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Gene: Hk3 (hexokinase 3) Rattus norvegicus

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Symbol:

Hk3

Name:

hexokinase 3

RGD ID:

2798

Description:

Enables enzyme binding activity; hexokinase activity; and hormone binding activity. Involved in fructose 6-phosphate metabolic process; glucose 6-phosphate metabolic process; and negative regulation of hydrogen peroxide-mediated programmed cell death. Part of protein-containing complex. Orthologous to human HK3 (hexokinase 3); PARTICIPATES IN amino sugar metabolic pathway; butirosin and neomycin biosynthetic pathway; fructose and mannose metabolic pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 4-amino-2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

hexokinase 3 (white cell); hexokinase type III; hexokinase-3; hexokinase-C; HK III; RNU73859

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HK3 (hexokinase 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Hk3 (hexokinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hk3 (hexokinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HK3 (hexokinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HK3 (hexokinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hk3 (hexokinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HK3 (hexokinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HK3 (hexokinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hk3 (hexokinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Hk3 (hexokinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SEC14L3 (SEC14 like lipid binding 3)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	HK3 (hexokinase 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Hk3 (hexokinase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Hex-A	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Hex-C	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Hex-t2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	hxk-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	hxk-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	hxk-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	hxk-2	Alliance	DIOPT (InParanoid\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	HXK1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	HXK1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Hex-t1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	hxk-3	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	HXK2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	HXK2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	hk2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	LOC100492955	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	9,602,119 - 9,620,038 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	9,605,016 - 9,620,037 (+)	Ensembl				GRCr8
mRatBN7.2	17	9,596,950 - 9,614,847 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	9,599,865 - 9,614,863 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	9,617,278 - 9,632,258 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	11,146,346 - 11,161,323 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	9,613,681 - 9,628,663 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	10,134,726 - 10,152,976 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	10,137,974 - 10,152,956 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	12,243,962 - 12,261,662 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	15,651,953 - 15,669,109 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	9,677,906 - 9,692,837 (+)	NCBI		Celera
RGSC_v3.1	17	15,651,952 - 15,669,109 (+)	NCBI
Cytogenetic Map	17	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

liver disease (ISO)

long QT syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bisphenol F (ISO)

bromobenzene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

D-glucose (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

diuron (EXP)

endosulfan (EXP)

ferroheme b (ISO)

fructose (ISO)

furan (EXP)

glucose (ISO)

glyphosate (ISO)

heme b (ISO)

lidocaine (EXP)

lipopolysaccharide (ISO)

methapyrilene (EXP)

N-nitrosodiethylamine (EXP)

niclosamide (ISO)

nitrobenzenes (EXP)

ozone (ISO)

paracetamol (EXP)

paraquat (EXP)

pirinixic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (EXP,ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

succimer (ISO)

tacrolimus hydrate (ISO)

tamibarotene (ISO)

testosterone (EXP,ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (EXP,ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

carbohydrate metabolic process (IEA)

carbohydrate phosphorylation (IEA)

fructose 6-phosphate metabolic process (IDA,IEA)

glucose 6-phosphate metabolic process (IBA,IDA,IEA)

glucose metabolic process (IBA)

glycolytic process (IBA,IEA)

hexose metabolic process (IEA)

intracellular glucose homeostasis (IBA,IEA)

negative regulation of hydrogen peroxide-mediated programmed cell death (IDA)

Cellular Component

cytosol (IBA)

mitochondrion (IBA)

protein-containing complex (IDA)

Molecular Function

ATP binding (IEA)

catalytic activity (IEA)

D-glucose binding (IEA)

enzyme binding (IPI)

fructokinase activity (IBA,IDA,IEA)

glucokinase activity (IBA,IDA,IEA)

hexokinase activity (IDA,IEA,ISO)

hormone binding (IPI)

kinase activity (IEA)

mannokinase activity (IBA)

nucleotide binding (IEA)

phosphotransferase activity, alcohol group as acceptor (IEA)

protein binding (IPI,ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

amino sugar metabolic pathway (IEA)

butirosin and neomycin biosynthetic pathway (IEA)

fructose and mannose metabolic pathway (IEA)

galactose metabolic pathway (IEA)

gluconeogenesis pathway (IEA)

glycolysis pathway (IEA,TAS)

glycolysis/gluconeogenesis pathway (IEA)

insulin signaling pathway (IEA)

nucleotide sugar metabolic pathway (IEA)

starch and sucrose metabolic pathway (IEA)

