Mras (muscle RAS oncogene homolog) - Rat Genome Database

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Gene: Mras (muscle RAS oncogene homolog) Rattus norvegicus
Analyze
Symbol: Mras
Name: muscle RAS oncogene homolog
RGD ID: 3111
Description: Predicted to enable GTP-dependent protein binding activity and GTPase activity. Predicted to be involved in Ras protein signal transduction and establishment or maintenance of cell polarity. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in membrane. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome 11. Orthologous to human MRAS (muscle RAS oncogene homolog); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: muscle and microspikes RAS; ras-related protein M-Ras; ras-related protein R-Ras3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88108,823,374 - 108,886,104 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8108,823,374 - 108,875,911 (-)EnsemblGRCr8
mRatBN7.2899,944,036 - 100,006,771 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl899,944,036 - 99,996,408 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8105,610,343 - 105,663,748 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08103,809,642 - 103,863,053 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08101,652,159 - 101,705,561 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd8109,728,859 - 109,782,305 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive8111,833,636 - 111,887,086 (-)NCBILyon_Normotensive
Lyon_Hypertensive8110,322,899 - 110,376,348 (-)NCBILyon_Hypertensive
F344_StmMcwi8101,732,313 - 101,785,765 (-)NCBIF344_StmMcwi
Rnor_6.08107,629,028 - 107,656,851 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8107,629,028 - 107,681,512 (-)Ensemblrn6Rnor6.0
Rnor_5.08107,054,728 - 107,082,497 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48104,244,660 - 104,272,556 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera899,345,811 - 99,373,539 (-)NCBICelera
RGSC_v3.18104,264,114 - 104,292,011 (-)NCBI
Cytogenetic Map8q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbonyl sulfide  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
D-glucose  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP,ISO)
Doramectin  (EXP)
ethanol  (ISO)
etoposide  (ISO)
febuxostat  (ISO)
fipronil  (EXP)
furan  (EXP)
glucose  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
ketamine  (EXP)
ketoconazole  (ISO)
leflunomide  (ISO)
lithocholic acid  (EXP)
manumycin A  (EXP)
methoxychlor  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
orphenadrine  (EXP)
ouabain  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
rac-lactic acid  (ISO)
rotenone  (EXP)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulindac sulfide  (ISO)
tetrachloromethane  (EXP)
thiram  (ISO)
tipifarnib  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton. Matsumoto K, etal., Oncogene 1997 Nov 13;15(20):2409-17.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
10. Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. Willard FS, etal., PLoS One. 2009;4(3):e4884. doi: 10.1371/journal.pone.0004884. Epub 2009 Mar 25.
Additional References at PubMed
PMID:10934204   PMID:12477932   PMID:16923128   PMID:19444311   PMID:20439489   PMID:23376485   PMID:28289718  


Genomics

Comparative Map Data
Mras
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88108,823,374 - 108,886,104 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8108,823,374 - 108,875,911 (-)EnsemblGRCr8
mRatBN7.2899,944,036 - 100,006,771 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl899,944,036 - 99,996,408 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8105,610,343 - 105,663,748 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08103,809,642 - 103,863,053 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08101,652,159 - 101,705,561 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd8109,728,859 - 109,782,305 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive8111,833,636 - 111,887,086 (-)NCBILyon_Normotensive
Lyon_Hypertensive8110,322,899 - 110,376,348 (-)NCBILyon_Hypertensive
F344_StmMcwi8101,732,313 - 101,785,765 (-)NCBIF344_StmMcwi
Rnor_6.08107,629,028 - 107,656,851 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8107,629,028 - 107,681,512 (-)Ensemblrn6Rnor6.0
Rnor_5.08107,054,728 - 107,082,497 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48104,244,660 - 104,272,556 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera899,345,811 - 99,373,539 (-)NCBICelera
RGSC_v3.18104,264,114 - 104,292,011 (-)NCBI
Cytogenetic Map8q31NCBI
MRAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383138,347,648 - 138,405,535 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3138,347,648 - 138,405,534 (+)Ensemblhg38GRCh38
GRCh373138,066,490 - 138,124,377 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363139,549,315 - 139,607,067 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343139,574,404 - 139,607,073NCBI
Celera3136,491,513 - 136,549,286 (+)NCBICelera
Cytogenetic Map3q22.3NCBI
HuRef3135,441,552 - 135,499,356 (+)NCBIHuRef
CHM1_13138,030,261 - 138,088,159 (+)NCBICHM1_1
T2T-CHM13v2.03141,088,198 - 141,146,101 (+)NCBIT2T-CHM13v2.0
Mras
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39999,267,473 - 99,319,505 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl999,267,473 - 99,319,434 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38999,385,420 - 99,437,700 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl999,385,420 - 99,437,381 (-)Ensemblmm10GRCm38
MGSCv37999,285,839 - 99,337,131 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36999,197,328 - 99,246,063 (-)NCBIMGSCv36mm8
Celera998,920,430 - 98,971,712 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map951.63NCBI
Mras
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955501615,303 - 670,782 (-)Ensembl
ChiLan1.0NW_004955501615,303 - 670,404 (-)NCBIChiLan1.0ChiLan1.0
MRAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22136,253,974 - 136,311,964 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13136,258,713 - 136,316,693 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03135,377,488 - 135,435,338 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13142,827,020 - 142,884,582 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3142,827,020 - 142,884,582 (+)EnsemblpanPan2panpan1.1
MRAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12334,558,278 - 34,613,987 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2334,582,314 - 34,611,763 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2334,550,398 - 34,607,319 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02335,098,326 - 35,155,275 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2335,099,325 - 35,157,728 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12334,779,709 - 34,836,613 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02334,845,153 - 34,902,406 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02335,096,331 - 35,153,294 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mras
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560273,933,041 - 73,985,346 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936540672,544 - 725,143 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936540672,783 - 725,129 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1379,139,764 - 79,211,135 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11379,137,489 - 79,211,139 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21386,781,175 - 86,826,924 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MRAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11552,137,409 - 52,195,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1552,135,727 - 52,170,020 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604125,149,689 - 25,208,288 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mras
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473014,879,484 - 14,940,255 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473014,879,631 - 14,938,683 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mras
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1890,726,227 - 90,778,971 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mras
295 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:962
Count of miRNA genes:331
Interacting mature miRNAs:443
Transcripts:ENSRNOT00000050374
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000050374   ⟹   ENSRNOP00000045851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8108,823,374 - 108,869,968 (-)Ensembl
mRatBN7.2 Ensembl899,944,036 - 99,978,327 (-)Ensembl
Rnor_6.0 Ensembl8107,629,028 - 107,656,861 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077963   ⟹   ENSRNOP00000072543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl899,946,502 - 99,996,408 (-)Ensembl
Rnor_6.0 Ensembl8107,631,488 - 107,681,512 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118697   ⟹   ENSRNOP00000085134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8108,823,374 - 108,875,911 (-)Ensembl
mRatBN7.2 Ensembl899,944,036 - 99,973,929 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000157189   ⟹   ENSRNOP00000099587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8108,823,374 - 108,858,008 (-)Ensembl
