237,620 - 143,507,725 (+)NCBIMGSCv36mm8
Celera2144,735,342 - 144,999,086 (+)NCBICelera
Cytogenetic Map2G1NCBI
cM Map270.89NCBI
Pcsk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541526,266,484 - 26,497,001 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541526,266,513 - 26,496,905 (+)NCBIChiLan1.0ChiLan1.0
PCSK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22118,114,726 - 18,371,018 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12018,111,564 - 18,367,856 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02017,184,878 - 17,443,355 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12017,163,675 - 17,421,157 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2017,163,675 - 17,421,157 (+)Ensemblpanpan1.1panPan2
PCSK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1245,507,997 - 5,765,911 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl245,508,714 - 5,766,153 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha245,440,841 - 5,698,548 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0245,915,819 - 6,173,890 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl245,915,828 - 6,173,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1245,528,990 - 5,786,629 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0245,622,926 - 5,880,531 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0245,898,980 - 6,157,570 (-)NCBIUU_Cfam_GSD_1.0
Pcsk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640154,177,620 - 154,434,915 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364852,608,353 - 2,866,294 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364852,611,313 - 2,866,260 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1725,681,197 - 25,923,004 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11725,681,424 - 25,920,690 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21729,095,048 - 29,329,854 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1246,293,983 - 46,548,902 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl246,294,005 - 46,549,609 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666078961,154 - 1,215,957 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcsk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474118,368,928 - 18,643,600 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474118,368,976 - 18,643,151 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pcsk2
1852 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:85
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000007249
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3115638168135181505Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3115638168135181505Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat

Markers in Region
RH94811  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23131,182,804 - 131,182,981 (+)MAPPERmRatBN7.2
Rnor_6.03137,923,063 - 137,923,239NCBIRnor6.0
Rnor_5.03144,362,439 - 144,362,615UniSTSRnor5.0
RGSC_v3.43132,255,856 - 132,256,032UniSTSRGSC3.4
Celera3130,080,651 - 130,080,827UniSTS
Cytogenetic Map3q42UniSTS
M55669  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23131,182,965 - 131,183,124 (+)MAPPERmRatBN7.2
Rnor_6.03137,923,224 - 137,923,382NCBIRnor6.0
Rnor_5.03144,362,600 - 144,362,758UniSTSRnor5.0
RGSC_v3.43132,256,017 - 132,256,175UniSTSRGSC3.4
Celera3130,080,812 - 130,080,970UniSTS
Cytogenetic Map3q42UniSTS
RH143576  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21554,877,277 - 54,877,390 (+)MAPPERmRatBN7.2
mRatBN7.23130,893,725 - 130,893,838 (+)MAPPERmRatBN7.2
Rnor_6.01561,759,128 - 61,759,240NCBIRnor6.0
Rnor_6.03137,632,193 - 137,632,305NCBIRnor6.0
Rnor_5.01565,423,167 - 65,423,279UniSTSRnor5.0
Rnor_5.03144,072,423 - 144,072,535UniSTSRnor5.0
RGSC_v3.43131,938,950 - 131,939,062UniSTSRGSC3.4
RGSC_v3.41561,530,065 - 61,530,177UniSTSRGSC3.4
Celera1554,458,637 - 54,458,749UniSTS
Celera3129,806,006 - 129,806,118UniSTS
RH 3.4 Map15459.9UniSTS
Cytogenetic Map15q12UniSTS
Cytogenetic Map3q42UniSTS
RH94397  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23131,182,932 - 131,183,092 (+)MAPPERmRatBN7.2
Rnor_6.03137,923,191 - 137,923,350NCBIRnor6.0
Rnor_5.03144,362,567 - 144,362,726UniSTSRnor5.0
RGSC_v3.43132,255,984 - 132,256,143UniSTSRGSC3.4
Celera3130,080,779 - 130,080,938UniSTS
RH 3.4 Map31176.7UniSTS
Cytogenetic Map3q42UniSTS
BE117645  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23130,894,126 - 130,894,280 (+)MAPPERmRatBN7.2
Rnor_6.03137,632,594 - 137,632,747NCBIRnor6.0
Rnor_5.03144,072,824 - 144,072,977UniSTSRnor5.0
