P2ry1 (purinergic receptor P2Y1) - Rat Genome Database

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Gene: P2ry1 (purinergic receptor P2Y1) Rattus norvegicus
Analyze
Symbol: P2ry1
Name: purinergic receptor P2Y1
RGD ID: 3242
Description: Enables several functions, including A1 adenosine receptor binding activity; G protein-coupled purinergic nucleotide receptor activity; and adenyl ribonucleotide binding activity. Involved in several processes, including positive regulation of biosynthetic process; purinergic nucleotide receptor signaling pathway; and regulation of secretion by cell. Located in several cellular components, including basolateral plasma membrane; postsynaptic density; and postsynaptic membrane. Is active in glutamatergic synapse and presynaptic active zone membrane. Used to study impotence. Orthologous to human P2RY1 (purinergic receptor P2Y1); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP receptor; P2 purinoreceptor subclass 2Y; P2y; P2Y ATP receptor 1; P2Y purinoceptor 1; P2y1; purinergic receptor P2Y, G-protein coupled 1; purinergic receptor P2Y, G-protein coupled, 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82147,391,661 - 147,397,870 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2147,390,681 - 147,398,027 (+)EnsemblGRCr8
mRatBN7.22145,241,975 - 145,248,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2145,241,849 - 145,248,457 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2151,917,488 - 151,923,701 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02150,001,941 - 150,008,136 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02144,634,335 - 144,640,530 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02151,314,818 - 151,320,312 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2151,314,818 - 151,320,319 (+)Ensemblrn6Rnor6.0
Rnor_5.02170,730,012 - 170,735,506 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42150,460,361 - 150,465,855 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2139,634,729 - 139,640,224 (+)NCBICelera
RGSC_v3.12150,410,323 - 150,415,818 (+)NCBI
Cytogenetic Map2q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-dinitrotoluene  (EXP)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
3'-phospho-5'-adenylyl sulfate  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
ATP  (EXP,ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (EXP,ISO)
butanal  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
dorsomorphin  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glycidol  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nickel atom  (ISO)
Nonylphenol  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
phencyclidine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rottlerin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulfadimethoxine  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Abundant and dynamic expression of G protein-coupled P2Y receptors in mammalian development. Cheung KK, etal., Dev Dyn. 2003 Oct;228(2):254-66.
2. Mechanically evoked reflex electrogenic chloride secretion in rat distal colon is triggered by endogenous nucleotides acting at P2Y1, P2Y2, and P2Y4 receptors. Christofi FL, etal., J Comp Neurol. 2004 Jan 26;469(1):16-36.
3. TGF-beta and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression. De Simone R, etal., J Neurochem. 2010 Oct;115(2):450-9. doi: 10.1111/j.1471-4159.2010.06937.x. Epub 2010 Aug 30.
4. Regulation of rat hepatocyte function by P2Y receptors: focus on control of glycogen phosphorylase and cyclic AMP by 2-methylthioadenosine 5'-diphosphate. Dixon CJ, etal., J Pharmacol Exp Ther. 2004 Oct;311(1):334-41. Epub 2004 May 19.
5. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. Dranoff JA, etal., Am J Physiol Gastrointest Liver Physiol 2001 Oct;281(4):G1059-67.
6. P2 receptor-mediated stimulation of the PI3-K/Akt-pathway in vivo. Franke H, etal., Glia. 2009 Aug 1;57(10):1031-45.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Purinergic receptor expression in the regeneration epidermis in a rat model of normal and delayed wound healing. Greig AV, etal., Exp Dermatol. 2003 Dec;12(6):860-71.
10. Management of erectile function by penile purinergic p2 receptors in the diabetic rat. Gur S, etal., J Urol. 2009 May;181(5):2375-82. Epub 2009 Mar 19.
11. Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. Honda S, etal., J Neurosci. 2001 Mar 15;21(6):1975-82.
12. Comparison of P2 receptor subtypes producing dilation in rat intracerebral arterioles. Horiuchi T, etal., Stroke. 2003 Jun;34(6):1473-8. Epub 2003 May 1.
