Itgb4 (integrin subunit beta 4) - Rat Genome Database

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Gene: Itgb4 (integrin subunit beta 4) Rattus norvegicus
Analyze
Symbol: Itgb4
Name: integrin subunit beta 4
RGD ID: 2928
Description: Predicted to enable G protein-coupled receptor binding activity and integrin binding activity. Predicted to contribute to insulin-like growth factor I binding activity and neuregulin binding activity. Predicted to be involved in several processes, including hemidesmosome assembly; integrin-mediated signaling pathway; and skin morphogenesis. Predicted to act upstream of or within several processes, including filopodium assembly; peripheral nervous system myelin formation; and trophoblast cell migration. Located in cell cortex. Is active in glutamatergic synapse and postsynaptic membrane. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGB4 (integrin subunit beta 4); PARTICIPATES IN integrin mediated signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GP150; integrin beta 4; integrin beta-4; integrin, beta 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,705,592 - 101,741,933 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10101,705,587 - 101,741,932 (+)EnsemblGRCr8
mRatBN7.210101,206,657 - 101,243,012 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,206,665 - 101,243,012 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10106,268,387 - 106,304,610 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,731,475 - 105,767,696 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,127,619 - 101,163,963 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,524,000 - 104,560,180 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,523,996 - 104,561,078 (+)Ensemblrn6Rnor6.0
Rnor_5.010103,725,179 - 103,761,358 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410106,080,452 - 106,116,632 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1099,781,746 - 99,817,137 (+)NCBICelera
RGSC_v3.110106,094,955 - 106,131,136 (+)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(E)-roxithromycin  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
alpha-pinene  (ISO)
aristolochic acids  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butane-2,3-dione  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium nitrate  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clarithromycin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dichromium trioxide  (ISO)
doxorubicin  (EXP,ISO)
drometrizole  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethylparaben  (ISO)
fipronil  (EXP)
folic acid  (ISO)
furan  (EXP)
furfural  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
glycidyl methacrylate  (ISO)
glycine betaine  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylseleninic acid  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
naled  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
ofloxacin  (ISO)
okadaic acid  (ISO)
omega-6 fatty acid  (ISO)
organophosphorus compound  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP)
perfluorodecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sotorasib  (ISO)
sulindac  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (EXP)
Y-27632  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Beta 4 integrin expression in myelinating Schwann cells is polarized, developmentally regulated and axonally dependent. Feltri ML, etal., Development 1994 May;120(5):1287-301.
2. Cloning and sequence of the cDNA encoding the beta 4 integrin subunit in rat peripheral nerve. Feltri ML, etal., Gene 1997 Feb 28;186(2):299-304.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins. Heintz TG, etal., PLoS One. 2016 Aug 12;11(8):e0158558. doi: 10.1371/journal.pone.0158558. eCollection 2016.
6. Berberine regulates the microRNA-21-ITGΒ4-PDCD4 axis and inhibits colon cancer viability. Lü Y, etal., Oncol Lett. 2018 Apr;15(4):5971-5976. doi: 10.3892/ol.2018.7997. Epub 2018 Feb 8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
15. Differential localization of laminin gamma and integrin beta in primary cultures of the rat gingival epithelium. Tanno M, etal., J Periodontal Res. 2006 Feb;41(1):15-22.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8707838   PMID:11891657   PMID:12482924   PMID:12867433   PMID:16365040   PMID:16436605   PMID:17011173   PMID:19199708   PMID:19403692   PMID:19765400   PMID:19933311   PMID:20510671  
PMID:20682778   PMID:21310825   PMID:21464233   PMID:21606200   PMID:22274697   PMID:22351760   PMID:23154389   PMID:23382219   PMID:23496044   PMID:24007983   PMID:24851274   PMID:29315582  
PMID:32220495  


Genomics

Comparative Map Data
Itgb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,705,592 - 101,741,933 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10101,705,587 - 101,741,932 (+)EnsemblGRCr8
mRatBN7.210101,206,657 - 101,243,012 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,206,665 - 101,243,012 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10106,268,387 - 106,304,610 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,731,475 - 105,767,696 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,127,619 - 101,163,963 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,524,000 - 104,560,180 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,523,996 - 104,561,078 (+)Ensemblrn6Rnor6.0
