Pam (peptidylglycine alpha-amidating monooxygenase) - Rat Genome Database

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Gene: Pam (peptidylglycine alpha-amidating monooxygenase) Rattus norvegicus
Analyze
Symbol: Pam
Name: peptidylglycine alpha-amidating monooxygenase
RGD ID: 3252
Description: Enables several functions, including metal ion binding activity; peptidylamidoglycolate lyase activity; and peptidylglycine monooxygenase activity. Involved in several processes, including fatty acid primary amide biosynthetic process; lactation; and peptide amidation. Located in several cellular components, including perikaryon; perinuclear region of cytoplasm; and trans-Golgi network. Biomarker of hypothyroidism. Orthologous to human PAM (peptidylglycine alpha-amidating monooxygenase); PARTICIPATES IN melanocortin system pathway; INTERACTS WITH (R)-noradrenaline; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: basic salivary proline-rich protein 4-like; LOC102553671; peptidyl-glycine alpha-amidating monooxygenase; PHM; uncharacterized LOC102553671
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89105,445,812 - 105,719,287 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9105,445,929 - 105,719,285 (+)EnsemblGRCr8
mRatBN7.2997,998,581 - 98,271,966 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl998,122,916 - 98,271,965 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9106,535,688 - 106,685,815 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09111,663,678 - 111,813,798 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09110,007,065 - 110,157,189 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.09111,028,543 - 111,177,588 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9111,028,575 - 111,177,602 (+)Ensemblrn6Rnor6.0
Rnor_5.09110,584,141 - 110,737,487 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4996,893,071 - 97,047,523 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera995,564,414 - 95,713,546 (+)NCBICelera
RGSC_v3.1997,102,550 - 97,257,003 (+)NCBI
Cytogenetic Map9q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chloropicrin  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
disulfiram  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (EXP)
glafenine  (EXP)
irinotecan  (ISO)
L-methionine  (ISO)
menadione  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
parathion  (ISO)
pentetrazol  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
reserpine  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Novel proteins that interact with the COOH-terminal cytosolic routing determinants of an integral membrane peptide-processing enzyme. Alam MR, etal., J Biol Chem 1996 Nov 8;271(45):28636-40.
2. Signaling mediated by the cytosolic domain of peptidylglycine alpha-amidating monooxygenase. Alam MR, etal., Mol Biol Cell. 2001 Mar;12(3):629-44.
3. New structures reveal flexible dynamics between the subdomains of peptidylglycine monooxygenase. Implications for an open to closed mechanism. Arias RJ, etal., Protein Sci. 2023 Apr;32(4):e4615. doi: 10.1002/pro.4615.
4. Anti-inflammatory effects of 4-phenyl-3-butenoic acid and 5-(acetylamino)-4-oxo-6-phenyl-2-hexenoic acid methyl ester, potential inhibitors of neuropeptide bioactivation. Bauer JD, etal., J Pharmacol Exp Ther. 2007 Mar;320(3):1171-7. Epub 2006 Nov 30.
5. Large scale production of the copper enzyme peptidylglycine monooxygenase using an automated bioreactor. Bauman AT, etal., Protein Expr Purif. 2007 Jan;51(1):34-8. Epub 2006 Jun 27.
6. Response of an integral granule membrane protein to changes in pH. Bell-Parikh LC, etal., J Biol Chem. 2001 Aug 10;276(32):29854-63. Epub 2001 Jun 6.
7. Cloning and characterization of two alternatively spliced rat alpha-amidating enzyme cDNAs from rat medullary thyroid carcinoma. Bertelsen AH, etal., Arch Biochem Biophys 1990 May 15;279(1):87-96.
8. P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes. Chen L, etal., J Biol Chem 1998 Dec 11;273(50):33524-32.
9. Ubiquitin and ubiquitin-derived peptides as substrates for peptidylglycine alpha-amidating monooxygenase. Chew GH, etal., FEBS Lett. 2005 Aug 29;579(21):4678-84.
10. Amidation of bioactive peptides: the structure of the lyase domain of the amidating enzyme. Chufan EE, etal., Structure. 2009 Jul 15;17(7):965-73.
11. Differential regulation of peptide alpha-amidation by dexamethasone and disulfiram. Driscoll WJ, etal., Mol Pharmacol. 1999 Jun;55(6):1067-76.
12. The catalytic core of peptidylglycine alpha-hydroxylating monooxygenase: investigation by site-directed mutagenesis, Cu X-ray absorption spectroscopy, and electron paramagnetic resonance. Eipper BA, etal., Biochemistry. 1995 Mar 7;34(9):2857-65. doi: 10.1021/bi00009a016.
