Itga1 (integrin subunit alpha 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Itga1 (integrin subunit alpha 1) Rattus norvegicus
Analyze
Symbol: Itga1
Name: integrin subunit alpha 1
RGD ID: 2923
Description: Enables collagen binding activity and signaling receptor binding activity. Involved in several processes, including positive regulation of MAPK cascade; positive regulation of neuron apoptotic process; and vasodilation. Located in acrosomal vesicle; external side of plasma membrane; and perikaryon. Orthologous to human ITGA1 (integrin subunit alpha 1); PARTICIPATES IN altered integrin mediated signaling pathway; myocardial infarction pathway; integrin mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD49 antigen-like family member A; integrin alpha 1; integrin alpha-1; integrin, alpha 1; laminin and collagen receptor; VLA-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8248,379,181 - 48,545,336 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl248,386,249 - 48,545,284 (-)EnsemblGRCr8
mRatBN7.2246,646,125 - 46,812,237 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,653,193 - 46,812,238 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx253,760,440 - 53,912,547 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0251,818,812 - 51,971,755 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0246,688,983 - 46,841,874 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0247,127,403 - 47,281,387 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl247,127,219 - 47,281,421 (-)Ensemblrn6Rnor6.0
Rnor_5.0271,666,601 - 71,823,120 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4247,107,849 - 47,206,261 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera242,407,780 - 42,559,904 (-)NCBICelera
RGSC_v3.1247,036,084 - 47,134,488 (-)NCBI
Cytogenetic Map2q14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-dichloroaniline  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
aluminium oxide  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP,ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
genistein  (ISO)
GSK-J4  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
leflunomide  (ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
Methylazoxymethanol acetate  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. alpha1 Integrin activation: a link between beta-amyloid deposition and neuronal death in aging hippocampal neurons. Anderson KL and Ferreira A, J Neurosci Res. 2004 Mar 1;75(5):688-97.
2. Alpha1beta1-integrin is an essential signal for neurite outgrowth induced by thrombospondin type 1 repeats of SCO-spondin. Bamdad M, etal., Cell Tissue Res. 2004 Jan;315(1):15-25. Epub 2003 Oct 16.
3. Integrin expression on normal and neoplastic human breast epithelium. Damjanovich L, etal., Acta Chir Hung. 1997;36(1-4):69-71.
4. Integrin signaling in inflammatory and neuropathic pain in the rat. Dina OA, etal., Eur J Neurosci. 2004 Feb;19(3):634-42.
5. Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia. Dina OA, etal., Pain. 2005 May;115(1-2):191-203.
6. Crucial role of fibroblast integrins alpha2 and beta1 in maintaining the structural and mechanical properties of the skin. Fujimura T, etal., J Dermatol Sci. 2007 Jan;45(1):45-53. Epub 2006 Nov 21.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Localization of integrin beta 1, alpha 1, alpha 5 and alpha 9 subunits in the rat testis. Giebel J, etal., Int J Androl. 1997 Feb;20(1):3-9.
9. Human and rodent bone marrow mesenchymal stem cells that express primitive stem cell markers can be directly enriched by using the CD49a molecule. Gindraux F, etal., Cell Tissue Res. 2007 Mar;327(3):471-83. Epub 2006 Nov 16.
10. Molecular cloning of the rat integrin alpha 1-subunit: a receptor for laminin and collagen. Ignatius MJ, etal., J Cell Biol 1990 Aug;111(2):709-20.
11. Endothelin-1 is a potent stimulator of alpha1beta1 integrin-mediated collagen matrix remodeling by rat mesangial cells. Kitamura A, etal., Biochem Biophys Res Commun 2002 Dec 13;299(4):555-61.
12. Key role of alpha(1)beta(1)-integrin in the activation of PI3-kinase-Akt by flow (shear stress) in resistance arteries. Loufrani L, etal., Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1906-13. Epub 2008 Feb 1.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Differential expression of alpha 1, alpha 3 and alpha 5 integrin subunits in acute and chronic stages of myocardial infarction in rats. Nawata J, etal., Cardiovasc Res 1999 Aug 1;43(2):371-81.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Lebestatin, a disintegrin from Macrovipera venom, inhibits integrin-mediated cell adhesion, migration and angiogenesis. Olfa KZ, etal., Lab Invest. 2005 Dec;85(12):1507-16.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Genetic deletion or antibody blockade of alpha1beta1 integrin induces a stable plaque phenotype in ApoE-/- mice. Schapira K, etal., Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1917-24. Epub 2005 Jun 23.
22. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
23. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
24. Calcium-sensing receptor modulates cell adhesion and migration via integrins. Tharmalingam S, etal., J Biol Chem. 2011 Nov 25;286(47):40922-33. doi: 10.1074/jbc.M111.265454. Epub 2011 Oct 3.
