Aadat (aminoadipate aminotransferase) - Rat Genome Database

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Gene: Aadat (aminoadipate aminotransferase) Rattus norvegicus
Analyze
Symbol: Aadat
Name: aminoadipate aminotransferase
RGD ID: 2948
Description: Enables 2-aminoadipate transaminase activity; kynurenine-glyoxylate transaminase activity; and kynurenine-oxoglutarate transaminase activity. Predicted to be involved in 2-oxoglutarate metabolic process; glutamate metabolic process; and kynurenine metabolic process. Is active in cytosol and mitochondrial matrix. Orthologous to human AADAT (aminoadipate aminotransferase); PARTICIPATES IN tryptophan metabolic pathway; 2-aminoadipic 2-oxoadipic aciduria pathway; glutaric aciduria type I pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; alpha-aminoadipate aminotransferase; glycine transaminase AADAT; KAT/AadAT; Kat2; kynurenine aminotransferase 2; kynurenine aminotransferase II; kynurenine--glyoxylate transaminase AADAT; kynurenine--oxoglutarate aminotransferase II; kynurenine--oxoglutarate transaminase 2; kynurenine--oxoglutarate transaminase II; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; methionine--glyoxylate transaminase AADAT
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81634,520,236 - 34,566,388 (-)NCBIGRCr8
mRatBN7.21629,509,392 - 29,544,332 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1629,509,394 - 29,544,332 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1633,104,268 - 33,139,214 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01636,538,015 - 36,572,956 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01632,738,925 - 32,773,893 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01632,832,001 - 32,868,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1632,832,061 - 32,868,702 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01632,665,727 - 32,705,543 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41632,845,006 - 32,885,600 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11632,845,082 - 32,885,675 (-)NCBI
Celera1629,503,305 - 29,538,406 (-)NCBICelera
Cytogenetic Map16p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AadatRatExperimental Liver Cirrhosis  ISOAADAT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
AadatRathepatocellular carcinoma  ISOAADAT (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28284560

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AadatRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of AADAT mRNA]CTDPMID:31150632
AadatRat1,1-dichloroethene decreases expressionISOAadat (Mus musculus)6480464vinylidene chloride results in decreased expression of AADAT mRNACTDPMID:26682919
AadatRat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of AADAT mRNACTDPMID:25380136
AadatRat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in increased expression of AADAT mRNA and [Testosterone co-treated with Estradiol] results in increased expression of AADAT mRNACTDPMID:26496021 and PMID:32741896
AadatRat17beta-estradiol increases expressionISOAadat (Mus musculus)6480464Estradiol results in increased expression of AADAT mRNACTDPMID:39298647
AadatRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of AADAT mRNACTDPMID:32145629
AadatRat17beta-estradiol multiple interactionsISOAADAT (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of AADAT mRNACTDPMID:30165855
AadatRat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOAADAT (Homo sapiens)6480464Dihydrotestosterone results in increased expression of AADAT mRNACTDPMID:29581250
AadatRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of AADAT mRNACTDPMID:16054898 more ...
AadatRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of AADAT mRNACTDPMID:33387578
AadatRat2,4-diaminotoluene increases expressionISOAadat (Mus musculus)64804642 and 4-diaminotoluene results in increased expression of AADAT mRNACTDPMID:22016648
AadatRat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOAadat (Mus musculus)64804642 more ...CTDPMID:38648751
AadatRat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of AADAT mRNACTDPMID:21346803
AadatRat3,3',4,4',5-pentachlorobiphenyl decreases expressionEXP 64804643 more ...CTDPMID:20959002
AadatRat3,3',5-triiodo-L-thyronine decreases activityEXP 6480464Triiodothyronine results in decreased activity of AADAT proteinCTDPMID:32663543
AadatRat4,4'-diaminodiphenylmethane decreases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in decreased expression of AADAT mRNACTDPMID:25380136
AadatRat4,4'-sulfonyldiphenol increases expressionISOAadat (Mus musculus)6480464bisphenol S results in increased expression of AADAT mRNACTDPMID:39298647
AadatRat6-propyl-2-thiouracil multiple interactionsEXP 6480464Thyroxine inhibits the reaction [Propylthiouracil results in decreased activity of AADAT protein]CTDPMID:32663543
AadatRat6-propyl-2-thiouracil decreases activityEXP 6480464Propylthiouracil results in decreased activity of AADAT proteinCTDPMID:32663543
AadatRatacetamide decreases expressionEXP 6480464acetamide results in decreased expression of AADAT mRNACTDPMID:31881176

