Inha (inhibin subunit alpha) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Inha (inhibin subunit alpha) Rattus norvegicus
Analyze
Symbol: Inha
Name: inhibin subunit alpha
RGD ID: 2912
Description: Enables inhibin binding activity. Involved in male gonad development; negative regulation of follicle-stimulating hormone secretion; and ovarian follicle development. Located in several cellular components, including neuronal cell body; photoreceptor inner segment; and photoreceptor outer segment. Part of inhibin A complex and inhibin B complex. Biomarker of Leydig cell tumor. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human INHA (inhibin subunit alpha); INTERACTS WITH (S)-amphetamine; (S)-colchicine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: inhibin alpha; inhibin alpha chain; inhibin alpha subunit; MGC93593
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Bp34  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,443,109 - 84,446,010 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl984,443,109 - 84,446,009 (+)EnsemblGRCr8
mRatBN7.2976,994,465 - 76,997,366 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,993,589 - 76,997,248 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx985,438,700 - 85,441,597 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,567,579 - 90,570,476 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,953,758 - 88,956,655 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,700,482 - 82,703,383 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,700,468 - 82,703,400 (+)Ensemblrn6Rnor6.0
Rnor_5.0982,469,743 - 82,472,644 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4974,781,223 - 74,784,124 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera974,564,342 - 74,567,243 (+)NCBICelera
RGSC_v3.1974,928,355 - 74,931,217 (+)NCBI
Cytogenetic Map9q33NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (EXP)
(S)-colchicine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
25-hydroxycholesterol  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
clofibrate  (EXP)
clozapine  (EXP)
cocaine  (ISO)
DDE  (EXP,ISO)
dexamethasone  (EXP)
Di-n-hexyl phthalate  (EXP)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (EXP)
diheptyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
dimethomorph  (EXP)
dipentyl phthalate  (EXP)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Ethylenethiourea  (ISO)
flavonoids  (EXP)
fonofos  (ISO)
furan  (EXP)
gentamycin  (EXP)
ginsenoside Rg1  (ISO)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
haloperidol  (EXP)
lead(0)  (ISO)
levonorgestrel  (ISO)
linuron  (EXP)
methamphetamine  (EXP)
methimazole  (EXP)
methoxyacetic acid  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
nitrofen  (EXP)
Nonylphenol  (EXP)
okadaic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
PCB138  (EXP)
phenformin  (EXP)
phenylephrine  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
Ptaquiloside  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
risperidone  (ISO)
rotenone  (EXP)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Changes in the reproductive functions of mice due to injection of a plasmid expressing an inhibin alpha-subunit into muscle: a transient transgenic model. Ahn JM, etal., Mol Cells. 2004 Aug 31;18(1):79-86.
2. Gonadal malignant germ cell tumors express immunoreactive inhibin/activin subunits. Cobellis L, etal., Eur J Endocrinol. 2001 Dec;145(6):779-84.
3. Analysis of the 5'-flanking regions of rat inhibin alpha- and beta-B-subunit genes suggests two different regulatory mechanisms. Feng ZM, etal., Mol Endocrinol 1989 Dec;3(12):1914-25.
4. Inhibin alpha-subunit and the inhibin coreceptor betaglycan are downregulated in endometrial carcinoma. Florio P, etal., Eur J Endocrinol. 2005 Feb;152(2):277-84.
5. Immunological localization and ontogenetic development of inhibin alpha subunit in rat brain. Fujimura H, etal., J Neuroendocrinol. 1999 Mar;11(3):157-63.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Development and evaluation of a novel DNA vaccine expressing inhibin alpha (1-32) fragment for improving the fertility in rats and sheep. Han L, etal., Anim Reprod Sci. 2007 Dec 31;.
9. Elevated levels of inhibin-A and immunoreactive inhibin in aged male Wistar rats with testicular Leydig cell tumor. Herath CB, etal., J Androl. 2001 Sep-Oct;22(5):838-46.
10. Cytokine modulation of inhibin secretion in cultured rat granulosa cells. Imai M, etal., J Endocrinol. 1996 Dec;151(3):449-57.
