Muc17 (mucin 17, cell surface associated) - Rat Genome Database

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Gene: Muc17 (mucin 17, cell surface associated) Rattus norvegicus
Analyze
Symbol: Muc17 (Ensembl: Muc3)
Name: mucin 17, cell surface associated (Ensembl:mucin 3)
RGD ID: 3124
Description: Used to study colitis. Biomarker of cholangitis; colitis; liver cirrhosis; and otitis media. Orthologous to human MUC17 (mucin 17, cell surface associated); INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; atrazine; chlorpyrifos.
Type: protein-coding (Ensembl: pseudogene)
RefSeq Status: VALIDATED
Previously known as: Muc3; Muc3a; mucin 3; mucin 3, intestinal; mucin 3A, cell surface associated; mucin-12; mucin-17; Mucin3; uncharacterized protein Muc3
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Candidate Gene For: Edcs2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,139,076 - 25,175,249 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21219,527,251 - 19,536,924 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,527,321 - 19,538,522 (+)EnsemblmRatBN7.2
Rnor_6.01222,535,663 - 22,584,775 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01224,587,334 - 24,596,304 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1221,304,256 - 21,315,545 (+)NCBICelera
Celera1221,282,333 - 21,289,881 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Intestinal anti-inflammatory activity of hydroalcoholic extracts of Phlomis purpurea L. and Phlomis lychnitis L. in the trinitrobenzenesulphonic acid model of rat colitis. Algieri F, etal., J Ethnopharmacol. 2013 Apr 19;146(3):750-9. doi: 10.1016/j.jep.2013.01.041. Epub 2013 Feb 7.
2. Mucosal function in rat jejunum and ileum is altered by induction of colitis. Amit-Romach E, etal., Int J Mol Med. 2006 Oct;18(4):721-7.
3. Bacterial population and innate immunity-related genes in rat gastrointestinal tract are altered by vitamin A-deficient diet. Amit-Romach E, etal., J Nutr Biochem. 2009 Jan;20(1):70-7. Epub 2008 May 20.
4. Tumor necrosis factor-alpha and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis. Dharmani P, etal., PLoS One. 2011;6(9):e25058. doi: 10.1371/journal.pone.0025058. Epub 2011 Sep 19.
5. Leptin modulates the expression of secreted and membrane-associated mucins in colonic epithelial cells by targeting PKC, PI3K, and MAPK pathways. El Homsi M, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G365-73. Epub 2007 May 10.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Molecular cloning of rat intestinal mucin. Lack of conservation between mammalian species. Gum JR Jr, etal., J Biol Chem 1991 Nov 25;266(33):22733-8.
8. Bifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis. Khailova L, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Aug 27.
9. Characteristics of rodent intestinal mucin Muc3 and alterations in a mouse model of human cystic fibrosis. Khatri IA, etal., Am J Physiol Gastrointest Liver Physiol. 2001 Jun;280(6):G1321-30.
10. The carboxyl-terminal sequence of rat intestinal mucin RMuc3 contains a putative transmembrane region and two EGF-like motifs. Khatri IA, etal., Biochim Biophys Acta 1997 May 22;1326(1):7-11.
11. Altered mucin gene expression in stone-containing intrahepatic bile ducts and cholangiocarcinomas. Lee KT and Liu TS, Dig Dis Sci. 2001 Oct;46(10):2166-72.
12. Proliferating cell nuclear antigen shRNA treatment attenuates chronic proliferative cholangitis in rats. Li FY, etal., J Gastroenterol Hepatol. 2009 May;24(5):920-6. Epub 2008 Nov 20.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Aberrant expression of MUC3 and MUC4 membrane-associated mucins and sialyl Le(x) antigen in pancreatic intraepithelial neoplasia. Park HU, etal., Pancreas. 2003 Apr;26(3):e48-54.
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. Downregulation of mucins in graft bile ducts after liver transplantation in rats. Tian F, etal., Transplantation. 2011 Sep 15;92(5):529-35. doi: 10.1097/TP.0b013e318229f785.
19. Pattern changes of mucin gene expression with pneumococcal otitis media. Tsuboi Y, etal., Int J Pediatr Otorhinolaryngol. 2001 Oct 19;61(1):23-30.
20. Intestinal microbiota and innate immunity-related gene alteration in cirrhotic rats with liver transplantation. Xie YR, etal., Transplant Proc. 2011 Dec;43(10):3973-9. doi: 10.1016/j.transproceed.2011.08.113.
21. Altered expression of goblet cell- and mucin glycosylation-related genes in the intestinal epithelium during infection with the nematode Nippostrongylus brasiliensis in rat. Yamauchi J, etal., APMIS. 2006 Apr;114(4):270-8.
Additional References at PubMed
PMID:14572308   PMID:18401557   PMID:19561031   PMID:19605529   PMID:23784542   PMID:25459886  