type 2 diabetes mellitus pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Evolution and regulatory role of the hexokinases.	Cardenas ML, etal., Biochim Biophys Acta. 1998 Mar 5;1401(3):242-64.
2.	A leucine zipper-like motif and a basic region-leucine zipper-like element in rat ribosomal protein L13a. Identification of the tum- transplantation antigen P198.	Chan YL, etal., J Biol Chem 1994 Feb 25;269(8):5589-94.
3.	Defect in glucokinase translocation in Zucker diabetic fatty rats.	Fujimoto Y, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Multiple molecular forms of ATP:hexose 6-phosphotransferase from rat liver.	González C, etal., Biochem Biophys Res Commun. 1964 Jul 1;16(4):347-52. doi: 10.1016/0006-291x(64)90038-5.
7.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation
14.	Complete amino acid sequence of the type III isozyme of rat hexokinase, deduced from the cloned cDNA.	Schwab DA and Wilson JE, Arch Biochem Biophys 1991 Mar;285(2):365-70.
15.	Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase.	Sui D and Wilson JE, Arch Biochem Biophys. 2000 Oct 15;382(2):262-74.
16.	Regulation and cytoprotective role of hexokinase III.	Wyatt E, etal., PLoS One. 2010 Nov 3;5(11):e13823. doi: 10.1371/journal.pone.0013823.

Additional References at PubMed

PMID:8717435	PMID:12477932	PMID:15489334	PMID:18614015	PMID:29196144

Genomics

Comparative Map Data

Hk3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	9,602,119 - 9,620,038 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	9,605,016 - 9,620,037 (+)	Ensembl				GRCr8
mRatBN7.2	17	9,596,950 - 9,614,847 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	9,599,865 - 9,614,863 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	9,617,278 - 9,632,258 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	11,146,346 - 11,161,323 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	9,613,681 - 9,628,663 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	10,134,726 - 10,152,976 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	10,137,974 - 10,152,956 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	12,243,962 - 12,261,662 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	15,651,953 - 15,669,109 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	9,677,906 - 9,692,837 (+)	NCBI		Celera
RGSC_v3.1	17	15,651,952 - 15,669,109 (+)	NCBI
Cytogenetic Map	17	p14	NCBI

HK3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	176,880,869 - 176,899,346 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	176,880,820 - 176,899,437 (-)	Ensembl			hg38	GRCh38
GRCh37	5	176,307,870 - 176,326,347 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	176,240,476 - 176,258,921 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	176,240,476 - 176,258,921	NCBI
Celera	5	172,175,889 - 172,194,352 (+)	NCBI		Celera
Cytogenetic Map	5	q35.2	NCBI
HuRef	5	171,230,595 - 171,249,057 (-)	NCBI		HuRef
CHM1_1	5	175,740,078 - 175,758,541 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	177,426,695 - 177,445,172 (-)	NCBI		T2T-CHM13v2.0

Hk3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	55,153,798 - 55,169,233 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	55,153,798 - 55,169,198 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	13	55,005,985 - 55,021,475 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	55,005,985 - 55,021,385 (-)	Ensembl			mm10	GRCm38
MGSCv37	13	55,107,347 - 55,122,695 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	13	55,015,608 - 55,030,956 (-)	NCBI		MGSCv36	mm8
Celera	13	56,066,914 - 56,082,258 (-)	NCBI		Celera
Cytogenetic Map	13	B1	NCBI
cM Map	13	29.8	NCBI

Hk3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	29,132,717 - 29,146,280 (-)	Ensembl
ChiLan1.0	NW_004955408	29,132,717 - 29,149,030 (-)	NCBI	ChiLan1.0	ChiLan1.0

HK3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	171,964,336 - 171,988,216 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	170,103,888 - 170,122,200 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	172,181,600 - 172,200,418 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	179,248,348 - 179,266,657 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	179,248,155 - 179,266,533 (-)	Ensembl			panPan2	panpan1.1

