Mx1 (MX dynamin like GTPase 1) - Rat Genome Database

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Gene: Mx1 (MX dynamin like GTPase 1) Rattus norvegicus
Analyze
Symbol: Mx1
Name: MX dynamin like GTPase 1
RGD ID: 3127
Description: Predicted to enable GTPase activity; identical protein binding activity; and microtubule binding activity. Involved in response to virus. Located in nucleus. Human ortholog(s) of this gene implicated in alopecia areata; avian influenza; liver disease; and prostate cancer. Orthologous to human MX1 (MX dynamin like GTPase 1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IFI78; interferon-induced GTP-binding protein Mx1; myxoma resistance protein 1; myxovirus (influenza virus) resistance; myxovirus (influenza virus) resistance 1; Myxovirus (influenza) resistance homolog of murine Mx (also interferon-inducible protein IFI78); Myxovirus (influenza) resistance, homolog of murine Mx (also interferon-inducible protein IFI78); myxovirus resistance protein 1
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,269,056 - 50,294,699 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1150,269,057 - 50,292,904 (-)EnsemblGRCr8
mRatBN7.21136,799,659 - 36,825,209 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1136,799,660 - 36,823,507 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1145,448,179 - 45,473,727 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01138,119,559 - 38,145,105 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,279,482 - 37,305,028 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01137,891,150 - 37,916,775 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1137,891,156 - 37,914,983 (-)Ensemblrn6Rnor6.0
Rnor_5.01141,398,737 - 41,424,277 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41137,438,473 - 37,462,363 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1136,686,487 - 36,712,040 (-)NCBICelera
RGSC_v3.11137,496,062 - 37,517,940 (-)NCBI
Cytogenetic Map11q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dimethoxyphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
Actein  (EXP)
actinomycin D  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
alvocidib  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chlorophyllin  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dieldrin  (EXP,ISO)
diethyl maleate  (EXP)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP)
disulfiram  (ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
fentanyl  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
hydroquinone  (ISO)
inulin  (ISO)
iopamidol  (ISO)
isoflurane  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
metam  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylarsonic acid  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
prednisolone  (ISO)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
Triptolide  (EXP)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Human MxA is a potent interspecies barrier for the novel bat-derived influenza A-like virus H18N11. Ciminski K, etal., Emerg Microbes Infect. 2019;8(1):556-563. doi: 10.1080/22221751.2019.1599301.
2. In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein. Deeg CM, etal., J Exp Med. 2017 May 1;214(5):1239-1248. doi: 10.1084/jem.20161033. Epub 2017 Apr 10.
3. Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study. García-Álvarez M, etal., Sci Rep. 2017 Jan 31;7:41516. doi: 10.1038/srep41516.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. The myxovirus resistance A (MxA) gene -88G>T single nucleotide polymorphism is associated with prostate cancer. Glymph S, etal., Infect Genet Evol. 2013 Jun;16:186-90. doi: 10.1016/j.meegid.2013.02.010. Epub 2013 Feb 22.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Aetiology of febrile pharyngitis in children: Potential of myxovirus resistance protein A (MxA) as a biomarker of viral infection. Ivaska L, etal., J Infect. 2017 Apr;74(4):385-392. doi: 10.1016/j.jinf.2017.01.002. Epub 2017 Jan 7.
8. Cell-Penetrating Mx1 Enhances Anti-Viral Resistance against Mucosal Influenza Viral Infection. Jung HE, etal., Viruses. 2019 Jan 28;11(2). pii: v11020109. doi: 10.3390/v11020109.
9. Resistance to influenza virus infection of Mx transgenic mice expressing Mx protein under the control of two constitutive promoters. Kolb E, etal., J Virol. 1992 Mar;66(3):1709-16. doi: 10.1128/JVI.66.3.1709-1716.1992.
10. Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium. Lee S, etal., Sci Immunol. 2019 Oct 25;4(40). pii: 4/40/eaau4643. doi: 10.1126/sciimmunol.aau4643.
11. Activity of rat Mx proteins against a rhabdovirus. Meier E, etal., J Virol 1990 Dec;64(12):6263-9.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients. Murakawa M, etal., J Med Virol. 2017 Jul;89(7):1241-1247. doi: 10.1002/jmv.24763. Epub 2017 Feb 27.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Plasmacytoid dendritic cells and type I interferon in the immunological response against warts. Saadeh D, etal., Clin Exp Dermatol. 2017 Dec;42(8):857-862. doi: 10.1111/ced.13187. Epub 2017 Jul 24.
18. Gene polymorphisms of IL-10 and MxA in responders and non-responders to interferon therapy in HCV Egyptian patients genotype 4. Shaker OG, etal., Cell Biochem Biophys. 2015 Mar;71(2):617-25. doi: 10.1007/s12013-014-0241-9.
19. Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region. Tazi-Ahnini R, etal., Hum Genet. 2000 Jun;106(6):639-45. doi: 10.1007/s004390000318.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Blood MxA protein as a marker for respiratory virus infections in young children. Toivonen L, etal., J Clin Virol. 2015 Jan;62:8-13. doi: 10.1016/j.jcv.2014.11.018. Epub 2014 Nov 18.
22. Influence of IL28B and MxA gene polymorphisms on HCV clearance in Han Chinese population. Zang F, etal., Epidemiol Infect. 2018 Feb;146(3):379-385. doi: 10.1017/S0950268817002928. Epub 2017 Dec 22.
23. Association of functional polymorphisms in the MxA gene with susceptibility to enterovirus 71 infection. Zhang X, etal., Hum Genet. 2014 Feb;133(2):187-97. doi: 10.1007/s00439-013-1367-3. Epub 2013 Oct 2.
24. Identification of potentially relevant genes for myocardial infarction using RNA sequencing data analysis. Zhao Q, etal., Exp Ther Med. 2018 Feb;15(2):1456-1464. doi: 10.3892/etm.2017.5580. Epub 2017 Nov 28.
Additional References at PubMed
PMID:12477932   PMID:12892903   PMID:25930096   PMID:28064310   PMID:31904090  


