Il3 (interleukin 3) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Il3 (interleukin 3) Rattus norvegicus
Analyze
Symbol: Il3
Name: interleukin 3
RGD ID: 2897
Description: Enables cytokine activity and interleukin-3 receptor binding activity. Involved in several processes, including hemopoiesis; positive regulation of cell population proliferation; and regulation of cell growth. Located in extracellular space. Used to study osteosarcoma. Biomarker of prostatic hypertrophy and pyelonephritis. Human ortholog(s) of this gene implicated in Graves ophthalmopathy; Graves' disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-3 signaling pathway; apoptotic cell death pathway; INTERACTS WITH ammonium chloride; bisphenol A; Calcimycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hematopoietic growth factor; IL-3; interleukin-3; mast cell growth factor; MCGF; multipotential colony-stimulating factor; P-cell-stimulating factor
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau7
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,906,460 - 38,908,810 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1038,906,460 - 38,908,810 (-)EnsemblGRCr8
mRatBN7.21038,405,716 - 38,408,066 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,405,716 - 38,408,066 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1043,090,254 - 43,092,770 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,580,351 - 42,582,867 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,084,063 - 38,086,579 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,620,535 - 39,622,973 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,620,563 - 39,622,973 (-)Ensemblrn6Rnor6.0
Rnor_5.01039,397,782 - 39,400,192 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41039,684,691 - 39,687,041 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1037,746,256 - 37,748,606 (-)NCBICelera
RGSC_v3.11039,698,313 - 39,700,664 (-)NCBI
Cytogenetic Map10q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-chloro-2,4-dinitrobenzene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alclometasone dipropionate  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aspartame  (ISO)
Azoxymethane  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
betamethasone valerate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
Calcimycin  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
chloroquine  (ISO)
ciprofloxacin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
emamectin benzoate  (ISO)
entinostat  (ISO)
ethanol  (ISO)
formaldehyde  (ISO)
hydralazine  (ISO)
ionomycin  (ISO)
L-arginine  (EXP)
lipopolysaccharide  (ISO)
luteolin  (EXP)
methotrexate  (ISO)
microcystin-LR  (ISO)
monodansylcadaverine  (ISO)
mycophenolic acid  (ISO)
N-acetyl-L-cysteine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
naproxen  (EXP)
neocuproine  (ISO)
nitroprusside  (EXP)
nonanoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenylarsine oxide  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
poly(I:C)  (ISO)
resveratrol  (EXP,ISO)
sirolimus  (ISO)
sterigmatocystin  (ISO)
sumatriptan  (EXP)
tacrolimus hydrate  (ISO)
tert-butyl hydroperoxide  (ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO,ISS)

