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Gene: Npr1 (natriuretic peptide receptor 1) Rattus norvegicus

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Symbol:

Npr1

Name:

natriuretic peptide receptor 1

RGD ID:

3195

Description:

Enables guanylate cyclase activity. Involved in several processes, including cGMP-mediated signaling; positive regulation of cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Part of ANPR-A receptor complex. Used to study hypertension. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human NPR1 (natriuretic peptide receptor 1); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ANP-A; ANPR-A; Anpra; atrial natriuretic peptide A-type receptor; atrial natriuretic peptide receptor 1; atrial natriuretic peptide receptor A; atrial natriuretic peptide receptor type A; GC-A; Gca; guanylate cyclase A; Natriuretic peptide receptor A/Guanylate cyclase A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); NPR-A; Npra

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NPR1 (natriuretic peptide receptor 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Npr1 (natriuretic peptide receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Npr1 (natriuretic peptide receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NPR1 (natriuretic peptide receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NPR1 (natriuretic peptide receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Npr1 (natriuretic peptide receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NPR1 (natriuretic peptide receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NPR1 (natriuretic peptide receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Npr1 (natriuretic peptide receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Npr1 (natriuretic peptide receptor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	VPS37A (VPS37A subunit of ESCRT-I)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Npr1 (natriuretic peptide receptor 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NPR1 (natriuretic peptide receptor 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	npr1a (natriuretic peptide receptor 1a)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	npr1a (natriuretic peptide receptor 1a)	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	npr1b (natriuretic peptide receptor 1b)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	npr1b (natriuretic peptide receptor 1b)	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG31183	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG31183	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gcy-28	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gcy-28	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	npr1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	npr1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)

Is Marker For:

Strains: SS.MNS-(Mme-Gca)/Ayd
QTLs: Niddm8 Bp19 Cm67 Bp363 Cm89 Cm90 Am4 Kidm56 Bw176

Candidate Gene For:

Bp10 Bp363

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	178,231,766 - 178,247,591 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	178,231,766 - 178,247,088 (-)	Ensembl				GRCr8
mRatBN7.2	2	175,934,181 - 175,950,118 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	175,934,181 - 175,949,505 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	183,074,109 - 183,089,476 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	181,096,360 - 181,111,730 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	175,696,310 - 175,711,670 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	189,840,403 - 189,857,032 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	189,840,403 - 189,856,090 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	209,271,276 - 209,287,892 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	182,724,916 - 182,740,242 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	169,869,831 - 169,885,101 (-)	NCBI		Celera
RGSC_v3.1	2	182,675,021 - 182,690,348 (-)	NCBI
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aortic Rupture (ISO)

Cardiomegaly (ISO)

congestive heart failure (ISO)

Fibrosis (ISO)

hypertension (IAGP,ISO)

kidney disease (ISO)

Left Ventricular Hypertrophy (IEP)

myocardial infarction (ISO)

Pain (ISO)

Sudden Death (ISO)

ureteral obstruction (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

2-palmitoylglycerol (ISO)

3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetylsalicylic acid (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

calcium atom (EXP)

calcium(0) (EXP)

carmustine (EXP)

chlordecone (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

D-glucose (ISO)

dexamethasone (EXP,ISO)

disodium selenite (ISO)

endosulfan (EXP)

genistein (ISO)

gentamycin (EXP)

glucose (ISO)

glycidol (EXP)

hydralazine (ISO)

indometacin (EXP)

Lasiocarpine (ISO)

lead diacetate (EXP)

losartan (ISO)

methotrexate (EXP)

nickel atom (ISO)

niclosamide (ISO)

nitrofen (EXP)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP)

perfluorooctanoic acid (EXP)

phenylephrine (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium atom (ISO)

tacrolimus hydrate (ISO)

testosterone (EXP)

tioguanine (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood vessel diameter maintenance (IEA)

cell surface receptor signaling pathway (IMP)

cGMP biosynthetic process (IBA,IEA,ISO)

cyclic nucleotide biosynthetic process (IEA)

dopamine metabolic process (IMP)

intracellular signal transduction (IDA,IEA)

negative regulation of smooth muscle cell proliferation (IMP)

receptor guanylyl cyclase signaling pathway (IBA,IDA,IEA,ISO)

regulation of blood pressure (IEA,ISO,NAS)

regulation of vascular permeability (IEA,ISO)

Cellular Component

endoplasmic reticulum membrane (IDA)

membrane (IEA)

nuclear membrane (IDA)

plasma membrane (IBA)

receptor complex (IEA,ISO)

Molecular Function

ATP binding (IEA)

GTP binding (IEA)

guanylate cyclase activity (IBA,IDA,IEA,ISO)

hormone binding (IEA,ISO)

lyase activity (IEA)

natriuretic peptide receptor activity (IEA,ISO)

nucleotide binding (IEA)

peptide hormone binding (IEA,ISO)

peptide receptor activity (IBA)

phosphorus-oxygen lyase activity (IEA)

protein kinase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

purine metabolic pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

increased systemic arterial blood pressure (IAGP)

