Muc3 (mucin 3) - Rat Genome Database

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Gene: Muc3 (mucin 3) Rattus norvegicus
Analyze
Symbol: Muc3
Name: mucin 3
RGD ID: 3124
Description: Predicted to enable PDZ domain binding activity. Involved in response to Gram-positive bacterium; response to hormone; and response to vitamin A. Located in apical plasma membrane. Used to study colitis. Biomarker of cholangitis; colitis; liver cirrhosis; and otitis media; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; atrazine; methoxychlor.
Type: protein-coding (Ensembl: pseudogene)
RefSeq Status: MODEL
Previously known as: Muc3a; mucin 3, intestinal; mucin 3A, cell surface associated; mucin-12; mucin-17; Mucin3; uncharacterized protein Muc3
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Alliance Genes
More Info more info ...
Candidate Gene For: Edcs2
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,139,076 - 25,175,249 (+)NCBIGRCr8
mRatBN7.21219,527,251 - 19,536,924 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,527,321 - 19,538,522 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01222,535,663 - 22,584,775 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01224,587,334 - 24,596,304 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1221,304,256 - 21,315,545 (+)NCBICelera
Celera1221,282,333 - 21,289,881 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Intestinal anti-inflammatory activity of hydroalcoholic extracts of Phlomis purpurea L. and Phlomis lychnitis L. in the trinitrobenzenesulphonic acid model of rat colitis. Algieri F, etal., J Ethnopharmacol. 2013 Apr 19;146(3):750-9. doi: 10.1016/j.jep.2013.01.041. Epub 2013 Feb 7.
2. Mucosal function in rat jejunum and ileum is altered by induction of colitis. Amit-Romach E, etal., Int J Mol Med. 2006 Oct;18(4):721-7.
3. Bacterial population and innate immunity-related genes in rat gastrointestinal tract are altered by vitamin A-deficient diet. Amit-Romach E, etal., J Nutr Biochem. 2009 Jan;20(1):70-7. Epub 2008 May 20.
4. Tumor necrosis factor-alpha and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis. Dharmani P, etal., PLoS One. 2011;6(9):e25058. doi: 10.1371/journal.pone.0025058. Epub 2011 Sep 19.
5. Leptin modulates the expression of secreted and membrane-associated mucins in colonic epithelial cells by targeting PKC, PI3K, and MAPK pathways. El Homsi M, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G365-73. Epub 2007 May 10.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Molecular cloning of rat intestinal mucin. Lack of conservation between mammalian species. Gum JR Jr, etal., J Biol Chem 1991 Nov 25;266(33):22733-8.
8. Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis. Khailova L, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Aug 27.
9. Characteristics of rodent intestinal mucin Muc3 and alterations in a mouse model of human cystic fibrosis. Khatri IA, etal., Am J Physiol Gastrointest Liver Physiol. 2001 Jun;280(6):G1321-30.
10. The carboxyl-terminal sequence of rat intestinal mucin RMuc3 contains a putative transmembrane region and two EGF-like motifs. Khatri IA, etal., Biochim Biophys Acta 1997 May 22;1326(1):7-11.
11. Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas. Lee KT and Liu TS, Dig Dis Sci. 2001 Oct;46(10):2166-72.
12. Proliferating cell nuclear antigen shRNA treatment attenuates chronic proliferative cholangitis in rats. Li FY, etal., J Gastroenterol Hepatol. 2009 May;24(5):920-6. Epub 2008 Nov 20.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Aberrant expression of MUC3 and MUC4 membrane-associated mucins and sialyl Le(x) antigen in pancreatic intraepithelial neoplasia. Park HU, etal., Pancreas. 2003 Apr;26(3):e48-54.
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Downregulation of mucins in graft bile ducts after liver transplantation in rats. Tian F, etal., Transplantation. 2011 Sep 15;92(5):529-35. doi: 10.1097/TP.0b013e318229f785.
19. Pattern changes of mucin gene expression with pneumococcal otitis media. Tsuboi Y, etal., Int J Pediatr Otorhinolaryngol. 2001 Oct 19;61(1):23-30.
20. Intestinal microbiota and innate immunity-related gene alteration in cirrhotic rats with liver transplantation. Xie YR, etal., Transplant Proc. 2011 Dec;43(10):3973-9. doi: 10.1016/j.transproceed.2011.08.113.
21. Altered expression of goblet cell- and mucin glycosylation-related genes in the intestinal epithelium during infection with the nematode Nippostrongylus brasiliensis in rat. Yamauchi J, etal., APMIS. 2006 Apr;114(4):270-8.
Additional References at PubMed
PMID:14572308   PMID:18401557   PMID:19561031   PMID:19605529   PMID:23784542   PMID:25459886  