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Biological Process
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AadatRat2-oxoglutarate metabolic process involved_inISSUniProtKB:Q8N5Z01600115GO_REF:0000024UniProtGO_REF:0000024
AadatRat2-oxoglutarate metabolic process involved_inISOAADAT (Homo sapiens)1624291 PMID:18620547RGDPMID:18620547
AadatRatalpha-amino acid metabolic process involved_inIBACGD:CAL0000187633 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
AadatRatbiosynthetic process involved_inIEAInterPro:IPR0048391600115GO_REF:0000002InterProGO_REF:0000002
AadatRatglutamate metabolic process involved_inISSUniProtKB:Q8N5Z01600115GO_REF:0000024UniProtGO_REF:0000024
AadatRatglutamate metabolic process involved_inISOAADAT (Homo sapiens)1624291 PMID:18620547RGDPMID:18620547
AadatRatkynurenine metabolic process involved_inISSUniProtKB:Q8N5Z01600115GO_REF:0000024UniProtGO_REF:0000024
AadatRatkynurenine metabolic process involved_inISOAADAT (Homo sapiens)1624291 PMID:18620547RGDPMID:18620547
AadatRatL-lysine catabolic process to acetyl-CoA via saccharopine involved_inIEAUniPathway:UPA008681600115GO_REF:0000041UniProtGO_REF:0000041
1 to 9 of 9 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AadatRatcytosol is_active_inIDA 408345200PMID:1111529FlyBase 
AadatRatmitochondrial matrix is_active_inIDA 408345200PMID:1111529FlyBase 
AadatRatmitochondrion located_inIEAUniProtKB-SubCell:SL-01731600115GO_REF:0000044UniProtGO_REF:0000044
AadatRatmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function
1 to 20 of 30 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AadatRat2-aminoadipate transaminase activity enablesISSUniProtKB:Q8N5Z01600115GO_REF:0000024UniProtGO_REF:0000024
AadatRat2-aminoadipate transaminase activity enablesIEARHEA:126011600115GO_REF:0000116RHEAGO_REF:0000116
AadatRat2-aminoadipate transaminase activity enablesIEAEC:2.6.1.391600115GO_REF:0000003UniProtGO_REF:0000003
AadatRat2-aminoadipate transaminase activity enablesIDA 408345200PMID:1111529FlyBase 
AadatRat2-aminoadipate transaminase activity enablesISOAADAT (Homo sapiens)1624291 PMID:18620547RGDPMID:18620547
AadatRat2-aminoadipate transaminase activity enablesIDA 69866PMID:7493966UniProt 
AadatRatglycine:2-oxoglutarate aminotransferase activity enablesISSUniProtKB:Q8N5Z01600115GO_REF:0000024UniProtGO_REF:0000024
AadatRatglycine:2-oxoglutarate aminotransferase activity enablesIEARHEA:140891600115GO_REF:0000116RHEAGO_REF:0000116
AadatRatglycine:2-oxoglutarate aminotransferase activity enablesISOAADAT (Homo sapiens)1624291 PMID:18620547RGDPMID:18620547
AadatRatkynurenine-glyoxylate transaminase activity enablesISSUniProtKB:Q8N5Z01600115GO_REF:0000024UniProtGO_REF:0000024
AadatRatkynurenine-glyoxylate transaminase activity enablesISOAADAT (Homo sapiens)1624291 PMID:18620547RGDPMID:18620547
AadatRatkynurenine-glyoxylate transaminase activity enablesIDA 69866PMID:7493966UniProt 
AadatRatkynurenine-oxoglutarate transaminase activity  IDA 2290313 RGD 
AadatRatkynurenine-oxoglutarate transaminase activity enablesIEAEC:2.6.1.71600115GO_REF:0000003UniProtGO_REF:0000003
AadatRatkynurenine-oxoglutarate transaminase activity enablesIBAPANTHER:PTN000922977 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
AadatRatkynurenine-oxoglutarate transaminase activity enablesIEARHEA:655601600115GO_REF:0000116RHEAGO_REF:0000116
AadatRatkynurenine-oxoglutarate transaminase activity enablesIDA 408345200PMID:1111529FlyBase 
AadatRatkynurenine-oxoglutarate transaminase activity enablesISOAADAT (Homo sapiens)1624291 PMID:18620547RGDPMID:18620547
AadatRatkynurenine-oxoglutarate transaminase activity enablesIDA 69866PMID:7493966UniProt 
AadatRatkynurenine-oxoglutarate transaminase activity enablesISSUniProtKB:Q8N5Z01600115GO_REF:0000024UniProtGO_REF:0000024
1 to 20 of 30 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AadatRatkynurenine metabolic pathway   TAS 11081066 RGD 
AadatRattryptophan metabolic pathway  IDA 2290312 RGD 
AadatRattryptophan metabolic pathway  IDA 2290313 RGD 