13. Alternative splicing and endoproteolytic processing generate tissue-specific forms of pituitary peptidylglycine alpha-amidating monooxygenase (PAM). Eipper BA, etal., J Biol Chem 1992 Feb 25;267(6):4008-15.
14. Supplying copper to the cuproenzyme peptidylglycine alpha-amidating monooxygenase. El Meskini R, etal., J Biol Chem. 2003 Apr 4;278(14):12278-84. Epub 2003 Jan 14.
15. Evidence of high expression of peptidylglycine alpha-amidating monooxygenase in the rat uterus: estrogen regulation. El Meskini R, etal., Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7191-6.
16. Hyperplasia of alveolar neuroendocrine cells in rat lung carcinogenesis by silica with selective expression of proadrenomedullin-derived peptides and amidating enzymes. Elizegi E, etal., Lab Invest. 2001 Dec;81(12):1627-38.
17. Retrieval and reuse of pituitary secretory granule proteins. Ferraro F, etal., J Biol Chem. 2005 Jul 8;280(27):25424-35. Epub 2005 May 19.
18. Effect of thyroid hormones on peptidylglycine alpha-amidating monooxygenase gene expression in anterior pituitary gland: transcriptional studies and messenger ribonucleic acid stability. Fraboulet S, etal., Endocrinology. 1996 Dec;137(12):5493-501.
19. Signaling from the secretory granule to the nucleus: Uhmk1 and PAM. Francone VP, etal., Mol Endocrinol. 2010 Aug;24(8):1543-58. Epub 2010 Jun 23.
20. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
21. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
22. Identification of the promoter for the gene encoding the bifunctional enzyme, peptidylglycine alpha-amidating monooxygenase. Hand TA, etal., DNA Cell Biol 1996 Dec;15(12):1093-104.
23. The membrane-bound bifunctional peptidylglycine alpha-amidating monooxygenase protein. Exploration of its domain structure through limited proteolysis. Husten EJ and Eipper BA, J Biol Chem. 1991 Sep 15;266(26):17004-10.
24. Isolation and functional expression of pituitary peptidylglycine alpha-amidating enzyme mRNA. A variant lacking the transmembrane domain. Kato I, etal., FEBS Lett 1990 Sep 3;269(2):319-23.
25. Peptidyl-glycine alpha-amidating monooxygenase targeting and shaping of atrial secretory vesicles: inhibition by mutated N-terminal ProANP and PBA. Labrador V, etal., Circ Res. 2004 Dec 10;95(12):e98-109. Epub 2004 Nov 11.
26. Cloning, co-expression with an amidating enzyme, and activity of the scorpion toxin BmK ITa1 cDNA in insect cells. Liu Z, etal., Mol Biotechnol. 2003 May;24(1):21-6.
27. Regulation of peptide amidation in cultured pituitary cells. May V and Eipper BA, J Biol Chem. 1985 Dec 25;260(30):16224-31.
28. Thiorphan, tiopronin, and related analogs as substrates and inhibitors of peptidylglycine alpha-amidating monooxygenase (PAM). McIntyre NR, etal., FEBS Lett. 2006 Jan 23;580(2):521-32. Epub 2005 Dec 28.
29. Fatty acid amide biosynthesis: a possible new role for peptidylglycine alpha-amidating enzyme and acyl-coenzyme A: glycine N-acyltransferase. Merkler DJ, etal., Arch Biochem Biophys. 1996 Jun 15;330(2):430-4.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. Identification of routing determinants in the cytosolic domain of a secretory granule-associated integral membrane protein. Milgram SL, etal., J Biol Chem. 1996 Jul 19;271(29):17526-35.
32. Proteomic analysis of rat atrial secretory granules: a platform for testable hypotheses. Muth E, etal., Biochim Biophys Acta. 2004 Jun 1;1699(1-2):263-75.
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. The multifunctional peptidylglycine alpha-amidating monooxygenase gene: exon/intron organization of catalytic, processing, and routing domains. Ouafik LH, etal., Mol Endocrinol 1992 Oct;6(10):1571-84.
35. Substrate-mediated electron transfer in peptidylglycine alpha-hydroxylating monooxygenase. Prigge ST, etal., Nat Struct Biol. 1999 Oct;6(10):976-83. doi: 10.1038/13351.
36. Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity. Pritchard LE, etal., J Endocrinol 2002 Mar;172(3):411-21.