Genomics

Comparative Map Data
Muc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,139,076 - 25,175,249 (+)NCBIGRCr8
mRatBN7.21219,527,251 - 19,536,924 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,527,321 - 19,538,522 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01222,535,663 - 22,584,775 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01224,587,334 - 24,596,304 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1221,304,256 - 21,315,545 (+)NCBICelera
Celera1221,282,333 - 21,289,881 (+)NCBICelera
Cytogenetic Map12q12NCBI
MUC17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387101,020,081 - 101,058,859 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7101,020,072 - 101,058,859 (+)EnsemblGRCh38hg38GRCh38
GRCh377100,663,362 - 100,702,140 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,450,084 - 100,488,860 (+)NCBINCBI36Build 36hg18NCBI36
Build 347100,256,798 - 100,295,455NCBI
Celera795,671,073 - 95,710,172 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef795,258,494 - 95,296,579 (+)NCBIHuRef
CHM1_17100,593,779 - 100,632,528 (+)NCBICHM1_1
T2T-CHM13v2.07102,342,897 - 102,381,677 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27100,021,753 - 100,060,529 (+)NCBI
Muc17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,163,772 - 137,202,809 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,163,770 - 137,202,830 (-)EnsemblGRCm39 Ensembl
GRCm385137,134,924 - 137,166,048 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,134,922 - 137,149,322 (-)EnsemblGRCm38mm10GRCm38
MGSCv375137,610,792 - 137,625,988 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,419,551 - 137,445,679 (-)NCBIMGSCv36mm8
Celera5134,151,710 - 134,169,106 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.22NCBI
LOC100971047
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26119,050,857 - 119,055,193 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17167,315,486 - 167,340,262 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0793,178,939 - 93,198,279 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,419,804 - 106,440,369 (+)NCBIpanpan1.1PanPan1.1panPan2
MUC17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.068,670,002 - 8,682,699 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.168,569,562 - 8,581,646 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,540,038 - 8,556,219 (-)NCBIUNSW_CanFamBas_1.0
LOC101964013
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,049,114 - 133,066,205 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936543976,794 - 987,062 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0

Variants

.
Variants in Muc3
340 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat

Markers in Region
AU049010  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,537,467 - 19,537,677 (+)MAPPERmRatBN7.2
Rnor_6.01222,584,233 - 22,584,442NCBIRnor6.0
Rnor_5.01224,596,771 - 24,596,980UniSTSRnor5.0
Celera1221,314,492 - 21,314,701UniSTS
Cytogenetic Map12q12UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000111775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,527,321 - 19,538,522 (+)Ensembl
RefSeq Acc Id: XM_063271879   ⟹   XP_063127949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,139,076 - 25,175,249 (+)NCBI
Protein Sequences
Protein RefSeqs XP_063127949 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41642 (Get FASTA)   NCBI Sequence Viewer  
  AAB83956 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_063127949   ⟸   XM_063271879

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-19682 BioCyc
Ensembl Genes ENSRNOG00000064303 Ensembl
NCBI Gene Muc3 ENTREZGENE
PhenoGen Muc3 PhenoGen
RatGTEx ENSRNOG00000064303 RatGTEx


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-02-10 Muc3  mucin 3  Muc3  mucin 3, intestinal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-02-10 Muc3  mucin 3, intestinal  Muc3  mucin 3, intestinal  Data merged from RGD:149736452 737654 PROVISIONAL
2021-08-09 Muc3  mucin 3, intestinal      Symbol and Name status set to provisional 45752 PROVISIONAL
2013-09-20 Muc3  mucin 3, intestinal  Muc3a  mucin 3A, cell surface associated  Name and Symbol changed 629549 APPROVED
2008-02-15 Muc3a  mucin 3A, cell surface associated  Muc3  mucin 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Muc3  Mucin3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two EGF motifs and a putative transmembrane domain 633411
gene_expression expressed in small intestine and colon 633411