Map1a (microtubule-associated protein 1A) - Rat Genome Database

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Gene: Map1a (microtubule-associated protein 1A) Rattus norvegicus
Analyze
Symbol: Map1a
Name: microtubule-associated protein 1A
RGD ID: 3042
Description: Enables actin binding activity; collagen binding activity; and microtubule binding activity. A structural constituent of presynapse. Involved in negative regulation of microtubule depolymerization. Located in several cellular components, including axon; dendrite; and neuronal cell body. Part of microtubule associated complex. Is active in glutamatergic synapse; postsynaptic density; and presynaptic active zone. Biomarker of hypothyroidism. Orthologous to human MAP1A (microtubule associated protein 1A); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MAP-1A; microtubule-associated protein 1 A; Mtap1a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83128,716,907 - 128,736,638 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3128,716,940 - 128,740,159 (+)EnsemblGRCr8
mRatBN7.23108,263,217 - 108,283,936 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3108,263,151 - 108,282,899 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3111,944,164 - 111,958,119 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03120,539,685 - 120,553,639 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03118,200,086 - 118,214,040 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03113,251,918 - 113,272,193 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3113,251,778 - 113,272,186 (+)Ensemblrn6Rnor6.0
Rnor_5.03119,791,740 - 119,811,429 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43108,097,119 - 108,111,060 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3107,171,142 - 107,185,083 (+)NCBICelera
RGSC_v3.13107,996,094 - 108,010,036 (+)NCBI
Cytogenetic Map3q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,5-hexanedione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
cantharidin  (ISO)
clozapine  (EXP,ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
FR900359  (ISO)
haloperidol  (EXP,ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
Moniliformin  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
razoxane  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
zebularine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Effect of hypothyroidism on the expression of three microtubule-associated proteins (1A, 1B and 2) in developing rat cerebellum. Benjamin S, etal., Neuroscience. 1988 Dec;27(3):931-9.
2. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. Brenman JE, etal., J Neurosci. 1998 Nov 1;18(21):8805-13.
3. Microtubule formation and neurite growth in cerebellar macroneurons which develop in vitro: evidence for the involvement of the microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau. Ferreira A, etal., Brain Res Dev Brain Res. 1989 Oct 1;49(2):215-28.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons. Gumy LF, etal., Neuron. 2017 Apr 19;94(2):347-362.e7. doi: 10.1016/j.neuron.2017.03.046.
7. Microtubule-associated proteins 1A and LC2. Two proteins encoded in one messenger RNA. Langkopf A, etal., J Biol Chem 1992 Aug 15;267(23):16561-6.
8. The role of MAP1A light chain 2 in synaptic surface retention of Cav2.2 channels in hippocampal neurons. Leenders AG, etal., J Neurosci. 2008 Oct 29;28(44):11333-46. doi: 10.1523/JNEUROSCI.3078-08.2008.
9. Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A. Magiera MM, etal., Biochem J. 2004 Sep 15;382(Pt 3):803-10.
10. Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B. Mann SS and Hammarback JA, J Biol Chem 1994 Apr 15;269(15):11492-7.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Microtubule-associated protein 1A (MAP1A) and MAP1B: light chains determine distinct functional properties. Noiges R, etal., J Neurosci 2002 Mar 15;22(6):2106-14.
14. Interactions between adaptor protein-1 of the clathrin coat and microtubules via type 1a microtubule-associated proteins. Orzech E, etal., J Biol Chem 2001 Aug 17;276(33):31340-8.
15. Microtubule-associated protein 1a is involved in the early development of the rat spinal cord. Oudega M, etal., Neurosci Lett. 1998 Apr 24;246(2):81-4.
16. Direct interaction between BKCa potassium channel and microtubule-associated protein 1A. Park SM, etal., FEBS Lett. 2004 Jul 16;570(1-3):143-8.
17. The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a. Reese ML, etal., Nat Struct Mol Biol. 2007 Feb;14(2):155-63. Epub 2007 Jan 14.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Transcortical alterations in Na(+)-K+ ATPase and microtubule-associated proteins immunoreactivity in the rat cortical atrophy model induced by hypoxic ischemia. Suh JG, etal., Neural Plast 2002;9(3):135-46.
22. Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Tortosa E, etal., Neuron. 2017 May 17;94(4):809-825.e7. doi: 10.1016/j.neuron.2017.04.042.
Additional References at PubMed
PMID:8990203   PMID:11925566   PMID:12480186   PMID:15136571   PMID:16243028   PMID:17114649   PMID:17360631   PMID:17643062   PMID:21700703   PMID:22252785   PMID:22323461   PMID:22779921  
PMID:22871113   PMID:24664738   PMID:25788676   PMID:26609151   PMID:29476059   PMID:32357304   PMID:35352799   PMID:36414406   PMID:37705167  


Genomics

Comparative Map Data
Map1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83128,716,907 - 128,736,638 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3128,716,940 - 128,740,159 (+)EnsemblGRCr8
mRatBN7.23108,263,217 - 108,283,936 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3108,263,151 - 108,282,899 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3111,944,164 - 111,958,119 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03120,539,685 - 120,553,639 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03118,200,086 - 118,214,040 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03113,251,918 - 113,272,193 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3113,251,778 - 113,272,186 (+)Ensemblrn6Rnor6.0
Rnor_5.03119,791,740 - 119,811,429 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43108,097,119 - 108,111,060 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3107,171,142 - 107,185,083 (+)NCBICelera
RGSC_v3.13107,996,094 - 108,010,036 (+)NCBI
Cytogenetic Map3q35NCBI
MAP1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381543,510,954 - 43,531,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1543,510,958 - 43,531,620 (+)Ensemblhg38GRCh38
GRCh371543,803,152 - 43,823,809 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361541,597,098 - 41,611,110 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341541,597,132 - 41,611,109NCBI
Celera1520,580,478 - 20,594,490 (+)NCBICelera
Cytogenetic Map15q15.3NCBI
HuRef1520,657,744 - 20,671,755 (+)NCBIHuRef
CHM1_11543,928,513 - 43,942,525 (+)NCBICHM1_1
T2T-CHM13v2.01541,318,305 - 41,338,962 (+)NCBIT2T-CHM13v2.0
Map1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392121,119,608 - 121,141,313 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2121,120,081 - 121,141,313 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382121,289,590 - 121,310,832 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2121,289,600 - 121,310,832 (+)Ensemblmm10GRCm38
MGSCv372121,115,338 - 121,136,568 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362121,115,336 - 121,136,568 (+)NCBIMGSCv36mm8
Celera2122,440,757 - 122,461,952 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.37NCBI
Map1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541610,053,010 - 10,071,421 (+)Ensembl
ChiLan1.0NW_00495541610,052,964 - 10,073,318 (+)NCBIChiLan1.0ChiLan1.0
MAP1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21632,763,190 - 32,784,258 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11536,925,299 - 36,945,980 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01522,472,641 - 22,493,293 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11540,627,099 - 40,647,752 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1540,627,099 - 40,647,752 (+)EnsemblpanPan2panpan1.1
MAP1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13010,361,871 - 10,382,780 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3010,361,909 - 10,381,376 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3010,420,363 - 10,441,256 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03010,498,020 - 10,519,195 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3010,497,473 - 10,519,193 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13010,413,992 - 10,434,829 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03010,535,945 - 10,556,802 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03010,655,574 - 10,676,454 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Map1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864088,837,633 - 88,858,797 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364716,685,728 - 6,705,477 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364716,685,565 - 6,706,860 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1127,916,644 - 127,936,955 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11127,916,639 - 127,936,952 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21142,763,146 - 142,783,427 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12639,469,013 - 39,489,666 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2639,468,222 - 39,489,613 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048101,524,663 - 101,545,324 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480410,611,672 - 10,630,881 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480410,611,657 - 10,632,199 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Map1a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1599,442,471 - 99,462,117 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Map1a
135 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:202
Count of miRNA genes:124
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000019320
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
MDB0962  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23108,282,689 - 108,282,842 (+)MAPPERmRatBN7.2
Rnor_6.03113,271,420 - 113,271,572NCBIRnor6.0
Rnor_5.03119,811,218 - 119,811,370UniSTSRnor5.0
RGSC_v3.43108,110,851 - 108,111,003UniSTSRGSC3.4
Celera3107,184,874 - 107,185,026UniSTS
Cytogenetic Map3q36UniSTS
AI711500  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23108,282,689 - 108,282,880 (+)MAPPERmRatBN7.2
Rnor_6.03113,271,420 - 113,271,610NCBIRnor6.0
Rnor_5.03119,811,218 - 119,811,408UniSTSRnor5.0
RGSC_v3.43108,110,851 - 108,111,041UniSTSRGSC3.4
Celera3107,184,874 - 107,185,064UniSTS
RH 3.4 Map3948.4UniSTS
Cytogenetic Map3q36UniSTS
BE118757  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23108,278,273 - 108,278,450 (+)MAPPERmRatBN7.2
Rnor_6.03113,267,004 - 113,267,180NCBIRnor6.0
Rnor_5.03119,806,802 - 119,806,978UniSTSRnor5.0
RGSC_v3.43108,106,435 - 108,106,611UniSTSRGSC3.4
Celera3107,180,458 - 107,180,634UniSTS
RH 3.4 Map3948.4UniSTS
Cytogenetic Map3q36UniSTS
stSG627752  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23108,273,238 - 108,274,432 (+)MAPPERmRatBN7.2
Rnor_6.03113,261,969 - 113,263,162NCBIRnor6.0
Rnor_5.03119,801,767 - 119,802,960UniSTSRnor5.0
RGSC_v3.43108,101,400 - 108,102,593UniSTSRGSC3.4
Celera3107,175,423 - 107,176,616UniSTS
Cytogenetic Map3q36UniSTS
ksks17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23108,272,921 - 108,273,275 (+)MAPPERmRatBN7.2
Rnor_6.03113,261,652 - 113,262,005NCBIRnor6.0
Rnor_5.03119,801,450 - 119,801,803UniSTSRnor5.0
RGSC_v3.43108,101,083 - 108,101,436UniSTSRGSC3.4
Celera3107,175,106 - 107,175,459UniSTS
Cytogenetic Map3q36UniSTS
D15S801  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83128,727,204 - 128,727,315 (+)Marker Load Pipeline
mRatBN7.23108,273,466 - 108,273,578 (+)MAPPERmRatBN7.2
Rnor_6.03113,262,197 - 113,262,308NCBIRnor6.0
Rnor_5.03119,801,995 - 119,802,106UniSTSRnor5.0
RGSC_v3.43108,101,628 - 108,101,739UniSTSRGSC3.4
Celera3107,175,651 - 107,175,762UniSTS
Cytogenetic Map3q36UniSTS
ECD00556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23108,274,296 - 108,275,190 (+)MAPPERmRatBN7.2
Rnor_6.03113,263,027 - 113,263,920NCBIRnor6.0
Rnor_5.03119,802,825 - 119,803,718UniSTSRnor5.0
RGSC_v3.43108,102,458 - 108,103,351UniSTSRGSC3.4
Celera3107,176,481 - 107,177,374UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 73 59 6 332 173 11 143 76 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019320   ⟹   ENSRNOP00000019320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3128,722,657 - 128,740,159 (+)Ensembl
mRatBN7.2 Ensembl3108,268,958 - 108,282,899 (+)Ensembl
Rnor_6.0 Ensembl3113,257,688 - 113,271,629 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083005   ⟹   ENSRNOP00000073375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3128,716,940 - 128,736,638 (+)Ensembl