Genomics

Comparative Map Data
Muc17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81225,139,076 - 25,175,249 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.21219,527,251 - 19,536,924 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,527,321 - 19,538,522 (+)EnsemblmRatBN7.2
Rnor_6.01222,535,663 - 22,584,775 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01224,587,334 - 24,596,304 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1221,304,256 - 21,315,545 (+)NCBICelera
Celera1221,282,333 - 21,289,881 (+)NCBICelera
Cytogenetic Map12q12NCBI
MUC17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387101,020,081 - 101,058,859 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7101,020,072 - 101,058,859 (+)Ensemblhg38GRCh38
GRCh377100,663,362 - 100,702,140 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,450,084 - 100,488,860 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347100,256,798 - 100,295,455NCBI
Celera795,671,073 - 95,710,172 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef795,258,494 - 95,296,579 (+)NCBIHuRef
CHM1_17100,593,779 - 100,632,528 (+)NCBICHM1_1
T2T-CHM13v2.07102,342,897 - 102,381,677 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27100,021,753 - 100,060,529 (+)NCBI
Muc17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,163,772 - 137,202,809 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,163,770 - 137,202,830 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385137,134,924 - 137,166,048 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,134,922 - 137,149,322 (-)Ensemblmm10GRCm38
MGSCv375136,105,837 - 136,121,208 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365137,419,551 - 137,445,679 (-)NCBIMGSCv36mm8
Celera5134,151,710 - 134,169,106 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.22NCBI
LOC100971047
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26119,050,857 - 119,055,193 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17167,315,486 - 167,340,262 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0793,178,939 - 93,198,279 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,419,804 - 106,440,369 (+)NCBIPanPan1.1PanPan1.1panPan2
MUC17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.068,670,002 - 8,682,699 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.168,569,562 - 8,581,646 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,540,038 - 8,556,219 (-)NCBIUNSW_CanFamBas_1.0
LOC101964013
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,049,114 - 133,066,205 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543976,875 - 986,924 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936543976,794 - 987,062 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUC17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,138,287 - 12,142,284 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660704,191,344 - 4,224,366 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Muc17
305 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)122013902826430640Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
AU049010  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21219,537,467 - 19,537,677 (+)MAPPERmRatBN7.2
Rnor_6.01222,584,233 - 22,584,442NCBIRnor6.0
Rnor_5.01224,596,771 - 24,596,980UniSTSRnor5.0
Celera1221,314,492 - 21,314,701UniSTS
Cytogenetic Map12q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
hemolymphoid system
mesenchyme
mesoderm
renal system
reproductive system
7 2 10 2 1 6

Sequence


Ensembl Acc Id: ENSRNOT00000111775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1219,527,321 - 19,538,522 (+)Ensembl
RefSeq Acc Id: XM_063271879   ⟹   XP_063127949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81225,139,076 - 25,175,249 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001419348 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127949 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41642 (Get FASTA)   NCBI Sequence Viewer  
  AAB83956 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_063127949   ⟸   XM_063271879

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3124 AgrOrtholog
BioCyc Gene G2FUF-19682 BioCyc
Ensembl Genes ENSRNOG00000064303 Ensembl
NCBI Gene Muc3 ENTREZGENE
PhenoGen Muc17 PhenoGen
RatGTEx ENSRNOG00000064303 RatGTEx


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-07-30 Muc17  mucin 17, cell surface associated  Muc3  mucin 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-02-10 Muc3  mucin 3  Muc3  mucin 3, intestinal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-02-10 Muc3  mucin 3, intestinal  Muc3  mucin 3, intestinal  Data merged from RGD:149736452 737654 PROVISIONAL
2021-08-09 Muc3  mucin 3, intestinal      Symbol and Name status set to provisional 45752 PROVISIONAL
2013-09-20 Muc3  mucin 3, intestinal  Muc3a  mucin 3A, cell surface associated  Name and Symbol changed 629549 APPROVED
2008-02-15 Muc3a  mucin 3A, cell surface associated  Muc3  mucin 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Muc3  Mucin3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two EGF motifs and a putative transmembrane domain 633411
gene_expression expressed in small intestine and colon 633411