increased systemic arterial diastolic blood pressure (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Atrial natriuretic peptide induces natriuretic peptide receptor-cGMP-dependent protein kinase interaction.	Airhart N, etal., J Biol Chem. 2003 Oct 3;278(40):38693-8. Epub 2003 Jul 10.
2.	Renal hyporesponsiveness to atrial natriuretic peptide in congestive heart failure results from reduced atrial natriuretic peptide receptor concentrations.	Bryan PM, etal., Am J Physiol Renal Physiol. 2007 May;292(5):F1636-44. Epub 2007 Jan 30.
3.	Osmoregulation of endothelial nitric-oxide synthase gene expression in inner medullary collecting duct cells. Role in activation of the type A natriuretic peptide receptor.	Chen S, etal., J Biol Chem. 2002 Sep 6;277(36):32498-504. Epub 2002 Jun 24.
4.	Molecular cloning of a regulatory protein for membrane-bound guanylate cyclase GC-A.	Chen ZJ, etal., Biochem Biophys Res Commun 2000 Nov 11;278(1):106-11.
5.	A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor.	Chinkers M, etal., Nature 1989 Mar 2;338(6210):78-83.
6.	Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy.	Christoffersen TE, etal., Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1635-41. Epub 2005 Nov 4.
7.	Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.	Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6
8.	Mapping of rat chromosome 2 markers generated from chromosome-sorted DNA.	Deng AY, etal., Mamm Genome 1997 Oct;8(10):731-5.
9.	Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats.	Deng Y and Rapp JP, Nat Genet 1992 Jul;1(4):267-72
10.	Site-directed mutational analysis of a membrane guanylate cyclase cDNA reveals the atrial natriuretic factor signaling site.	Duda T, etal., Proc Natl Acad Sci U S A 1991 Sep 1;88(17):7882-6.
11.	Atrial natriuretic factor stimulates renal dopamine uptake mediated by natriuretic peptide-type A receptor.	Fernandez BE, etal., Regul Pept. 2005 Jan 15;124(1-3):137-44.
12.	NPRA-mediated suppression of AngII-induced ROS production contribute to the antiproliferative effects of B-type natriuretic peptide in VSMC.	Gao P, etal., Mol Cell Biochem. 2009 Apr;324(1-2):165-72. Epub 2008 Dec 23.
13.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
15.	Heart mass and blood pressure have separate genetic determinants in the New Zealand genetically hypertensive (GH) rat.	Harris EL, etal., J Hypertens 1995 Apr;13(4):397-404.
16.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
17.	Novel NPR1 polymorphic variants and its exclusion as a candidate gene for medullary cystic kidney disease (ADMCKD) type 1.	Koptides M, etal., Mol Cell Probes. 2001 Dec;15(6):357-61.
18.	Chronic metabolic acidosis upregulates rat kidney Na-HCO cotransporters NBCn1 and NBC3 but not NBC1.	Kwon TH, etal., Am J Physiol Renal Physiol 2002 Feb;282(2):F341-51.
19.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
20.	Missense mutation of exon 3 in the type A human natriuretic peptide receptor gene is associated with myocardial infarction.	Nakayama T, etal., Med Sci Monit. 2003 Dec;9(12):CR505-10.
21.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
22.	Natriuretic peptide/natriuretic peptide receptor-A (NPR-A) system has inhibitory effects in renal fibrosis in mice.	Nishikimi T, etal., Regul Pept. 2009 Apr 10;154(1-3):44-53. doi: 10.1016/j.regpep.2009.02.006. Epub 2009 Feb 15.
23.	Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A.	Oliver PM, etal., Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14730-5.
24.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
25.	Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype.	Pitzalis MV, etal., J Hypertens. 2003 Aug;21(8):1491-6.
26.	GOA pipeline	RGD automated data pipeline
27.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
28.	Comprehensive gene review and curation	RGD comprehensive gene curation
29.	A biometrical genome search in rats reveals the multigenic basis of blood pressure variation.	Schork NJ, etal., Genome Res 1995 Sep;5(2):164-72
30.	Detection of membrane-bound guanylate cyclase activity in rat C6 glioma cells at different growth states following activation by natriuretic peptides.	Sorci G, etal., Brain Res. 1995 Jun 12;683(1):51-8.
31.	TA repeat variation, Npr1 expression, and blood pressure: impact of the Ace locus.	Tremblay J, etal., Hypertension 2003 Jan;41(1):16-24.
32.	Structure of the dimerized hormone-binding domain of a guanylyl-cyclase-coupled receptor.	van den Akker F, etal., Nature. 2000 Jul 6;406(6791):101-4. doi: 10.1038/35017602.
33.	A-type natriuretic peptide receptor in the spontaneously hypertensive rat kidney.	Woodard GE, etal., Peptides 2002 Sep;23(9):1637-47.
34.	The primary structure of the rat guanylyl cyclase A/atrial natriuretic peptide receptor gene.	Yamaguchi M, etal., J Biol Chem 1990 Nov 25;265(33):20414-20.

Additional References at PubMed

PMID:1660465	PMID:1672777	PMID:9528788	PMID:11556325	PMID:11997476	PMID:12477932	PMID:12547834	PMID:14500707	PMID:14630722	PMID:15093696	PMID:15096467	PMID:15117952
PMID:17033090	PMID:17440494	PMID:18778744	PMID:19837875	PMID:20097258	PMID:20214400	PMID:20304036	PMID:20880010	PMID:20977274	PMID:21187974	PMID:21375693	PMID:22131352
PMID:22474982	PMID:23382219	PMID:23441479	PMID:24333928	PMID:26660905	PMID:26934489	PMID:27283501	PMID:28743500	PMID:35534926	PMID:38713329

Genomics

Comparative Map Data

Npr1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	178,231,766 - 178,247,591 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	178,231,766 - 178,247,088 (-)	Ensembl				GRCr8
mRatBN7.2	2	175,934,181 - 175,950,118 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	175,934,181 - 175,949,505 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	183,074,109 - 183,089,476 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	181,096,360 - 181,111,730 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	175,696,310 - 175,711,670 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	189,840,403 - 189,857,032 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	189,840,403 - 189,856,090 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	209,271,276 - 209,287,892 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	182,724,916 - 182,740,242 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	169,869,831 - 169,885,101 (-)	NCBI		Celera
RGSC_v3.1	2	182,675,021 - 182,690,348 (-)	NCBI
Cytogenetic Map	2	q34	NCBI