Additional References at PubMed
PMID:9553049   PMID:10386626   PMID:10528208   PMID:11518510   PMID:11767049   PMID:15592458   PMID:16271045   PMID:16973387   PMID:17161391   PMID:19056867   PMID:19581412   PMID:19933311  
PMID:19946888   PMID:20563599   PMID:21423176   PMID:22847004   PMID:23023225   PMID:23658023   PMID:24823363   PMID:26520903   PMID:27108411   PMID:27484337  


Genomics

Comparative Map Data
Itga1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8248,379,181 - 48,545,336 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl248,386,249 - 48,545,284 (-)EnsemblGRCr8
mRatBN7.2246,646,125 - 46,812,237 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,653,193 - 46,812,238 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx253,760,440 - 53,912,547 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0251,818,812 - 51,971,755 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0246,688,983 - 46,841,874 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0247,127,403 - 47,281,387 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl247,127,219 - 47,281,421 (-)Ensemblrn6Rnor6.0
Rnor_5.0271,666,601 - 71,823,120 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4247,107,849 - 47,206,261 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera242,407,780 - 42,559,904 (-)NCBICelera
RGSC_v3.1247,036,084 - 47,134,488 (-)NCBI
Cytogenetic Map2q14NCBI
ITGA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38552,787,916 - 52,959,209 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl552,787,916 - 52,959,209 (+)Ensemblhg38GRCh38
GRCh37552,083,750 - 52,255,039 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,119,893 - 52,285,242 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34552,119,892 - 52,285,241NCBI
Celera549,037,686 - 49,203,085 (+)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef549,055,982 - 49,221,542 (+)NCBIHuRef
CHM1_1552,086,786 - 52,252,111 (+)NCBICHM1_1
T2T-CHM13v2.0553,615,621 - 53,786,944 (+)NCBIT2T-CHM13v2.0
Itga1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913115,094,615 - 115,238,500 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13115,089,632 - 115,238,500 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3813114,958,079 - 115,101,964 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,953,096 - 115,101,964 (-)Ensemblmm10GRCm38
MGSCv3713115,748,287 - 115,892,172 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3613116,080,957 - 116,222,842 (-)NCBIMGSCv36mm8
Celera13119,308,615 - 119,462,806 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.61NCBI
Itga1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544614,446,300 - 14,577,605 (-)Ensembl
ChiLan1.0NW_00495544614,439,571 - 14,582,236 (-)NCBIChiLan1.0ChiLan1.0
ITGA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2460,984,567 - 61,160,262 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1559,135,090 - 59,312,685 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0561,073,507 - 61,247,565 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1562,692,673 - 62,865,771 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl562,692,673 - 62,865,769 (-)EnsemblpanPan2panpan1.1
ITGA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1462,287,823 - 62,455,940 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl462,293,082 - 62,455,650 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha462,062,740 - 62,230,868 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0462,785,836 - 62,953,966 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl462,791,553 - 62,953,332 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1462,561,013 - 62,729,609 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0462,685,631 - 62,847,651 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0463,212,383 - 63,380,850 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Itga1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213205,502,947 - 205,654,957 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648014,443,685 - 14,591,380 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648014,442,481 - 14,591,574 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,129,612 - 32,304,592 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11632,130,265 - 32,309,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21633,940,969 - 34,132,541 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,081,687 - 49,248,321 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl449,082,787 - 49,246,186 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660821,876,808 - 2,052,640 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247596,404,758 - 6,543,211 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247596,397,743 - 6,543,652 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Itga1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13181,620,151 - 181,764,885 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Itga1
896 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:68
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000016353
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)23561408353462005Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9685065Swd6Spike wave discharge measurement QTL 65.80.01brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge rate (CMO:0001739)24095742350526673Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
RH130277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2246,797,854 - 46,798,034 (+)MAPPERmRatBN7.2
Rnor_6.0247,266,760 - 47,266,939NCBIRnor6.0
Rnor_5.0271,808,493 - 71,808,672UniSTSRnor5.0
RGSC_v3.4245,900,725 - 45,900,904UniSTSRGSC3.4
Celera242,545,598 - 42,545,777UniSTS
RH 3.4 Map2307.3UniSTS
Cytogenetic Map2q14UniSTS