HK3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	36,471,389 - 36,491,757 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	36,472,949 - 36,529,903 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	36,439,140 - 36,464,621 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	36,838,190 - 36,863,673 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	36,838,410 - 36,895,345 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	36,664,279 - 36,689,761 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	36,852,128 - 36,877,608 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	37,360,223 - 37,385,703 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Hk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	122,097,741 - 122,118,657 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936597	1,122,648 - 1,138,396 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936597	1,122,648 - 1,143,342 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HK3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	81,042,755 - 81,060,826 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	81,042,401 - 81,060,832 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	82,650,985 - 82,669,061 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HK3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	78,888,087 - 78,908,608 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	78,888,291 - 78,906,995 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666075	10,050,093 - 10,071,104 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hk3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	13,245,845 - 13,262,184 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624733	13,245,822 - 13,262,300 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Hk3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	73,343,081 - 73,358,209 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Hk3
72 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	38
Count of miRNA genes:	33
Interacting mature miRNAs:	35
Transcripts:	ENSRNOT00000031935
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354581	Bp247	Blood pressure QTL 247	4.5		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	17	1	43999106	Rat
2300002	Iddm36	Insulin dependent diabetes mellitus QTL 36	1.98		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	17	9266755	40968173	Rat
2293664	Bmd28	Bone mineral density QTL 28	5.1	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	17	4360057	27233623	Rat
1300123	Bp194	Blood pressure QTL 194	2.82		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	2120843	42054133	Rat
1582224	Epfw4	Epididymal fat weight QTL 4	3.5	0.0058	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	17	9206505	23859062	Rat
1582225	Bw67	Body weight QTL 67	6.2	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
2302377	Scl61	Serum cholesterol level QTL 61	4.36		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	17	6221998	58177198	Rat
1582226	Bw64	Body weight QTL 64	4.2	0.0017	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
10401807	Kidm52	Kidney mass QTL 52			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	1	31706603	Rat
10054088	Scort28	Serum corticosterone level QTL 28	2.04	0.0102	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	4733534	49733534	Rat
1582208	Kidm32	Kidney mass QTL 32	3.9	0.0018	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	17	9206505	23859062	Rat
1549900	Iddm20	Insulin dependent diabetes mellitus QTL 20	3.7		pancreas integrity trait (VT:0010560)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	17	1	22181410	Rat
1354613	Kidm14	Kidney mass QTL 14	6.2		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	17	1	36045694	Rat
2324619	Coatc4	Coat color QTL 4		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)	17	1	21499218	Rat
2303627	Vencon8	Ventilatory control QTL 8		0.001	respiration trait (VT:0001943)	tidal volume (CMO:0000222)	17	4733534	49733534	Rat
1581553	Pur14	Proteinuria QTL 14	5.3	0.0001	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	17	7985243	16523460	Rat
70184	BpQTLcluster14	Blood pressure QTL cluster 14	3.38		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	17	8574342	32199534	Rat
1582258	Bw76	Body weight QTL 76	4.6	0.0005	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
631207	Niddm41	Non-insulin dependent diabetes mellitus QTL 41			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	1	38037084	Rat
1582199	Insul5	Insulin level QTL 5	3.4	0.0119	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	17	9206505	23859062	Rat
1354662	Rf49	Renal function QTL 49	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	17	1	43999106	Rat
2293648	Bmd31	Bone mineral density QTL 31	4.5	0.0001	femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	17	4360057	27233623	Rat
1354658	Spl8	Serum phospholipid level QTL 8	3.8		blood VLDL phospholipid amount (VT:0010507)	blood very low density lipoprotein phospholipid level (CMO:0001571)	17	1	43999106	Rat
1641902	Colcr7	Colorectal carcinoma resistance QTL 7	3.35	0.0044	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	17	2120843	22087569	Rat
1582241	Bw70	Body weight QTL 70	4.6	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
1582245	Bw73	Body weight QTL 73	4.6	0.0004	body mass (VT:0001259)	body weight (CMO:0000012)	17	9206505	23859062	Rat
9590316	Scort21	Serum corticosterone level QTL 21	4.75	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	17	1	22877318	Rat

Markers in Region

D17Wox28

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	17	9,604,452 - 9,604,635 (+)	Marker Load Pipeline
mRatBN7.2	17	9,599,286 - 9,599,469 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	10,137,396 - 10,137,578	NCBI	Rnor6.0
Rnor_5.0	17	12,246,238 - 12,246,420	UniSTS	Rnor5.0
RGSC_v3.4	17	15,651,375 - 15,651,557	UniSTS	RGSC3.4
Celera	17	9,677,308 - 9,677,510	UniSTS
Cytogenetic Map	17	q12	UniSTS

BF386623

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	9,614,697 - 9,614,847 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	10,152,806 - 10,152,955	NCBI	Rnor6.0
Rnor_5.0	17	12,261,486 - 12,261,635	UniSTS	Rnor5.0
RGSC_v3.4	17	15,668,960 - 15,669,109	UniSTS	RGSC3.4
Celera	17	9,692,688 - 9,692,837	UniSTS
RH 3.4 Map	17	74.8	UniSTS
Cytogenetic Map	17	q12	UniSTS

BE109885

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	9,614,860 - 9,615,042 (+)	MAPPER	mRatBN7.2
Rnor_6.0	17	10,152,969 - 10,153,150	NCBI	Rnor6.0
Rnor_5.0	17	12,261,649 - 12,261,830	UniSTS	Rnor5.0
RGSC_v3.4	17	15,669,123 - 15,669,304	UniSTS	RGSC3.4
Celera	17	9,692,851 - 9,693,032	UniSTS
RH 3.4 Map	17	79.5	UniSTS
Cytogenetic Map	17	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	8	61	134	87	86	55	81	55	6	328	173	11	106	78	91	31	11	11

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022179	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006253602	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006253603	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008771484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063276075	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005495237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC139592	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC100648	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB877582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC934991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000031935 ⟹ ENSRNOP00000031587

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	9,605,016 - 9,620,037 (+)	Ensembl
mRatBN7.2 Ensembl	17	9,599,865 - 9,614,847 (+)	Ensembl
Rnor_6.0 Ensembl	17	10,137,974 - 10,152,955 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000079850 ⟹ ENSRNOP00000068888

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	9,605,048 - 9,620,037 (+)	Ensembl
mRatBN7.2 Ensembl	17	9,600,856 - 9,614,863 (+)	Ensembl
Rnor_6.0 Ensembl	17	10,138,810 - 10,152,956 (+)	Ensembl

RefSeq Acc Id:

