Lhcgr (luteinizing hormone/choriogonadotropin receptor) - Rat Genome Database

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Gene: Lhcgr (luteinizing hormone/choriogonadotropin receptor) Rattus norvegicus
Analyze
Symbol: Lhcgr
Name: luteinizing hormone/choriogonadotropin receptor
RGD ID: 3007
Description: Enables several functions, including ATPase binding activity; identical protein binding activity; and peptide hormone binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; arachidonate secretion; and positive regulation of calcium ion transmembrane transport. Located in endosome and extracellular space. Part of receptor complex. Human ortholog(s) of this gene implicated in Leydig cell hypoplasia; Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; peptide and protein hormone signaling pathway; luteinizing hormone signaling pathway; INTERACTS WITH (E)-thiamethoxam; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LH receptor; LH/CG receptor; LH/CG-R; Lhr; LSH-R; LSHR; luteinizing hormone receptor; luteinizing hormone/chorionic gonadotropin receptor; lutropin-choriogonadotropic hormone receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8611,415,361 - 11,480,834 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl611,415,415 - 11,478,061 (+)EnsemblGRCr8
mRatBN7.265,661,871 - 5,728,109 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl65,661,871 - 5,724,521 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx65,950,334 - 6,013,310 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.066,259,709 - 6,322,689 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.065,786,872 - 5,849,858 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0612,493,182 - 12,554,482 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl612,493,943 - 12,554,439 (-)Ensemblrn6Rnor6.0
Rnor_5.0622,455,216 - 22,516,430 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4612,613,622 - 12,651,587 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera65,442,191 - 5,504,330 (+)NCBICelera
RGSC_v3.1612,613,621 - 12,651,587 (-)NCBI
Cytogenetic Map6q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(E)-thiamethoxam  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-tert-Octylphenol  (EXP)
8-Br-cAMP  (EXP,ISO)
acetamiprid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alpha-naphthoflavone  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
Bisphenol B  (EXP)
bucladesine  (EXP)
butylated hydroxyanisole  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
captan  (ISO)
carvacrol  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
Chorionic gonadotropin  (EXP,ISO)
chromium(6+)  (EXP)
colforsin daropate hydrochloride  (ISO)
cyanamide  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
DDE  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
dibutyl phthalate  (EXP,ISO)
dibutylstannane  (EXP)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diheptyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dipentyl phthalate  (EXP)
disulfiram  (ISO)
erythrosin B  (EXP)
fenvalerate  (EXP)
flurbiprofen  (EXP)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP)
isoflavones  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (EXP)
L-mimosine  (EXP,ISO)
letrozole  (ISO)
leuprolide  (ISO)
linuron  (EXP)
LY294002  (EXP)
melatonin  (ISO)
melittin  (ISO)
methoxychlor  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-ethyl-N-nitrosourea  (EXP)
p-tert-Amylphenol  (EXP)
paraquat  (EXP)
perfluorododecanoic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (EXP)
picrotoxin  (EXP)
potassium dichromate  (EXP)
prostaglandin F2alpha  (EXP)
pyrethrins  (EXP)
quercetin  (EXP)
resveratrol  (EXP)
royal jelly  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
streptozocin  (EXP)
sulfur dioxide  (ISO)
T-2 toxin  (ISO)
tartrazine  (EXP)
testosterone  (ISO)
testosterone enanthate  (EXP)
Tetrachlorobisphenol A  (EXP,ISO)
thiamethoxam  (EXP,ISO)
titanium dioxide  (ISO)
tofacitinib  (EXP)
tributylstannane  (EXP)
triphenylstannane  (EXP)
tyrphostin AG 1478  (EXP)
uranium atom  (EXP)
vinclozolin  (EXP)
wortmannin  (ISO)
