P4hb (prolyl 4-hydroxylase subunit beta) - Rat Genome Database

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Gene: P4hb (prolyl 4-hydroxylase subunit beta) Rattus norvegicus
Analyze
Symbol: P4hb
Name: prolyl 4-hydroxylase subunit beta
RGD ID: 3244
Description: Enables enzyme binding activity and protein disulfide isomerase activity. Predicted to be involved in several processes, including positive regulation of substrate adhesion-dependent cell spreading; positive regulation of viral entry into host cell; and protein maturation. Predicted to act upstream of with a positive effect on endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to act upstream of or within cellular response to interleukin-7. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum-Golgi intermediate compartment; and lamellipodium. Predicted to be part of endoplasmic reticulum chaperone complex and procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum lumen and external side of plasma membrane. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to human P4HB (prolyl 4-hydroxylase subunit beta); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-nicotine; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cellular thyroid hormone-binding protein; PDI; PDIR; prolyl 4-hydroxylase, beta polypeptide; protein disulfide isomerase; protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide); protein disulfide-isomerase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,335,300 - 106,346,911 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10106,335,300 - 106,346,911 (-)EnsemblGRCr8
mRatBN7.210105,836,972 - 105,848,583 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,836,982 - 105,848,500 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10110,941,098 - 110,952,604 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,404,126 - 110,415,632 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,757,420 - 105,769,031 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,736,459 - 109,748,070 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,736,458 - 109,747,987 (-)Ensemblrn6Rnor6.0
Rnor_5.010109,329,596 - 109,341,091 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410109,950,221 - 109,961,716 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10104,380,384 - 104,391,995 (-)NCBICelera
RGSC_v3.110109,964,724 - 109,976,220 (-)NCBI
Cytogenetic Map10q32.3NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dichlorophenol  (EXP)
2,6-dimethoxyphenol  (ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (EXP)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
4-octylphenol  (EXP)
5-azacytidine  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
Brodifacoum  (EXP)
bromobenzene  (EXP)
bucladesine  (ISO)
Bufotalin  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcidiol  (EXP)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
CDN1163  (ISO)
chlorogenic acid  (EXP)
chloropicrin  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
furfural  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
indinavir  (ISO)
indometacin  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-serine  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
medroxyprogesterone acetate  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
motexafin gadolinium  (ISO)
myristicin  (ISO)
N-nitrosomorpholine  (EXP)
N-Phenylmaleimide  (ISO)
nafenopin  (EXP)
naphthalene  (ISO)
nicotine  (EXP)
obeticholic acid  (ISO)
oxidopamine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (EXP)
perfluorododecanoic acid  (EXP)
phenobarbital  (ISO)
phenylarsonous acid  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (EXP)
Propiverine  (EXP)
quercetin  (ISO)
rifampicin  (ISO)
S-nitrosoglutathione  (EXP)
sarin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
Tetrachlorobisphenol A  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toxoflavin  (ISO)
triadimefon  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nucleotide sequence of rat liver iodothyronine 5'-monodeiodinase (5' MD): its identity with the protein disulfide isomerase. Boado RJ, etal., Biochem Biophys Res Commun 1988 Sep 30;155(3):1297-304.
2. Enzyme binding-inhibiting assay for iodothyronine 5'-monodeiodinase (5'-MD) and its application to isolation of complementary deoxyribonucleic acid clones for the 5'-MD in rat liver. Boado RJ, etal., Endocrinology 1988 Sep;123(3):1264-73.
3. SOD1 aggregation in astrocytes following ischemia/reperfusion injury: a role of NO-mediated S-nitrosylation of protein disulfide isomerase (PDI). Chen X, etal., J Neuroinflammation. 2012 Oct 12;9:237. doi: 10.1186/1742-2094-9-237.