NM_022179 ⟹ NP_071515

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	9,605,031 - 9,620,011 (+)	NCBI
mRatBN7.2	17	9,599,865 - 9,614,847 (+)	NCBI
Rnor_6.0	17	10,137,974 - 10,152,955 (+)	NCBI
Rnor_5.0	17	12,243,962 - 12,261,662 (+)	NCBI
RGSC_v3.4	17	15,651,953 - 15,669,109 (+)	RGD
Celera	17	9,677,906 - 9,692,837 (+)	RGD

Sequence:

show sequence

GTCGTCTTATTTGGGAGCTGAGACTTGAGGAAGGTGATAACTTCTGAATCCCCCCAGGTAGTCA
ATACCATTGTGGAAACATGGCCGCCATTGAGCCTTCTGGTCTGCACCCGGGAGAAAGAGACTCA
AGCTGCCCCCAGGAGGGCATTCCAAGGCCCTCAGGTAGCTTAGAACTGGCACAGGAATACTTGC
AACAATTCAAGGTGACCATGACACAGCTGCAGCAGATCCAAGCCAGTCTTCTGTGTTCCATGGA
GCAGGCGCTGAAGGGACAGGACAGTCCCGCTCCTTCTGTCCGGATGTTGCCCACATACGTGAGG
TCCACACCACATGGCACCGAGCAAGGAGACTTCCTGGTGCTGGAGCTGGGGGCCACAGGAGCCT
CACTACGTGTGTTGTGGGTAACACTGACGGGCACCAAGGAACACAGCGTGGAGACCAGGAGCCA
GGAGTTTGTGATCCCTCAAGAGGTGATCCTAGGTGCTGGCCAGCAGCTCTTTGACTTTGCTGCC
CGCTGCCTCTCTGAATTCCTGGATGCATACCCCGTGGAGAATCAGGGTCTGAAGCTTGGGTTTA
ATTTCTCTTTTCCTTGTCACCAGACAGGCTTGGACAAGAGCACCCTCATTTCCTGGACAAAAGG
TTTTAGGTGCAGTGGTGTGGAAGGCCAGGATGTGGTCCAGTTGCTAAGGGATGCCATTCAGAGG
CAGGGGACCTACAATATTGATGTGGTAGCCATGGTGAATGACACAGTGGGTACCATGATGGGCT
GTGAGCTGGGCACCAGGCCATGTGAAGTCGGGCTTATTGTAGACACTGGTACCAATGCCTGTTA
TATGGAGGAAGCGAGGCACGTGGCAGCTCTGGATGAGGACCGCGGCCGTACCTGTGTCAGCATC
GAGTGGGGCTCCTTCTATGACGAAGAGGCCCTAGGGCCAGTACTGACCACCTTCGACGATGCCC
TGGACCACGAGTCCCTGGTTCCTGGTGCTCAGAGGTTTGAGAAGATGATTGGTGGCCTTTACTT
GGGTGAGCTGGTAAGGCTGGTGCTGGTCCACTTGTCCCAGCATGGGGTCCTCTTTGGTGGCTGC
GCCTCTCCTGCGTTGCTGAGTCAAAACAGCATCCTCCTGGAACATGTGGCCAAAATGGAGGACC
CTGCCACTGGGATAGCCCACGTCCACACAGTCCTGCAGGGCTTGGGTCTGAGCCCTCAGGCCTC
AGATGCTGAGCTCGTGCAGCGCGTGTGCATGGCTGTGTGCACGCGAGCTGCCCAGCTCTGTGCC
TCTGCCCTGGCTGCAGTCCTATCCCGCCTCCAGCACAGCAGGGAGCAGCAGACACTGCACGTGG
CCGTGGCCACTGGAGGGCGAGTGTTCGAATGGCACCCCAGGTTCCTCTGCATCCTAAAGGAGAC
GGTAATGCTCTTGGCCCCAGAGTGTGATGTCTCCTTCATCCCCTCTGTGGATGGTGGTGGCCGG
GGTGTGGCAATGGTGACTGCTGTGGCAGCCCGCCTGGCTACCCACAGGCGCATCCTGGAAGAGA
CCCTGGCACCATTTCAGCTGAGCTTGGAGCAGCTGACAGCGGTGCAGGCACAAATGCGGGAAGC
CATGATCAGGGGGCTTCAAGGAGAGAGCTCCTCCCTCCGCATGCTGCCCACTTACGTCCGAGCA
ACGCCCGATGGCAGCGAACGAGGTGACTTCCTGGCTTTGGACCTAGGGGGCACCAACTTCCGTG
TCCTGTTGGTACGCGTGGCCGAGGGCAGTGTTCAGATCACCAACCAGGTCTACTCTATTCCTGA
GTATGTAGCCCAGGGCTCTGGACAGAAGCTCTTTGATCATATTGTGGACTGCATCGTGGACTTC
CAGAAGAGGCAAGGCCTTAGCGGACAGAGCCTACCCCTGGGTTTCACCTTCTCTTTTCCTTGCA
AGCAGCTTGGCCTGGACCAGGGCATCCTCCTCAACTGGACTAAGGGGTTCAATGCATCAGGCTG
CGAGGGCCAAGATGTTGTGTATTTATTACGGGAAGCCATTAGGCGCAGACAGGCAGTGGAGCTG
AATGTGGTTGCCATTGTCAATGACACGGTGGGGACCATGATGTCCTGTGGCTATGATGATCCCT
GTTGTGAGATGGGCCTCATTGTCGGAACCGGTACCAACGCCTGCTATATGGAAGAACTCCGGAA
TGTGGCGAGTGTGCCCGGGGACTCAGGCCACATGTGTATCAACATGGAGTGGGGTGCCTTTGGG
GATGACGGCTCACTGAGCATGCTCGGCACCTGCTTTGATGCTAGCGTGGACCAGGCATCCATCA
ACCCAGGCAAACAGAGGTTTGAGAAAATGATCAGCGGAATGTACCTGGGGGAGATCGTCCGCCA
TATCCTCCTGCACTTAACCAGTCTTGGAGTTCTCTTCCGGGGCCAGAAGACGCAATGCCTTCAG
ACCAGGGACATCTTTAAGACCAAGTTTCTCTCCGAGATTGAGAGCGACAGCCTGGCCCTGCGTC
AGGTCCGAGCCATCCTGGAGGACCTGGGGCTGACTCTGACGTCTGATGATGCCTTGATGGTCCT
AGAGGTGTGCCAGGCTGTGTCCCGCAGGGCCGCCCAACTCTGCGGGGCAGGTGTGGCTGCAGTG
GTGGAAAAGATACGGGAGAACCGGGGCCTGCAGGAGCTGACAGTGTCTGTGGGAGTGGATGGGA
CGCTCTACAAGCTACATCCCCACTTCTCCAGGCTGGTGTCAGTGACAGTTCGGAAGCTAGCCCC
TCAGTGCACAGTCACCTTTTTGCAATCGGAGGATGGGTCTGGGAAAGGGGCAGCGTTGGTCACT
CGTGTCGCTTGCCGCCTGACCCAGATGGCCTGCGTTTGAGGAAAATCTCCAAAGAGCAATTGGG
ATCTCCCTGGACTAAGGATTCAGCCCACACGGACCCTCTGGCGGGCCCAGCCACCCACAACTCC
CAAAGAAACCCACGGGTGGTGCCCTCATAACTGTCCGCCCACACCCAATGGCTTTCTGAGAGAA
GCACCACTCTGGTTAGCAA