zearalenone  (ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (IDA)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,IEA,ISO)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IDA,IEA,IMP)
arachidonate secretion  (IDA)
cellular response to gonadotropin stimulus  (IEA,ISO)
cellular response to hormone stimulus  (IEA)
cellular response to luteinizing hormone stimulus  (IEA,ISO,ISS)
cognition  (IEA,ISO)
development of secondary male sexual characteristics  (ISO)
female gonad development  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
hormone-mediated signaling pathway  (IBA,IDA)
luteinizing hormone signaling pathway  (IBA,IDA,IEA,ISO)
male gonad development  (IBA,ISO)
ovarian follicle development  (IBA,ISO)
ovulation cycle process  (IBA,ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IBA,IDA,IEA,ISO)
positive regulation of calcium ion transport into cytosol  (IDA)
positive regulation of calcium-mediated signaling  (IDA)
positive regulation of hormone biosynthetic process  (IDA)
positive regulation of inositol trisphosphate biosynthetic process  (IEA,ISO)
positive regulation of release of sequestered calcium ion into cytosol  (IDA)
protein targeting to lysosome  (IMP)
regulation of hormone biosynthetic process  (IEA)
regulation of steroid biosynthetic process  (IEA,IEP)
regulation of steroid hormone biosynthetic process  (ISO)
response to gonadotropin  (IEA)
response to luteinizing hormone  (IDA)
response to xenobiotic stimulus  (IEP)
seminiferous tubule development  (ISO)
signal transduction  (IEA)
spermatogenesis  (ISO)
uterus development  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Expression of the LH/CG receptor gene in rat ovarian tissue is regulated by an extensive alternative splicing of the primary transcript. Aatsinki JT, etal., Mol Cell Endocrinol 1992 Mar;84(1-2):127-35.
2. Differential responses of an invariant region in the ectodomain of three glycoprotein hormone receptors to mutagenesis and assay conditions. Angelova K and Puett D, Endocrine 2002 Nov;19(2):147-54.
3. A model for constitutive lutropin receptor activation based on molecular simulation and engineered mutations in transmembrane helices 6 and 7. Angelova K, etal., J Biol Chem 2002 Aug 30;277(35):32202-13.
4. Identification and structural characterization of the neuronal luteinizing hormone receptor associated with sensory systems. Apaja PM, etal., J Biol Chem. 2004 Jan 16;279(3):1899-906. Epub 2003 Oct 27.
5. Luteinizing hormone receptor ectodomain splice variant misroutes the full-length receptor into a subcompartment of the endoplasmic reticulum. Apaja PM, etal., Mol Biol Cell. 2006 May;17(5):2243-55. Epub 2006 Feb 22.
6. A novel targeted therapy of Leydig and granulosa cell tumors through the luteinizing hormone receptor using a hecate-chorionic gonadotropin beta conjugate in transgenic mice. Bodek G, etal., Neoplasia. 2005 May;7(5):497-508.
7. Multiple luteinizing hormone receptor (LHR) protein variants, interspecies reactivity of anti-LHR mAb clone 3B5, subcellular localization of LHR in human placenta, pelvic floor and brain, and possible role for LHR in the development of abnormal pregnancy, pelvic floor disorders and Alzheimer's disease. Bukovsky A, etal., Reprod Biol Endocrinol. 2003 Jun 3;1:46.
8. Mutational analysis of the luteinizing hormone receptor gene in two individuals with Leydig cell tumors. Canto P, etal., Am J Med Genet. 2002 Mar 1;108(2):148-52.
9. FSH-regulated gene expression profiles in ovarian tumours and normal ovaries. Chu S, etal., Mol Hum Reprod. 2002 May;8(5):426-33.
10. The dual regulation of cyclic AMP and calcium by luteinizing hormone and the mechanisms of desensitization and recycling of the luteinizing hormone receptor. Cooke BA, etal., Biochem Soc Trans. 1987 Feb;15(1):26-8.
11. Luteinizing hormone stimulates the formation of inositol trisphosphate and cyclic AMP in rat granulosa cells. Evidence for phospholipase C generated second messengers in the action of luteinizing hormone. Davis JS, etal., Biochem J. 1986 Sep 1;238(2):597-604.
12. Effect of a dopamine agonist on luteinizing hormone receptors, cyclic AMP production and steroidogenesis in rat Leydig cells. Dirami G and Cooke BA, Toxicol Appl Pharmacol. 1998 Jun;150(2):393-401.