RefSeq Acc Id: NM_001388501   ⟹   NP_001375430
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,823,374 - 108,876,147 (-)NCBI
mRatBN7.2899,944,036 - 99,996,814 (-)NCBI
Dahl_SR_JrHsd8109,728,859 - 109,782,305 (-)NCBI
Lyon_Normotensive8111,833,636 - 111,887,086 (-)NCBI
Lyon_Hypertensive8110,322,899 - 110,376,348 (-)NCBI
F344_StmMcwi8101,732,313 - 101,785,765 (-)NCBI
RefSeq Acc Id: NM_012981   ⟹   NP_037113
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,823,374 - 108,875,911 (-)NCBI
mRatBN7.2899,944,036 - 99,996,578 (-)NCBI
Dahl_SR_JrHsd8109,728,859 - 109,782,069 (-)NCBI
Lyon_Normotensive8111,833,636 - 111,886,850 (-)NCBI
Lyon_Hypertensive8110,322,899 - 110,376,112 (-)NCBI
F344_StmMcwi8101,732,313 - 101,785,529 (-)NCBI
Rnor_6.08107,629,028 - 107,656,851 (-)NCBI
Rnor_5.08107,054,728 - 107,082,497 (-)NCBI
RGSC_v3.48104,244,660 - 104,272,556 (-)RGD
Celera899,345,811 - 99,373,539 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080883   ⟹   XP_038936811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,823,377 - 108,857,628 (-)NCBI
mRatBN7.2899,944,039 - 99,978,326 (-)NCBI
RefSeq Acc Id: XM_039080884   ⟹   XP_038936812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,823,377 - 108,875,859 (-)NCBI
mRatBN7.2899,944,039 - 99,996,526 (-)NCBI
RefSeq Acc Id: XM_039080887   ⟹   XP_038936815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,823,377 - 108,886,104 (-)NCBI
mRatBN7.2899,944,039 - 100,006,771 (-)NCBI
RefSeq Acc Id: XM_063264949   ⟹   XP_063121019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88108,823,377 - 108,875,859 (-)NCBI
RefSeq Acc Id: NP_037113   ⟸   NM_012981
- UniProtKB: P97538 (UniProtKB/Swiss-Prot),   O09021 (UniProtKB/Swiss-Prot),   Q5RKJ7 (UniProtKB/TrEMBL),   A6I2D6 (UniProtKB/TrEMBL),   A0A0G2K389 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072543   ⟸   ENSRNOT00000077963
Ensembl Acc Id: ENSRNOP00000045851   ⟸   ENSRNOT00000050374
RefSeq Acc Id: NP_001375430   ⟸   NM_001388501
- UniProtKB: P97538 (UniProtKB/Swiss-Prot),   O09021 (UniProtKB/Swiss-Prot),   Q5RKJ7 (UniProtKB/TrEMBL),   A6I2D6 (UniProtKB/TrEMBL),   A0A0G2K389 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936815   ⟸   XM_039080887
- Peptide Label: isoform X2
- UniProtKB: P97538 (UniProtKB/Swiss-Prot),   O09021 (UniProtKB/Swiss-Prot),   Q5RKJ7 (UniProtKB/TrEMBL),   A6I2D6 (UniProtKB/TrEMBL),   A0A0G2K389 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936812   ⟸   XM_039080884
- Peptide Label: isoform X2
- UniProtKB: P97538 (UniProtKB/Swiss-Prot),   O09021 (UniProtKB/Swiss-Prot),   Q5RKJ7 (UniProtKB/TrEMBL),   A6I2D6 (UniProtKB/TrEMBL),   A0A0G2K389 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936811   ⟸   XM_039080883
- Peptide Label: isoform X1
- UniProtKB: F7FMZ0 (UniProtKB/TrEMBL),   A0A8I6A109 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085134   ⟸   ENSRNOT00000118697
RefSeq Acc Id: XP_063121019   ⟸   XM_063264949
- Peptide Label: isoform X2
- UniProtKB: P97538 (UniProtKB/Swiss-Prot),   O09021 (UniProtKB/Swiss-Prot),   A0A0G2K389 (UniProtKB/TrEMBL),   A6I2D6 (UniProtKB/TrEMBL),   Q5RKJ7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099587   ⟸   ENSRNOT00000157189

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97538-F1-model_v2 AlphaFold P97538 1-208 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3111 AgrOrtholog
BioCyc Gene G2FUF-29396 BioCyc
Ensembl Genes ENSRNOG00000014060 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000050374 ENTREZGENE
  ENSRNOT00000118697 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7130510 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
  Small_GTPase_Ras-type UniProtKB/Swiss-Prot
MGC_CLONE MGC:93575 IMAGE-MGC_LOAD
NCBI Gene 25482 ENTREZGENE
PANTHER PTHR24070 UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PhenoGen Mras PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014060 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAN UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
TIGR TC206441
UniProt A0A0G2K389 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A109 ENTREZGENE
  A0ABK0L9P9_RAT UniProtKB/TrEMBL
  A6I2D6 ENTREZGENE, UniProtKB/TrEMBL
  F7FMZ0 ENTREZGENE, UniProtKB/TrEMBL
  O09021 ENTREZGENE
  P97538 ENTREZGENE
  Q5RKJ7 ENTREZGENE
  RASM_RAT UniProtKB/Swiss-Prot
UniProt Secondary O09021 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-11 Mras  muscle RAS oncogene homolog  Mras  muscle and microspikes RAS  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mras  Muscle and microspikes RAS      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function has GTP-binding and GTPase activities 729080