mRatBN7.2 Ensembl3108,263,151 - 108,282,899 (+)Ensembl
Rnor_6.0 Ensembl3113,251,778 - 113,272,186 (+)Ensembl
RefSeq Acc Id: NM_030995   ⟹   NP_112257
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,722,695 - 128,736,638 (+)NCBI
mRatBN7.23108,268,958 - 108,282,901 (+)NCBI
Rnor_6.03113,257,688 - 113,271,629 (+)NCBI
Rnor_5.03119,791,740 - 119,811,429 (+)NCBI
RGSC_v3.43108,097,119 - 108,111,060 (+)RGD
Celera3107,171,142 - 107,185,083 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234826   ⟹   XP_006234888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,716,907 - 128,736,635 (+)NCBI
mRatBN7.23108,263,218 - 108,283,936 (+)NCBI
Rnor_6.03113,251,918 - 113,272,193 (+)NCBI
Rnor_5.03119,791,740 - 119,811,429 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234828   ⟹   XP_006234890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,723,153 - 128,736,635 (+)NCBI
mRatBN7.23108,269,197 - 108,283,936 (+)NCBI
Rnor_6.03113,257,890 - 113,272,193 (+)NCBI
Rnor_5.03119,791,740 - 119,811,429 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762145   ⟹   XP_008760367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,722,738 - 128,736,635 (+)NCBI
mRatBN7.23108,269,003 - 108,283,936 (+)NCBI
Rnor_6.03113,257,774 - 113,272,193 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104338   ⟹   XP_038960266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83128,716,907 - 128,736,635 (+)NCBI
mRatBN7.23108,263,217 - 108,283,936 (+)NCBI
RefSeq Acc Id: NP_112257   ⟸   NM_030995
- UniProtKB: P34926 (UniProtKB/Swiss-Prot),   G3V7U2 (UniProtKB/TrEMBL),   A6HPN2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234888   ⟸   XM_006234826
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5C6 (UniProtKB/TrEMBL),   A6HPN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234890   ⟸   XM_006234828
- Peptide Label: isoform X3
- UniProtKB: P34926 (UniProtKB/Swiss-Prot),   G3V7U2 (UniProtKB/TrEMBL),   A6HPN2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760367   ⟸   XM_008762145
- Peptide Label: isoform X3
- UniProtKB: P34926 (UniProtKB/Swiss-Prot),   G3V7U2 (UniProtKB/TrEMBL),   A6HPN2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073375   ⟸   ENSRNOT00000083005
Ensembl Acc Id: ENSRNOP00000019320   ⟸   ENSRNOT00000019320
RefSeq Acc Id: XP_038960266   ⟸   XM_039104338
- Peptide Label: isoform X2
- UniProtKB: A6HPN1 (UniProtKB/TrEMBL)
Protein Domains
Microtubule-associated protein 1A/B/S-like MBL-like   Microtubule-associated protein 1B/S N-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692353
Promoter ID:EPDNEW_R2878
Type:multiple initiation site
Name:Map1a_1
Description:microtubule-associated protein 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03113,257,688 - 113,257,748EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3042 AgrOrtholog
BioCyc Gene G2FUF-48139 BioCyc
Ensembl Genes ENSRNOG00000014230 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000083005 ENTREZGENE
InterPro MAP1 UniProtKB/Swiss-Prot
  RibonucZ/Hydroxyglut_hydro UniProtKB/Swiss-Prot
KEGG Report rno:25152 UniProtKB/Swiss-Prot
NCBI Gene 25152 ENTREZGENE
PANTHER PTHR13843 UniProtKB/Swiss-Prot
  PTHR13843:SF6 UniProtKB/Swiss-Prot
Pfam MBL_MAP1B UniProtKB/Swiss-Prot
PhenoGen Map1a PhenoGen
RatGTEx ENSRNOG00000014230 RatGTEx
Superfamily-SCOP SSF56281 UniProtKB/Swiss-Prot
UniProt A0A0G2K5C6 ENTREZGENE, UniProtKB/TrEMBL
  A6HPN1 ENTREZGENE, UniProtKB/TrEMBL
  A6HPN2 ENTREZGENE, UniProtKB/TrEMBL
  G3V7U2 ENTREZGENE, UniProtKB/TrEMBL
  MAP1A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-08-29 Map1a  microtubule-associated protein 1A  Mtap1a  microtubule-associated protein 1 A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Mtap1a  microtubule-associated protein 1 A  Map1a  Microtubule-associated protein 1a  Name updated 625702 APPROVED
2002-06-10 Map1a  Microtubule-associated protein 1a      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein translated as a pre-MAP1A/LC2-protein with the structurally related polypeptides, associated light chain LC2 633244