Nrdc (nardilysin convertase) - Rat Genome Database

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Gene: Nrdc (nardilysin convertase) Rattus norvegicus
Analyze
Symbol: Nrdc
Name: nardilysin convertase
RGD ID: 3210
Description: Enables peptidase activity. Predicted to be involved in negative regulation of cold-induced thermogenesis; positive regulation of membrane protein ectodomain proteolysis; and regulation of nervous system development. Predicted to be located in mitochondrion. Orthologous to human NRDC (nardilysin convertase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: N-arginine dibasic convertase 1; nardilysin; nardilysin 1; nardilysin 1 (N-arginine dibasic convertase); nardilysin, N-arginine dibasic convertase 1; nardilysin, N-arginine dibasic convertase, NRD convertase 1; NRD convertase; NRD-C; Nrd1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85128,983,395 - 129,047,578 (+)NCBIGRCr8
mRatBN7.25123,755,807 - 123,818,910 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5123,755,806 - 123,818,595 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5126,372,097 - 126,434,688 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05128,095,183 - 128,157,761 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05128,146,456 - 128,209,043 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05128,629,949 - 128,694,209 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5128,629,942 - 128,694,060 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05132,471,862 - 132,534,473 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45130,345,980 - 130,408,734 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15130,351,205 - 130,413,960 (+)NCBI
Celera5122,487,057 - 122,549,568 (+)NCBICelera
Cytogenetic Map5q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)
dendrite  (IEA)
mitochondrion  (IEA,ISO)
peroxisomal matrix  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase. Chow KM, etal., Biochim Biophys Acta. 2005 May 25;1723(1-3):292-301. Epub 2005 Mar 10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Critical roles of nardilysin in the maintenance of body temperature homoeostasis. Hiraoka Y, etal., Nat Commun. 2014;5:3224. doi: 10.1038/ncomms4224.
5. Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family. Hospital V, etal., Biochem J 1997 Nov 1;327 ( Pt 3):773-9.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. N-arginine dibasic convertase, a metalloendopeptidase as a prototype of a class of processing enzymes. Pierotti AR, etal., Proc Natl Acad Sci U S A 1994 Jun 21;91(13):6078-82.
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7819328   PMID:16805830   PMID:18355445   PMID:18614015   PMID:28017472  


Genomics

Comparative Map Data
Nrdc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85128,983,395 - 129,047,578 (+)NCBIGRCr8
mRatBN7.25123,755,807 - 123,818,910 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5123,755,806 - 123,818,595 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5126,372,097 - 126,434,688 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05128,095,183 - 128,157,761 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05128,146,456 - 128,209,043 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05128,629,949 - 128,694,209 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5128,629,942 - 128,694,060 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05132,471,862 - 132,534,473 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45130,345,980 - 130,408,734 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15130,351,205 - 130,413,960 (+)NCBI
Celera5122,487,057 - 122,549,568 (+)NCBICelera
Cytogenetic Map5q34NCBI
NRDC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38151,789,210 - 51,878,727 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl151,789,191 - 51,878,805 (-)EnsemblGRCh38hg38GRCh38
GRCh37152,254,882 - 52,344,399 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36152,027,452 - 52,117,197 (-)NCBINCBI36Build 36hg18NCBI36
Build 34151,966,904 - 52,056,443NCBI
Celera150,541,402 - 50,631,711 (-)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef150,371,501 - 50,461,746 (-)NCBIHuRef
CHM1_1152,372,212 - 52,461,925 (-)NCBICHM1_1
T2T-CHM13v2.0151,669,503 - 51,759,610 (-)NCBIT2T-CHM13v2.0
Nrdc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394108,857,852 - 108,918,974 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4108,857,852 - 108,918,974 (+)EnsemblGRCm39 Ensembl
GRCm384109,000,655 - 109,061,777 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4109,000,655 - 109,061,777 (+)EnsemblGRCm38mm10GRCm38
MGSCv374108,673,410 - 108,734,376 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364108,498,737 - 108,559,703 (+)NCBIMGSCv36mm8
Celera4107,342,897 - 107,403,815 (+)NCBICelera
