Klk1b3 (kallikrein 1-related peptidase B3) - Rat Genome Database

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Gene: Klk1b3 (kallikrein 1-related peptidase B3) Rattus norvegicus
Analyze
Symbol: Klk1b3
Name: kallikrein 1-related peptidase B3
RGD ID: 3175
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in regulation of systemic arterial blood pressure and zymogen activation. Predicted to be active in extracellular space and secretory granule. Used to study hypertension. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to several human genes including KLK1 (kallikrein 1); INTERACTS WITH 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil; bacitracin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: gamma-NGF; kallikrein 1; kallikrein a4; Klk1; Klk1c1; Klna4; nerve growth factor gamma chain; Nerve growth factor gamma polypeptide; nerve growth factor, gamma; Ngfg; pancreatic kallikrein; preprokallikrein; PS kallikrein; rGK-1; rK-1; true kallikrein; true tissue kallikrein
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp267
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,845,647 - 103,849,854 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1103,845,603 - 103,849,855 (+)EnsemblGRCr8
mRatBN7.2194,709,105 - 94,713,308 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,709,105 - 94,713,308 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1100,094,513 - 100,098,718 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,567,159 - 108,571,362 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,857,570 - 101,861,794 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,199,057 - 100,203,260 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,059,967 - 100,203,329 (+)Ensemblrn6Rnor6.0
Rnor_5.01101,264,168 - 101,268,371 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4194,692,856 - 94,697,059 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera188,976,256 - 88,978,461 (+)NCBICelera
RGSC_v3.1194,770,966 - 94,775,170 (+)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
hypertension  (IAGP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide sequences of four distinct types including tonin. Ashley PL and MacDonald RJ, Biochemistry 1985 Aug 13;24(17):4512-20.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Immunological identification of rat tissue kallikrein cDNA and characterization of the kallikrein gene family. Gerald WL, etal., Biochim Biophys Acta 1986 Feb 24;866(1):1-14.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Klk1 as one of the genes contributing to hypertension in Dahl salt-sensitive rat. Iwai N, etal., Hypertension 2005 May;45(5):947-53. Epub 2005 Apr 4.
6. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. Iwai N, etal., J Hypertens. 2004 Jun;22(6):1119-26.
7. Significance of the tissue kallikrein promoter and transforming growth factor-beta1 polymorphisms with renal progression in children with vesicoureteral reflux. Lee-Chen GJ, etal., Kidney Int. 2004 Apr;65(4):1467-72.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Rat pancreatic kallikrein mRNA: nucleotide sequence and amino acid sequence of the encoded preproenzyme. Swift GH, etal., Proc Natl Acad Sci U S A 1982 Dec;79(23):7263-7.
13. Association of the tissue kallikrein gene promoter with ESRD and hypertension. Yu H, etal., Kidney Int. 2002 Mar;61(3):1030-9.
Additional References at PubMed
PMID:2708383   PMID:2753879   PMID:12473665   PMID:12477932   PMID:15203212   PMID:15489334   PMID:15546918   PMID:16129698   PMID:17060174   PMID:19879874   PMID:22739815   PMID:22865451  
PMID:24019890  


Genomics

Comparative Map Data
Klk1b3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,845,647 - 103,849,854 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1103,845,603 - 103,849,855 (+)EnsemblGRCr8
mRatBN7.2194,709,105 - 94,713,308 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl194,709,105 - 94,713,308 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1100,094,513 - 100,098,718 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01108,567,159 - 108,571,362 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01101,857,570 - 101,861,794 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,199,057 - 100,203,260 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,059,967 - 100,203,329 (+)Ensemblrn6Rnor6.0
Rnor_5.01101,264,168 - 101,268,371 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4194,692,856 - 94,697,059 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera188,976,256 - 88,978,461 (+)NCBICelera
RGSC_v3.1194,770,966 - 94,775,170 (+)NCBI
Cytogenetic Map1q22NCBI
Klk1b3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,847,615 - 43,851,775 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,847,615 - 43,851,776 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38744,198,191 - 44,202,351 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,198,191 - 44,202,352 (+)Ensemblmm10GRCm38
MGSCv37751,453,600 - 51,457,721 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36744,066,272 - 44,070,393 (+)NCBIMGSCv36mm8
Celera739,656,532 - 39,660,613 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.71NCBI