11. Testicular and serum levels of inhibin and expression of inhibin subunit mRNAs are differentially affected by hemicastration in rats of various ages. Klaij IA, etal., J Endocrinol. 1994 Apr;141(1):143-51.
12. Effects of inhibin on rat gonadal differentiation and development in vitro. Koike S and Noumura T, Zoolog Sci. 1996 Jun;13(3):385-92.
13. A role of inhibin as a tumor suppressor in Sertoli cells: down-regulation upon aging and repression by a viral oncogene. Lopez P, etal., Oncogene. 1999 Dec 2;18(51):7303-9.
14. Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice. Matzuk MM, etal., Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8817-21.
15. Ovarian sertoli-leydig cell tumors with pseudoendometrioid tubules (pseudoendometrioid sertoli-leydig cell tumors). McCluggage WG and Young RH, Am J Surg Pathol. 2007 Apr;31(4):592-7.
16. Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer. Mellor SL, etal., J Clin Endocrinol Metab. 1998 Mar;83(3):969-75.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Inhibin/activin subunits (inhibin-alpha, -betaA and -betaB) are differentially expressed in human breast cancer and their metastasis. Mylonas I, etal., Oncol Rep. 2005 Jan;13(1):81-8.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Regulation of the alpha inhibin gene by cyclic adenosine 3',5'-monophosphate after transfection into rat granulosa cells. Pei L, etal., Mol Endocrinol 1991 Apr;5(4):521-34.
21. Genetic variation in the inhibin pathway and risk of testicular germ cell tumors. Purdue MP, etal., Cancer Res. 2008 Apr 15;68(8):3043-8.
22. Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9. Rapp JP, etal., Genomics 1998 Jul 15;51(2):191-6
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Immunoneutralization of endogenous inhibin modifies hormone secretion and ovulation rate in the rat. Rivier C and Vale W, Endocrinology. 1989 Jul;125(1):152-7.
26. Inhibin forms in serum from postmenopausal women with ovarian cancers. Robertson DM, etal., Clin Endocrinol (Oxf). 1999 Mar;50(3):381-6.
27. Hypermethylation of the inhibin alpha-subunit gene in prostate carcinoma. Schmitt JF, etal., Mol Endocrinol. 2002 Feb;16(2):213-20.
28. Correlation between inhibin secretion and damage of seminiferous tubules in a model of experimental autoimmune orchitis. Suescun MO, etal., J Endocrinol. 2001 Jul;170(1):113-20.
29. Rat inhibin: molecular cloning of alpha- and beta-subunit complementary deoxyribonucleic acids and expression in the ovary. Woodruff TK, etal., Mol Endocrinol 1987 Aug;1(8):561-8.
30. Expression of the inhibin/activin subunits (-alpha, -betaA and -betaB) in normal and carcinogenic endometrial tissue: possible immunohistochemical differentiation markers. Worbs S, etal., Oncol Rep. 2007 Jan;17(1):97-104.
31. Increasing blunting of inhibin responses to dynamic ovarian challenge is associated with reproductive aging in the rat. Yeh J and Kim B, Reprod Sci. 2007 Jan;14(1):10-9.
32. Expression and localization of inhibin alpha-subunit in rat retinal photoreceptor cells. Ying SY, etal., Life Sci. 1995;57(1):45-52.
33. Effects of alpha-inhibin-92 fragments and alpha-inhibin-92 antiserum on the control of follicle-stimulating hormone release in male rats. Yu WH, etal., Life Sci. 1994;55(2):93-102.
