Lyz2 (lysozyme 2) - Rat Genome Database

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Gene: Lyz2 (lysozyme 2) Rattus norvegicus
Analyze
Symbol: Lyz2
Name: lysozyme 2
RGD ID: 3026
Description: Enables lysozyme activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Located in several cellular components, including Golgi cis cisterna; cytoplasmic vesicle; and rough endoplasmic reticulum lumen. Orthologous to human LYZ (lysozyme); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1,4-beta-N-acetylmuramidase C; lysozyme; lysozyme C-1; Lysz; Lyz; Lyz1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8754,792,715 - 54,798,060 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl754,792,716 - 54,798,011 (-)EnsemblGRCr8
mRatBN7.2752,906,810 - 52,912,154 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl752,906,811 - 52,912,106 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx754,813,530 - 54,818,826 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0757,016,639 - 57,021,935 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0756,794,518 - 56,799,814 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0760,335,968 - 60,341,264 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,335,969 - 60,341,264 (-)Ensemblrn6Rnor6.0
Rnor_5.0760,337,950 - 60,343,281 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4756,607,708 - 56,613,004 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera749,680,647 - 49,685,943 (-)NCBICelera
RGSC_v3.1756,628,438 - 56,633,734 (-)NCBI
RH 3.4 Map7480.1RGD
Cytogenetic Map7q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-Ethyl-2-benzimidazolinone  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
ampicillin  (EXP)
antirheumatic drug  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
captan  (ISO)
carbachol  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dodecanoic acid  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gemcitabine  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyburide  (ISO)
heme b  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
irinotecan  (ISO)
L-methionine  (ISO)
lead(II) chloride  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methylglyoxal  (ISO)
methylmercury chloride  (EXP)
metronidazole  (EXP)
milrinone  (EXP)
Muraglitazar  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
neomycin  (EXP)
nickel atom  (ISO)
nickel subsulfide  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
SB 203580  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
T-2 toxin  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
triticonazole  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP,ISO)
tungsten  (ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (EXP)
vancomycin  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Role of acid back-diffusion, glutathione, oxyradical, and histamine in antral hemorrhagic ulcer in rats: the protective effect of lysozyme chloride and antioxidants. Hung CR and Wang PS, J Lab Clin Med 2002 Sep;140(3):142-51.
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Human lysozyme gene mutations cause hereditary systemic amyloidosis. Pepys MB, etal., Nature. 1993 Apr 8;362(6420):553-7.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Lysozyme expression in the rat parotid gland: light and electron microscopic immunogold studies. Staneva-Dobrovski L Histochem Cell Biol. 1997 May;107(5):371-81.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Effects of lead administration at low doses by different routes on rat spleens. Study of response of splenic lymphocytes and tissue lysozyme. Teijon C, etal., Toxicology. 2003 Sep 30;191(2-3):245-58.
14. Bactericidal activity of testicular macrophages. Wei RQ, etal., Biol Reprod. 1988 May;38(4):830-5.
15. A novel lysozyme mutation Phe57Ile associated with hereditary renal amyloidosis. Yazaki M, etal., Kidney Int. 2003 May;63(5):1652-7.
Additional References at PubMed
PMID:851497   PMID:8081549   PMID:9727055   PMID:12411294   PMID:14977423   PMID:16502470   PMID:19056867   PMID:19199708   PMID:21093056   PMID:21805676   PMID:22664934   PMID:23353684  
PMID:23376485   PMID:23533145   PMID:23580065  


Genomics

Comparative Map Data
Lyz2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8754,792,715 - 54,798,060 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl754,792,716 - 54,798,011 (-)EnsemblGRCr8
mRatBN7.2752,906,810 - 52,912,154 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl752,906,811 - 52,912,106 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx754,813,530 - 54,818,826 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0757,016,639 - 57,021,935 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0756,794,518 - 56,799,814 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0760,335,968 - 60,341,264 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl760,335,969 - 60,341,264 (-)Ensemblrn6Rnor6.0
Rnor_5.0760,337,950 - 60,343,281 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4756,607,708 - 56,613,004 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera749,680,647 - 49,685,943 (-)NCBICelera
RGSC_v3.1756,628,438 - 56,633,734 (-)NCBI