4. Sequence of protein disulphide isomerase and implications of its relationship to thioredoxin. Edman JC, etal., Nature 1985 Sep 19-25;317(6034):267-70.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Localization of microsomal triglyceride transfer protein in the Golgi: possible role in the assembly of chylomicrons. Levy E, etal., J Biol Chem. 2002 May 10;277(19):16470-7. Epub 2002 Feb 5.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:2757644   PMID:7753822   PMID:8251535   PMID:8366073   PMID:9493907   PMID:9806833   PMID:12095988   PMID:12475965   PMID:14622145   PMID:15225124   PMID:15308636   PMID:15489334  
PMID:15720785   PMID:15767459   PMID:15767678   PMID:16677074   PMID:17928132   PMID:18094359   PMID:18515855   PMID:19199708   PMID:20855262   PMID:21423176   PMID:21670307   PMID:22505424  
PMID:22658674   PMID:22681889   PMID:23152784   PMID:23475612   PMID:23979707   PMID:24333444   PMID:24415753   PMID:28198441   PMID:29476059   PMID:29581031   PMID:35352799  


Genomics

Comparative Map Data
P4hb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,335,300 - 106,346,911 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10106,335,300 - 106,346,911 (-)EnsemblGRCr8
mRatBN7.210105,836,972 - 105,848,583 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,836,982 - 105,848,500 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10110,941,098 - 110,952,604 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,404,126 - 110,415,632 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,757,420 - 105,769,031 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,736,459 - 109,748,070 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,736,458 - 109,747,987 (-)Ensemblrn6Rnor6.0
Rnor_5.010109,329,596 - 109,341,091 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410109,950,221 - 109,961,716 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10104,380,384 - 104,391,995 (-)NCBICelera
RGSC_v3.110109,964,724 - 109,976,220 (-)NCBI
Cytogenetic Map10q32.3NCBI
P4HB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,843,166 - 81,860,535 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,843,159 - 81,860,856 (-)Ensemblhg38GRCh38
GRCh371779,801,042 - 79,818,411 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,394,323 - 77,411,833 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1776,404,498 - 76,422,010 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,202,821 - 75,220,332 (-)NCBIHuRef
CHM1_11779,887,239 - 79,904,780 (-)NCBICHM1_1
T2T-CHM13v2.01782,710,331 - 82,727,700 (-)NCBIT2T-CHM13v2.0
P4hb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,451,124 - 120,464,079 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,451,124 - 120,464,079 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811120,560,298 - 120,573,253 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,560,298 - 120,573,253 (-)Ensemblmm10GRCm38
MGSCv3711120,421,618 - 120,434,250 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611120,376,394 - 120,389,026 (-)NCBIMGSCv36mm8
Celera11132,295,664 - 132,308,296 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.27NCBI
P4hb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,307,932 - 1,324,027 (+)Ensembl
ChiLan1.0NW_0049555061,307,932 - 1,322,011 (+)NCBIChiLan1.0ChiLan1.0
P4HB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,378,767 - 98,396,916 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,279,545 - 103,297,401 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,248,252 - 76,266,152 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11781,950,826 - 81,968,329 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1781,950,422 - 81,968,109 (-)EnsemblpanPan2panpan1.1
P4HB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19427,827 - 436,880 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9427,830 - 436,064 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha91,029,990 - 1,039,034 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.091,021,195 - 1,030,242 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,021,122 - 1,030,242 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,046,356 - 1,055,402 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,172,930 - 1,181,988 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,251,854 - 1,260,908 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
P4hb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,032,744 - 1,043,760 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,367,816 - 5,379,252 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,368,199 - 5,379,215 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P4HB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,121,824 - 1,131,289 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1121,121,816 - 1,131,291 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
