PTGDS (prostaglandin D2 synthase 21kDa (brain))

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Keyword

Gene: PTGDS (prostaglandin D2 synthase 21kDa (brain)) Homo sapiens

Symbol:

PTGDS

Name:

prostaglandin D2 synthase 21kDa (brain)

Description:

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

beta-trace protein; cerebrin-28; glutathione-independent PGD synthase; glutathione-independent PGD synthetase; L-PGDS; lipocalin-type prostaglandin D synthase; lipocalin-type prostaglandin-D synthase; LPGDS; OTTHUMP00000022638; OTTHUMP00000022640; OTTHUMP00000022642; PDS; PGD2; PGD2 synthase; PGDS; PGDS2; prostaglandin D synthase; prostaglandin d2 synthase; prostaglandin-D2 synthase; prostaglandin-H2 D-isomerase

Orthologs:

Mus musculus : Ptgds (prostaglandin D2 synthase (brain)) MGI
Rattus norvegicus : Ptgds (prostaglandin D2 synthase (brain))

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	9	139,908,768 - 139,913,010	+	NCBI
Human Genome Assembly HuRef	9	109,331,058 - 109,335,300	+	NCBI
Human Genome Assembly GRCh37	9	139,871,956 - 139,876,194	+	NCBI
Human Genome Assembly Build 36	9	138,991,777 - 138,996,015	+	NCBI
Human Cytogenetic Map	9	q34.2-q34.3		NCBI
Human Genome Assembly	9	137,147,792 - 137,152,030		NCBI