RH 3.4 Map7480.1RGD
Cytogenetic Map7q22NCBI
LYZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381269,348,381 - 69,354,234 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1269,348,381 - 69,354,234 (+)Ensemblhg38GRCh38
GRCh371269,742,161 - 69,748,014 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361268,028,431 - 68,034,280 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341268,028,430 - 68,034,280NCBI
Celera1269,405,811 - 69,411,693 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1266,791,650 - 66,797,534 (+)NCBIHuRef
CHM1_11269,710,537 - 69,716,432 (+)NCBICHM1_1
T2T-CHM13v2.01269,327,311 - 69,333,169 (+)NCBIT2T-CHM13v2.0
Lyz2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910117,113,446 - 117,118,177 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10117,113,236 - 117,118,226 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810117,277,541 - 117,282,272 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10117,277,331 - 117,282,321 (-)Ensemblmm10GRCm38
MGSCv3710116,714,597 - 116,719,328 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610116,681,443 - 116,686,374 (-)NCBIMGSCv36mm8
Celera10119,220,558 - 119,225,289 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1065.34NCBI
LYZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21077,375,766 - 77,381,645 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11277,372,162 - 77,378,043 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01266,870,373 - 66,876,250 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11269,646,794 - 69,652,677 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1269,646,794 - 69,652,677 (+)EnsemblpanPan2panpan1.1
LYZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11011,346,500 - 11,350,639 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1011,346,435 - 11,351,040 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1011,278,390 - 11,282,529 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01011,469,702 - 11,473,856 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1011,469,637 - 11,474,257 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11011,337,085 - 11,341,219 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01011,583,952 - 11,588,107 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01011,706,255 - 11,710,386 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101959346
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494546,939,255 - 46,944,566 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365457,134,165 - 7,170,474 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365457,165,917 - 7,170,840 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LYZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl533,612,567 - 33,618,945 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1533,612,593 - 33,618,953 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2536,179,190 - 36,185,552 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5p11NCBI
LYZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11164,978,153 - 64,984,351 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1164,978,119 - 64,984,495 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037180,708,862 - 180,715,047 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lyz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462494816,041 - 21,560 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462494816,850 - 21,578 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Lyz2
28 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:239
Count of miRNA genes:164
Interacting mature miRNAs:179
Transcripts:ENSRNOT00000007747, ENSRNOT00000064784
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)74968283263890004Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74299622658678836Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
D7Mgh22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2752,888,326 - 52,888,450 (+)MAPPERmRatBN7.2
Rnor_6.0760,317,489 - 60,317,612NCBIRnor6.0
Rnor_5.0760,319,471 - 60,319,594UniSTSRnor5.0
RGSC_v3.4756,589,319 - 56,589,443RGDRGSC3.4
RGSC_v3.4756,589,320 - 56,589,443UniSTSRGSC3.4
Celera749,662,162 - 49,662,285UniSTS
RGSC_v3.1756,610,049 - 56,610,173RGD
RH 3.4 Map7488.5UniSTS
RH 3.4 Map7488.5RGD
RH 2.0 Map7411.2RGD
Cytogenetic Map7q22UniSTS
D7Wox39  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2752,912,956 - 52,913,192 (+)MAPPERmRatBN7.2
Rnor_6.0760,342,115 - 60,342,350NCBIRnor6.0
Rnor_5.0760,344,097 - 60,344,332UniSTSRnor5.0
RGSC_v3.4756,613,855 - 56,614,090UniSTSRGSC3.4
Celera749,686,794 - 49,687,029UniSTS
Cytogenetic Map7q22UniSTS
RH127643  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2752,894,025 - 52,894,214 (-)MAPPERmRatBN7.2
mRatBN7.2752,894,025 - 52,894,214 (+)MAPPERmRatBN7.2
mRatBN7.2752,907,042 - 52,907,229 (+)MAPPERmRatBN7.2
Rnor_6.0760,336,201 - 60,336,387NCBIRnor6.0
Rnor_6.0760,323,189 - 60,323,377NCBIRnor6.0
Rnor_5.0760,338,183 - 60,338,369UniSTSRnor5.0
Rnor_5.0760,325,171 - 60,325,359UniSTSRnor5.0
RGSC_v3.4756,594,924 - 56,595,112UniSTSRGSC3.4
RGSC_v3.4756,607,941 - 56,608,127UniSTSRGSC3.4
Celera749,680,880 - 49,681,066UniSTS