37. Plasma peptidylglycine alpha-amidating monooxygenase (PAM) and ceruloplasmin are affected by age and copper status in rats and mice. Prohaska JR and Broderius M, Comp Biochem Physiol B Biochem Mol Biol. 2006 Mar;143(3):360-6. Epub 2006 Jan 31.
38. Peptidylglycine-alpha-amidating monooxygenase activity and protein are lower in copper-deficient rats and suckling copper-deficient mice. Prohaska JR, etal., Arch Biochem Biophys. 2005 Feb 1;434(1):212-20.
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Expression of adrenomedullin and peptide amidation activity in human prostate cancer and in human prostate cancer cell lines. Rocchi P, etal., Cancer Res. 2001 Feb 1;61(3):1196-206.
42. Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing. Sharma SD, etal., J Appl Physiol. 2009 Jan;106(1):12-9. Epub 2008 Sep 25.
43. Dynamics of peptidergic secretory granule transport are regulated by neuronal stimulation. Sobota JA, etal., BMC Neurosci. 2010 Mar 4;11:32.
44. Alternative mRNA splicing generates multiple forms of peptidyl-glycine alpha-amidating monooxygenase in rat atrium. Stoffers DA, etal., Proc Natl Acad Sci U S A 1989 Jan;86(2):735-9.
45. N-acylglycine amidation: implications for the biosynthesis of fatty acid primary amides. Wilcox BJ, etal., Biochemistry. 1999 Mar 16;38(11):3235-45. doi: 10.1021/bi982255j.
46. Cdk5 and Trio modulate endocrine cell exocytosis. Xin X, etal., J Cell Sci. 2004 Sep 15;117(Pt 20):4739-48. Epub 2004 Aug 25.
47. In Vitro Amidating Processing of Products Expressed by Gene Engineering. Yang YH, etal., Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2000;32(3):312-315.
48. Embryonic and uterine expression patterns of peptidylglycine alpha-amidating monooxygenase transcripts suggest a widespread role for amidated peptides in development. Zhang J, etal., Dev Biol. 1997 Dec 15;192(2):375-91.
Additional References at PubMed
PMID:1491686   PMID:1572293   PMID:1699535   PMID:1988445   PMID:2211657   PMID:2357221   PMID:7680192   PMID:9360928   PMID:10574929   PMID:12369828   PMID:12699694   PMID:14559897  
PMID:15131304   PMID:16325307   PMID:17301036   PMID:19199708   PMID:19946888   PMID:22871113   PMID:23247335   PMID:23376485   PMID:23533145   PMID:24627494   PMID:26170456   PMID:34061983  


Genomics

Comparative Map Data
Pam
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89105,445,812 - 105,719,287 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9105,445,929 - 105,719,285 (+)EnsemblGRCr8
mRatBN7.2997,998,581 - 98,271,966 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl998,122,916 - 98,271,965 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx9106,535,688 - 106,685,815 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09111,663,678 - 111,813,798 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09110,007,065 - 110,157,189 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.09111,028,543 - 111,177,588 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9111,028,575 - 111,177,602 (+)Ensemblrn6Rnor6.0
Rnor_5.09110,584,141 - 110,737,487 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4996,893,071 - 97,047,523 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera995,564,414 - 95,713,546 (+)NCBICelera
RGSC_v3.1997,102,550 - 97,257,003 (+)NCBI
Cytogenetic Map9q36NCBI
PAM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385102,754,783 - 103,031,105 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5102,753,981 - 103,031,149 (+)Ensemblhg38GRCh38
GRCh375102,090,487 - 102,366,809 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365102,229,426 - 102,393,316 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345102,229,425 - 102,393,315NCBI
Celera598,149,342 - 98,314,632 (+)NCBICelera
Cytogenetic Map5q21.1NCBI
HuRef597,382,969 - 97,548,060 (+)NCBIHuRef
CHM1_15101,633,901 - 101,799,441 (+)NCBICHM1_1
T2T-CHM13v2.05103,262,795 - 103,539,139 (+)NCBIT2T-CHM13v2.0
Pam
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39197,748,816 - 98,023,578 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl197,722,839 - 98,023,371 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38197,821,091 - 98,095,853 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl197,795,114 - 98,095,646 (-)Ensemblmm10GRCm38
MGSCv37199,717,671 - 99,992,209 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36199,651,500 - 99,925,919 (-)NCBIMGSCv36mm8
Celera1100,701,674 - 100,975,784 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.76NCBI
Pam
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541810,953,696 - 11,107,667 (-)Ensembl
ChiLan1.0NW_00495541810,953,044 - 11,107,668 (-)NCBIChiLan1.0ChiLan1.0