Variants

.
Variants in Klk1b3
78 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 1 16 24 23 22 10 10 10 6 105 36 2 15 46 38 12 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000025831   ⟹   ENSRNOP00000025831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1103,845,603 - 103,849,854 (+)Ensembl
mRatBN7.2 Ensembl194,709,105 - 94,713,308 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072124   ⟹   ENSRNOP00000067862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1103,847,401 - 103,849,855 (+)Ensembl
mRatBN7.2 Ensembl194,710,859 - 94,713,308 (+)Ensembl
RefSeq Acc Id: NM_031523   ⟹   NP_113711
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81103,845,647 - 103,849,854 (+)NCBI
mRatBN7.2194,709,105 - 94,713,308 (+)NCBI
Rnor_6.01100,199,057 - 100,203,260 (+)NCBI
Rnor_5.01101,264,168 - 101,268,371 (+)NCBI
RGSC_v3.4194,692,856 - 94,697,059 (+)RGD
Celera188,976,256 - 88,978,461 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_113711 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41462 (Get FASTA)   NCBI Sequence Viewer  
  AAA41464 (Get FASTA)   NCBI Sequence Viewer  
  AAH78784 (Get FASTA)   NCBI Sequence Viewer  
  BAA00346 (Get FASTA)   NCBI Sequence Viewer  
  CAA27247 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025831
GenBank Protein P00758 (Get FASTA)   NCBI Sequence Viewer  
  SFW93260 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113711   ⟸   NM_031523
- Peptide Label: precursor
- UniProtKB: Q68G17 (UniProtKB/Swiss-Prot),   P00758 (UniProtKB/Swiss-Prot),   A0A0G2JSQ7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067862   ⟸   ENSRNOT00000072124
Ensembl Acc Id: ENSRNOP00000025831   ⟸   ENSRNOT00000025831
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00758-F1-model_v2 AlphaFold P00758 1-261 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689994
Promoter ID:EPDNEW_R518
Type:multiple initiation site
Name:Klk1b3_1
Description:kallikrein 1-related peptidase B3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R517  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01100,199,057 - 100,199,117EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3175 AgrOrtholog
BioCyc Gene G2FUF-59794 BioCyc
Ensembl Genes ENSRNOG00000032857 Ensembl
  ENSRNOG00000068069 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000025831 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7128287 IMAGE-MGC_LOAD
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:24594 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93329 IMAGE-MGC_LOAD
NCBI Gene 24594 ENTREZGENE
PANTHER KALLIKREIN-1 UniProtKB/Swiss-Prot
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Klk1b3 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032857 RatGTEx
  ENSRNOG00000068069 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt A0A0G2JSQ7 ENTREZGENE, UniProtKB/TrEMBL
  KLK1_RAT UniProtKB/Swiss-Prot
  M0RDZ8_RAT UniProtKB/TrEMBL
  P00758 ENTREZGENE
  Q68G17 ENTREZGENE
UniProt Secondary Q68G17 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-15 Klk1b3  kallikrein 1-related peptidase B3  Klk1  kallikrein 1  Name and Symbol changed 629549 APPROVED
2011-06-29 Klk1  kallikrein 1  Klk1b3  kallikrein 1-related peptidase b3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Klk1b3  kallikrein 1-related peptidase b3  Ngfg  nerve growth factor, gamma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ngfg  Nerve growth factor, gamma polypeptide      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA levels are significantly reduced in kidneys of Dahl salt-sensitive rats compared with Lewis rats 1358144
gene_expression expressed in the pancreas, submaxillary and parotid glands, spleen, and kidney 633346