Genomics

Comparative Map Data
Mx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,269,056 - 50,294,699 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1150,269,057 - 50,292,904 (-)EnsemblGRCr8
mRatBN7.21136,799,659 - 36,825,209 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1136,799,660 - 36,823,507 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1145,448,179 - 45,473,727 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01138,119,559 - 38,145,105 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,279,482 - 37,305,028 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01137,891,150 - 37,916,775 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1137,891,156 - 37,914,983 (-)Ensemblrn6Rnor6.0
Rnor_5.01141,398,737 - 41,424,277 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41137,438,473 - 37,462,363 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1136,686,487 - 36,712,040 (-)NCBICelera
RGSC_v3.11137,496,062 - 37,517,940 (-)NCBI
Cytogenetic Map11q12NCBI
MX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382141,420,558 - 41,459,214 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2141,420,020 - 41,470,071 (+)Ensemblhg38GRCh38
GRCh372142,792,485 - 42,831,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362141,720,024 - 41,753,008 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342141,720,023 - 41,753,008NCBI
Celera2127,990,716 - 28,029,320 (+)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2128,261,373 - 28,300,013 (+)NCBIHuRef
CHM1_12142,353,308 - 42,391,928 (+)NCBICHM1_1
T2T-CHM13v2.02139,807,998 - 39,847,898 (+)NCBIT2T-CHM13v2.0
Mx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391697,248,235 - 97,264,106 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1697,248,235 - 97,264,107 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381697,447,035 - 97,462,906 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1697,447,035 - 97,462,907 (-)Ensemblmm10GRCm38
MGSCv371697,668,642 - 97,684,513 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361697,551,947 - 97,567,815 (-)NCBIMGSCv36mm8
Celera1698,507,376 - 98,523,260 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1657.46NCBI

Variants

.
Variants in Mx1
76 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:393
Count of miRNA genes:189
Interacting mature miRNAs:213
Transcripts:ENSRNOT00000039876
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)111080612555806125Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)113532319955805892Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)112995899657754989Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)112631803155806125Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat

Markers in Region
AA997168  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map11261.71UniSTS
Cytogenetic Map11q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 64 163 91 90 59 92 59 6 353 189 11 142 81 92 31 16 16

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC099784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000002695   ⟹   ENSRNOP00000002695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1150,273,396 - 50,283,826 (-)Ensembl
mRatBN7.2 Ensembl1136,803,999 - 36,814,429 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000039876   ⟹   ENSRNOP00000043001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1150,269,057 - 50,292,904 (-)Ensembl
mRatBN7.2 Ensembl1136,799,660 - 36,823,507 (-)Ensembl
Rnor_6.0 Ensembl1137,891,156 - 37,914,983 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094076   ⟹   ENSRNOP00000086162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1150,269,057 - 50,292,904 (-)Ensembl
mRatBN7.2 Ensembl1136,799,660 - 36,823,507 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115496   ⟹   ENSRNOP00000091403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1150,269,057 - 50,292,904 (-)Ensembl
mRatBN7.2 Ensembl1136,799,660 - 36,814,429 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000122776   ⟹   ENSRNOP00000103241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1150,269,057 - 50,292,904 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000134006   ⟹   ENSRNOP00000103032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1150,269,057 - 50,292,904 (-)Ensembl
RefSeq Acc Id: NM_001271058   ⟹   NP_001257987
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,294,606 (-)NCBI
mRatBN7.21136,799,659 - 36,825,209 (-)NCBI
Rnor_6.01137,891,150 - 37,916,690 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Celera1136,686,487 - 36,712,040 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271059   ⟹   NP_001257988
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,294,606 (-)NCBI
mRatBN7.21136,799,659 - 36,825,209 (-)NCBI
Rnor_6.01137,891,150 - 37,916,690 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Celera1136,686,487 - 36,712,040 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271060   ⟹   NP_001257989
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,292,904 (-)NCBI
mRatBN7.21136,799,659 - 36,823,507 (-)NCBI
Rnor_6.01137,891,150 - 37,914,983 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Celera1136,686,487 - 36,710,338 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271061   ⟹   NP_001257990
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,292,904 (-)NCBI
mRatBN7.21136,799,659 - 36,823,507 (-)NCBI
Rnor_6.01137,891,150 - 37,914,983 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Celera1136,686,487 - 36,710,338 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271062   ⟹   NP_001257991
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,292,904 (-)NCBI
mRatBN7.21136,799,659 - 36,823,507 (-)NCBI
Rnor_6.01137,891,150 - 37,914,983 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Celera1136,686,487 - 36,710,338 (-)NCBI
Sequence:
RefSeq Acc Id: NM_173096   ⟹   NP_775119
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,292,904 (-)NCBI
mRatBN7.21136,799,659 - 36,823,507 (-)NCBI
Rnor_6.01137,891,150 - 37,914,983 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
RGSC_v3.41137,438,473 - 37,462,363 (-)RGD
Celera1136,686,487 - 36,710,338 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248146   ⟹   XP_006248208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,294,673 (-)NCBI
mRatBN7.21136,799,659 - 36,825,171 (-)NCBI
Rnor_6.01137,891,150 - 37,916,775 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597877   ⟹   XP_017453366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,294,699 (-)NCBI
mRatBN7.21136,799,659 - 36,825,170 (-)NCBI
Rnor_6.01137,891,150 - 37,916,775 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597878   ⟹   XP_017453367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,293,442 (-)NCBI
mRatBN7.21136,799,659 - 36,824,041 (-)NCBI
Rnor_6.01137,891,150 - 37,915,203 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039087955   ⟹   XP_038943883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,293,455 (-)NCBI
mRatBN7.21136,799,659 - 36,824,040 (-)NCBI
RefSeq Acc Id: XM_039087956   ⟹   XP_038943884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,293,442 (-)NCBI
mRatBN7.21136,799,659 - 36,824,041 (-)NCBI
RefSeq Acc Id: XM_063270276   ⟹   XP_063126346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,294,646 (-)NCBI
RefSeq Acc Id: NP_775119   ⟸   NM_173096
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257988   ⟸   NM_001271059
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257987   ⟸   NM_001271058
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257990   ⟸   NM_001271061
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257989   ⟸   NM_001271060
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257991   ⟸   NM_001271062
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248208   ⟸   XM_006248146
- Peptide Label: isoform X1
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453366   ⟸   XM_017597877
- Peptide Label: isoform X1
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453367   ⟸   XM_017597878
- Peptide Label: isoform X1
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043001   ⟸   ENSRNOT00000039876
RefSeq Acc Id: XP_038943884   ⟸   XM_039087956
- Peptide Label: isoform X1
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943883   ⟸   XM_039087955
- Peptide Label: isoform X1
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086162   ⟸   ENSRNOT00000094076
Ensembl Acc Id: ENSRNOP00000002695   ⟸   ENSRNOT00000002695
Ensembl Acc Id: ENSRNOP00000091403   ⟸   ENSRNOT00000115496
RefSeq Acc Id: XP_063126346   ⟸   XM_063270276
- Peptide Label: isoform X1
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   F7EXA4 (UniProtKB/TrEMBL),   Q499S4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103032   ⟸   ENSRNOT00000134006
Ensembl Acc Id: ENSRNOP00000103241   ⟸   ENSRNOT00000122776
Protein Domains
Dynamin-type G   GED