RGSC_v3.43131,939,351 - 131,939,504UniSTSRGSC3.4
Celera3129,806,407 - 129,806,560UniSTS
RH 3.4 Map31173.8UniSTS
Cytogenetic Map3q42UniSTS
Cytogenetic Map15q12UniSTS
RH136607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23130,880,462 - 130,880,590 (+)MAPPERmRatBN7.2
Rnor_6.03137,618,932 - 137,619,059NCBIRnor6.0
Rnor_5.03144,059,162 - 144,059,289UniSTSRnor5.0
RGSC_v3.43131,925,689 - 131,925,816UniSTSRGSC3.4
Celera3129,792,740 - 129,792,867UniSTS
Cytogenetic Map3q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 58
Low 3 23 7 17 7 1 1 16 17 22 9 1
Below cutoff 18 9 9 2 9 7 9 17 15 2 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007249   ⟹   ENSRNOP00000007249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3130,880,422 - 131,183,127 (+)Ensembl
Rnor_6.0 Ensembl3137,618,898 - 137,925,605 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106660   ⟹   ENSRNOP00000085912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3130,880,422 - 131,183,127 (+)Ensembl
RefSeq Acc Id: NM_012746   ⟹   NP_036878
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83151,333,938 - 151,636,628 (+)NCBI
mRatBN7.23130,880,422 - 131,183,127 (+)NCBI
Rnor_6.03137,618,891 - 137,923,385 (+)NCBI
Rnor_5.03144,059,121 - 144,362,761 (+)NCBI
RGSC_v3.43131,925,648 - 132,256,178 (+)RGD
Celera3129,792,699 - 130,080,973 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036878 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40946 (Get FASTA)   NCBI Sequence Viewer  
  AAA41477 (Get FASTA)   NCBI Sequence Viewer  
  EDL95184 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007249
  ENSRNOP00000007249.3
  ENSRNOP00000085912.1
  ENSRNOP00055032926
  ENSRNOP00060001279
  ENSRNOP00065039282
GenBank Protein P28841 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_036878   ⟸   NM_012746
- Peptide Label: precursor
- UniProtKB: P28841 (UniProtKB/Swiss-Prot),   A6K734 (UniProtKB/TrEMBL),   A0A8I6A2I9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007249   ⟸   ENSRNOT00000007249
RefSeq Acc Id: ENSRNOP00000085912   ⟸   ENSRNOT00000106660
Protein Domains
P/Homo B   Peptidase S8

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28841-F1-model_v2 AlphaFold P28841 1-637 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692478
Promoter ID:EPDNEW_R3001
Type:initiation region
Name:Pcsk2_1
Description:proprotein convertase subtilisin/kexin type 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03137,618,928 - 137,618,988EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3273 AgrOrtholog
BioCyc Gene G2FUF-47628 BioCyc
Ensembl Genes ENSRNOG00000005438 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055023581 UniProtKB/Swiss-Prot
  ENSRNOG00060001418 UniProtKB/Swiss-Prot
  ENSRNOG00065027777 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007249 ENTREZGENE
  ENSRNOT00000007249.5 UniProtKB/Swiss-Prot
  ENSRNOT00000106660.1 UniProtKB/TrEMBL
  ENSRNOT00055040528 UniProtKB/Swiss-Prot
  ENSRNOT00060002083 UniProtKB/Swiss-Prot
  ENSRNOT00065047874 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.850 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kexin/furin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_Asp-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25121 ENTREZGENE
PANTHER NEUROENDOCRINE CONVERTASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam P_proprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pcsk2 PhenoGen
PRINTS SUBTILISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P_HOMO_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_ASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005438 RatGTEx
  ENSRNOG00055023581 RatGTEx
  ENSRNOG00060001418 RatGTEx
  ENSRNOG00065027777 RatGTEx
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52743 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC208898
UniProt A0A8I6A2I9 ENTREZGENE, UniProtKB/TrEMBL
  A6K734 ENTREZGENE, UniProtKB/TrEMBL
  NEC2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pcsk2  proprotein convertase subtilisin/kexin type 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed at high levels in the islets of Langerhans 70278
gene_expression expressed in endocrine and neuroendocrine tissues 70278
gene_function releases protein hormones and neuropeptides from their precursors, usually by cleavage of -lys-arg- 70278
gene_process involved in the maturation and processing of hormones and other protein precursors 70278
gene_protein during secretion, immature 75-kD protein cleaved to produce active 68-kD protein 70278