13. Enhanced food intake after stimulation of hypothalamic P2Y1 receptors in rats: modulation of feeding behaviour by extracellular nucleotides. Kittner H, etal., Eur J Neurosci. 2006 Oct;24(7):2049-56.
14. Mitochondrial localization of P2Y1, P2Y2 and P2Y12 receptors in rat astrocytes and glioma C6 cells. Krzeminski P, etal., Brain Res Bull. 2007 Mar 30;71(6):587-92. Epub 2006 Dec 22.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Age-related changes in P2 receptor mRNA of rat cerebral arteries. Miao LY, etal., Exp Gerontol. 2001 Dec;37(1):67-79.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Complementary role of extracellular ATP and adenosine in ischemic preconditioning in the rat heart. Ninomiya H, etal., Am J Physiol Heart Circ Physiol 2002 May;282(5):H1810-20.
19. The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. Quintas C, etal., Neurochem Int. 2009 Dec;55(7):505-13. Epub 2009 May 15.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. Rodrigues RJ, etal., J Neurosci. 2005 Jul 6;25(27):6286-95.
24. ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors. Siow NL, etal., Mol Pharmacol. 2010 Dec;78(6):1059-71. doi: 10.1124/mol.110.066506. Epub 2010 Sep 16.
25. Role of purinergic P2Y1 receptors in regulation of vasopressin and oxytocin secretion. Song Z, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R478-84. Epub 2009 Jun 10.
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Cloning of rat and mouse P2Y purinoceptors. Tokuyama Y, etal., Biochem Biophys Res Commun 1995 Jun 6;211(1):211-8.
28. Expression and function of P2Y receptors on Muller cells of the postnatal rat retina. Wurm A, etal., Glia. 2009 Nov 15;57(15):1680-90.
29. Inhibitory, facilitatory, and excitatory effects of ATP and purinergic receptor agonists on the activity of rat cutaneous nociceptors in vitro. Yajima H, etal., Neurosci Res. 2005 Apr;51(4):405-16. Epub 2005 Jan 20.
30. Agonist-promoted heteromeric oligomerization between adenosine A(1) and P2Y(1) receptors in living cells. Yoshioka K, etal., FEBS Lett. 2002 Jul 17;523(1-3):147-51.
31. Hetero-oligomerization of adenosine A1 receptors with P2Y1 receptors in rat brains. Yoshioka K, etal., FEBS Lett. 2002 Nov 6;531(2):299-303.
32. Heteromeric association creates a P2Y-like adenosine receptor. Yoshioka K, etal., Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7617-22. Epub 2001 Jun 5.
Additional References at PubMed
PMID:9442040   PMID:12629523   PMID:12799304   PMID:12850289   PMID:14564529   PMID:14645457   PMID:14729222   PMID:15103469   PMID:15172882   PMID:15494980   PMID:15528188   PMID:15574734  
PMID:15670583   PMID:15914557   PMID:16336659   PMID:16624826   PMID:16643864   PMID:16882655   PMID:16944453   PMID:17598884   PMID:17869006   PMID:18072286   PMID:18174215   PMID:18384646  
PMID:18627435   PMID:18668152   PMID:18756525   PMID:18841035   PMID:19196799   PMID:19223012   PMID:19396875   PMID:19906120   PMID:20570683   PMID:20720114   PMID:21487414   PMID:21540076  
PMID:21879346   PMID:22065011   PMID:22349022   PMID:22759594   PMID:23382103   PMID:23479225   PMID:23753413   PMID:24048730   PMID:24401144   PMID:24687862   PMID:24733747   PMID:24857820  
PMID:24879869   PMID:24998877   PMID:25027332   PMID:25449358   PMID:25526634   PMID:25822790   PMID:26743169   PMID:27318677   PMID:28153540   PMID:28154160   PMID:28974901   PMID:29463792  
PMID:31689490   PMID:33848220   PMID:34166321   PMID:35907034   PMID:38043889  


Genomics

Comparative Map Data
P2ry1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82147,391,661 - 147,397,870 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2147,390,681 - 147,398,027 (+)EnsemblGRCr8
mRatBN7.22145,241,975 - 145,248,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2145,241,849 - 145,248,457 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2151,917,488 - 151,923,701 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02150,001,941 - 150,008,136 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02144,634,335 - 144,640,530 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02151,314,818 - 151,320,312 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2151,314,818 - 151,320,319 (+)Ensemblrn6Rnor6.0
Rnor_5.02170,730,012 - 170,735,506 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42150,460,361 - 150,465,855 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2139,634,729 - 139,640,224 (+)NCBICelera
RGSC_v3.12150,410,323 - 150,415,818 (+)NCBI
Cytogenetic Map2q31NCBI