NPR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	153,678,688 - 153,693,992 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	153,677,965 - 153,694,110 (+)	Ensembl			hg38	GRCh38
GRCh37	1	153,651,164 - 153,666,468 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	151,917,737 - 151,933,088 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	150,464,185 - 150,479,536	NCBI
Celera	1	126,722,358 - 126,737,655 (+)	NCBI		Celera
Cytogenetic Map	1	q21.3	NCBI
HuRef	1	125,014,421 - 125,029,723 (+)	NCBI		HuRef
CHM1_1	1	155,047,152 - 155,062,430 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	152,815,953 - 152,831,256 (+)	NCBI		T2T-CHM13v2.0

Npr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	90,357,898 - 90,373,235 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	90,357,898 - 90,373,173 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	90,450,591 - 90,465,928 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	90,450,591 - 90,465,866 (-)	Ensembl			mm10	GRCm38
MGSCv37	3	90,254,514 - 90,269,788 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	90,536,519 - 90,552,265 (-)	NCBI		MGSCv36	mm8
Celera	3	90,488,131 - 90,503,567 (-)	NCBI		Celera
Cytogenetic Map	3	F1	NCBI
cM Map	3	39.23	NCBI

Npr1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955545	323,956 - 338,097 (+)	Ensembl
ChiLan1.0	NW_004955545	323,386 - 338,654 (+)	NCBI	ChiLan1.0	ChiLan1.0

NPR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	96,138,643 - 96,160,742 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	95,873,841 - 95,889,322 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	129,034,972 - 129,050,439 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	132,663,941 - 132,679,905 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	132,664,948 - 132,679,327 (+)	Ensembl			panPan2	panpan1.1

NPR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	43,382,246 - 43,396,464 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	43,283,418 - 43,396,027 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	42,875,275 - 42,888,999 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	43,331,940 - 43,345,662 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	43,153,680 - 43,345,719 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	43,034,052 - 43,047,778 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	43,087,306 - 43,101,030 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	43,370,926 - 43,384,656 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Npr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	24,449,225 - 24,465,782 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	3,480,267 - 3,495,643 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	3,479,858 - 3,496,896 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NPR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	95,957,228 - 95,973,430 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	95,957,220 - 95,974,253 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	104,855,577 - 104,870,667 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NPR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	10,115,319 - 10,131,933 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	10,115,105 - 10,131,200 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	9,492,241 - 9,508,732 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Npr1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624885	3,460,438 - 3,475,720 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624885	3,462,334 - 3,475,735 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Npr1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	63,151,845 - 63,166,826 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Npr1
191 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	75
Count of miRNA genes:	58
Interacting mature miRNAs:	64
Transcripts:	ENSRNOT00000020307
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	163997722	225110681	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	169358774	214358774	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170656145	239614549	Rat
631566	Bp90	Blood pressure QTL 90		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	149957381	221199885	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	138595962	205135428	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
61457	Niddm8	Non-insulin dependent diabetes mellitus QTL 8	4.1	0.01	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	2	176840779	178247591	Rat
152025245	Scl81	Serum cholesterol level QTL 81	3.49		blood cholesterol amount (VT:0000180)		2	124537199	209621565	Rat
1581578	Cm49	Cardiac mass QTL 49	4.9	0.01	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	145807215	220931416	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	122597372	215234002	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	154723085	199723085	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	145807215	190807215	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	154723085	199723085	Rat
10043139	Iddm55	Insulin dependent diabetes mellitus QTL 55	3.1	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	150313808	195313808	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	154723085	199723085	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	205135267	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	154723085	199723085	Rat
1549833	Bp257	Blood pressure QTL 257		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170652929	215652929	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	220931218	Rat
4889834	Pur24	Proteinuria QTL 24	5.8	0.014	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	171994826	205135428	Rat
12879845	Cm89	Cardiac mass QTL 89		0.008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	154723085	178247591	Rat
61473	Bp19	Blood pressure QTL 19	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	175008837	178247591	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	143565208	188565208	Rat
12879846	Cm90	Cardiac mass QTL 90		0.011	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	2	154723085	178247591	Rat
12879847	Am4	Aortic mass QTL 4		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	154723085	178247591	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	154723085	199723085	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	139067258	192287892	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	159440760	195313808	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	144882354	205135428	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
1357991	Ael2	Aortic elastin QTL 2	4.2	0.000071	aorta elastin amount (VT:0003905)	aortic elastin	2	169227906	214227906	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1578671	Bmd10	Bone mineral density QTL 10	5.4		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	175931416	220931416	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	139067258	184067258	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	159440760	228950743	Rat
2301415	Cm67	Cardiac mass QTL 67		0.003	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	154723085	178247591	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	143746578	205135428	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
11565180	Kidm56	Kidney mass QTL 56		0.003	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	154723085	178247591	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	114384617	215381366	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150096616	195096616	Rat
11565181	Bw176	Body weight QTL 176		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	2	154723085	178247591	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	145306936	212705578	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	113746222	205135428	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	147287892	192287892	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	114384617	215381366	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	223841096	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	117415288	205135428	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150096616	195096616	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
631522	Bp74	Blood pressure QTL 74		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	175008837	220008837	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	165453811	210453811	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	163253030	208253030	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166372086	229820014	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat
7488904	Bp363	Blood pressure QTL 363		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	175279960	178247591	Rat

Markers in Region

D2Mit21

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	2	209,270,725 - 209,288,751	NCBI	Rnor5.0
RGSC_v3.4	2	182,724,363 - 182,742,030	RGD	RGSC3.4
Celera	2	169,871,949 - 169,872,083	UniSTS
RH 3.4 Map	2	1162.7	RGD
RH 3.4 Map	2	1162.7	UniSTS
RH 2.0 Map	2	881.5	RGD
Cytogenetic Map	2	q34	UniSTS