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AadatRatlysine biosynthetic pathway  IEA 6907045 KEGGrno:00300
AadatRatlysine degradation pathway  IEA 6907045 KEGGrno:00310
AadatRattryptophan metabolic pathway  IEA 6907045 KEGGrno:00380

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#
Reference Title
Reference Citation
1. Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney. Buchli R, etal., J Biol Chem 1995 Dec 8;270(49):29330-5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Structure, expression, and function of kynurenine aminotransferases in human and rodent brains. Han Q, etal., Cell Mol Life Sci. 2010 Feb;67(3):353-68. doi: 10.1007/s00018-009-0166-4. Epub 2009 Oct 15.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Enzymatic studies on tryptophan metabolism disorder in rats chronically exposed to carbon disulfide. Okayama A, etal., Toxicol Appl Pharmacol. 1988 Jul;94(3):356-61.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Kynurenine metabolism in vitamin-B-6-deficient rat liver after tryptophan injection. Takeuchi F and Shibata Y, Biochem J. 1984 Jun 15;220(3):693-9.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. L-kynurenine aminotransferase and L-alpha-aminoadipate aminotransferase. I. Evidence for identity. Tobes MC and Mason M, Biochem Biophys Res Commun. 1975 Jan 20;62(2):390-7. doi: 10.1016/s0006-291x(75)80151-3.
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PMID:14651853   PMID:15489334   PMID:15880762   PMID:16258845   PMID:17024659   PMID:18056995   PMID:18056996   PMID:18614015   PMID:18620547   PMID:34800366  



Aadat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81634,520,236 - 34,566,388 (-)NCBIGRCr8
mRatBN7.21629,509,392 - 29,544,332 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1629,509,394 - 29,544,332 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1633,104,268 - 33,139,214 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01636,538,015 - 36,572,956 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01632,738,925 - 32,773,893 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01632,832,001 - 32,868,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1632,832,061 - 32,868,702 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01632,665,727 - 32,705,543 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41632,845,006 - 32,885,600 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11632,845,082 - 32,885,675 (-)NCBI
Celera1629,503,305 - 29,538,406 (-)NCBICelera
Cytogenetic Map16p12NCBI
AADAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384170,060,222 - 170,094,292 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4170,060,222 - 170,091,699 (-)EnsemblGRCh38hg38GRCh38
GRCh374170,981,373 - 171,011,538 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364171,217,948 - 171,247,947 (-)NCBINCBI36Build 36hg18NCBI36
Celera4168,313,662 - 168,343,661 (-)NCBICelera
Cytogenetic Map4q33NCBI
HuRef4166,736,223 - 166,766,217 (-)NCBIHuRef
CHM1_14170,957,912 - 170,987,911 (-)NCBICHM1_1
T2T-CHM13v2.04173,420,406 - 173,454,472 (-)NCBIT2T-CHM13v2.0
Aadat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39860,958,877 - 60,998,711 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl860,958,966 - 60,998,711 (+)EnsemblGRCm39 Ensembl
GRCm38860,505,843 - 60,545,677 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl860,505,932 - 60,545,677 (+)EnsemblGRCm38mm10GRCm38
MGSCv37862,984,921 - 63,024,474 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36863,398,266 - 63,437,819 (+)NCBIMGSCv36mm8
Celera863,093,543 - 63,132,626 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map830.85NCBI
AADAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23167,840,395 - 167,870,662 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14168,196,263 - 168,228,815 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04162,283,569 - 162,313,720 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14174,353,766 - 174,383,471 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4174,353,766 - 174,383,471 (-)Ensemblpanpan1.1panPan2
AADAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12520,920,118 - 20,944,251 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2520,920,139 - 20,945,387 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2521,552,316 - 21,578,183 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02521,095,996 - 21,122,120 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2521,095,909 - 21,122,348 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12520,979,787 - 21,005,336 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02520,916,219 - 20,941,386 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02521,013,862 - 21,039,554 (-)NCBIUU_Cfam_GSD_1.0
Aadat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494321,612,298 - 21,637,776 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365162,029,715 - 2,052,041 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365162,030,032 - 2,052,025 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AADAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1419,768,776 - 19,792,256 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11419,768,816 - 19,792,254 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21421,067,885 - 21,091,280 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AADAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17116,268,241 - 116,299,509 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7116,268,253 - 116,298,336 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603796,208,477 - 96,238,271 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aadat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247691,581,727 - 1,610,793 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247691,586,036 - 1,611,092 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Aadat
248 total Variants