hide sequence

RefSeq Acc Id:

XM_006253603 ⟹ XP_006253665

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	9,602,119 - 9,620,038 (+)	NCBI
mRatBN7.2	17	9,596,950 - 9,614,675 (+)	NCBI
Rnor_6.0	17	10,134,726 - 10,152,976 (+)	NCBI
Rnor_5.0	17	12,243,962 - 12,261,662 (+)	NCBI

Sequence:

show sequence

CCACCCAAACCTTAGACTTAGACAAATGGAAACCTTCCATAAATCAGTCGGGGAAATGGGTTGC
GTCTGAACCTAGGCCTGTCTGATACTATGCTGATGACTCTGGAAATTGGAGTTTGGATCAAGCT
ACTTGCCTGTGAGGCAAGGCAGCTTTGACCTTGGTTGATTTTAGCCAATGGGAGTTGGGGAGAG
GAAAAGGGAGATTGTAAATTGATGGGAGGTTGGTGATTACCCTTGGGAAGATGGGACATGGTCG
ACACTCCGGAAGAGTGCTGAGAGCATGTGCACCAGAAGCAGATTGCTTTCTTGCTGTTTCAAAA
GCCCTGGACTGTTGGGGTTGAGGGAGGGCACTTCCGTTTAGCAGAAGTTAAATGATACTTCCTC
CATATCAGAATCCAGGATCTGGCACCAAGGCTCATAAGGTGTGCCCAAAGTTGGGCAGGTAAGG
TAGTCAATACCATTGTGGAAACATGGCCGCCATTGAGCCTTCTGGTCTGCACCCGGGAGAAAGA
GACTCAAGCTGCCCCCAGGAGGGCATTCCAAGGCCCTCAGGTAGCTTAGAACTGGCACAGGAAT
ACTTGCAACAATTCAAGGTGACCATGACACAGCTGCAGCAGATCCAAGCCAGTCTTCTGTGTTC
CATGGAGCAGGCGCTGAAGGGACAGGACAGTCCCGCTCCTTCTGTCCGGATGTTGCCCACATAC
GTGAGGTCCACACCACATGGCACCGAGCAAGGAGACTTCCTGGTGCTGGAGCTGGGGGCCACAG
GAGCCTCACTACGTGTGTTGTGGGTAACACTGACGGGCACCAAGGAACACAGCGTGGAGACCAG
GAGCCAGGAGTTTGTGATCCCTCAAGAGGTGATCCTAGGTGCTGGCCAGCAGCTCTTTGACTTT
GCTGCCCGCTGCCTCTCTGAATTCCTGGATGCATACCCCGTGGAGAATCAGGGTCTGAAGCTTG
GGTTTAATTTCTCTTTTCCTTGTCACCAGACAGGCTTGGACAAGAGCACCCTCATTTCCTGGAC
AAAAGGTTTTAGGTGCAGTGGTGTGGAAGGCCAGGATGTGGTCCAGTTGCTAAGGGATGCCATT
CAGAGGCAGGGGACCTACAATATTGATGTGGTAGCCATGGTGAATGACACAGTGGGTACCATGA
TGGGCTGTGAGCTGGGCACCAGGCCATGTGAAGTCGGGCTTATTGTAGACACTGGTACCAATGC
CTGTTATATGGAGGAAGCGAGGCACGTGGCAGCTCTGGATGAGGACCGCGGCCGTACCTGTGTC
AGCATCGAGTGGGGCTCCTTCTATGACGAAGAGGCCCTAGGGCCAGTACTGACCACCTTCGACG
ATGCCCTGGACCACGAGTCCCTGGTTCCTGGTGCTCAGAGGTTTGAGAAGATGATTGGTGGCCT
TTACTTGGGTGAGCTGGTAAGGCTGGTGCTGGTCCACTTGTCCCAGCATGGGGTCCTCTTTGGT
GGCTGCGCCTCTCCTGCGTTGCTGAGTCAAAACAGCATCCTCCTGGAACATGTGGCCAAAATGG
AGGACCCTGCCACTGGGATAGCCCACGTCCACACAGTCCTGCAGGGCTTGGGTCTGAGCCCTCA