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18588-F1-model_v2 AlphaFold P18588 1-652 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698092
Promoter ID:EPDNEW_R8616
Type:single initiation site
Name:Mx1_1
Description:myxovirus resistance 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01137,914,983 - 37,915,043EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3127 AgrOrtholog
BioCyc Gene G2FUF-21685 BioCyc
Ensembl Genes ENSRNOG00000001959 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000039876 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
  Dynamin, middle domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7933587 IMAGE-MGC_LOAD
InterPro Dynamin_central UniProtKB/Swiss-Prot
  Dynamin_GTPase UniProtKB/Swiss-Prot
  Dynamin_GTPase_CS UniProtKB/Swiss-Prot
  Dynamin_N UniProtKB/Swiss-Prot
  Dynamin_SF UniProtKB/Swiss-Prot
  G_DYNAMIN_dom UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
  GED_dom UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
MGC_CLONE MGC:124551 IMAGE-MGC_LOAD
NCBI Gene 24575 ENTREZGENE
PANTHER INTERFERON-INDUCED GTP-BINDING PROTEIN MX1 UniProtKB/Swiss-Prot
  PTHR11566 UniProtKB/Swiss-Prot
Pfam Dynamin_M UniProtKB/Swiss-Prot
  Dynamin_N UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
PhenoGen Mx1 PhenoGen
PRINTS DYNAMIN UniProtKB/Swiss-Prot
PROSITE G_DYNAMIN_1 UniProtKB/Swiss-Prot
  G_DYNAMIN_2 UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001959 RatGTEx
SMART DYNc UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
TIGR TC216795
UniProt A0A8I6A1P4_RAT UniProtKB/TrEMBL
  A0A8I6AF56_RAT UniProtKB/TrEMBL
  A0ABK0LF03_RAT UniProtKB/TrEMBL
  A0ABK0LNK6_RAT UniProtKB/TrEMBL
  F7EXA4 ENTREZGENE, UniProtKB/TrEMBL
  F7FNG9_RAT UniProtKB/TrEMBL
  MX1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q499S4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-18 Mx1  MX dynamin like GTPase 1  Mx1  myxovirus (influenza virus) resistance 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Mx1  myxovirus (influenza virus) resistance 1    myxovirus (influenza virus) resistance  Name updated 1299863 APPROVED
2003-04-09 Mx1  myxovirus (influenza virus) resistance    Myxovirus (influenza) resistance, homolog of murine Mx (also interferon-inducible protein IFI78)  Name updated 629478 APPROVED
2002-06-10 Mx1  Myxovirus (influenza) resistance, homolog of murine Mx (also interferon-inducible protein IFI78)      Symbol and Name status set to approved 70586 APPROVED