PAM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2498,032,957 - 98,314,224 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1596,297,289 - 96,467,871 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0598,104,058 - 98,385,157 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15103,803,846 - 104,085,774 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5103,913,456 - 104,085,774 (+)EnsemblpanPan2panpan1.1
PAM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.138,141,508 - 8,312,081 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl38,142,061 - 8,290,477 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha39,543,047 - 9,693,485 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.038,029,782 - 8,180,284 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl38,029,980 - 8,180,292 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.137,970,219 - 8,120,392 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.037,988,856 - 8,139,107 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.038,148,827 - 8,299,174 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213163,307,429 - 163,485,516 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365231,493,450 - 1,750,524 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365231,492,795 - 1,786,942 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2108,255,930 - 108,536,880 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12108,255,923 - 108,536,192 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22112,397,471 - 112,553,945 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,316,428 - 6,482,959 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,316,428 - 6,486,751 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660367,849,169 - 8,133,685 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pam
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474320,988,916 - 21,178,933 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474320,834,664 - 21,178,933 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pam
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14168,442,963 - 168,702,758 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pam
1121 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:743
Count of miRNA genes:238
Interacting mature miRNAs:291
Transcripts:ENSRNOT00000041418, ENSRNOT00000043451, ENSRNOT00000044154, ENSRNOT00000049205, ENSRNOT00000049286, ENSRNOT00000056457
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat

Markers in Region
AI170526  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2998,191,436 - 98,191,591 (+)MAPPERmRatBN7.2
Rnor_6.09111,097,092 - 111,097,246NCBIRnor6.0
Rnor_5.09110,668,057 - 110,668,211UniSTSRnor5.0
RGSC_v3.4996,964,578 - 96,964,732UniSTSRGSC3.4
Celera995,632,772 - 95,632,926UniSTS
RH 3.4 Map9817.3UniSTS
Cytogenetic Map9q36UniSTS
U79523  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2998,271,363 - 98,271,452 (+)MAPPERmRatBN7.2
Rnor_6.09111,176,986 - 111,177,074NCBIRnor6.0
Rnor_5.09110,584,655 - 110,584,743UniSTSRnor5.0
RGSC_v3.4997,046,931 - 97,047,019UniSTSRGSC3.4
Celera995,712,954 - 95,713,042UniSTS
Cytogenetic Map9q36UniSTS
RH144149  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2998,124,574 - 98,124,684 (+)MAPPERmRatBN7.2
Rnor_6.09111,030,236 - 111,030,345NCBIRnor6.0
Rnor_5.09110,735,673 - 110,735,782UniSTSRnor5.0
RGSC_v3.4996,894,614 - 96,894,723UniSTSRGSC3.4
Celera995,565,957 - 95,566,066UniSTS
RH 3.4 Map9817.4UniSTS
Cytogenetic Map9q36UniSTS
RH139176  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2998,122,201 - 98,122,321 (+)MAPPERmRatBN7.2
Rnor_6.09111,027,863 - 111,027,982NCBIRnor6.0
Rnor_5.09110,738,036 - 110,738,155UniSTSRnor5.0
RGSC_v3.4996,892,241 - 96,892,360UniSTSRGSC3.4
Celera995,563,584 - 95,563,703UniSTS
RH 3.4 Map9819.59UniSTS
Cytogenetic Map9q36UniSTS
BE106993  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2998,226,653 - 98,226,823 (+)MAPPERmRatBN7.2
Rnor_6.09111,132,308 - 111,132,477NCBIRnor6.0
Rnor_5.09110,632,357 - 110,632,526UniSTSRnor5.0
RGSC_v3.4997,001,707 - 97,001,876UniSTSRGSC3.4
Celera995,668,305 - 95,668,474UniSTS
RH 3.4 Map9818.6UniSTS
Cytogenetic Map9q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_013000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039083049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M82845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000041418   ⟹   ENSRNOP00000050784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl998,122,916 - 98,271,298 (+)Ensembl
Rnor_6.0 Ensembl9111,028,824 - 111,109,582 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000043451   ⟹   ENSRNOP00000046774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9105,446,022 - 105,719,285 (+)Ensembl