Celera749,667,862 - 49,668,050UniSTS
RH 3.4 Map7480.9UniSTS
Cytogenetic Map7q22UniSTS
RH127838  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2752,894,050 - 52,894,271 (-)MAPPERmRatBN7.2
mRatBN7.2752,894,050 - 52,894,271 (+)MAPPERmRatBN7.2
mRatBN7.2752,906,985 - 52,907,204 (+)MAPPERmRatBN7.2
Rnor_6.0760,336,144 - 60,336,362NCBIRnor6.0
Rnor_6.0760,323,214 - 60,323,434NCBIRnor6.0
Rnor_5.0760,338,126 - 60,338,344UniSTSRnor5.0
Rnor_5.0760,325,196 - 60,325,416UniSTSRnor5.0
RGSC_v3.4756,594,949 - 56,595,169UniSTSRGSC3.4
RGSC_v3.4756,607,884 - 56,608,102UniSTSRGSC3.4
Celera749,680,823 - 49,681,041UniSTS
Celera749,667,887 - 49,668,107UniSTS
RH 3.4 Map7480.9UniSTS
Cytogenetic Map7q22UniSTS
RH94553  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2752,887,468 - 52,887,631 (-)MAPPERmRatBN7.2
mRatBN7.2752,887,468 - 52,887,631 (+)MAPPERmRatBN7.2
mRatBN7.2752,911,578 - 52,911,741 (-)MAPPERmRatBN7.2
mRatBN7.2752,911,578 - 52,911,741 (+)MAPPERmRatBN7.2
Rnor_6.0760,340,737 - 60,340,899NCBIRnor6.0
Rnor_6.0760,316,631 - 60,316,793NCBIRnor6.0
Rnor_5.0760,318,613 - 60,318,775UniSTSRnor5.0
Rnor_5.0760,342,719 - 60,342,881UniSTSRnor5.0
RGSC_v3.4756,588,462 - 56,588,624UniSTSRGSC3.4
RGSC_v3.4756,612,477 - 56,612,639UniSTSRGSC3.4
Celera749,685,416 - 49,685,578UniSTS
Celera749,661,304 - 49,661,466UniSTS
RH 3.4 Map7480.1UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC058490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L12459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000007747   ⟹   ENSRNOP00000007747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl754,792,716 - 54,798,011 (-)Ensembl
mRatBN7.2 Ensembl752,906,811 - 52,912,106 (-)Ensembl
Rnor_6.0 Ensembl760,335,969 - 60,341,264 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097754   ⟹   ENSRNOP00000088305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl754,792,716 - 54,798,011 (-)Ensembl
mRatBN7.2 Ensembl752,907,008 - 52,912,106 (-)Ensembl
RefSeq Acc Id: NM_012771   ⟹   NP_036903
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,792,715 - 54,798,011 (-)NCBI
mRatBN7.2752,906,810 - 52,912,106 (-)NCBI
Rnor_6.0760,335,968 - 60,341,264 (-)NCBI
Rnor_5.0760,337,950 - 60,343,281 (-)NCBI
RGSC_v3.4756,607,708 - 56,613,004 (-)RGD
Celera749,680,647 - 49,685,943 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078440   ⟹   XP_038934368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8754,792,715 - 54,798,060 (-)NCBI
mRatBN7.2752,906,810 - 52,912,154 (-)NCBI
Protein Sequences
Protein RefSeqs NP_036903 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934368 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41551 (Get FASTA)   NCBI Sequence Viewer  
  AAH58490 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007747
  ENSRNOP00000088305
GenBank Protein P00697 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036903   ⟸   NM_012771
- Peptide Label: precursor
- UniProtKB: P00697 (UniProtKB/Swiss-Prot),   Q6PDV1 (UniProtKB/TrEMBL),   A0A077S1I6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007747   ⟸   ENSRNOT00000007747
RefSeq Acc Id: XP_038934368   ⟸   XM_039078440
- Peptide Label: isoform X1
- UniProtKB: F1M8E9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088305   ⟸   ENSRNOT00000097754
Protein Domains
C-type lysozyme   Glycosyl hydrolases family 22 (GH22)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P00697-F1-model_v2 AlphaFold P00697 1-148 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695213
Promoter ID:EPDNEW_R5737
Type:multiple initiation site
Name:Lyz2_1
Description:lysozyme 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0760,341,264 - 60,341,324EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3026 AgrOrtholog
BioCyc Gene G2FUF-34008 BioCyc
Ensembl Genes ENSRNOG00000005825 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000007747 ENTREZGENE
  ENSRNOT00000097754 ENTREZGENE
Gene3D-CATH 1.10.530.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6919643 IMAGE-MGC_LOAD
InterPro Glyco_hydro_22 UniProtKB/Swiss-Prot
  Glyco_hydro_22_CS UniProtKB/Swiss-Prot
  Glyco_hydro_22_lys UniProtKB/Swiss-Prot
  Lysozyme-like_dom_sf UniProtKB/Swiss-Prot
MGC_CLONE MGC:72912 IMAGE-MGC_LOAD
NCBI Gene 25211 ENTREZGENE
PANTHER PTHR11407 UniProtKB/Swiss-Prot
  PTHR11407:SF28 UniProtKB/Swiss-Prot
Pfam Lys UniProtKB/Swiss-Prot
PhenoGen Lyz2 PhenoGen
PRINTS LYSOZYME UniProtKB/Swiss-Prot
  LYZLACT UniProtKB/Swiss-Prot
PROSITE LACTALBUMIN_LYSOZYME_1 UniProtKB/Swiss-Prot
  LACTALBUMIN_LYSOZYME_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005825 RatGTEx
SMART LYZ1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53955 UniProtKB/Swiss-Prot
UniProt A0A077S1I6 ENTREZGENE, UniProtKB/TrEMBL
  F1M8E9 ENTREZGENE, UniProtKB/TrEMBL
  LYSC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6PDV1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-15 Lyz2  lysozyme 2  Lyz  lysozyme  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Lyz  Lysozyme      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process improves antral hemorrhagic ulcer caused by glutathione and histamine 724421
gene_protein 18 amino acids 724421