Cytogenetic Map4C7NCBI
cM Map450.77NCBI
Nrdc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554647,222,948 - 7,298,234 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554647,222,948 - 7,298,234 (+)NCBIChiLan1.0ChiLan1.0
NRDC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21174,980,901 - 175,072,651 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11174,122,404 - 174,213,193 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0151,038,711 - 51,130,404 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1152,535,563 - 52,625,998 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl152,535,603 - 52,625,998 (-)Ensemblpanpan1.1panPan2
NRDC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1159,413,878 - 9,505,355 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl159,413,295 - 9,505,448 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,565,904 - 9,656,554 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0159,538,552 - 9,629,226 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl159,538,557 - 9,629,226 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1159,348,951 - 9,440,061 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0159,438,324 - 9,528,835 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0159,456,202 - 9,547,376 (+)NCBIUU_Cfam_GSD_1.0
Nrdc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505866,286,628 - 66,374,923 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365229,041,111 - 9,129,327 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365229,041,204 - 9,129,674 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRDC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6160,299,131 - 160,388,502 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16160,299,101 - 160,388,511 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26148,002,234 - 148,091,486 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NRDC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12081,075,671 - 81,175,469 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2081,075,869 - 81,175,447 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603336,067,000 - 36,168,310 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nrdc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248591,284,266 - 1,352,226 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248591,284,251 - 1,351,497 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nrdc
229 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:113
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000010440, ENSRNOT00000010462
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
7794739Bp372Blood pressure QTL 3720.0058arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5117913688125222967Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5119085612128034027Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat

Markers in Region
D5Got44  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25123,783,115 - 123,783,392 (+)MAPPERmRatBN7.2
Rnor_6.05128,658,448 - 128,658,724NCBIRnor6.0
Rnor_5.05132,499,476 - 132,499,752UniSTSRnor5.0
RGSC_v3.45130,372,998 - 130,373,275RGDRGSC3.4
RGSC_v3.45130,372,999 - 130,373,275UniSTSRGSC3.4
RGSC_v3.15130,378,225 - 130,378,501RGD
Celera5122,514,170 - 122,514,446UniSTS
RH 3.4 Map5817.9UniSTS
RH 3.4 Map5817.9RGD
RH 2.0 Map5767.1RGD
Cytogenetic Map5q35UniSTS
Nrd1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25123,755,052 - 123,755,311 (+)MAPPERmRatBN7.2
Rnor_6.05128,629,210 - 128,629,468NCBIRnor6.0
Rnor_5.05132,471,123 - 132,471,381UniSTSRnor5.0
RGSC_v3.45130,345,104 - 130,345,362UniSTSRGSC3.4
Celera5122,486,181 - 122,486,439UniSTS
Cytogenetic Map5q35UniSTS
RH127768  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25123,787,773 - 123,787,975 (+)MAPPERmRatBN7.2
Rnor_6.05128,663,108 - 128,663,309NCBIRnor6.0
Rnor_5.05132,504,136 - 132,504,337UniSTSRnor5.0
RGSC_v3.45130,377,659 - 130,377,860UniSTSRGSC3.4
Celera5122,518,824 - 122,519,025UniSTS
RH 3.4 Map5811.3UniSTS
Cytogenetic Map5q35UniSTS
AI875733  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25123,818,425 - 123,818,506 (+)MAPPERmRatBN7.2
Rnor_6.05128,693,727 - 128,693,807NCBIRnor6.0
Rnor_5.05132,533,991 - 132,534,071UniSTSRnor5.0
RGSC_v3.45130,408,568 - 130,408,648UniSTSRGSC3.4
Celera5122,549,402 - 122,549,482UniSTS
Cytogenetic Map5q35UniSTS
RH127781  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25123,818,571 - 123,818,764 (+)MAPPERmRatBN7.2
Rnor_6.05128,693,873 - 128,694,065NCBIRnor6.0
Rnor_5.05132,534,137 - 132,534,329UniSTSRnor5.0
RGSC_v3.45130,408,714 - 130,408,906UniSTSRGSC3.4
Celera5122,549,548 - 122,549,740UniSTS
RH 3.4 Map5812.7UniSTS
Cytogenetic Map5q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000010440   ⟹   ENSRNOP00000010440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5123,755,806 - 123,818,595 (+)Ensembl