mRatBN7.2 Ensembl998,123,032 - 98,271,956 (+)Ensembl
Rnor_6.0 Ensembl9111,028,575 - 111,177,602 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000056457   ⟹   ENSRNOP00000053295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl998,123,213 - 98,271,961 (+)Ensembl
Rnor_6.0 Ensembl9111,028,874 - 111,177,583 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102263   ⟹   ENSRNOP00000079092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9105,445,929 - 105,719,284 (+)Ensembl
mRatBN7.2 Ensembl998,122,916 - 98,271,956 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117663   ⟹   ENSRNOP00000089015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl998,122,916 - 98,271,956 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118414   ⟹   ENSRNOP00000087123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9105,570,499 - 105,651,256 (+)Ensembl
mRatBN7.2 Ensembl998,122,916 - 98,271,965 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120994   ⟹   ENSRNOP00000098552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9105,446,019 - 105,719,285 (+)Ensembl
RefSeq Acc Id: NM_013000   ⟹   NP_037132
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,570,368 - 105,719,277 (+)NCBI
mRatBN7.2998,123,032 - 98,271,956 (+)NCBI
Rnor_6.09111,028,693 - 111,177,578 (+)NCBI
Rnor_5.09110,584,141 - 110,737,487 (-)NCBI
RGSC_v3.4996,893,071 - 97,047,523 (+)RGD
Celera995,564,414 - 95,713,546 (+)RGD
Sequence:
RefSeq Acc Id: XM_006245594   ⟹   XP_006245656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,938 - 105,719,287 (+)NCBI
mRatBN7.2997,998,581 - 98,271,298 (+)NCBI
Rnor_6.09111,028,543 - 111,177,588 (+)NCBI
Rnor_5.09110,584,141 - 110,737,487 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245597   ⟹   XP_006245659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,938 - 105,719,287 (+)NCBI
mRatBN7.2997,998,581 - 98,271,966 (+)NCBI
Rnor_6.09111,028,543 - 111,177,588 (+)NCBI
Rnor_5.09110,584,141 - 110,737,487 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767360   ⟹   XP_008765582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,938 - 105,719,287 (+)NCBI
mRatBN7.2997,998,581 - 98,271,966 (+)NCBI
Rnor_6.09111,028,543 - 111,177,588 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596286   ⟹   XP_017451775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,938 - 105,719,287 (+)NCBI
mRatBN7.2997,998,581 - 98,271,966 (+)NCBI
Rnor_6.09111,028,543 - 111,177,588 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017596287   ⟹   XP_017451776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,938 - 105,719,287 (+)NCBI
mRatBN7.2997,998,581 - 98,271,298 (+)NCBI
Rnor_6.09111,028,543 - 111,177,588 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083038   ⟹   XP_038938966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,911 - 105,719,287 (+)NCBI
mRatBN7.2997,998,593 - 98,271,298 (+)NCBI
RefSeq Acc Id: XM_039083039   ⟹   XP_038938967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,569,326 - 105,719,287 (+)NCBI
mRatBN7.2998,121,990 - 98,271,298 (+)NCBI
RefSeq Acc Id: XM_039083040   ⟹   XP_038938968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,812 - 105,719,287 (+)NCBI
mRatBN7.2997,998,581 - 98,271,966 (+)NCBI
RefSeq Acc Id: XM_039083041   ⟹   XP_038938969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,938 - 105,719,287 (+)NCBI
mRatBN7.2997,998,581 - 98,271,955 (+)NCBI
RefSeq Acc Id: XM_039083042   ⟹   XP_038938970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,938 - 105,719,287 (+)NCBI
mRatBN7.2997,998,581 - 98,271,955 (+)NCBI
RefSeq Acc Id: XM_039083043   ⟹   XP_038938971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,938 - 105,719,287 (+)NCBI
mRatBN7.2997,998,581 - 98,271,298 (+)NCBI
RefSeq Acc Id: XM_039083044   ⟹   XP_038938972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,913 - 105,719,287 (+)NCBI
mRatBN7.2997,998,581 - 98,271,955 (+)NCBI
RefSeq Acc Id: XM_039083045   ⟹   XP_038938973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,938 - 105,719,287 (+)NCBI
mRatBN7.2997,998,581 - 98,271,298 (+)NCBI
RefSeq Acc Id: XM_039083046   ⟹   XP_038938974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,890 - 105,719,287 (+)NCBI
mRatBN7.2997,998,581 - 98,271,298 (+)NCBI
RefSeq Acc Id: XM_039083047   ⟹   XP_038938975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,926 - 105,719,287 (+)NCBI
mRatBN7.2997,998,581 - 98,271,955 (+)NCBI
RefSeq Acc Id: XM_039083048   ⟹   XP_038938976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,938 - 105,719,287 (+)NCBI
mRatBN7.2997,998,581 - 98,271,298 (+)NCBI