Rnor_5.010103,725,179 - 103,761,358 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410106,080,452 - 106,116,632 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1099,781,746 - 99,817,137 (+)NCBICelera
RGSC_v3.110106,094,955 - 106,131,136 (+)NCBI
Cytogenetic Map10q32.1NCBI
ITGB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381775,721,459 - 75,757,818 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1775,721,190 - 75,757,821 (+)Ensemblhg38GRCh38
GRCh371773,717,539 - 73,753,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,229,111 - 71,265,494 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341771,229,110 - 71,265,493NCBI
Celera1770,307,618 - 70,343,945 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1769,141,364 - 69,178,763 (+)NCBIHuRef
CHM1_11773,782,244 - 73,818,973 (+)NCBICHM1_1
T2T-CHM13v2.01776,614,671 - 76,651,043 (+)NCBIT2T-CHM13v2.0
Itgb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,865,556 - 115,899,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,865,535 - 115,899,238 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811115,974,725 - 116,008,412 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,974,709 - 116,008,412 (+)Ensemblmm10GRCm38
MGSCv3711115,836,039 - 115,869,725 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611115,791,069 - 115,824,502 (+)NCBIMGSCv36mm8
Celera11127,737,663 - 127,770,611 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.91NCBI
Itgb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555066,493,466 - 6,526,778 (-)Ensembl
ChiLan1.0NW_0049555066,493,466 - 6,526,778 (-)NCBIChiLan1.0ChiLan1.0
ITGB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21991,764,488 - 91,801,919 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11796,589,205 - 96,626,633 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01769,671,252 - 69,708,520 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11775,222,441 - 75,259,401 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1775,222,376 - 75,259,401 (+)EnsemblpanPan2panpan1.1
ITGB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,825,148 - 4,855,266 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,825,292 - 4,855,820 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha95,504,986 - 5,534,992 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.095,495,318 - 5,525,359 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl95,495,318 - 5,525,460 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.195,534,766 - 5,564,815 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,644,907 - 5,674,940 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,705,723 - 5,735,767 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Itgb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056025,467,140 - 5,499,662 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936594912,291 - 946,012 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936594912,302 - 944,819 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,651,292 - 5,685,611 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1125,651,292 - 5,685,601 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2125,597,667 - 5,631,833 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11645,926,543 - 45,962,967 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607716,683,754 - 16,721,078 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgb4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248015,613,861 - 5,650,214 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248015,613,752 - 5,646,046 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Itgb4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1968,051,638 - 68,087,645 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Itgb4
272 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:134
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000065339
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat

Markers in Region
RH130868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,242,714 - 101,242,912 (+)MAPPERmRatBN7.2
Rnor_6.010104,559,891 - 104,560,088NCBIRnor6.0
Rnor_5.010103,725,271 - 103,725,468UniSTSRnor5.0
RGSC_v3.410106,116,343 - 106,116,540UniSTSRGSC3.4
Celera1099,816,848 - 99,817,045UniSTS
Cytogenetic Map10q32.3UniSTS
RH94625  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,242,819 - 101,242,981 (+)MAPPERmRatBN7.2
Rnor_6.010104,559,996 - 104,560,157NCBIRnor6.0
Rnor_5.010103,725,202 - 103,725,363UniSTSRnor5.0
RGSC_v3.410106,116,448 - 106,116,609UniSTSRGSC3.4
Celera1099,816,953 - 99,817,114UniSTS
Cytogenetic Map10q32.3UniSTS
AU047884  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,240,329 - 101,240,474 (+)MAPPERmRatBN7.2
Rnor_6.010104,557,506 - 104,557,650NCBIRnor6.0
Rnor_5.010103,727,709 - 103,727,853UniSTSRnor5.0
RGSC_v3.410106,113,958 - 106,114,102UniSTSRGSC3.4
Celera1099,814,463 - 99,814,607UniSTS
Cytogenetic Map10q32.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 71 59 6 334 171 11 139 80 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000065339   ⟹   ENSRNOP00000059783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10101,705,587 - 101,741,932 (+)Ensembl
mRatBN7.2 Ensembl10101,206,665 - 101,243,012 (+)Ensembl