D2Wox24

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	175,947,534 - 175,947,839 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	189,854,122 - 189,854,424	NCBI	Rnor6.0
Rnor_5.0	2	209,284,995 - 209,285,297	UniSTS	Rnor5.0
RGSC_v3.4	2	182,738,274 - 182,738,576	UniSTS	RGSC3.4
Celera	2	169,883,157 - 169,883,435	UniSTS
Cytogenetic Map	2	q34	UniSTS

D2Arb44

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	175,935,868 - 175,936,299 (+)	MAPPER	mRatBN7.2
mRatBN7.2	2	175,935,868 - 175,936,259 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	189,842,092 - 189,842,482	NCBI	Rnor6.0
Rnor_6.0	2	189,842,092 - 189,842,728	NCBI	Rnor6.0
Rnor_5.0	2	209,272,965 - 209,273,355	UniSTS	Rnor5.0
Rnor_5.0	2	209,272,965 - 209,273,601	UniSTS	Rnor5.0
RGSC_v3.4	2	182,726,605 - 182,726,995	UniSTS	RGSC3.4
Celera	2	169,871,506 - 169,871,920	UniSTS
Cytogenetic Map	2	q34	UniSTS

RH132833

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	175,934,243 - 175,934,437 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	189,840,466 - 189,840,659	NCBI	Rnor6.0
Rnor_5.0	2	209,271,339 - 209,271,532	UniSTS	Rnor5.0
RGSC_v3.4	2	182,724,979 - 182,725,172	UniSTS	RGSC3.4
Celera	2	169,869,894 - 169,870,087	UniSTS
RH 3.4 Map	2	1164.4	UniSTS
Cytogenetic Map	2	q34	UniSTS

Related Rat Strains

The following Strains have been annotated to Npr1

SS.MNS-(Mme-Gca)/Ayd

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
18	13	70	176	91	90	59	118	59	6	409	222	13	157	102	106	31	22	22

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006232591	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005500239	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC081831	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC128742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J05677	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M74535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X14773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000020307 ⟹ ENSRNOP00000020307

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	178,231,766 - 178,247,088 (-)	Ensembl
mRatBN7.2 Ensembl	2	175,934,181 - 175,949,505 (-)	Ensembl
Rnor_6.0 Ensembl	2	189,840,403 - 189,856,090 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103125 ⟹ ENSRNOP00000081330

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	178,231,766 - 178,247,088 (-)	Ensembl
mRatBN7.2 Ensembl	2	175,934,181 - 175,949,505 (-)	Ensembl

RefSeq Acc Id:

NM_012613 ⟹ NP_036745

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	178,231,766 - 178,247,088 (-)	NCBI
mRatBN7.2	2	175,934,181 - 175,949,505 (-)	NCBI
Rnor_6.0	2	189,840,403 - 189,856,090 (-)	NCBI
Rnor_5.0	2	209,271,276 - 209,287,892 (-)	NCBI
RGSC_v3.4	2	182,724,916 - 182,740,242 (-)	RGD
Celera	2	169,869,831 - 169,885,101 (-)	RGD

Sequence:

show sequence

ACTCCTGGGGCAAGCGCGAGCGCACACTCCCCTTTCCTTGCTGGCGCTCCCTCTCCCCTCGCTC
TCTCTCTCTAGACCGTCCTCTCCTTCCCTCGCTCTCCACCGACTCCCTTCGGGTGCTGTGCTTG
CTCCCACCTGCTCTGAAGCGCTCTCCGCTCTCGGACGCTCCCAATTTAGCGCTCCTGCTCGACG
GCCGAACCGTCGCAGCCTCCGCAGGCAGCGTGCCCTCGGGGTTGCGGCTTCAACCCACCCCAGC
TTCCTCCCTCGCTACGACTCGGGCGCCCTGGACGTTCGACCCTCGCCGCTGAGCCCGAGGATGG
CGAGCAGACCATGGTGACAGCGCTGCCCGGTCGCTGCACTCGCTGAGGCCATGCCGGGCTCCCG
ACGCGTCCGTCCGCGCCTAAGGGCGCTGCTGCTGCTGCCGCCGCTTCTGCTACTCCGGGGCGGC
CACGCGAGCGACCTGACCGTGGCTGTGGTGCTGCCGCTGACCAACACCTCGTACCCGTGGTCCT
GGGCGCGTGTAGGGCCGGCCGTGGAACTGGCTCTCGCGCGGGTGAAGGCTCGGCCGGACTTGCT
GCCGGGTTGGACGGTCCGCATGGTGCTGGGCAGCAGTGAGAACGCGGCGGGCGTCTGCTCGGAC
ACCGCCGCACCGCTGGCCGCGGTGGACCTCAAGTGGGAGCACAGCCCCGCGGTGTTCCTGGGCC
CCGGCTGCGTCTACTCCGCTGCCCCGGTGGGGCGCTTCACCGCGCACTGGCGGGTGCCGCTGCT
GACCGCCGGCGCCCCGGCTCTGGGCATCGGGGTCAAGGATGAGTATGCGCTAACCACCCGCACA
GGACCCAGCCATGTCAAGCTGGGCGATTTCGTGACGGCGCTGCATCGACGGCTGGGCTGGGAGC
ACCAGGCGCTGGTGCTCTATGCAGATCGGCTGGGCGACGACCGGCCTTGCTTCTTCATAGTGGA
GGGGCTGTACATGCGGGTGCGTGAACGCCTCAACATCACAGTGAATCACCAGGAGTTCGTCGAG
GGCGACCCGGACCACTACCCCAAGCTACTGCGGGCCGTGCGGCGAAAGGGCAGAGTTATCTACA
TCTGCAGTTCTCCGGATGCCTTCAGGAATCTGATGCTTCTGGCCCTGAACGCTGGCCTGACTGG
GGAGGACTATGTTTTCTTCCACCTGGATGTGTTTGGGCAAAGCCTTAAGAGTGCTCAGGGCCTT
GTTCCCCAGAAACCCTGGGAAAGAGGAGATGGGCAGGACAGGAGTGCCCGCCAGGCCTTTCAGG
CTGCCAAAATTATTACTTACAAAGAGCCTGATAATCCTGAGTACTTGGAATTCCTGAAGCAGCT
GAAACTCTTGGCTGACAAGAAGTTCAACTTCACCGTGGAGGATGGCCTGAAGAATATCATCCCA
GCCTCCTTCCACGACGGGCTCCTGCTCTATGTCCAGGCAGTGACAGAGACTCTGGCACAGGGGG
GAACTGTCACAGATGGAGAGAACATCACTCAGCGGATGTGGAACCGAAGCTTCCAAGGTGTGAC
AGGATACCTGAAAATTGATAGAAACGGAGATCGGGACACCGATTTCTCTCTCTGGGATATGGAT
CCAGAGACGGGTGCCTTCAGGGTTGTCCTGAACTATAATGGTACTTCCCAGGAGCTAATGGCTG
TGTCAGAACACAAATTATACTGGCCTCTGGGATATCCACCTCCTGACGTCCCTAAATGTGGCTT
TGACAATGAGGACCCAGCCTGCAACCAAGACCACTTTTCCACACTGGAGGTTCTGGCTTTGGTG
GGCAGCCTCTCTCTGATTAGCTTTCTGATTGTGTCTTTCTTCATATACAGGAAGATGCAGCTGG
AAAAGGAGCTGGTCTCAGAGTTGTGGCGGGTGCGCTGGGAGGACTTGCAGCCCAGCAGCCTGGA
GAGGCATCTTCGGAGCGCTGGCAGCCGGCTGACCCTGAGTGGGCGAGGCTCCAATTATGGCTCC
CTGCTAACCACCGAGGGCCAGTTCCAAGTCTTTGCCAAGACAGCATACTATAAGGGCAACCTTG
TGGCTGTGAAACGTGTGAACCGGAAACGCATTGAGTTGACACGAAAAGTCCTGTTTGAACTTAA
ACATATGCGGGATGTGCAGAATGAGCACTTGACAAGATTTGTGGGTGCTTGTACCGACCCCCCC
AACATCTGTATCCTCACAGAGTACTGTCCCCGTGGAAGCCTACAGGACATTCTAGAGAATGAGA
GTATCACCCTGGACTGGATGTTTCGGTACTCGCTCACCAATGACATTGTCAAGGGAATGCTCTT
TCTACACAATGGGGCCATTTGTTCCCATGGGAACCTCAAGTCATCCAACTGTGTGGTAGACGGG
CGCTTCGTGTTAAAGATCACAGACTACGGTCTTGAGAGCTTCAGAGACCCGGAGCCAGAGCAAG
GACACACCCTCTTTGCCAAAAAATTGTGGACGGCACCTGAGCTCCTGCGAATGGCTTCGCCACC
TGCCCGTGGCTCCCAAGCTGGGGATGTGTACAGCTTTGGTATCATCCTGCAGGAGATTGCCCTA
AGAAGTGGGGTCTTCTATGTGGAAGGTTTGGACCTCAGCCCAAAAGAGATCATTGAGCGTGTGA
CTCGGGGTGAGCAGCCCCCATTCCGACCCTCCATGGATCTGCAGAGCCACCTGGAGGAACTGGG
GCAGCTGATGCAGCGGTGCTGGGCAGAGGACCCACAGGAGCGGCCACCCTTTCAGCAGATTCGC
CTGGCGCTGCGCAAGTTCAACAAGGAGAACAGCAGCAACATCCTGGACAACCTGCTGTCACGCA
TGGAGCAGTATGCTAACAACCTGGAGGAACTGGTAGAGGAGAGAACACAAGCTTATCTGGAGGA
GAAGCGCAAAGCTGAGGCCTTGCTTTACCAGATTCTGCCTCACTCCGTGGCTGAGCAGCTGAAG
AGAGGCGAGACAGTCCAGGCTGAGGCCTTTGATAGTGTTACCATCTACTTCAGTGATATTGTGG
GCTTTACAGCTCTTTCAGCAGAAAGCACACCCATGCAGGTGGTGACTCTGCTCAATGATCTGTA
CACCTGTTTTGATGCTGTCATAGACAACTTTGATGTGTACAAGGTGGAGACCATTGGTGATGCT
TACATGGTGGTGTCAGGGCTCCCAGTGCGGAATGGACAACTCCACGCCCGAGAGGTGGCCCGAA
TGGCACTTGCACTACTGGATGCTGTGCGCTCCTTCCGCATCCGCCATAGGCCCCAGGAACAGCT
GCGCTTGCGCATTGGCATCCACACAGGTCCTGTGTGTGCTGGTGTGGTAGGGCTAAAGATGCCC
CGATACTGCCTCTTTGGAGACACAGTCAACACAGCTTCAAGAATGGAGTCTAATGGAGAAGCCC
TCAAGATCCACTTGTCTTCAGAGACCAAGGCTGTGCTGGAAGAGTTCGATGGTTTCGAGCTGGA
GCTCCGAGGGGATGTGGAAATGAAGGGCAAAGGCAAGGTTCGGACCTATTGGCTCCTGGGGGAG
CGGGGATGTAGCACTCGAGGCTGACCTACTGCCCTGCTGTTCCTTGTCACCCCTCCTCCCTGTG
CCAGAGGTGACAGAGGTGTCCAGCTTCCACCTCTCCCACAGCAGCCCAGCCACTGTGGAAGGAT
TAGGGACCTGACCAGCACAGTCACCAGATGTGACCTCTGAGAGAGGATGGAGATGGTGGGGACT
GCAGGGGACACCTAAGTTTGTAGGACTGACTGAAACACACAGTCCCTCCCATGGCACCCTTGTG
GCACACATGCCCAGTCCCACCCTTACTCTGCTGCCTAGATTGGGACAGCGATTCCTTCTCTGCC
CTCAACTTAGCTCCACTGTGACTTATAGGGAGGGAATTGCCACCTGAAGGAAACAGAAAGAGGT
TAGAGTTTGCAGGAGGCGGGCAGTCCTGTGTCACAAATACTCCCCTCACTTCCAGCCCACCACC
TGCCCCACAGACTTTGGACACAGCTCACTGAGGAGAAGAGAAGCTGCCGGTTACCTTGCTTCTC
CTGTGAACCAAACCATTAAAGTCTTTATTCCTGTGA

hide sequence

RefSeq Acc Id:

XM_006232591 ⟹ XP_006232653

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	178,231,766 - 178,247,591 (-)	NCBI
mRatBN7.2	2	175,934,181 - 175,950,105 (-)	NCBI
Rnor_6.0	2	189,840,403 - 189,857,032 (-)	NCBI
Rnor_5.0	2	209,271,276 - 209,287,892 (-)	NCBI

Sequence:

show sequence

GTTATGCCGTCAACATCTAACTGGCACTTGACATAGCTGTCCTCTTGAAATGTTTGCTGATCTT
AGTTCCTGTTTGTGCTCAAGACTGGCGAAGCTGATGGCGCAATACGGTTAATGAATCCGGATGA
CCATTAGAGGGCACACTAATCCCATGCCGTTCCGTCCCAAAGGCCCAGCAGTTTGGAGTTCCCC
AGACTCGCTCCTTCATTTATTCTTCCCATGATCATTTCCACCCAGAACTCCACAGTCCCATTTT
AATAATCTTCCACACAAAACACTCAAACGACGTTACATCTCTTCCCTAGCCACCCACCCTCTCT
CCCCAGTTTCTGTTAGTATTTGGGAATTAAAGAGTTAACTCCACCCTCCCACCTGGTCATCTTG
CTCAGTTAATCTGCGCGATCTGGGAGGCGGCGAAGAAGAAAGGGGAGGTACTCATTGATGGACT
GGGTAACCCGGACTCTGGCTCGCCCCTACTTGATTGCCTTTTCTAGAAACCCTCCCAAACTCCT
ATTAGCCACACACACCTTTTCCGGCCAAGATCCAAACAAGCTTTCCTCTCCCTAGGAACCAGAC
CGTCCTCTCCTTCCCTCGCTCTCCACCGACTCCCTTCGGGTGCTGTGCTTGCTCCCACCTGCTC
TGAAGCGCTCTCCGCTCTCGGACGCTCCCAATTTAGCGCTCCTGCTCGACGGCCGAACCGTCGC
AGCCTCCGCAGGCAGCGTGCCCTCGGGGTTGCGGCTTCAACCCACCCCAGCTTCCTCCCTCGCT
ACGACTCGGGCGCCCTGGACGTTCGACCCTCGCCGCTGAGCCCGAGGATGGCGAGCAGACCATG
GTGACAGCGCTGCCCGGTCGCTGCACTCGCTGAGGCCATGCCGGGCTCCCGACGCGTCCGTCCG
CGCCTAAGGGCGCTGCTGCTGCTGCCGCCGCTTCTGCTACTCCGGGGCGGCCACGCGAGCGACC
TGACCGTGGCTGTGGTGCTGCCGCTGACCAACACCTCGTACCCGTGGTCCTGGGCGCGTGTAGG
GCCGGCCGTGGAACTGGCTCTCGCGCGGGTGAAGGCTCGGCCGGACTTGCTGCCGGGTTGGACG
GTCCGCATGGTGCTGGGCAGCAGTGAGAACGCGGCGGGCGTCTGCTCGGACACCGCCGCACCGC
TGGCCGCGGTGGACCTCAAGTGGGAGCACAGCCCCGCGGTGTTCCTGGGCCCCGGCTGCGTCTA
CTCCGCTGCCCCGGTGGGGCGCTTCACCGCGCACTGGCGGGTGCCGCTGCTGACCGCCGGCGCC
CCGGCTCTGGGCATCGGGGTCAAGGATGAGTATGCGCTAACCACCCGCACAGGACCCAGCCATG
TCAAGCTGGGCGATTTCGTGACGGCGCTGCATCGACGGCTGGGCTGGGAGCACCAGGCGCTGGT
GCTCTATGCAGATCGGCTGGGCGACGACCGGCCTTGCTTCTTCATAGTGGAGGGGCTGTACATG
CGGGTGCGTGAACGCCTCAACATCACAGTGAATCACCAGGAGTTCGTCGAGGGCGACCCGGACC
ACTACCCCAAGCTACTGCGGGCCGTGCGGCGAAAGGGCAGAGTTATCTACATCTGCAGTTCTCC
GGATGCCTTCAGGAATCTGATGCTTCTGGCCCTGAACGCTGGCCTGACTGGGGAGGACTATGTT
TTCTTCCACCTGGATGTGTTTGGGCAAAGCCTTAAGAGTGCTCAGGGCCTTGTTCCCCAGAAAC
CCTGGGAAAGAGGAGATGGGCAGGACAGGAGTGCCCGCCAGGCCTTTCAGGCTGCCAAAATTAT
TACTTACAAAGAGCCTGATAATCCTGAGTACTTGGAATTCCTGAAGCAGCTGAAACTCTTGGCT
GACAAGAAGTTCAACTTCACCGTGGAGGATGGCCTGAAGAATATCATCCCAGCCTCCTTCCACG
ACGGGCTCCTGCTCTATGTCCAGGCAGTGACAGAGACTCTGGCACAGGGGGGAACTGTCACAGA
TGGAGAGAACATCACTCAGCGGATGTGGAACCGAAGCTTCCAAGGTGTGACAGGATACCTGAAA
ATTGATAGAAACGGAGATCGGGACACCGATTTCTCTCTCTGGGATATGGATCCAGAGACGGGTG
CCTTCAGGGTTGTCCTGAACTATAATGGTACTTCCCAGGAGCTAATGGCTGTGTCAGAACACAA