Molecular Function
cytokine activity  (IBA,IDA,IEA,IMP,ISO,ISS)
growth factor activity  (IEA,ISO)
interleukin-3 receptor binding  (IEA,IMP,ISO)
protein binding  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Cloning and expression of the rat interleukin-3 gene. Cohen DR, etal., Nucleic Acids Res 1986 May 12;14(9):3641-58.
2. Adenovirus-mediated interleukin 3 beta gene transfer by isolated limb perfusion inhibits growth of limb sarcoma in rats. de Wilt JH, etal., Hum Gene Ther. 2001 Mar 20;12(5):489-502.
3. Cloning, biological characterization and high-level expression of rat interleukin-3 using recombinant adenovirus: description of a new splicing variant. del C Esandi M, etal., Gene 1998 Apr 28;211(1):151-8.
4. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
5. A dual role for the immune response in a mouse model of inflammation-associated lung cancer. Dougan M, etal., J Clin Invest. 2011 Jun 1;121(6):2436-46. doi: 10.1172/JCI44796. Epub 2011 May 2.
6. Strongyloides ratti infection induces transient nematode-specific Th2 response and reciprocal suppression of IFN-gamma production in mice. Eschbach ML, etal., Parasite Immunol. 2010 May;32(5):370-83.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Identification of a 5-protein biomarker molecular signature for predicting Alzheimer's disease. Gomez Ravetti M and Moscato P, PLoS One. 2008 Sep 3;3(9):e3111.
9. Rat IL-3 stimulates the growth of rat mucosal mast cells in culture. Haig DM, etal., Immunology. 1988 Oct;65(2):205-11.
10. The cytokine response to human traumatic brain injury: temporal profiles and evidence for cerebral parenchymal production. Helmy A, etal., J Cereb Blood Flow Metab. 2011 Feb;31(2):658-70. Epub 2010 Aug 18.
11. Rheumatoid arthritis-associated gene-gene interaction network for rheumatoid arthritis candidate genes. Huang CH, etal., BMC Proc. 2009 Dec 15;3 Suppl 7:S75.
12. Global gene expression profiling of renal scarring in a rat model of pyelonephritis. Ichino M, etal., Pediatr Nephrol. 2008 Jul;23(7):1059-71. Epub 2008 Jan 23.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. IL3 SNP rs40401 variant is a risk factor for rhinoconjunctivitis in Japanese women: the Kyushu Okinawa maternal and child health study. Miyake Y, etal., Cytokine. 2013 Oct;64(1):86-9. doi: 10.1016/j.cyto.2013.07.020. Epub 2013 Aug 15.
15. IL3 rs40401 polymorphism and interaction with smoking in risk of asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health study. Miyake Y, etal., Scand J Immunol. 2014 Jun;79(6):410-4. doi: 10.1111/sji.12171.
16. Hematopoietic cytokines in the sera of patients with pancreatic cancer. Mroczko B, etal., Clin Chem Lab Med. 2005;43(2):146-50.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats. Nishihara T, etal., Exp Neurol. 2011 Jun;229(2):507-16. Epub 2011 Apr 16.
19. Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy. Park BL, etal., J Hum Genet. 2004;49(10):517-27. doi: 10.1007/s10038-004-0184-x. Epub 2004 Sep 11.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Ray S, etal., Nat Med. 2007 Nov;13(11):1359-62. Epub 2007 Oct 14.
24. GOA pipeline RGD automated data pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. LHRH antagonist Cetrorelix reduces prostate size and gene expression of proinflammatory cytokines and growth factors in a rat model of benign prostatic hyperplasia. Rick FG, etal., Prostate. 2011 May 15;71(7):736-47. doi: 10.1002/pros.21289. Epub 2010 Oct 13.
28. Keratinocytes play a role in the immunity to Herpes simplex virus type 2 infection. Shao Y, etal., Acta Virol. 2010;54(4):261-7.
29. Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. Shelton RC, etal., Mol Psychiatry. 2011 Jul;16(7):751-62. doi: 10.1038/mp.2010.52. Epub 2010 May 18.
30. Plasma protein profiling reveals protein clusters related to BMI and insulin levels in middle-aged overweight subjects. van Dijk SJ, etal., PLoS One. 2010 Dec 23;5(12):e14422.
31. Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis. Wauquier N, etal., PLoS Negl Trop Dis. 2010 Oct 5;4(10). pii: e837.
32. Differential cytokine secretion of cultured bone marrow stromal cells from patients with psoriasis and healthy volunteers. Zhang K, etal., Eur J Dermatol. 2010 Jan-Feb;20(1):49-53. Epub 2009 Nov 4.
33. Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease. Zhu W, etal., J Endocrinol Invest. 2010 Nov;33(10):751-5. Epub 2010 Mar 22.
Additional References at PubMed
PMID:1350248   PMID:1375116   PMID:7519779   PMID:7690439   PMID:7736574   PMID:7957045   PMID:8378315   PMID:9202146   PMID:9697835   PMID:9722506   PMID:9747458   PMID:10652277  
PMID:10872802   PMID:11527400   PMID:12124386   PMID:12714518   PMID:12944463   PMID:14967141   PMID:15231831   PMID:15680329   PMID:15947484   PMID:17437992   PMID:19109256   PMID:20696593  
PMID:21149635   PMID:25389122   PMID:34183475  