GGCCTCAGATGCTGAGCTCGTGCAGCGCGTGTGCATGGCTGTGTGCACGCGAGCTGCCCAGCTC
TGTGCCTCTGCCCTGGCTGCAGTCCTATCCCGCCTCCAGCACAGCAGGGAGCAGCAGACACTGC
ACGTGGCCGTGGCCACTGGAGGGCGAGTGTTCGAATGGCACCCCAGGTTCCTCTGCATCCTAAA
GGAGACGGTAATGCTCTTGGCCCCAGAGTGTGATGTCTCCTTCATCCCCTCTGTGGATGGTGGT
GGCCGGGGTGTGGCAATGGTGACTGCTGTGGCAGCCCGCCTGGCTACCCACAGGCGCATCCTGG
AAGAGACCCTGGCACCATTTCAGCTGAGCTTGGAGCAGCTGACAGCGGTGCAGGCACAAATGCG
GGAAGCCATGATCAGGGGGCTTCAAGGAGAGAGCTCCTCCCTCCGCATGCTGCCCACTTACGTC
CGAGCAACGCCCGATGGCAGCGAACGAGGTGACTTCCTGGCTTTGGACCTAGGGGGCACCAACT
TCCGTGTCCTGTTGGTACGCGTGGCCGAGGGCAGTGTTCAGATCACCAACCAGGTCTACTCTAT
TCCTGAGTATGTAGCCCAGGGCTCTGGACAGAAGCTCTTTGATCATATTGTGGACTGCATCGTG
GACTTCCAGAAGAGGCAAGGCCTTAGCGGACAGAGCCTACCCCTGGGTTTCACCTTCTCTTTTC
CTTGCAAGCAGCTTGGCCTGGACCAGGGCATCCTCCTCAACTGGACTAAGGGGTTCAATGCATC
AGGCTGCGAGGGCCAAGATGTTGTGTATTTATTACGGGAAGCCATTAGGCGCAGACAGGCAGTG
GAGCTGAATGTGGTTGCCATTGTCAATGACACGGTGGGGACCATGATGTCCTGTGGCTATGATG
ATCCCTGTTGTGAGATGGGCCTCATTGTCGGAACCGGTACCAACGCCTGCTATATGGAAGAACT
CCGGAATGTGGCGAGTGTGCCCGGGGACTCGGGCCACATGTGTATCAACATGGAGTGGGGTGCC
TTTGGGGATGACGGCTCACTGAGCATGCTCGGCACCTGCTTTGATGCTAGCGTGGACCAGGCAT
CCATCAACCCAGGCAAACAGAGGTTTGAGAAAATGATCAGCGGAATGTACCTGGGGGAGATCGT
CCGCCATATCCTCCTGCACTTAACCAGTCTTGGAGTTCTCTTCCGGGGCCAGAAGACGCAATGC
CTTCAGACCAGGGACATCTTTAAGACCAAGTTTCTCTCCGAGATTGAGAGTGACAGCCTGGCCC
TGCGTCAGGTCCGAGCCATCCTGGAGGACCTGGGGCTGACTCTGACGTCTGATGATGCCTTGAT
GGTCCTAGAGGTGTGCCAGGCTGTGTCCCGCAGGGCCGCCCAACTCTGCGGGGCAGGTGTGGCT
GCAGTGGTGGAAAAGATACGGGAGAACCGGGGCCTGCAGGAGCTGACAGTGTCTGTGGGAGTGG
ATGGGACGCTCTACAAGCTACATCCCCACTTCTCCAGGCTGGTGTCAGTGACAGTTCGGAAGCT
AGCCCCTCAGTGCACAGTCACCTTTTTGCAATCGGAGGATGGGTCTGGGAAAGGGGCAGCGTTG
GTCACTGCTGTCGCTTGCCGCCTGACCCAGATGGCCTGCGTTTGAGGAAAATCTCCAAAGAGCA
ATTGGGATCTCCCTGGACTAAGGATTCAGCCCACACGGACCCTCTGGCGGGCCCAGCCACCCAC
AACTCCCAAAGAAACCCACGGGTGGTGCCCTCATAACTGTCCGCCCACACCCAATGGCTTTCTG
AGAGAAGCACCACTCTGGTTAGCAATATATATATATAATTTATTTA