RefSeq Acc Id: XM_039083049   ⟹   XP_038938977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,913 - 105,719,287 (+)NCBI
mRatBN7.2997,998,581 - 98,271,664 (+)NCBI
RefSeq Acc Id: XM_063266683   ⟹   XP_063122753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,569,933 - 105,719,287 (+)NCBI
RefSeq Acc Id: XM_063266684   ⟹   XP_063122754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,941 - 105,719,287 (+)NCBI
RefSeq Acc Id: XM_063266685   ⟹   XP_063122755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,994 - 105,719,287 (+)NCBI
RefSeq Acc Id: XM_063266686   ⟹   XP_063122756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,911 - 105,719,287 (+)NCBI
RefSeq Acc Id: XM_063266687   ⟹   XP_063122757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,911 - 105,719,287 (+)NCBI
RefSeq Acc Id: XM_063266688   ⟹   XP_063122758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,912 - 105,719,287 (+)NCBI
RefSeq Acc Id: XM_063266689   ⟹   XP_063122759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,949 - 105,719,287 (+)NCBI
RefSeq Acc Id: XM_063266690   ⟹   XP_063122760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,911 - 105,719,287 (+)NCBI
RefSeq Acc Id: XM_063266691   ⟹   XP_063122761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,812 - 105,719,287 (+)NCBI
RefSeq Acc Id: XM_063266692   ⟹   XP_063122762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,569,910 - 105,719,287 (+)NCBI
RefSeq Acc Id: XM_063266693   ⟹   XP_063122763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,914 - 105,719,287 (+)NCBI
RefSeq Acc Id: XM_063266694   ⟹   XP_063122764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,911 - 105,719,287 (+)NCBI
RefSeq Acc Id: XM_063266695   ⟹   XP_063122765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89105,445,911 - 105,719,287 (+)NCBI
Protein Sequences
Protein RefSeqs NP_037132 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245656 (Get FASTA)   NCBI Sequence Viewer  
  XP_006245659 (Get FASTA)   NCBI Sequence Viewer  
  XP_008765582 (Get FASTA)   NCBI Sequence Viewer  
  XP_017451775 (Get FASTA)   NCBI Sequence Viewer  
  XP_017451776 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938966 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938967 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938968 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938969 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938970 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938971 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938972 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938973 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938974 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938975 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938976 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938977 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122753 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122754 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122755 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122756 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122757 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122758 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122759 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122760 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122761 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122762 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122763 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122764 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122765 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41803 (Get FASTA)   NCBI Sequence Viewer  
  AAA41804 (Get FASTA)   NCBI Sequence Viewer  
  AAB00162 (Get FASTA)   NCBI Sequence Viewer  
  AAC05607 (Get FASTA)   NCBI Sequence Viewer  
  CAA42206 (Get FASTA)   NCBI Sequence Viewer  
  CAA42207 (Get FASTA)   NCBI Sequence Viewer  
  CAA42208 (Get FASTA)   NCBI Sequence Viewer  
  CAA42209 (Get FASTA)   NCBI Sequence Viewer  
  CAA42210 (Get FASTA)   NCBI Sequence Viewer  
  EDL91859 (Get FASTA)   NCBI Sequence Viewer  
  EDL91860 (Get FASTA)   NCBI Sequence Viewer  
  EDL91861 (Get FASTA)   NCBI Sequence Viewer  
  EDL91862 (Get FASTA)   NCBI Sequence Viewer  
  EDL91863 (Get FASTA)   NCBI Sequence Viewer  
  EDL91864 (Get FASTA)   NCBI Sequence Viewer  
  EDL91865 (Get FASTA)   NCBI Sequence Viewer  
  EDL91866 (Get FASTA)   NCBI Sequence Viewer  
  EDL91867 (Get FASTA)   NCBI Sequence Viewer  
  EDL91868 (Get FASTA)   NCBI Sequence Viewer  
  EDL91869 (Get FASTA)   NCBI Sequence Viewer  