13. Characterization and structure of ovarian and testicular LH/hCG receptors. Dufau ML, etal., J Steroid Biochem. 1989 Oct;33(4B):715-20.
14. A new point mutation in the luteinising hormone receptor gene in familial and sporadic male limited precocious puberty: genotype does not always correlate with phenotype. Evans BA, etal., J Med Genet. 1996 Feb;33(2):143-7.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Luteinizing hormone receptors are self-associated in slowly diffusing complexes during receptor desensitization. Horvat RD, etal., Mol Endocrinol. 2001 Apr;15(4):534-42.
18. Asp383 in the second transmembrane domain of the lutropin receptor is important for high affinity hormone binding and cAMP production. Ji I and Ji TH, J Biol Chem. 1991 Aug 15;266(23):14953-7.
19. Identification of a hormonally regulated luteinizing hormone/human chorionic gonadotropin receptor mRNA binding protein. Increased mrna binding during receptor down-regulation. Kash JC and Menon KM, J Biol Chem. 1998 Apr 24;273(17):10658-64.
20. The C-terminal tail of the rat lutropin/choriogonadotropin (CG) receptor independently modulates human (h)CG-induced internalization of the cell surface receptor and the lysosomal targeting of the internalized hCG-receptor complex. Kishi M and Ascoli M, Mol Endocrinol. 2000 Jun;14(6):926-36.
21. Purification and characterization of the rat ovarian receptor for luteinizing hormone. Structural studies of subunit interaction. Kusuda S and Dufau ML, J Biol Chem. 1986 Dec 5;261(34):16161-8.
22. Regulation of intracellular free Ca2+ by the LH/CG receptor in an established cell line 293 expressing transfected rat receptor. Lakkakorpi JT and Rajaniemi HJ, Mol Cell Endocrinol. 1994 Feb;99(1):39-47.
23. Two defective heterozygous luteinizing hormone receptors can rescue hormone action. Lee C, etal., J Biol Chem 2002 May 3;277(18):15795-800.
24. Luteinizing hormone receptor mediates neuronal pregnenolone production via up-regulation of steroidogenic acute regulatory protein expression. Liu T, etal., J Neurochem. 2007 Mar;100(5):1329-39. Epub 2007 Jan 11.
25. Dicyclohexyl phthalate blocks Leydig cell regeneration in adult rat testis. Lv Y, etal., Toxicology. 2019 Jan 1;411:60-70. doi: 10.1016/j.tox.2018.10.020. Epub 2018 Nov 1.
26. Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. McFarland KC, etal., Science. 1989 Aug 4;245(4917):494-9.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Arachidonic acid release from rat Leydig cells depends on the presence of luteinizing hormone/human chorionic gonadotrophin receptors. Moraga PF, etal., J Endocrinol. 1997 Aug;154(2):201-9.
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
31. GnRH and LHR gene variants predict adverse outcome in premenopausal breast cancer patients. Piersma D, etal., Breast Cancer Res. 2007;9(4):R51.
32. Polymorphic variations in exon 10 of the luteinizing hormone receptor: functional consequences and associations with breast cancer. Piersma D, etal., Mol Cell Endocrinol. 2007 Sep 30;276(1-2):63-70. Epub 2007 Jul 17.
33. Inefficient maturation of the rat luteinizing hormone receptor. A putative way to regulate receptor numbers at the cell surface. Pietila EM, etal., J Biol Chem. 2005 Jul 15;280(28):26622-9. Epub 2005 May 18.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
36. Luteinizing hormone signaling and breast cancer: polymorphisms and age of onset. Powell BL, etal., J Clin Endocrinol Metab. 2003 Apr;88(4):1653-7.
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Purification, characterization, and amino-terminal sequence of rat ovarian receptor for luteinizing hormone/human choriogonadotropin. Roche PC and Ryan RJ, J Biol Chem. 1989 Mar 15;264(8):4636-41.