ATTATACTGGCCTCTGGGATATCCACCTCCTGACGTCCCTAAATGTGGCTTTGACAATGAGGAC
CCAGCCTGCAACCAAGACCACTTTTCCACACTGGAGGTTCTGGCTTTGGTGGGCAGCCTCTCTC
TGATTAGCTTTCTGATTGTGTCTTTCTTCATATACAGGAAGATGCAGCTGGAAAAGGAGCTGGT
CTCAGAGTTGTGGCGGGTGCGCTGGGAGGACTTGCAGCCCAGCAGCCTGGAGAGGCATCTTCGG
AGCGCTGGCAGCCGGCTGACCCTGAGTGGGCGAGGCTCCAATTATGGCTCCCTGCTAACCACCG
AGGGCCAGTTCCAAGTCTTTGCCAAGACAGCATACTATAAGGGCAACCTTGTGGCTGTGAAACG
TGTGAACCGGAAACGCATTGAGTTGACACGAAAAGTCCTGTTTGAACTTAAACATATGCGGGAT
GTGCAGAATGAGCACTTGACAAGATTTGTGGGTGCTTGTACCGACCCCCCCAACATCTGTATCC
TCACAGAGTACTGTCCCCGTGGAAGCCTACAGGACATTCTAGAGAATGAGAGTATCACCCTGGA
CTGGATGTTTCGGTACTCGCTCACCAATGACATTGTCAAGGGAATGCTCTTTCTACACAATGGG
GCCATTTGTTCCCATGGGAACCTCAAGTCATCCAACTGTGTGGTAGACGGGCGCTTCGTGTTAA
AGATCACAGACTACGGTCTTGAGAGCTTCAGAGACCCGGAGCCAGAGCAAGGGCACACCCTCTT
TGCCAAAAAATTGTGGACGGCACCTGAGCTCCTGCGAATGGCTTCGCCACCTGCCCGTGGCTCC
CAAGCTGGGGATGTGTACAGCTTTGGTATCATCCTGCAGGAGATTGCCCTAAGAAGTGGGGTCT
TCTATGTGGAAGGTTTGGACCTCAGCCCAAAAGAGATCATTGAGCGTGTGACTCGGGGTGAGCA
GCCCCCATTCCGACCCTCCATGGATCTGCAGAGCCACCTGGAGGAACTGGGGCAGCTGATGCAG
CGGTGCTGGGCAGAGGACCCACAGGAGCGGCCACCCTTTCAGCAGATCCGCCTGGCGCTGCGCA
AGTTCAACAAGGAGAACAGCAGCAACATCCTGGACAACCTGCTGTCACGCATGGAGCAGTATGC
TAACAACCTGGAGGAACTGGTAGAGGAGAGAACACAAGCTTATCTGGAGGAGAAGCGCAAAGCT
GAGGCCTTGCTTTACCAGATTCTGCCTCACTCCGTGGCTGAGCAGCTGAAGAGAGGCGAGACAG
TCCAGGCTGAGGCCTTTGATAGTGTTACCATCTACTTCAGTGATATTGTGGGCTTTACAGCTCT
TTCAGCAGAAAGCACACCCATGCAGGTGGTGACTCTGCTCAATGATCTGTACACCTGTTTTGAT
GCTGTCATAGACAACTTTGATGTGTACAAGGTGGAGACCATTGGTGATGCTTACATGGTGGTGT
CAGGGCTCCCAGTGCGGAATGGACAACTCCACGCCCGAGAGGTGGCCCGAATGGCACTTGCACT
ACTGGATGCTGTGCGCTCCTTCCGCATCCGCCATAGGCCCCAGGAACAGCTGCGCTTGCGCATT
GGCATCCACACAGGTCCTGTGTGTGCTGGTGTGGTAGGGCTAAAGATGCCCCGATACTGCCTCT
TTGGAGACACAGTCAACACAGCTTCAAGAATGGAGTCTAATGGAGAAGCCCTCAAGATCCACTT
GTCTTCAGAGACCAAGGCTGTGCTGGAAGAGTTCGATGGTTTCGAGCTGGAGCTCCGAGGGGAT
GTGGAAATGAAGGGCAAAGGCAAGGTTCGGACCTATTGGCTCCTGGGGGAGCGGGGATGTAGCA
CTCGAGGCTGACCTACTGCCCTGCTGTTCCTTGTCACCCCTCCTCCCTGTGCCAGAGGTGACAG
AGGTGTCCAGCTTCCACCTCTCCCACAGCAGCCCAGCCACTGTGGAAGGATTAGGGACCTGACC
AGCACAGTCACCAGATGTGACCTCTGAGAGAGGATGGAGATGGTGGGGACTGCAGGGGACACCT
AAGTTTGTAGGACTGACTGAAACACACAGTCCCTCCCATGGCACCCTTGTGGCACACATGCCCA
GTCCCACCCTTACTCTGCTGCCTAGATTGGGACAGCGATTCCTTCTCTGCCCTCAACTTAGCTC
CACTGTGACTTATAGGGAGGGAATTGCCACCTGAAGGAAACAGAAAGAGGTTAGAGTTTGCAGG
AGGCGGGCAGTCCTGTGTCACAAATACTCCCCTCACTTCCAGCCCACCACCTGCCCCACAGACT
TTGGACACAGCTCACTGAGGAGAAGAGAAGCTGCCGGTTACCTTGCTTCTCCTGTGAACCAAAC
CATTAAAGTCTTTATTCCTGTGA

hide sequence

RefSeq Acc Id:

XR_005500239

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	178,238,922 - 178,247,465 (-)	NCBI
mRatBN7.2	2	175,941,337 - 175,950,118 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_036745	(Get FASTA)	NCBI Sequence Viewer
	XP_006232653	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41200	(Get FASTA)	NCBI Sequence Viewer
	AAA41202	(Get FASTA)	NCBI Sequence Viewer
	AAI28743	(Get FASTA)	NCBI Sequence Viewer
	CAA32881	(Get FASTA)	NCBI Sequence Viewer
	EDM00568	(Get FASTA)	NCBI Sequence Viewer
	EDM00569	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020307
	ENSRNOP00000020307.2
GenBank Protein	P18910	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_036745 ⟸ NM_012613
- Peptide Label:	precursor
- UniProtKB:	A1A5N8 (UniProtKB/Swiss-Prot), P18910 (UniProtKB/Swiss-Prot), A6J6M1 (UniProtKB/TrEMBL), A0A8I5ZSQ4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPGSRRVRPRLRALLLLPPLLLLRGGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKA RPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHW RVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPC FFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALN AGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLE FLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRS FQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYWPLGYPPPDV PKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQ PSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKV LFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIV KGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLFAKKLWTAPELLR MASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQSH LEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQ AYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTL LNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHR PQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFD GFELELRGDVEMKGKGKVRTYWLLGERGCSTRG hide sequence

RefSeq Acc Id:	XP_006232653 ⟸ XM_006232591
- Peptide Label:	isoform X1
- UniProtKB:	A1A5N8 (UniProtKB/Swiss-Prot), P18910 (UniProtKB/Swiss-Prot), A6J6M1 (UniProtKB/TrEMBL), A0A8I5ZSQ4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPGSRRVRPRLRALLLLPPLLLLRGGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKA RPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHW RVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPC FFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALN AGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLE FLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRS FQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYWPLGYPPPDV PKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQ PSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKV LFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIV KGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLFAKKLWTAPELLR MASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQSH LEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQ AYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTL LNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHR PQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFD GFELELRGDVEMKGKGKVRTYWLLGERGCSTRG hide sequence

Ensembl Acc Id:

ENSRNOP00000020307 ⟸ ENSRNOT00000020307

Ensembl Acc Id:

ENSRNOP00000081330 ⟸ ENSRNOT00000103125

Protein Domains

Guanylate cyclase Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P18910-F1-model_v2	AlphaFold	P18910	1-1057	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691501

Promoter ID:

EPDNEW_R2026

Type:

single initiation site

Name:

Npr1_1

Description:

natriuretic peptide receptor 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	189,856,092 - 189,856,152	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3195	AgrOrtholog
BioCyc Gene	G2FUF-52347	BioCyc
Ensembl Genes	ENSRNOG00000014684	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000020307	ENTREZGENE
	ENSRNOT00000020307.4	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.70.1230	UniProtKB/Swiss-Prot
	3.40.50.2300	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7458324	IMAGE-MGC_LOAD
InterPro	A/G_cyclase	UniProtKB/Swiss-Prot
	A/G_cyclase_CS	UniProtKB/Swiss-Prot
	ANF_lig-bd_rcpt	UniProtKB/Swiss-Prot
	ANPR/GUC	UniProtKB/Swiss-Prot
	Cyclic_nucleotide_synthase	UniProtKB/Swiss-Prot
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Nucleotide_cyclase	UniProtKB/Swiss-Prot
	Peripla_BP_I	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:24603	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:156671	IMAGE-MGC_LOAD
NCBI Gene	24603	ENTREZGENE
PANTHER	ATRIAL NATRIURETIC PEPTIDE RECEPTOR 1	UniProtKB/Swiss-Prot
	GUANYLYL CYCLASE	UniProtKB/Swiss-Prot
Pfam	ANF_receptor	UniProtKB/Swiss-Prot
	Guanylate_cyc	UniProtKB/Swiss-Prot
	Pkinase_Tyr	UniProtKB/Swiss-Prot
PhenoGen	Npr1	PhenoGen
PRINTS	NATPEPTIDER	UniProtKB/Swiss-Prot
PROSITE	ANF_RECEPTORS	UniProtKB/Swiss-Prot
	GUANYLATE_CYCLASE_1	UniProtKB/Swiss-Prot
	GUANYLATE_CYCLASE_2	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000014684	RatGTEx
SMART	CYCc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF53822	UniProtKB/Swiss-Prot
	SSF55073	UniProtKB/Swiss-Prot
	SSF56112	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZSQ4	ENTREZGENE, UniProtKB/TrEMBL
	A1A5N8	ENTREZGENE
	A6J6M1	ENTREZGENE, UniProtKB/TrEMBL
	ANPRA_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A1A5N8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-03-07	Npr1	natriuretic peptide receptor 1	Npr1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-10	Npr1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	Npr1	natriuretic peptide receptor 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-02-26	Npr1	natriuretic peptide receptor 1			Symbol and Name status set to approved	625702	APPROVED
2002-06-10	Npr1	natriuretic peptide receptor 1			Name updated	70585	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_disease	cosegregates strongly with increased blood pressure in the SHRSP and WKY rats	1357231
gene_domains	contains extracellular ligand binding domain, transmembrane domain, kinase-like domain, and a cyclase catalytic domain	728930
gene_expression	expressed on the cell surface of vascular endothelial, smooth muscle cells and epithelial cells lining the inner medullary collecting duct	70580
gene_function	binds to natriuretic peptide precursor A (Nppa)	628585
gene_process	induces an increase in intracellular cGMP and initiates natriuresis, diuresis, and vasodilation, which contribute to lowering blood pressure	628585
gene_regulation	activity and gene expression increased by extracellular osmolality through a specific p38-dependent mechanism	70580
gene_regulation	regulated by glucocorticoids, transforming growth factor-b and chorionic gonadotrophin	70580

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Mammalian Phenotype

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Mammalian Phenotype