Grm4 (glutamate metabotropic receptor 4) - Rat Genome Database

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Gene: Grm4 (glutamate metabotropic receptor 4) Rattus norvegicus
Analyze
Symbol: Grm4
Name: glutamate metabotropic receptor 4
RGD ID: 2745
Description: Enables calcium-dependent protein binding activity and calmodulin binding activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; modulation of chemical synaptic transmission; and positive regulation of MAPK cascade. Predicted to act upstream of or within chemical synaptic transmission and learning. Located in dendritic shaft; presynaptic active zone membrane; and terminal bouton. Orthologous to human GRM4 (glutamate metabotropic receptor 4); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutamate receptor, metabotropic 4; metabotropic glutamate receptor 4; mGluR4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, the 5' end of this gene was annotated on NW_007906049.1 and the 3' end was annotated on NW_007906047.1 in NCBI's Rattus norvegicus Annotation Release 105. [17 Jun 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,486,024 - 5,574,668 (-)NCBIGRCr8
mRatBN7.2205,484,172 - 5,572,821 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,481,124 - 5,572,821 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx206,196,275 - 6,284,979 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,558,028 - 5,646,733 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0206,038,439 - 6,126,915 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0206,745,682 - 6,791,521 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,745,682 - 6,791,519 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,986,551 - 9,064,972 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,627,733 - 5,727,274 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,627,959 - 5,727,501 (-)NCBI
Celera207,048,565 - 7,156,973 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS. Corti C, etal., Neuroscience. 2002;110(3):403-20.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Expression of metabotropic glutamate receptors in rat meningeal and brain microvasculature and choroid plexus. Gillard SE, etal., J Comp Neurol 2003 Jun 30;461(3):317-32.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Targeting the metabotropic glutamate receptor mGluR4 for the treatment of diseases of the central nervous system. Marino MJ, etal., Curr Top Med Chem. 2005;5(9):885-95.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Ca2+-dependent binding of calcium-binding protein 1 to presynaptic group III metabotropic glutamate receptors and blockage by phosphorylation of the receptors. Nakajima Y Biochem Biophys Res Commun. 2011 Sep 9;412(4):602-5. doi: 10.1016/j.bbrc.2011.08.006. Epub 2011 Aug 10.
8. Ca2+-dependent release of Munc18-1 from presynaptic mGluRs in short-term facilitation. Nakajima Y, etal., Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18385-9. doi: 10.1073/pnas.0910088106. Epub 2009 Oct 12.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. O'Hara PJ, etal., Neuron 1993 Jul;11(1):41-52.
11. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. A family of metabotropic glutamate receptors. Tanabe Y, etal., Neuron 1992 Jan;8(1):169-79.
Additional References at PubMed
PMID:8738157   PMID:8815915   PMID:9473604   PMID:11122333   PMID:11891216   PMID:14592619   PMID:14593202   PMID:15047615   PMID:15102938   PMID:15494036   PMID:15730868   PMID:17177262  
PMID:17401670   PMID:18593581   PMID:20824730   PMID:21288202   PMID:21358553   PMID:21795692   PMID:22528491   PMID:22570379   PMID:22653971   PMID:23374450   PMID:26176363   PMID:28487067  
PMID:28661401   PMID:28829739   PMID:32052426   PMID:34244459  


Genomics

Comparative Map Data
Grm4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,486,024 - 5,574,668 (-)NCBIGRCr8
mRatBN7.2205,484,172 - 5,572,821 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,481,124 - 5,572,821 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx206,196,275 - 6,284,979 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,558,028 - 5,646,733 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0206,038,439 - 6,126,915 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0206,745,682 - 6,791,521 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,745,682 - 6,791,519 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,986,551 - 9,064,972 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,627,733 - 5,727,274 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,627,959 - 5,727,501 (-)NCBI
Celera207,048,565 - 7,156,973 (-)NCBICelera
Cytogenetic Map20p12NCBI
GRM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38634,018,643 - 34,155,622 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl634,018,643 - 34,155,622 (-)EnsemblGRCh38hg38GRCh38
GRCh37633,986,420 - 34,123,399 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36634,097,606 - 34,209,421 (-)NCBINCBI36Build 36hg18NCBI36
Build 34634,097,606 - 34,209,421NCBI
Celera635,543,989 - 35,655,835 (-)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef633,731,329 - 33,846,092 (-)NCBIHuRef
CHM1_1633,991,696 - 34,125,948 (-)NCBICHM1_1
T2T-CHM13v2.0633,839,943 - 33,979,214 (-)NCBIT2T-CHM13v2.0
Grm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,641,361 - 27,732,800 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,641,361 - 27,740,377 (-)EnsemblGRCm39 Ensembl
GRCm381727,422,387 - 27,513,826 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,422,387 - 27,521,403 (-)EnsemblGRCm38mm10GRCm38
MGSCv371727,559,332 - 27,640,249 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361727,149,976 - 27,230,893 (-)NCBIMGSCv36mm8
Celera1727,978,671 - 28,055,379 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.05NCBI
Grm4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,358,795 - 2,430,260 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554372,358,839 - 2,449,145 (-)NCBIChiLan1.0ChiLan1.0
GRM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2548,497,758 - 48,623,190 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1644,364,920 - 44,490,422 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0633,592,030 - 33,718,712 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,696,058 - 34,822,328 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,696,058 - 34,830,868 (-)Ensemblpanpan1.1panPan2
GRM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,346,395 - 3,459,722 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,346,395 - 3,459,878 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha123,362,032 - 3,477,778 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,679,385 - 3,795,489 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,679,675 - 3,783,992 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1123,344,448 - 3,461,207 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,426,828 - 3,542,627 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,523,998 - 3,640,232 (-)NCBIUU_Cfam_GSD_1.0
Grm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,991,868 - 39,095,441 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647624,876,688 - 24,967,473 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647624,866,356 - 24,968,362 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl730,179,305 - 30,267,715 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1730,179,723 - 30,278,579 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,838,381 - 34,928,232 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRM4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11737,944,462 - 38,070,105 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,001,325 - 38,069,461 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604433,902,368 - 34,062,062 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grm4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475422,932,967 - 22,999,735 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475422,931,964 - 23,000,003 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Grm4
834 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:99
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000066115
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat

Markers in Region
D20Got103  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,587,972 - 5,588,116 (+)MAPPERmRatBN7.2
Rnor_6.0206,846,191 - 6,846,334NCBIRnor6.0
Rnor_6.0207,109,783 - 7,109,926NCBIRnor6.0
Rnor_5.0209,085,931 - 9,086,074UniSTSRnor5.0
Celera207,151,743 - 7,151,886UniSTS
Cytogenetic Map20p12UniSTS
RH138230  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,487,325 - 5,487,446 (+)MAPPERmRatBN7.2
Rnor_6.0206,748,835 - 6,748,955NCBIRnor6.0
Rnor_5.0208,989,704 - 8,989,824UniSTSRnor5.0
RGSC_v3.4205,630,889 - 5,631,009UniSTSRGSC3.4
Celera207,051,718 - 7,051,838UniSTS
RH 3.4 Map2055.53UniSTS
Cytogenetic Map20p12UniSTS
BF401962  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera207,127,654 - 7,127,777UniSTS
RH 3.4 Map2055.43UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 2 37 105 38 33 23 14 23 6 136 58 93 44 54 10

Sequence


Ensembl Acc Id: ENSRNOT00000066115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl205,488,390 - 5,572,821 (-)Ensembl
Rnor_6.0 Ensembl206,746,577 - 6,791,519 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl205,484,172 - 5,572,821 (-)Ensembl
Rnor_6.0 Ensembl206,745,744 - 6,791,519 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl206,791,320 - 6,791,516 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl205,484,172 - 5,572,821 (-)Ensembl
Rnor_6.0 Ensembl206,745,682 - 6,772,903 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115661   ⟹   ENSRNOP00000094691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl205,481,124 - 5,572,821 (-)Ensembl
RefSeq Acc Id: NM_022666   ⟹   NP_073157
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,486,025 - 5,574,668 (-)NCBI
mRatBN7.2205,484,172 - 5,572,821 (-)NCBI
Rnor_6.0206,745,682 - 6,791,521 (-)NCBI
Rnor_5.0208,986,551 - 9,064,972 (-)NCBI
RGSC_v3.4205,627,733 - 5,727,274 (-)RGD
Celera207,048,565 - 7,156,973 (-)RGD
Sequence:
RefSeq Acc Id: XM_063278955   ⟹   XP_063135025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,486,024 - 5,574,495 (-)NCBI
RefSeq Acc Id: XM_063278956   ⟹   XP_063135026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,486,024 - 5,570,583 (-)NCBI
RefSeq Acc Id: NP_073157   ⟸   NM_022666
- Peptide Label: precursor
- UniProtKB: P31423 (UniProtKB/Swiss-Prot),   A6JJL9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000094691   ⟸   ENSRNOT00000115661
RefSeq Acc Id: XP_063135025   ⟸   XM_063278955
- Peptide Label: isoform X1
- UniProtKB: P31423 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063135026   ⟸   XM_063278956
- Peptide Label: isoform X2
Protein Domains
G-protein coupled receptors family 3 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31423-F1-model_v2 AlphaFold P31423 1-912 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2745 AgrOrtholog
BioCyc Gene G2FUF-4473 BioCyc
Ensembl Genes ENSRNOG00000000487 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055007857 UniProtKB/Swiss-Prot
  ENSRNOG00060005451 UniProtKB/Swiss-Prot
  ENSRNOG00065026408 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000066115.4 UniProtKB/TrEMBL
  ENSRNOT00000083426.2 UniProtKB/TrEMBL
  ENSRNOT00000093633.2 UniProtKB/Swiss-Prot
  ENSRNOT00000115661.1 UniProtKB/TrEMBL
  ENSRNOT00055013207 UniProtKB/Swiss-Prot
  ENSRNOT00060009094 UniProtKB/Swiss-Prot
  ENSRNOT00065045634 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.50.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mGluR4 UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_3_mtglu_rcpt_4 UniProtKB/Swiss-Prot
  mGluR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24417 UniProtKB/Swiss-Prot
NCBI Gene 24417 ENTREZGENE
PANTHER METABOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  METABOTROPIC GLUTAMATE RECEPTOR 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NCD3G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Grm4 PhenoGen
PRINTS GPCRMGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPC4R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTABOTROPICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000487 RatGTEx
  ENSRNOG00055007857 RatGTEx
  ENSRNOG00060005451 RatGTEx
  ENSRNOG00065026408 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZVP4_RAT UniProtKB/TrEMBL
  A0A8I6A4M8_RAT UniProtKB/TrEMBL
  A0A8I6AI99_RAT UniProtKB/TrEMBL
  A6JJL8_RAT UniProtKB/TrEMBL
  A6JJL9 ENTREZGENE, UniProtKB/TrEMBL
  GRM4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Grm4  glutamate metabotropic receptor 4  Grm4  glutamate receptor, metabotropic 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Grm4  glutamate receptor, metabotropic 4    Glutamate receptor, metabotropic 4  Name updated 625702 APPROVED
2002-06-10 Grm4  Glutamate receptor, metabotropic 4      Symbol and Name status set to approved 70586 APPROVED