  EDL91870 (Get FASTA)   NCBI Sequence Viewer  
  EDL91871 (Get FASTA)   NCBI Sequence Viewer  
  EDL91872 (Get FASTA)   NCBI Sequence Viewer  
  EDL91873 (Get FASTA)   NCBI Sequence Viewer  
  EDL91874 (Get FASTA)   NCBI Sequence Viewer  
  EDL91875 (Get FASTA)   NCBI Sequence Viewer  
  EDL91876 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046774
  ENSRNOP00000050784.3
  ENSRNOP00000053295.2
  ENSRNOP00000079092
  ENSRNOP00000087123.1
  ENSRNOP00000089015.1
  ENSRNOP00000098552
GenBank Protein P14925 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037132   ⟸   NM_013000
- Peptide Label: precursor
- UniProtKB: Q64616 (UniProtKB/Swiss-Prot),   P70710 (UniProtKB/Swiss-Prot),   Q64668 (UniProtKB/Swiss-Prot),   P14925 (UniProtKB/Swiss-Prot),   A6JR60 (UniProtKB/TrEMBL),   A0A8L2QMN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245659   ⟸   XM_006245597
- Peptide Label: isoform X8
- UniProtKB: A0A8L2QMN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245656   ⟸   XM_006245594
- Peptide Label: isoform X4
- UniProtKB: A0A8L2QMN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765582   ⟸   XM_008767360
- Peptide Label: isoform X6
- UniProtKB: A0A8L2QMN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451775   ⟸   XM_017596286
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QMN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451776   ⟸   XM_017596287
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QMN5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046774   ⟸   ENSRNOT00000043451
Ensembl Acc Id: ENSRNOP00000050784   ⟸   ENSRNOT00000041418
Ensembl Acc Id: ENSRNOP00000053295   ⟸   ENSRNOT00000056457
RefSeq Acc Id: XP_038938968   ⟸   XM_039083040
- Peptide Label: isoform X2
- UniProtKB: Q64616 (UniProtKB/Swiss-Prot),   P70710 (UniProtKB/Swiss-Prot),   P14925 (UniProtKB/Swiss-Prot),   Q64668 (UniProtKB/Swiss-Prot),   A6JR60 (UniProtKB/TrEMBL),   A0A8L2QMN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938969   ⟸   XM_039083041
- Peptide Label: isoform X5
- UniProtKB: A6JR64 (UniProtKB/TrEMBL),   A0A8L2QMN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938970   ⟸   XM_039083042
- Peptide Label: isoform X7
- UniProtKB: A6JR66 (UniProtKB/TrEMBL),   A0A8L2QMN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938972   ⟸   XM_039083044
- Peptide Label: isoform X10
- UniProtKB: A6JR70 (UniProtKB/TrEMBL),   A0A8I5ZMR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938975   ⟸   XM_039083047
- Peptide Label: isoform X13
- UniProtKB: A6JR72 (UniProtKB/TrEMBL),   A0A8I5ZMR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938977   ⟸   XM_039083049
- Peptide Label: isoform X16
- UniProtKB: A0A8I5ZMR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938971   ⟸   XM_039083043
- Peptide Label: isoform X9
- UniProtKB: A0A8I5ZMR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938973   ⟸   XM_039083045
- Peptide Label: isoform X11
- UniProtKB: A0A8I5ZMR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938974   ⟸   XM_039083046
- Peptide Label: isoform X12
- UniProtKB: A0A8I5ZMR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938976   ⟸   XM_039083048
- Peptide Label: isoform X15
- UniProtKB: A0A8I5ZMR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938966   ⟸   XM_039083038
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QMN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038938967   ⟸   XM_039083039
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QMN5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087123   ⟸   ENSRNOT00000118414
Ensembl Acc Id: ENSRNOP00000079092   ⟸   ENSRNOT00000102263
Ensembl Acc Id: ENSRNOP00000089015   ⟸   ENSRNOT00000117663
RefSeq Acc Id: XP_063122761   ⟸   XM_063266691
- Peptide Label: isoform X13
- UniProtKB: A0A8I5ZMR1 (UniProtKB/TrEMBL),   A6JR72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122756   ⟸   XM_063266686
- Peptide Label: isoform X2
- UniProtKB: Q64668 (UniProtKB/Swiss-Prot),   Q64616 (UniProtKB/Swiss-Prot),   P70710 (UniProtKB/Swiss-Prot),   P14925 (UniProtKB/Swiss-Prot),   A0A8L2QMN5 (UniProtKB/TrEMBL),   A6JR60 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122757   ⟸   XM_063266687
- Peptide Label: isoform X9
- UniProtKB: A0A8I5ZMR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122760   ⟸   XM_063266690
- Peptide Label: isoform X11
- UniProtKB: A0A8I5ZMR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122764   ⟸   XM_063266694
- Peptide Label: isoform X15
- UniProtKB: A0A8I5ZMR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122765   ⟸   XM_063266695
- Peptide Label: isoform X16