40. The orientation of the lutropin/choriogonadotropin receptor in rat luteal cells as revealed by site-specific antibodies. Rodriguez MC and Segaloff DL, Endocrinology. 1990 Aug;127(2):674-81.
41. Biochemical properties of the agonist-induced desensitization of the follicle-stimulating hormone and luteinizing hormone/chorionic gonadotropin-responsive adenylyl cyclase in cells expressing the recombinant gonadotropin receptors. Sanchez-Yague J, etal., Endocrinology. 1993 Mar;132(3):1007-16.
42. Intronic nature of the rat luteinizing hormone receptor gene defines a soluble receptor subspecies with hormone binding activity. Tsai-Morris CH, etal., J Biol Chem. 1990 Nov 15;265(32):19385-8.
43. The endoplasmic reticulum Ca2+-pump SERCA2b interacts with G protein-coupled receptors and enhances their expression at the cell surface. Tuusa JT, etal., J Mol Biol. 2007 Aug 17;371(3):622-38. Epub 2007 Mar 15.
44. Early growth response gene-1 regulates the expression of the rat luteinizing hormone receptor gene. Yoshino M, etal., Biol Reprod 2002 Jun;66(6):1813-9.
45. Growth repression in diethylstilbestrol/dimethylbenzanthracene-induced rat mammary gland tumor using Hecate-CGbeta conjugate. Zaleska M, etal., Exp Biol Med (Maywood). 2004 Apr;229(4):335-44.
Additional References at PubMed
PMID:1976554   PMID:2019252   PMID:2040640   PMID:2281186   PMID:7776964   PMID:8026488   PMID:8305508   PMID:8571710   PMID:10493819   PMID:11145748   PMID:11847099   PMID:11940568  
PMID:11943741   PMID:12141913   PMID:12505611   PMID:15767047   PMID:15860556   PMID:15866423   PMID:15919743   PMID:15951841   PMID:16263716   PMID:16336998   PMID:17045394   PMID:17055149  
PMID:18313837   PMID:18467524   PMID:18494797   PMID:18653716   PMID:18848524   PMID:19293332   PMID:19716387   PMID:20610540   PMID:20619315   PMID:21389345   PMID:22367228   PMID:23175774  
PMID:23227193   PMID:23376535   PMID:23678542   PMID:23754802   PMID:24025743   PMID:24467743   PMID:25430649   PMID:25670721   PMID:26116232   PMID:26125464   PMID:26125466   PMID:27940300  
PMID:28605466   PMID:31041823   PMID:32422603  


Genomics

Comparative Map Data
Lhcgr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8611,415,361 - 11,480,834 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl611,415,415 - 11,478,061 (+)EnsemblGRCr8
mRatBN7.265,661,871 - 5,728,109 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl65,661,871 - 5,724,521 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx65,950,334 - 6,013,310 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.066,259,709 - 6,322,689 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.065,786,872 - 5,849,858 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0612,493,182 - 12,554,482 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl612,493,943 - 12,554,439 (-)Ensemblrn6Rnor6.0
Rnor_5.0622,455,216 - 22,516,430 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4612,613,622 - 12,651,587 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera65,442,191 - 5,504,330 (+)NCBICelera
RGSC_v3.1612,613,621 - 12,651,587 (-)NCBI
Cytogenetic Map6q12NCBI
LHCGR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38248,686,774 - 48,755,724 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl248,686,774 - 48,755,730 (-)Ensemblhg38GRCh38
GRCh37248,913,913 - 48,982,863 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36248,767,417 - 48,836,367 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34248,825,619 - 48,894,468NCBI
Celera248,754,221 - 48,823,183 (-)NCBICelera
Cytogenetic Map2p16.3NCBI
HuRef248,647,284 - 48,716,442 (-)NCBIHuRef
CHM1_1248,844,653 - 48,913,614 (-)NCBICHM1_1
T2T-CHM13v2.0248,682,806 - 48,751,772 (-)NCBIT2T-CHM13v2.0
Lhcgr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391789,023,812 - 89,099,487 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1789,023,909 - 89,099,418 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381788,716,384 - 88,792,059 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1788,716,481 - 88,791,990 (-)Ensemblmm10GRCm38
MGSCv371789,140,889 - 89,191,316 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361788,649,875 - 88,700,302 (-)NCBIMGSCv36mm8
