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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3007
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lhcgr
Name: luteinizing hormone/choriogonadotropin receptor
Acc ID: CHEBI:17347
Term: testosterone
Definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
Chemical ID: MESH:D013739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lhcgraffects response to substanceISOLhcgr (Mus musculus)6480464CTDLHCGR affects the susceptibility to TestosteronePMID:20164437
Lhcgrincreases abundanceISOLhcgr (Mus musculus)6480464CTDLHCGR protein results in increased abundance of TestosteronePMID:15514086
Lhcgrmultiple interactionsISOLhcgr (Mus musculus)6480464CTD[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA; [Leuprolide co-treated with Testosterone] results in decreased expression of LHCGR mRNA; Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]; Tretinoin inhibits the reaction [Disulfiram inhibits the reaction [[FSHB protein co-treated with LHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNA]]PMID:16032706 PMID:22285649
Lhcgrmultiple interactionsISOLHCGR (Homo sapiens)6480464CTD[FSHB protein co-treated with Testosterone] results in increased expression of LHCGR mRNAPMID:18535249
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