Additional References at PubMed
PMID:1310063   PMID:2484214   PMID:2829170   PMID:7890768   PMID:9032295   PMID:10746731   PMID:12477932   PMID:12732619   PMID:15070852   PMID:15489334   PMID:15650079   PMID:16269517  
PMID:16770574   PMID:19372236   PMID:19464342   PMID:22249524   PMID:23767829  


Genomics

Comparative Map Data
Inha
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8984,443,109 - 84,446,010 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl984,443,109 - 84,446,009 (+)EnsemblGRCr8
mRatBN7.2976,994,465 - 76,997,366 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,993,589 - 76,997,248 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx985,438,700 - 85,441,597 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0990,567,579 - 90,570,476 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,953,758 - 88,956,655 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0982,700,482 - 82,703,383 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl982,700,468 - 82,703,400 (+)Ensemblrn6Rnor6.0
Rnor_5.0982,469,743 - 82,472,644 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4974,781,223 - 74,784,124 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera974,564,342 - 74,567,243 (+)NCBICelera
RGSC_v3.1974,928,355 - 74,931,217 (+)NCBI
Cytogenetic Map9q33NCBI
INHA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,572,310 - 219,575,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2219,569,162 - 219,575,711 (+)Ensemblhg38GRCh38
GRCh372220,437,032 - 220,440,433 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,145,198 - 220,148,671 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342220,262,458 - 220,265,932NCBI
Celera2214,206,917 - 214,210,389 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2212,289,982 - 212,293,463 (+)NCBIHuRef
CHM1_12220,442,773 - 220,446,254 (+)NCBICHM1_1
T2T-CHM13v2.02220,057,015 - 220,060,416 (+)NCBIT2T-CHM13v2.0
Inha
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39175,483,872 - 75,487,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl175,483,721 - 75,487,010 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38175,507,077 - 75,510,366 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl175,507,077 - 75,510,366 (+)Ensemblmm10GRCm38
MGSCv37175,503,652 - 75,506,929 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36175,390,225 - 75,393,502 (+)NCBIMGSCv36mm8
Celera175,996,369 - 75,999,645 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map139.16NCBI
Inha
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545313,902,277 - 13,905,008 (-)Ensembl
ChiLan1.0NW_00495545313,902,443 - 13,905,008 (-)NCBIChiLan1.0ChiLan1.0
INHA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213122,201,726 - 122,205,889 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B122,216,786 - 122,220,855 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,828,948 - 106,832,993 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B225,419,747 - 225,423,386 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B225,419,176 - 225,423,386 (+)EnsemblpanPan2panpan1.1
INHA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13726,080,465 - 26,083,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3726,080,510 - 26,083,391 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3726,905,885 - 26,908,990 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03726,095,548 - 26,098,652 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3726,095,593 - 26,098,473 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,999,522 - 26,002,625 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,935,517 - 25,938,622 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,956,124 - 25,959,282 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Inha
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303175,606,985 - 175,611,402 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,950,297 - 1,954,165 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,949,747 - 1,954,179 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INHA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15121,580,803 - 121,586,006 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115121,581,847 - 121,586,020 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215134,507,304 - 134,511,349 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap15q2.5NCBI
INHA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110105,467,575 - 105,471,388 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10105,467,963 - 105,471,688 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604093,930,128 - 93,933,947 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inha
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248235,487,278 - 5,491,635 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248235,487,930 - 5,491,447 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Inha
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14148,855,647 - 148,858,841 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Inha