P2RY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383152,835,131 - 152,841,439 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3152,835,131 - 152,841,439 (+)Ensemblhg38GRCh38
GRCh373152,552,920 - 152,559,228 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363154,035,426 - 154,038,535 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343154,035,433 - 154,038,539NCBI
Celera3150,971,424 - 150,974,533 (+)NCBICelera
Cytogenetic Map3q25.2NCBI
HuRef3149,943,255 - 149,946,364 (+)NCBIHuRef
CHM1_13152,516,451 - 152,519,560 (+)NCBICHM1_1
T2T-CHM13v2.03155,605,520 - 155,611,828 (+)NCBIT2T-CHM13v2.0
P2ry1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39360,910,206 - 60,916,403 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl360,910,216 - 60,916,403 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38361,002,785 - 61,008,982 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl361,002,795 - 61,008,982 (+)Ensemblmm10GRCm38
MGSCv37360,806,717 - 60,812,901 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36361,090,724 - 61,096,908 (+)NCBIMGSCv36mm8
Celera360,703,955 - 60,710,141 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map329.24NCBI
P2ry1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554484,366,706 - 4,372,626 (+)Ensembl
ChiLan1.0NW_0049554484,366,706 - 4,372,626 (+)NCBIChiLan1.0ChiLan1.0
P2RY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22150,726,644 - 150,733,886 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13150,731,389 - 150,738,619 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03149,859,748 - 149,865,873 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13157,426,423 - 157,432,339 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3157,426,692 - 157,427,813 (+)EnsemblpanPan2panpan1.1
P2RY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12347,249,496 - 47,253,203 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2347,249,496 - 47,253,203 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2347,112,593 - 47,116,262 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02347,878,074 - 47,881,878 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2347,878,074 - 47,881,878 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12347,462,527 - 47,466,223 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02347,517,721 - 47,521,447 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02347,800,041 - 47,803,744 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
P2ry1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560288,861,485 - 88,867,833 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936519866,208 - 872,393 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936519865,756 - 872,466 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RY1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1392,991,152 - 92,997,700 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11392,991,150 - 92,997,702 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213101,032,051 - 101,038,362 (+)NCBISscrofa10.2Sscrofa10.2susScr3
P2RY1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11537,822,474 - 37,827,245 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604110,556,129 - 10,561,290 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2ry1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473030,471,610 - 30,476,941 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473030,470,894 - 30,478,269 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
P2ry1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1394,056,980 - 94,061,973 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in P2ry1
93 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:582
Count of miRNA genes:266
Interacting mature miRNAs:341
Transcripts:ENSRNOT00000019305
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2124103798154505346Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2120039407159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2120039407151869825Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
9685068Swd7Spike wave discharge measurement QTL 73.20.01brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge rate (CMO:0001739)2143806628149738646Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2145807215173074435Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat

Markers in Region
PMC123072P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22145,242,893 - 145,243,144 (+)MAPPERmRatBN7.2
Rnor_6.02151,315,704 - 151,315,954NCBIRnor6.0
Rnor_5.02170,730,898 - 170,731,148UniSTSRnor5.0