hide sequence

RefSeq Acc Id:

XM_039095373 ⟹ XP_038951301

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	9,606,069 - 9,620,038 (+)	NCBI
mRatBN7.2	17	9,600,902 - 9,614,675 (+)	NCBI

RefSeq Acc Id:

XM_063276075 ⟹ XP_063132145

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	9,605,398 - 9,620,038 (+)	NCBI

RefSeq Acc Id:

XR_005495237

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	9,606,094 - 9,618,982 (+)	NCBI
mRatBN7.2	17	9,600,928 - 9,613,768 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_071515	(Get FASTA)	NCBI Sequence Viewer
	XP_006253665	(Get FASTA)	NCBI Sequence Viewer
	XP_038951301	(Get FASTA)	NCBI Sequence Viewer
	XP_063132145	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI00649	(Get FASTA)	NCBI Sequence Viewer
	CBF63119	(Get FASTA)	NCBI Sequence Viewer
	CBU87995	(Get FASTA)	NCBI Sequence Viewer
	EDL94015	(Get FASTA)	NCBI Sequence Viewer
	EDL94016	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000031587
GenBank Protein	P27926	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_071515 ⟸ NM_022179

- UniProtKB:

Q497A1 (UniProtKB/Swiss-Prot), P27926 (UniProtKB/Swiss-Prot), A0A0G2JTY2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAIEPSGLHPGERDSSCPQEGIPRPSGSLELAQEYLQQFKVTMTQLQQIQASLLCSMEQALKG
QDSPAPSVRMLPTYVRSTPHGTEQGDFLVLELGATGASLRVLWVTLTGTKEHSVETRSQEFVIP
QEVILGAGQQLFDFAARCLSEFLDAYPVENQGLKLGFNFSFPCHQTGLDKSTLISWTKGFRCSG
VEGQDVVQLLRDAIQRQGTYNIDVVAMVNDTVGTMMGCELGTRPCEVGLIVDTGTNACYMEEAR
HVAALDEDRGRTCVSIEWGSFYDEEALGPVLTTFDDALDHESLVPGAQRFEKMIGGLYLGELVR
LVLVHLSQHGVLFGGCASPALLSQNSILLEHVAKMEDPATGIAHVHTVLQGLGLSPQASDAELV
QRVCMAVCTRAAQLCASALAAVLSRLQHSREQQTLHVAVATGGRVFEWHPRFLCILKETVMLLA
PECDVSFIPSVDGGGRGVAMVTAVAARLATHRRILEETLAPFQLSLEQLTAVQAQMREAMIRGL
QGESSSLRMLPTYVRATPDGSERGDFLALDLGGTNFRVLLVRVAEGSVQITNQVYSIPEYVAQG
SGQKLFDHIVDCIVDFQKRQGLSGQSLPLGFTFSFPCKQLGLDQGILLNWTKGFNASGCEGQDV
VYLLREAIRRRQAVELNVVAIVNDTVGTMMSCGYDDPCCEMGLIVGTGTNACYMEELRNVASVP
GDSGHMCINMEWGAFGDDGSLSMLGTCFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHL
TSLGVLFRGQKTQCLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLTLTSDDALMVLEVCQA
VSRRAAQLCGAGVAAVVEKIRENRGLQELTVSVGVDGTLYKLHPHFSRLVSVTVRKLAPQCTVT
FLQSEDGSGKGAALVTRVACRLTQMACV