- UniProtKB: A0A8I5ZMR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122758   ⟸   XM_063266688
- Peptide Label: isoform X10
- UniProtKB: A0A8I5ZMR1 (UniProtKB/TrEMBL),   A6JR70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122763   ⟸   XM_063266693
- Peptide Label: isoform X14
- UniProtKB: A0A8I5ZMR1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122754   ⟸   XM_063266684
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QMN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122759   ⟸   XM_063266689
- Peptide Label: isoform X10
- UniProtKB: A0A8I5ZMR1 (UniProtKB/TrEMBL),   A6JR70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122755   ⟸   XM_063266685
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QMN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122762   ⟸   XM_063266692
- Peptide Label: isoform X13
- UniProtKB: A0A8I5ZMR1 (UniProtKB/TrEMBL),   A6JR72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122753   ⟸   XM_063266683
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QMN5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098552   ⟸   ENSRNOT00000120994
Protein Domains
Copper type II ascorbate-dependent monooxygenase C-   Copper type II ascorbate-dependent monooxygenase N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14925-F1-model_v2 AlphaFold P14925 1-976 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696894
Promoter ID:EPDNEW_R7419
Type:initiation region
Name:Pam_1
Description:peptidylglycine alpha-amidating monooxygenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7420  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09111,028,614 - 111,028,674EPDNEW
RGD ID:13696896
Promoter ID:EPDNEW_R7420
Type:initiation region
Name:Pam_2
Description:peptidylglycine alpha-amidating monooxygenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7419  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09111,028,728 - 111,028,788EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3252 AgrOrtholog
BioCyc Gene G2FUF-26583 BioCyc
Ensembl Genes ENSRNOG00000033280 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000041418.4 UniProtKB/Swiss-Prot
  ENSRNOT00000043451 ENTREZGENE
  ENSRNOT00000056457.6 UniProtKB/Swiss-Prot
  ENSRNOT00000102263 ENTREZGENE
  ENSRNOT00000117663.1 UniProtKB/Swiss-Prot
  ENSRNOT00000118414.1 UniProtKB/Swiss-Prot
  ENSRNOT00000120994 ENTREZGENE
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot
  2.60.120.230 UniProtKB/Swiss-Prot
  2.60.120.310 UniProtKB/Swiss-Prot
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot
  Cu2_ascorb_mOase-like_C UniProtKB/Swiss-Prot
  Cu2_ascorb_mOase_CS-1 UniProtKB/Swiss-Prot
  Cu2_ascorb_mOase_CS-2 UniProtKB/Swiss-Prot
  Cu2_ascorb_mOase_N UniProtKB/Swiss-Prot
  Cu2_ascorb_mOase_N_sf UniProtKB/Swiss-Prot
  Cu2_monoox_C UniProtKB/Swiss-Prot
  NHL_repeat UniProtKB/Swiss-Prot
  PHM/PAL UniProtKB/Swiss-Prot
  PHM/PNGase_F_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25508 UniProtKB/Swiss-Prot
NCBI Gene 25508 ENTREZGENE
PANTHER PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE UniProtKB/Swiss-Prot
  PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE UniProtKB/Swiss-Prot
Pfam Cu2_monoox_C UniProtKB/Swiss-Prot
  Cu2_monooxygen UniProtKB/Swiss-Prot
  NHL UniProtKB/Swiss-Prot
PhenoGen Pam PhenoGen
PRINTS PAMONOXGNASE UniProtKB/Swiss-Prot
PROSITE CU2_MONOOXYGENASE_1 UniProtKB/Swiss-Prot
  CU2_MONOOXYGENASE_2 UniProtKB/Swiss-Prot
  NHL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033280 RatGTEx
Superfamily-SCOP Calcium-dependent phosphotriesterase UniProtKB/Swiss-Prot
  SSF49742 UniProtKB/Swiss-Prot
UniProt A0A8I5ZMR1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QMN5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0KWC4_RAT UniProtKB/TrEMBL
  A6JR60 ENTREZGENE, UniProtKB/TrEMBL
  A6JR64 ENTREZGENE, UniProtKB/TrEMBL
  A6JR66 ENTREZGENE, UniProtKB/TrEMBL
  A6JR70 ENTREZGENE, UniProtKB/TrEMBL
  A6JR72 ENTREZGENE, UniProtKB/TrEMBL
  A6JR76_RAT UniProtKB/TrEMBL
  AMD_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P70710 ENTREZGENE
  Q64616 ENTREZGENE
  Q64668 ENTREZGENE
UniProt Secondary P70710 UniProtKB/Swiss-Prot
  Q64616 UniProtKB/Swiss-Prot
  Q64668 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Pam  peptidylglycine alpha-amidating monooxygenase  LOC102553671  uncharacterized LOC102553671  Data merged from RGD:7522793 737654 PROVISIONAL
2013-12-17 LOC102553671  uncharacterized LOC102553671      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Pam  Peptidylglycine alpha-amidating monooxygenase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation enzyme activity depends on copper, ascorbate, and molecular oxygen 729451