Predicted Target Of
Summary Value
Count of predictions:340
Count of miRNA genes:187
Interacting mature miRNAs:211
Transcripts:ENSRNOT00000015974
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 26 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat

1 to 10 of 26 rows
AI746383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21629,534,433 - 29,534,573 (+)MAPPERmRatBN7.2
Rnor_6.01632,858,777 - 32,858,916NCBIRnor6.0
Rnor_5.01632,692,503 - 32,692,642UniSTSRnor5.0
RGSC_v3.41632,875,697 - 32,875,836UniSTSRGSC3.4
Celera1629,528,506 - 29,528,645UniSTS
Cytogenetic Map16p12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 47 113 91 89 59 22 59 6 211 90 93 45 60 30



Ensembl Acc Id: ENSRNOT00000015974   ⟹   ENSRNOP00000015974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1629,509,394 - 29,544,332 (-)Ensembl
Rnor_6.0 Ensembl1632,832,061 - 32,868,680 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082392   ⟹   ENSRNOP00000073124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1632,832,611 - 32,868,702 (-)Ensembl
RefSeq Acc Id: NM_017193   ⟹   NP_058889
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,520,236 - 34,555,180 (-)NCBI
mRatBN7.21629,509,392 - 29,544,332 (-)NCBI
Rnor_6.01632,832,059 - 32,868,680 (-)NCBI
Rnor_5.01632,665,727 - 32,705,543 (-)NCBI
RGSC_v3.41632,845,006 - 32,885,600 (-)RGD
Celera1629,503,305 - 29,538,406 (-)RGD
Sequence:
RefSeq Acc Id: XM_063275270   ⟹   XP_063131340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,520,236 - 34,554,913 (-)NCBI
RefSeq Acc Id: XM_063275271   ⟹   XP_063131341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81634,520,236 - 34,566,388 (-)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_058889 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131340 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131341 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78864 (Get FASTA)   NCBI Sequence Viewer  
  CAA90507 (Get FASTA)   NCBI Sequence Viewer  
  EDL87183 (Get FASTA)   NCBI Sequence Viewer  
  EDL87184 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015974
  ENSRNOP00000105590
  ENSRNOP00000107369
GenBank Protein Q64602 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_058889   ⟸   NM_017193
- UniProtKB: Q64602 (UniProtKB/Swiss-Prot),   A6KIT5 (UniProtKB/TrEMBL),   A0A8L2Q812 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073124   ⟸   ENSRNOT00000082392
Ensembl Acc Id: ENSRNOP00000015974   ⟸   ENSRNOT00000015974
RefSeq Acc Id: XP_063131341   ⟸   XM_063275271
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q812 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131340   ⟸   XM_063275270
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q812 (UniProtKB/TrEMBL)
Aminotransferase class I/classII large

Name Modeler Protein Id AA Range Protein Structure
AF-Q64602-F1-model_v2 AlphaFold Q64602 1-425 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700074
Promoter ID:EPDNEW_R10597
Type:initiation region
Name:Aadat_1
Description:aminoadipate aminotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01632,868,695 - 32,868,755EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-11569 BioCyc
BioCyc Pathway LYSINE-DEG1-PWY [L-lysine degradation XI (mammalian)] BioCyc
BioCyc Pathway Image LYSINE-DEG1-PWY BioCyc
Ensembl Genes ENSRNOG00000011861 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015974 ENTREZGENE
  ENSRNOT00000128898 ENTREZGENE
  ENSRNOT00000133634 ENTREZGENE
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109210 IMAGE-MGC_LOAD
InterPro Aminotransferase_I/II UniProtKB/Swiss-Prot
  Class-I_PLP-Dep_Aminotransf UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot
KEGG Report rno:29416 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93526 IMAGE-MGC_LOAD
NCBI Gene 29416 ENTREZGENE
PANTHER AMINOTRANSFERASE UniProtKB/Swiss-Prot
  KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam Aminotran_1_2 UniProtKB/Swiss-Prot
PhenoGen Aadat PhenoGen
RatGTEx ENSRNOG00000011861 RatGTEx
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot
TIGR TC230508
UniProt A0A8L2Q812 ENTREZGENE, UniProtKB/TrEMBL
  A6KIT5 ENTREZGENE, UniProtKB/TrEMBL
  A6KIT6_RAT UniProtKB/TrEMBL
  AADAT_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Aadat  aminoadipate aminotransferase  Kat2  kynurenine aminotransferase 2  Symbol and Name updated 1299863 APPROVED
2002-06-10 Kat2  kynurenine aminotransferase 2      Name updated 70584 APPROVED

Note Type Note Reference
gene_function converts L-kynurenine into kynurenic acid 69866
gene_protein soluble protein of 425 amino acid 69866