31 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:31
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000027227
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)98216882386720295Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat

Markers in Region
D9Wox10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,994,123 - 76,994,246 (+)MAPPERmRatBN7.2
Rnor_6.0982,700,141 - 82,700,263NCBIRnor6.0
Rnor_5.0982,469,402 - 82,469,524UniSTSRnor5.0
RGSC_v3.4974,780,882 - 74,781,004UniSTSRGSC3.4
RGSC_v3.4974,780,881 - 74,781,004RGDRGSC3.4
Celera974,564,001 - 74,564,123UniSTS
RGSC_v3.1974,927,989 - 74,928,112RGD
RH 3.4 Map9757.3RGD
RH 3.4 Map9757.3UniSTS
Cytogenetic Map9q33UniSTS
RH136772  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,997,178 - 76,997,303 (+)MAPPERmRatBN7.2
Rnor_6.0982,703,196 - 82,703,320NCBIRnor6.0
Rnor_5.0982,472,457 - 82,472,581UniSTSRnor5.0
RGSC_v3.4974,783,937 - 74,784,061UniSTSRGSC3.4
Celera974,567,056 - 74,567,180UniSTS
RH 3.4 Map9744.1UniSTS
Cytogenetic Map9q33UniSTS
UniSTS:143587  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,996,427 - 76,996,872 (+)MAPPERmRatBN7.2
Rnor_6.0982,702,445 - 82,702,889NCBIRnor6.0
Rnor_5.0982,471,706 - 82,472,150UniSTSRnor5.0
RGSC_v3.4974,783,186 - 74,783,630UniSTSRGSC3.4
Celera974,566,305 - 74,566,749UniSTS
Cytogenetic Map9q33UniSTS
ECD17211  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8984,441,682 - 84,442,090 (+)Marker Load Pipeline
mRatBN7.2976,993,037 - 76,993,446 (+)MAPPERmRatBN7.2
Rnor_6.0982,699,055 - 82,699,463NCBIRnor6.0
Rnor_5.0982,468,316 - 82,468,724UniSTSRnor5.0
RGSC_v3.4974,779,796 - 74,780,204UniSTSRGSC3.4
Celera974,562,915 - 74,563,323UniSTS
Cytogenetic Map9q33UniSTS
REN53413  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,992,757 - 76,993,030 (+)MAPPERmRatBN7.2
Rnor_6.0982,698,775 - 82,699,047NCBIRnor6.0
Rnor_5.0982,468,036 - 82,468,308UniSTSRnor5.0
RGSC_v3.4974,779,516 - 74,779,788UniSTSRGSC3.4
Celera974,562,635 - 74,562,907UniSTS
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 149 89 88 57 91 57 6 352 190 11 128 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000027227   ⟹   ENSRNOP00000027227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl984,443,109 - 84,446,009 (+)Ensembl
mRatBN7.2 Ensembl976,993,589 - 76,997,248 (+)Ensembl
Rnor_6.0 Ensembl982,700,468 - 82,703,400 (+)Ensembl
RefSeq Acc Id: NM_012590   ⟹   NP_036722
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8984,443,109 - 84,446,010 (+)NCBI
mRatBN7.2976,994,465 - 76,997,366 (+)NCBI
Rnor_6.0982,700,482 - 82,703,383 (+)NCBI
Rnor_5.0982,469,743 - 82,472,644 (+)NCBI
RGSC_v3.4974,781,223 - 74,784,124 (+)RGD
Celera974,564,342 - 74,567,243 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036722 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41437 (Get FASTA)   NCBI Sequence Viewer  
  AAH83564 (Get FASTA)   NCBI Sequence Viewer  
  EDL75453 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027227
  ENSRNOP00000027227.2
GenBank Protein P17490 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036722   ⟸   NM_012590
- Peptide Label: precursor
- UniProtKB: P17490 (UniProtKB/Swiss-Prot),   A6JW45 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027227   ⟸   ENSRNOT00000027227
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17490-F1-model_v2 AlphaFold P17490 1-366 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696783
Promoter ID:EPDNEW_R7308
Type:initiation region
Name:Inha_1
Description:inhibin alpha subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0982,700,485 - 82,700,545EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2912 AgrOrtholog
BioCyc Gene G2FUF-27059 BioCyc
Ensembl Genes ENSRNOG00000020097 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027227 ENTREZGENE
  ENSRNOT00000027227.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112717 IMAGE-MGC_LOAD
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Inhibin_asu UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGF-beta-rel UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report rno:24504 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93593 IMAGE-MGC_LOAD
NCBI Gene 24504 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot
  PTHR11848:SF117 UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
PhenoGen Inha PhenoGen
PIRSF Inhibin_alpha_subunit UniProtKB/Swiss-Prot
PRINTS INHIBINA UniProtKB/Swiss-Prot
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020097 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A6JW45 ENTREZGENE, UniProtKB/TrEMBL
  INHA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-25 Inha  inhibin subunit alpha  Inha  inhibin alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-01 Inha  inhibin alpha subunit  Inha  inhibin alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Inha  Inhibin, alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in granulosa cells of the developing follicles 61638
gene_regulation expression stimulated by FSH in the ovary 729330