P4HB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,718,743 - 73,733,488 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,718,656 - 73,733,892 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607745,170,359 - 45,185,570 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P4hb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,699,161 - 10,712,896 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480110,700,301 - 10,712,889 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
P4hb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1963,450,480 - 63,462,697 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in P4hb
97 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:310
Count of miRNA genes:192
Interacting mature miRNAs:217
Transcripts:ENSRNOT00000054958
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat

Markers in Region
RH129632  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210105,837,024 - 105,837,226 (+)MAPPERmRatBN7.2
Rnor_6.010109,736,512 - 109,736,713NCBIRnor6.0
Rnor_5.010109,329,641 - 109,329,842UniSTSRnor5.0
RGSC_v3.410109,950,266 - 109,950,467UniSTSRGSC3.4
Celera10104,380,437 - 104,380,638UniSTS
Cytogenetic Map10q32.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC131537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB583787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM060266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM067812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000054958   ⟹   ENSRNOP00000051841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10106,335,300 - 106,346,911 (-)Ensembl
mRatBN7.2 Ensembl10105,836,982 - 105,848,500 (-)Ensembl
Rnor_6.0 Ensembl10109,736,458 - 109,747,987 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100112   ⟹   ENSRNOP00000086980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10106,335,300 - 106,346,762 (-)Ensembl
mRatBN7.2 Ensembl10105,836,982 - 105,848,434 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106240   ⟹   ENSRNOP00000084686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,836,982 - 105,848,261 (-)Ensembl
RefSeq Acc Id: NM_012998   ⟹   NP_037130
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,335,300 - 106,346,911 (-)NCBI
mRatBN7.210105,836,972 - 105,848,583 (-)NCBI
Rnor_6.010109,736,459 - 109,748,070 (-)NCBI
Rnor_5.010109,329,596 - 109,341,091 (-)NCBI
RGSC_v3.410109,950,221 - 109,961,716 (-)RGD
Celera10104,380,384 - 104,391,995 (-)NCBI
Sequence:
RefSeq Acc Id: NP_037130   ⟸   NM_012998
- Peptide Label: precursor
- UniProtKB: P13700 (UniProtKB/Swiss-Prot),   P04785 (UniProtKB/Swiss-Prot),   A6HLE8 (UniProtKB/TrEMBL),   A0A8I6A1R9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051841   ⟸   ENSRNOT00000054958
Ensembl Acc Id: ENSRNOP00000086980   ⟸   ENSRNOT00000100112
Ensembl Acc Id: ENSRNOP00000084686   ⟸   ENSRNOT00000106240
Protein Domains
Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04785-F1-model_v2 AlphaFold P04785 1-509 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697964
Promoter ID:EPDNEW_R8488
Type:initiation region
Name:P4hb_1
Description:prolyl 4-hydroxylase subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010109,747,987 - 109,748,047EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3244 AgrOrtholog
BioCyc Gene G2FUF-22409 BioCyc
Ensembl Genes ENSRNOG00000036689 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000054958 ENTREZGENE
  ENSRNOT00000054958.3 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623688 IMAGE-MGC_LOAD
InterPro Disulphide_isomerase UniProtKB/Swiss-Prot
  Prot_disulphide_isomerase UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
  Thioredoxin_CS UniProtKB/Swiss-Prot
  Thioredoxin_domain UniProtKB/Swiss-Prot
KEGG Report rno:25506 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72525 IMAGE-MGC_LOAD
NCBI Gene 25506 ENTREZGENE
PANTHER PROTEIN DISULFIDE ISOMERASE UniProtKB/Swiss-Prot
  PROTEIN DISULFIDE-ISOMERASE UniProtKB/Swiss-Prot
Pfam Thioredoxin UniProtKB/Swiss-Prot
  Thioredoxin_6 UniProtKB/Swiss-Prot
PhenoGen P4hb PhenoGen
PRINTS THIOREDOXIN UniProtKB/Swiss-Prot
PROSITE ER_TARGET UniProtKB/Swiss-Prot
  THIOREDOXIN_1 UniProtKB/Swiss-Prot
  THIOREDOXIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000036689 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt A0A8I6A1R9 ENTREZGENE
  A0A8I6A7J4_RAT UniProtKB/TrEMBL
  A6HLE8 ENTREZGENE, UniProtKB/TrEMBL
  A6HLE9_RAT UniProtKB/TrEMBL
  P04785 ENTREZGENE
  P13700 ENTREZGENE
  PDIA1_RAT UniProtKB/Swiss-Prot
UniProt Secondary P13700 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 P4hb  prolyl 4-hydroxylase subunit beta  P4hb  prolyl 4-hydroxylase, beta polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 P4hb  Protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 633506