Celera1793,149,952 - 93,199,996 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1758.35NCBI
Lhcgr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544115,207,252 - 15,242,914 (-)Ensembl
ChiLan1.0NW_00495544115,205,883 - 15,263,617 (-)NCBIChiLan1.0ChiLan1.0
LHCGR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21277,625,492 - 77,695,724 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A77,629,460 - 77,699,692 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A48,808,822 - 48,879,021 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A49,728,994 - 49,798,780 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A49,729,002 - 49,798,780 (-)EnsemblpanPan2panpan1.1
LHCGR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11050,540,706 - 50,594,336 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1050,541,960 - 50,598,036 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1050,394,259 - 50,456,607 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01051,416,899 - 51,479,209 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1051,417,733 - 51,474,628 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11051,119,798 - 51,182,164 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01051,404,008 - 51,466,313 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01051,595,139 - 51,657,483 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lhcgr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629232,499,857 - 32,557,352 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365083,928,466 - 3,983,890 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365083,928,467 - 3,983,481 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LHCGR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl391,964,415 - 92,021,398 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1391,964,415 - 92,023,821 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2397,929,099 - 97,949,675 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3q22-q23NCBI
LHCGR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11458,413,334 - 58,479,124 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1458,413,993 - 58,477,987 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604553,365,608 - 53,428,814 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lhcgr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473829,903,571 - 29,966,915 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473829,902,364 - 29,967,384 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lhcgr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v174,077,790 - 4,137,727 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lhcgr
314 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1551
Count of miRNA genes:291
Interacting mature miRNAs:369
Transcripts:ENSRNOT00000022481, ENSRNOT00000045535, ENSRNOT00000048394, ENSRNOT00000064845, ENSRNOT00000073504, ENSRNOT00000074508
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6120510098Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat

Markers in Region
RH138460  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.265,724,913 - 5,725,162 (-)MAPPERmRatBN7.2
Rnor_6.0612,492,541 - 12,492,789NCBIRnor6.0
Rnor_5.0622,454,575 - 22,454,823UniSTSRnor5.0
RGSC_v3.4612,612,981 - 12,613,229UniSTSRGSC3.4
Celera65,504,723 - 5,504,971UniSTS
Cytogenetic Map6q12UniSTS
LHCGR  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.265,722,956 - 5,723,449 (-)MAPPERmRatBN7.2
Rnor_6.0612,494,254 - 12,494,746NCBIRnor6.0
Rnor_5.0622,456,288 - 22,456,780UniSTSRnor5.0
RGSC_v3.4612,614,694 - 12,615,186UniSTSRGSC3.4
Celera65,502,766 - 5,503,258UniSTS
Cytogenetic Map6q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 4 33 111 46 43 23 37 23 6 200 88 3 100 80 92 20 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000022481   ⟹   ENSRNOP00000022481
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl611,415,415 - 11,478,061 (+)Ensembl
mRatBN7.2 Ensembl65,661,871 - 5,724,521 (+)Ensembl