Rnor_6.0 Ensembl5128,630,086 - 128,693,893 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000010462   ⟹   ENSRNOP00000010462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5123,755,806 - 123,818,595 (+)Ensembl
Rnor_6.0 Ensembl5128,629,942 - 128,694,060 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109464   ⟹   ENSRNOP00000082077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5123,755,806 - 123,818,595 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118442   ⟹   ENSRNOP00000088567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5123,755,806 - 123,818,595 (+)Ensembl
RefSeq Acc Id: NM_012993   ⟹   NP_037125
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85128,984,602 - 129,047,262 (+)NCBI
mRatBN7.25123,755,929 - 123,818,592 (+)NCBI
Rnor_6.05128,630,086 - 128,693,893 (+)NCBI
Rnor_5.05132,471,862 - 132,534,473 (+)NCBI
RGSC_v3.45130,345,980 - 130,408,734 (+)RGD
Celera5122,487,057 - 122,549,568 (+)RGD
Sequence:
RefSeq Acc Id: XM_006238499   ⟹   XP_006238561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85128,983,395 - 129,047,578 (+)NCBI
mRatBN7.25123,755,807 - 123,818,910 (+)NCBI
Rnor_6.05128,629,949 - 128,694,209 (+)NCBI
Rnor_5.05132,471,862 - 132,534,473 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109304   ⟹   XP_038965232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85129,001,305 - 129,047,578 (+)NCBI
mRatBN7.25123,772,626 - 123,818,910 (+)NCBI
RefSeq Acc Id: NP_037125   ⟸   NM_012993
- Peptide Label: precursor
- UniProtKB: O35836 (UniProtKB/Swiss-Prot),   P47245 (UniProtKB/Swiss-Prot),   A6JYX3 (UniProtKB/TrEMBL),   G3V700 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238561   ⟸   XM_006238499
- Peptide Label: isoform X1
- UniProtKB: D3ZQ59 (UniProtKB/TrEMBL),   A0A8I6GH79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010462   ⟸   ENSRNOT00000010462
RefSeq Acc Id: ENSRNOP00000010440   ⟸   ENSRNOT00000010440
RefSeq Acc Id: XP_038965232   ⟸   XM_039109304
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000088567   ⟸   ENSRNOT00000118442
RefSeq Acc Id: ENSRNOP00000082077   ⟸   ENSRNOT00000109464
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47245-F1-model_v2 AlphaFold P47245 1-1161 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693913
Promoter ID:EPDNEW_R4431
Type:initiation region
Name:Nrdc_1
Description:nardilysin convertase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05128,630,002 - 128,630,062EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3210 AgrOrtholog
BioCyc Gene G2FUF-40368 BioCyc
Ensembl Genes ENSRNOG00000007111 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010440 ENTREZGENE
  ENSRNOT00000010440.7 UniProtKB/TrEMBL
  ENSRNOT00000010462.8 UniProtKB/TrEMBL
  ENSRNOT00000109464.1 UniProtKB/TrEMBL
  ENSRNOT00000118442.1 UniProtKB/TrEMBL
Gene3D-CATH Metalloenzyme, LuxS/M16 peptidase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Metalloenz_LuxS/M16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M16_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M16_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25499 UniProtKB/Swiss-Prot
NCBI Gene 25499 ENTREZGENE
PANTHER INSULIN-DEGRADING ENZYME-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NARDILYSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M16_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nrdc PhenoGen
PROSITE INSULINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007111 RatGTEx
Superfamily-SCOP SSF63411 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZTD3_RAT UniProtKB/TrEMBL
  A0A8I6GH79 ENTREZGENE, UniProtKB/TrEMBL
  A6JYX3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQ59 ENTREZGENE, UniProtKB/TrEMBL
  G3V700 ENTREZGENE, UniProtKB/TrEMBL
  NRDC_RAT UniProtKB/Swiss-Prot
  O35836 ENTREZGENE
  P47245 ENTREZGENE
UniProt Secondary O35836 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-13 Nrdc  nardilysin convertase  Nrd1  nardilysin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-29 Nrd1  nardilysin 1  Nrd1  nardilysin 1 (N-arginine dibasic convertase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-12 Nrd1  nardilysin 1 (N-arginine dibasic convertase)  Nrd1  nardilysin, N-arginine dibasic convertase, NRD convertase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Nrd1  nardilysin, N-arginine dibasic convertase, NRD convertase 1  Nrd1  nardilysin, N-arginine dibasic convertase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Nrd1  nardilysin, N-arginine dibasic convertase 1    N-arginine dibasic convertase 1  Name updated 1299863 APPROVED
2002-06-10 Nrd1  N-arginine dibasic convertase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression predominantly expressed in testis 729085
gene_protein 133 kDa 729184