Cytogenetic Map2q16-q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 91 59 6 355 191 11 141 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000086114   ⟹   ENSRNOP00000074337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl248,390,257 - 48,545,284 (-)Ensembl
mRatBN7.2 Ensembl246,657,201 - 46,812,238 (-)Ensembl
Rnor_6.0 Ensembl247,127,219 - 47,281,421 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106157   ⟹   ENSRNOP00000086956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl248,386,249 - 48,545,284 (-)Ensembl
mRatBN7.2 Ensembl246,653,193 - 46,812,238 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000150403   ⟹   ENSRNOP00000101823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl248,386,249 - 48,545,284 (-)Ensembl
RefSeq Acc Id: NM_030994   ⟹   NP_112256
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8248,386,244 - 48,545,283 (-)NCBI
mRatBN7.2246,653,188 - 46,812,237 (-)NCBI
Rnor_6.0247,127,403 - 47,281,387 (-)NCBI
Rnor_5.0271,666,601 - 71,823,120 (-)NCBI
RGSC_v3.4247,107,849 - 47,206,261 (-)RGD
Celera242,407,780 - 42,559,904 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101763   ⟹   XP_038957691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8248,379,181 - 48,545,336 (-)NCBI
mRatBN7.2246,646,125 - 46,811,914 (-)NCBI
RefSeq Acc Id: XR_010063584
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8248,413,961 - 48,545,324 (-)NCBI
Protein Sequences
Protein RefSeqs NP_112256 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957691 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA36384 (Get FASTA)   NCBI Sequence Viewer  
  EDM10391 (Get FASTA)   NCBI Sequence Viewer  
  EDM10392 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000086956
  ENSRNOP00000086956.1
  ENSRNOP00000101823
GenBank Protein P18614 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112256   ⟸   NM_030994
- Peptide Label: precursor
- UniProtKB: P18614 (UniProtKB/Swiss-Prot),   A6I5T3 (UniProtKB/TrEMBL),   A0A8L2R8Q8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074337   ⟸   ENSRNOT00000086114
RefSeq Acc Id: XP_038957691   ⟸   XM_039101763
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R8Q8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086956   ⟸   ENSRNOT00000106157
Ensembl Acc Id: ENSRNOP00000101823   ⟸   ENSRNOT00000150403
Protein Domains
VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18614-F1-model_v2 AlphaFold P18614 1-1180 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691151
Promoter ID:EPDNEW_R1675
Type:multiple initiation site
Name:Itga1_2
Description:integrin subunit alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1676  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0247,281,160 - 47,281,220EPDNEW
RGD ID:13691152
Promoter ID:EPDNEW_R1676
Type:multiple initiation site
Name:Itga1_1
Description:integrin subunit alpha 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R1675  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0247,281,392 - 47,281,452EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2923 AgrOrtholog
BioCyc Gene G2FUF-54324 BioCyc
Ensembl Genes ENSRNOG00000053550 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000106157 ENTREZGENE
  ENSRNOT00000106157.1 UniProtKB/Swiss-Prot
  ENSRNOT00000150403 ENTREZGENE
Gene3D-CATH 2.130.10.130 UniProtKB/Swiss-Prot
  3.40.50.410 UniProtKB/Swiss-Prot
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/Swiss-Prot
  Integrin domains. Chain A, domain 2 UniProtKB/Swiss-Prot
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/Swiss-Prot
InterPro FG-GAP UniProtKB/Swiss-Prot
  Int_alpha_beta-p UniProtKB/Swiss-Prot
  Integrin_alpha UniProtKB/Swiss-Prot
  Integrin_alpha-2 UniProtKB/Swiss-Prot
  Integrin_alpha_C_CS UniProtKB/Swiss-Prot
  Integrin_alpha_Ig-like_2 UniProtKB/Swiss-Prot
  Integrin_alpha_Ig-like_3 UniProtKB/Swiss-Prot
  Integrin_alpha_N UniProtKB/Swiss-Prot
  Integrin_dom_sf UniProtKB/Swiss-Prot
  VWF_A UniProtKB/Swiss-Prot
  vWFA_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25118 UniProtKB/Swiss-Prot
NCBI Gene 25118 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/Swiss-Prot
  INTEGRIN ALPHA-1 UniProtKB/Swiss-Prot
Pfam FG-GAP UniProtKB/Swiss-Prot
  Integrin_A_Ig_2 UniProtKB/Swiss-Prot
  Integrin_A_Ig_3 UniProtKB/Swiss-Prot
  Integrin_alpha2 UniProtKB/Swiss-Prot
  VWA UniProtKB/Swiss-Prot
PhenoGen Itga1 PhenoGen
PRINTS INTEGRINA UniProtKB/Swiss-Prot
  VWFADOMAIN UniProtKB/Swiss-Prot
PROSITE FG_GAP UniProtKB/Swiss-Prot
  INTEGRIN_ALPHA UniProtKB/Swiss-Prot
  VWFA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000053550 RatGTEx
SMART Int_alpha UniProtKB/Swiss-Prot
  VWA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53300 UniProtKB/Swiss-Prot
  SSF69179 UniProtKB/Swiss-Prot
  SSF69318 UniProtKB/Swiss-Prot
UniProt A0A8L2R8Q8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LBD4_RAT UniProtKB/TrEMBL
  A6I5T3 ENTREZGENE, UniProtKB/TrEMBL
  A6I5T4_RAT UniProtKB/TrEMBL
  ITA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itga1  integrin subunit alpha 1  Itga1  integrin, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-09 Itga1  integrin, alpha 1  Itga1  integrin alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Itga1  integrin alpha 1    integrin, alpha 1  Name updated 629478 APPROVED
2002-06-10 Itga1  integrin, alpha 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function associates with the beta-1 chain to form a dual laminin/collagen receptor 729264
gene_process has a role in cell attachment and neurite outgrowth on laminin and collagen as well as in peripheral nerve regeneration  
gene_process involved in mesangial cell (MC) migration 727474
gene_regulation activity stimulated by Endothelin-1 (ET) in mesangial cells 727474