Genomics

Comparative Map Data
Il3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,906,460 - 38,908,810 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1038,906,460 - 38,908,810 (-)EnsemblGRCr8
mRatBN7.21038,405,716 - 38,408,066 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,405,716 - 38,408,066 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1043,090,254 - 43,092,770 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,580,351 - 42,582,867 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,084,063 - 38,086,579 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,620,535 - 39,622,973 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,620,563 - 39,622,973 (-)Ensemblrn6Rnor6.0
Rnor_5.01039,397,782 - 39,400,192 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41039,684,691 - 39,687,041 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1037,746,256 - 37,748,606 (-)NCBICelera
RGSC_v3.11039,698,313 - 39,700,664 (-)NCBI
Cytogenetic Map10q22NCBI
IL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,060,655 - 132,063,204 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,060,655 - 132,063,204 (+)Ensemblhg38GRCh38
GRCh375131,396,348 - 131,398,897 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,424,246 - 131,426,795 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345131,424,245 - 131,426,795NCBI
Celera5127,526,422 - 127,528,971 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5126,588,706 - 126,591,255 (+)NCBIHuRef
CHM1_15130,829,174 - 130,831,722 (+)NCBICHM1_1
T2T-CHM13v2.05132,580,524 - 132,583,073 (+)NCBIT2T-CHM13v2.0
Il3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,155,911 - 54,158,105 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,156,129 - 54,158,103 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381154,265,085 - 54,267,279 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,265,303 - 54,267,277 (-)Ensemblmm10GRCm38
MGSCv371154,078,587 - 54,080,781 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361154,108,726 - 54,110,700 (-)NCBIMGSCv36mm8
Celera1158,854,078 - 58,856,272 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
IL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,379,116 - 127,381,660 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15125,518,679 - 125,521,223 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,483,843 - 127,486,388 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15133,647,667 - 133,650,213 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5133,647,667 - 133,650,213 (+)EnsemblpanPan2panpan1.1
IL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,330,480 - 20,332,668 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,330,480 - 20,332,668 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1119,126,033 - 19,128,221 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
UMICH_Zoey_3.11119,835,277 - 19,837,465 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01119,683,253 - 19,685,440 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,324,838 - 20,327,026 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213116,100,160 - 116,101,996 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366473,102,922 - 3,104,758 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12334,894,630 - 34,899,105 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603443,059,393 - 43,061,627 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Il3
8 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:39
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000031762
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Wox10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21038,406,240 - 38,407,090 (+)MAPPERmRatBN7.2
Rnor_6.01039,621,088 - 39,621,997NCBIRnor6.0
Rnor_5.01039,398,307 - 39,399,216UniSTSRnor5.0
RGSC_v3.41039,685,216 - 39,686,065UniSTSRGSC3.4
Celera1037,746,781 - 37,747,630UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 14 1 7 1 9 7 2 1 2 13

Sequence


Ensembl Acc Id: ENSRNOT00000031762   ⟹   ENSRNOP00000030704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1038,906,460 - 38,908,810 (-)Ensembl
mRatBN7.2 Ensembl1038,405,716 - 38,408,066 (-)Ensembl
Rnor_6.0 Ensembl1039,620,563 - 39,622,973 (-)Ensembl
RefSeq Acc Id: NM_031513   ⟹   NP_113701
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,906,460 - 38,908,810 (-)NCBI
mRatBN7.21038,405,716 - 38,408,066 (-)NCBI
Rnor_6.01039,620,563 - 39,622,973 (-)NCBI
Rnor_5.01039,397,782 - 39,400,192 (-)NCBI
RGSC_v3.41039,684,691 - 39,687,041 (-)RGD
Celera1037,746,256 - 37,748,606 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246226   ⟹   XP_006246288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,906,460 - 38,908,804 (-)NCBI
mRatBN7.21038,405,716 - 38,408,060 (-)NCBI
Rnor_6.01039,620,535 - 39,622,956 (-)NCBI
Rnor_5.01039,397,782 - 39,400,192 (-)NCBI
Sequence:
RefSeq Acc Id: NP_113701   ⟸   NM_031513
- Peptide Label: precursor
- UniProtKB: F1LS41 (UniProtKB/TrEMBL),   P97688 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246288   ⟸   XM_006246226
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000030704   ⟸   ENSRNOT00000031762

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04823-F1-model_v2 AlphaFold P04823 1-166 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6850122
Promoter ID:EP14065
Type:single initiation site
Name:RN_IL3
Description:Interleukin-3, multi-colony stimulating factor, IL3 or IL-3 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 48; Mammalian interleukin-3
Experiment Methods:Sequencing of a full-length cDNA; experiments performed with; closely related gene
Regulation:T (repressed by or weakly expressed in) lymphocytes; (induced by or strongly expressed in) antigen
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41039,687,045 - 39,687,105EPD

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2897 AgrOrtholog
BioCyc Gene G2FUF-25117 BioCyc
Ensembl Genes ENSRNOG00000026786 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000031762 ENTREZGENE
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-3 UniProtKB/Swiss-Prot
NCBI Gene 24495 ENTREZGENE
PANTHER INTERLEUKIN-3 UniProtKB/Swiss-Prot
  INTERLEUKIN-3 UniProtKB/Swiss-Prot
Pfam IL3 UniProtKB/Swiss-Prot
PhenoGen Il3 PhenoGen
PIRSF IL-3 UniProtKB/Swiss-Prot
PRINTS INTERLEUKIN3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000026786 RatGTEx
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt A6HEH2 ENTREZGENE, UniProtKB/TrEMBL
  F1LS41 ENTREZGENE, UniProtKB/TrEMBL
  IL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P70513 ENTREZGENE
  P97688 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P70513 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il3  interleukin 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in bone marrow cells 728966