Rnor_6.0 Ensembl612,493,943 - 12,554,439 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096915   ⟹   ENSRNOP00000089069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl65,661,871 - 5,722,952 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098297   ⟹   ENSRNOP00000079785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl65,661,871 - 5,724,521 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101191   ⟹   ENSRNOP00000092292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl611,428,507 - 11,478,061 (+)Ensembl
mRatBN7.2 Ensembl65,674,856 - 5,724,521 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104322   ⟹   ENSRNOP00000081856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl65,661,871 - 5,724,521 (+)Ensembl
RefSeq Acc Id: NM_012978   ⟹   NP_037110
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8611,415,415 - 11,478,061 (+)NCBI
mRatBN7.265,661,871 - 5,724,521 (+)NCBI
Rnor_6.0612,493,182 - 12,554,482 (-)NCBI
Rnor_5.0622,455,216 - 22,516,430 (-)NCBI
RGSC_v3.4612,613,622 - 12,651,587 (-)RGD
Celera65,442,191 - 5,504,330 (+)RGD
Sequence:
RefSeq Acc Id: XM_039111807   ⟹   XP_038967735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8611,425,490 - 11,480,834 (+)NCBI
mRatBN7.265,671,998 - 5,728,109 (+)NCBI
RefSeq Acc Id: XM_039111808   ⟹   XP_038967736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8611,441,148 - 11,480,834 (+)NCBI
mRatBN7.265,687,605 - 5,728,109 (+)NCBI
RefSeq Acc Id: XM_063261562   ⟹   XP_063117632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8611,415,361 - 11,480,834 (+)NCBI
RefSeq Acc Id: NP_037110   ⟸   NM_012978
- Peptide Label: precursor
- UniProtKB: Q63809 (UniProtKB/Swiss-Prot),   Q63808 (UniProtKB/Swiss-Prot),   Q63807 (UniProtKB/Swiss-Prot),   P70646 (UniProtKB/Swiss-Prot),   Q6LDI7 (UniProtKB/Swiss-Prot),   P16235 (UniProtKB/Swiss-Prot),   A6H9B2 (UniProtKB/TrEMBL),   F1LMG6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022481   ⟸   ENSRNOT00000022481
RefSeq Acc Id: XP_038967735   ⟸   XM_039111807
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GK42 (UniProtKB/TrEMBL),   F1LMG6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967736   ⟸   XM_039111808
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000092292   ⟸   ENSRNOT00000101191
Ensembl Acc Id: ENSRNOP00000081856   ⟸   ENSRNOT00000104322
Ensembl Acc Id: ENSRNOP00000089069   ⟸   ENSRNOT00000096915
Ensembl Acc Id: ENSRNOP00000079785   ⟸   ENSRNOT00000098297
RefSeq Acc Id: XP_063117632   ⟸   XM_063261562
- Peptide Label: isoform X3
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16235-F1-model_v2 AlphaFold P16235 1-700 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3007 AgrOrtholog
BioCyc Gene G2FUF-38778 BioCyc
Ensembl Genes ENSRNOG00000016712 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022481 ENTREZGENE
  ENSRNOT00000022481.8 UniProtKB/Swiss-Prot
  ENSRNOT00000096915.1 UniProtKB/Swiss-Prot
  ENSRNOT00000098297.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Gphrmn_rcpt_fam UniProtKB/Swiss-Prot
  LRR_5 UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LSH_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:25477 UniProtKB/Swiss-Prot
NCBI Gene 25477 ENTREZGENE
PANTHER GLYCOPROTEIN HORMONE RECEPTOR UniProtKB/Swiss-Prot
  LUTROPIN-CHORIOGONADOTROPIC HORMONE RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
  LRR_5 UniProtKB/Swiss-Prot
PhenoGen Lhcgr PhenoGen
PRINTS GLYCHORMONER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
  LSHRECEPTOR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016712 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
  L domain-like UniProtKB/Swiss-Prot
UniProt A0A8I6GK42 ENTREZGENE, UniProtKB/TrEMBL
  A6H9B2 ENTREZGENE, UniProtKB/TrEMBL
  A6H9B3_RAT UniProtKB/TrEMBL
  F1LMG6 ENTREZGENE, UniProtKB/TrEMBL
  LSHR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P70646 ENTREZGENE
  Q63807 ENTREZGENE
  Q63808 ENTREZGENE
  Q63809 ENTREZGENE
  Q6LDI7 ENTREZGENE
UniProt Secondary P70646 UniProtKB/Swiss-Prot
  Q63807 UniProtKB/Swiss-Prot
  Q63808 UniProtKB/Swiss-Prot
  Q63809 UniProtKB/Swiss-Prot
  Q6LDI7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Lhcgr  Luteinizing hormone/choriogonadotropin receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is regulated by the Early growth response gene-1 (Egr-1) 729311
gene_transcript has five alternative splicing forms which regulate the expression of the 90 kDa LH/CG receptor 727541