Rnor_6.0 Ensembl10104,523,996 - 104,560,182 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086747   ⟹   ENSRNOP00000073188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10101,705,587 - 101,741,932 (+)Ensembl
mRatBN7.2 Ensembl10101,206,665 - 101,243,012 (+)Ensembl
Rnor_6.0 Ensembl10104,524,008 - 104,561,078 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000132965   ⟹   ENSRNOP00000099155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10101,705,840 - 101,741,931 (+)Ensembl
RefSeq Acc Id: NM_013180   ⟹   NP_037312
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,705,592 - 101,741,933 (+)NCBI
mRatBN7.210101,206,665 - 101,243,012 (+)NCBI
Rnor_6.010104,524,000 - 104,560,180 (+)NCBI
Rnor_5.010103,725,179 - 103,761,358 (-)NCBI
RGSC_v3.410106,080,452 - 106,116,632 (+)RGD
Celera1099,781,746 - 99,817,137 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085295   ⟹   XP_038941223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,705,783 - 101,741,933 (+)NCBI
mRatBN7.210101,206,657 - 101,243,012 (+)NCBI
RefSeq Acc Id: XM_039085296   ⟹   XP_038941224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,705,783 - 101,741,933 (+)NCBI
mRatBN7.210101,206,657 - 101,243,012 (+)NCBI
RefSeq Acc Id: XM_039085297   ⟹   XP_038941225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,705,783 - 101,741,933 (+)NCBI
mRatBN7.210101,206,658 - 101,243,012 (+)NCBI
RefSeq Acc Id: NP_037312   ⟸   NM_013180
- Peptide Label: precursor
- UniProtKB: Q64632 (UniProtKB/Swiss-Prot),   F1LSD3 (UniProtKB/TrEMBL),   A6HKS7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059783   ⟸   ENSRNOT00000065339
Ensembl Acc Id: ENSRNOP00000073188   ⟸   ENSRNOT00000086747
RefSeq Acc Id: XP_038941223   ⟸   XM_039085295
- Peptide Label: isoform X1
- UniProtKB: Q64632 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038941224   ⟸   XM_039085296
- Peptide Label: isoform X2
- UniProtKB: Q64632 (UniProtKB/Swiss-Prot),   A0A0G2K4V5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941225   ⟸   XM_039085297
- Peptide Label: isoform X3
- UniProtKB: Q64632 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000099155   ⟸   ENSRNOT00000132965
Protein Domains
Calx-beta   Fibronectin type-III   I-EGF   PSI   VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64632-F1-model_v2 AlphaFold Q64632 1-1807 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697899
Promoter ID:EPDNEW_R8424
Type:initiation region
Name:Itgb4_1
Description:integrin subunit beta 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010104,524,095 - 104,524,155EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2928 AgrOrtholog
BioCyc Gene G2FUF-22639 BioCyc
Ensembl Genes ENSRNOG00000005580 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000065339 ENTREZGENE
  ENSRNOT00000086747 ENTREZGENE
  ENSRNOT00000132965 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  2.60.40.2030 UniProtKB/Swiss-Prot
  3.40.50.410 UniProtKB/Swiss-Prot
  4.10.1240.30 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
  ligand-binding face of the semaphorins, domain 2 UniProtKB/Swiss-Prot
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot
InterPro CalX-like_sf UniProtKB/Swiss-Prot
  Calx_beta UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot
  I-EGF_1 UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Integrin_beta_N UniProtKB/Swiss-Prot
  Integrin_bsu UniProtKB/Swiss-Prot
  Integrin_bsu-4 UniProtKB/Swiss-Prot
  Integrin_bsu_tail UniProtKB/Swiss-Prot
  Integrin_bsu_tail_dom_sf UniProtKB/Swiss-Prot
  Integrin_bsu_VWA UniProtKB/Swiss-Prot
  vWFA_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25724 UniProtKB/Swiss-Prot
NCBI Gene 25724 ENTREZGENE
PANTHER PTHR10082 UniProtKB/Swiss-Prot
  PTHR10082:SF42 UniProtKB/Swiss-Prot
Pfam Calx-beta UniProtKB/Swiss-Prot
  EGF_Teneurin UniProtKB/Swiss-Prot
  fn3 UniProtKB/Swiss-Prot
  I-EGF_1 UniProtKB/Swiss-Prot
  Integrin_B_tail UniProtKB/Swiss-Prot
  Integrin_beta UniProtKB/Swiss-Prot
  PSI_integrin UniProtKB/Swiss-Prot
PhenoGen Itgb4 PhenoGen
PIRSF Integrin_B4 UniProtKB/Swiss-Prot
PRINTS INTEGRINB UniProtKB/Swiss-Prot
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  FN3 UniProtKB/Swiss-Prot
  I_EGF_2 UniProtKB/Swiss-Prot
  INTEGRIN_BETA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005580 RatGTEx
SMART Calx_beta UniProtKB/Swiss-Prot
  FN3 UniProtKB/Swiss-Prot
  INB UniProtKB/Swiss-Prot
  Integrin_B_tail UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  Plexin repeat UniProtKB/Swiss-Prot
  SSF141072 UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot
  SSF53300 UniProtKB/Swiss-Prot
  SSF69687 UniProtKB/Swiss-Prot
TIGR TC202060
UniProt A0A0G2K4V5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L8L6_RAT UniProtKB/TrEMBL
  A6HKS7 ENTREZGENE, UniProtKB/TrEMBL
  A6HKS8_RAT UniProtKB/TrEMBL
  F1LSD3 ENTREZGENE, UniProtKB/TrEMBL
  ITB4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itgb4  integrin subunit beta 4  Itgb4  integrin, beta 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-09 Itgb4  integrin, beta 4  Itgb4  integrin beta 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Itgb4  Integrin, beta 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the abaxonal surface of myelinating Schwann cells 729025
gene_expression expressed in myelinating Schwann cells 729025