hide sequence

RefSeq Acc Id:	XP_006253665 ⟸ XM_006253603
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JST6 (UniProtKB/TrEMBL), A6KAV7 (UniProtKB/TrEMBL), A0A0G2JTY2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAIEPSGLHPGERDSSCPQEGIPRPSGSLELAQEYLQQFKVTMTQLQQIQASLLCSMEQALKG QDSPAPSVRMLPTYVRSTPHGTEQGDFLVLELGATGASLRVLWVTLTGTKEHSVETRSQEFVIP QEVILGAGQQLFDFAARCLSEFLDAYPVENQGLKLGFNFSFPCHQTGLDKSTLISWTKGFRCSG VEGQDVVQLLRDAIQRQGTYNIDVVAMVNDTVGTMMGCELGTRPCEVGLIVDTGTNACYMEEAR HVAALDEDRGRTCVSIEWGSFYDEEALGPVLTTFDDALDHESLVPGAQRFEKMIGGLYLGELVR LVLVHLSQHGVLFGGCASPALLSQNSILLEHVAKMEDPATGIAHVHTVLQGLGLSPQASDAELV QRVCMAVCTRAAQLCASALAAVLSRLQHSREQQTLHVAVATGGRVFEWHPRFLCILKETVMLLA PECDVSFIPSVDGGGRGVAMVTAVAARLATHRRILEETLAPFQLSLEQLTAVQAQMREAMIRGL QGESSSLRMLPTYVRATPDGSERGDFLALDLGGTNFRVLLVRVAEGSVQITNQVYSIPEYVAQG SGQKLFDHIVDCIVDFQKRQGLSGQSLPLGFTFSFPCKQLGLDQGILLNWTKGFNASGCEGQDV VYLLREAIRRRQAVELNVVAIVNDTVGTMMSCGYDDPCCEMGLIVGTGTNACYMEELRNVASVP GDSGHMCINMEWGAFGDDGSLSMLGTCFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHL TSLGVLFRGQKTQCLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLTLTSDDALMVLEVCQA VSRRAAQLCGAGVAAVVEKIRENRGLQELTVSVGVDGTLYKLHPHFSRLVSVTVRKLAPQCTVT FLQSEDGSGKGAALVTAVACRLTQMACV hide sequence

Ensembl Acc Id:

ENSRNOP00000068888 ⟸ ENSRNOT00000079850

Ensembl Acc Id:

ENSRNOP00000031587 ⟸ ENSRNOT00000031935

RefSeq Acc Id:	XP_038951301 ⟸ XM_039095373
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JST6 (UniProtKB/TrEMBL), A6KAV7 (UniProtKB/TrEMBL), A0A0G2JTY2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063132145 ⟸ XM_063276075
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JST6 (UniProtKB/TrEMBL), A6KAV7 (UniProtKB/TrEMBL), A0A0G2JTY2 (UniProtKB/TrEMBL)

Protein Domains

Hexokinase Hexokinase C-terminal Hexokinase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P27926-F1-model_v2	AlphaFold	P27926	1-924	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2798	AgrOrtholog
BioCyc Gene	G2FUF-10190	BioCyc
BioCyc Pathway	ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)]	BioCyc
	PWY-3861 [mannitol degradation II]	BioCyc
	PWY-5941 [glycogen degradation II]	BioCyc
	PWY3O-1743 [D-mannose degradation II]	BioCyc
	UDPNACETYLGALSYN-PWY [UDP-N-acetyl-D-glucosamine biosynthesis II]	BioCyc
BioCyc Pathway Image	ANAGLYCOLYSIS-PWY	BioCyc
	PWY-3861	BioCyc
	PWY-5941	BioCyc
	PWY3O-1743	BioCyc
	UDPNACETYLGALSYN-PWY	BioCyc
Ensembl Genes	ENSRNOG00000026235	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000031935	ENTREZGENE
Gene3D-CATH	3.30.420.40	UniProtKB/Swiss-Prot
	3.40.367.20	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7932574	IMAGE-MGC_LOAD
InterPro	ATPase_NBD	UniProtKB/Swiss-Prot
	Hexokinase	UniProtKB/Swiss-Prot
	Hexokinase_BS	UniProtKB/Swiss-Prot
	Hexokinase_C	UniProtKB/Swiss-Prot
	Hexokinase_N	UniProtKB/Swiss-Prot
KEGG Report	rno:25060	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:124544	IMAGE-MGC_LOAD
NCBI Gene	25060	ENTREZGENE
PANTHER	HEXOKINASE-3	UniProtKB/Swiss-Prot
	PTHR19443	UniProtKB/Swiss-Prot
Pfam	Hexokinase_1	UniProtKB/Swiss-Prot
	Hexokinase_2	UniProtKB/Swiss-Prot
PhenoGen	Hk3	PhenoGen
PRINTS	HEXOKINASE	UniProtKB/Swiss-Prot
PROSITE	HEXOKINASE_1	UniProtKB/Swiss-Prot
	HEXOKINASE_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000026235	RatGTEx
Superfamily-SCOP	SSF53067	UniProtKB/Swiss-Prot
UniProt	A0A0G2JST6	ENTREZGENE, UniProtKB/TrEMBL
	A0A0G2JTY2	ENTREZGENE, UniProtKB/TrEMBL
	A6KAV7	ENTREZGENE, UniProtKB/TrEMBL
	A6KAV8_RAT	UniProtKB/TrEMBL
	HXK3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q497A1	ENTREZGENE
UniProt Secondary	Q497A1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-27	Hk3	hexokinase 3	Hk3	hexokinase 3 (white cell)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-24	Hk3	hexokinase 3 (white cell)	Hk3	hexokinase 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Hk3	Hexokinase 3			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

BioCyc Pathways