RGSC_v3.42150,461,247 - 150,461,497UniSTSRGSC3.4
Celera2139,635,616 - 139,635,866UniSTS
Cytogenetic Map2q31UniSTS
PMC34459P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22145,242,883 - 145,243,535 (+)MAPPERmRatBN7.2
Rnor_6.02151,315,694 - 151,316,345NCBIRnor6.0
Rnor_5.02170,730,888 - 170,731,539UniSTSRnor5.0
RGSC_v3.42150,461,237 - 150,461,888UniSTSRGSC3.4
Celera2139,635,606 - 139,636,257UniSTS
Cytogenetic Map2q31UniSTS
BF405988  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22145,244,674 - 145,244,834 (+)MAPPERmRatBN7.2
Rnor_6.02151,317,482 - 151,317,641NCBIRnor6.0
Rnor_5.02170,732,676 - 170,732,835UniSTSRnor5.0
RGSC_v3.42150,463,025 - 150,463,184UniSTSRGSC3.4
Celera2139,637,394 - 139,637,553UniSTS
RH 3.4 Map2897.2UniSTS
Cytogenetic Map2q31UniSTS
BE117641  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22145,247,400 - 145,247,555 (+)MAPPERmRatBN7.2
Rnor_6.02151,320,208 - 151,320,362NCBIRnor6.0
Rnor_5.02170,735,402 - 170,735,556UniSTSRnor5.0
RGSC_v3.42150,465,751 - 150,465,905UniSTSRGSC3.4
Celera2139,640,120 - 139,640,274UniSTS
RH 3.4 Map2899.6UniSTS
Cytogenetic Map2q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 87 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019305   ⟹   ENSRNOP00000019304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2147,390,681 - 147,398,027 (+)Ensembl
mRatBN7.2 Ensembl2145,241,849 - 145,248,457 (+)Ensembl
Rnor_6.0 Ensembl2151,314,818 - 151,320,319 (+)Ensembl
RefSeq Acc Id: NM_012800   ⟹   NP_036932
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82147,391,661 - 147,397,870 (+)NCBI
mRatBN7.22145,241,975 - 145,248,186 (+)NCBI
Rnor_6.02151,314,818 - 151,320,312 (+)NCBI
Rnor_5.02170,730,012 - 170,735,506 (+)NCBI
RGSC_v3.42150,460,361 - 150,465,855 (+)RGD
Celera2139,634,729 - 139,640,224 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036932 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA91303 (Get FASTA)   NCBI Sequence Viewer  
  EDM14829 (Get FASTA)   NCBI Sequence Viewer  
  EDM14830 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019304
  ENSRNOP00000019304.3
GenBank Protein P49651 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036932   ⟸   NM_012800
- UniProtKB: P49651 (UniProtKB/Swiss-Prot),   A6JVM2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019304   ⟸   ENSRNOT00000019305
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49651-F1-model_v2 AlphaFold P49651 1-373 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691356
Promoter ID:EPDNEW_R1878
Type:multiple initiation site
Name:P2ry1_1
Description:purinergic receptor P2Y1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02151,314,785 - 151,314,845EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3242 AgrOrtholog
BioCyc Gene G2FUF-52953 BioCyc
Ensembl Genes ENSRNOG00000014232 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019305 ENTREZGENE
  ENSRNOT00000019305.5 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  P2Y1_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:25265 UniProtKB/Swiss-Prot
NCBI Gene 25265 ENTREZGENE
PANTHER PTHR24231:SF2 UniProtKB/Swiss-Prot
  PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB P2RY1 RGD
PhenoGen P2ry1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  P2Y1PRNOCPTR UniProtKB/Swiss-Prot
  P2YPURNOCPTR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014232 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC213922
UniProt A6JVM2 ENTREZGENE, UniProtKB/TrEMBL
  A6JVM3_RAT UniProtKB/TrEMBL
  P2RY1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 P2ry1  purinergic receptor P2Y1  P2ry1  purinergic receptor P2Y, G-protein coupled, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-01-14 P2ry1  purinergic receptor P2Y, G-protein coupled, 1  P2ry1  purinergic receptor P2Y, G-protein coupled 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 P2ry1  purinergic receptor P2Y, G-protein coupled 1    P2 purinoreceptor subclass 2Y  Name updated 625702 APPROVED
2002-06-10 P2ry1  P2 purinoreceptor subclass 2Y      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the apical plasma membrane and basolateral domains 628452
gene_expression mRNA present in holangiocytes, hepatocytes and epithelial cells 628452
gene_physical_interaction coupled with both pertussis toxin-sensitive Gi/Go and -insensitive Gq/G11 proteins 729533
gene_process mediates vasomotor responses, neurotransmission, platelet aggregation, and secretion 628452
gene_regulation activated mainly by ADP, to a lesser degree by ATP 628452