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Gene: Grm4 (glutamate metabotropic receptor 4) Rattus norvegicus

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Symbol:

Grm4

Name:

glutamate metabotropic receptor 4

RGD ID:

2745

Description:

Enables calcium-dependent protein binding activity and calmodulin binding activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; modulation of chemical synaptic transmission; and positive regulation of MAPK cascade. Predicted to act upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; chemical synaptic transmission; and learning. Located in dendritic shaft; presynaptic active zone membrane; and terminal bouton. Orthologous to human GRM4 (glutamate metabotropic receptor 4); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

glutamate receptor, metabotropic 4; metabotropic glutamate receptor 4; mGluR4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GRM4 (glutamate metabotropic receptor 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Grm4 (glutamate receptor, metabotropic 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Grm4 (glutamate metabotropic receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GRM4 (glutamate metabotropic receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GRM4 (glutamate metabotropic receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Grm4 (glutamate metabotropic receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GRM4 (glutamate metabotropic receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GRM4 (glutamate metabotropic receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Grm4 (glutamate metabotropic receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Grm4 (glutamate metabotropic receptor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GRM8 (glutamate metabotropic receptor 8)	HGNC	OrthoDB
Homo sapiens (human):	GRM7 (glutamate metabotropic receptor 7)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	GRM4 (glutamate metabotropic receptor 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	GRM4 (glutamate metabotropic receptor 4)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Grm4 (glutamate receptor, metabotropic 4)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	grm4 (glutamate receptor, metabotropic 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	grm4 (glutamate receptor, metabotropic 4)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mgl-1	Alliance	DIOPT (InParanoid\|OMA\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mgl-3	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	mgl-3	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	grm4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

NCBI Annotation Information:

Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, the 5' end of this gene was annotated on NW_007906049.1 and the 3' end was annotated on NW_007906047.1 in NCBI's Rattus norvegicus Annotation Release 105. [17 Jun 2015]

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	5,486,024 - 5,574,668 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	5,482,977 - 5,574,668 (-)	Ensembl				GRCr8
mRatBN7.2	20	5,484,172 - 5,572,821 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	5,481,124 - 5,572,821 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	6,196,275 - 6,284,979 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	5,558,028 - 5,646,733 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	6,038,439 - 6,126,915 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	6,745,682 - 6,791,521 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	6,745,682 - 6,791,519 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	8,986,551 - 9,064,972 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	5,627,733 - 5,727,274 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	7,048,565 - 7,156,973 (-)	NCBI		Celera
RGSC_v3.1	20	5,627,959 - 5,727,501 (-)	NCBI
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Nerve Degeneration (ISO)

osteosarcoma (ISO)

temporal lobe epilepsy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

afimoxifene (ISO)

Aflatoxin B2 alpha (ISO)

ammonium chloride (EXP)

Ampullosporin (EXP)

antimycin A (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

atropine (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Brodifacoum (EXP)

butanal (ISO)

carbachol (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP)

choline (ISO)

copper atom (EXP)

copper(0) (EXP)

deguelin (ISO)

dextran sulfate (ISO)

diazinon (EXP)

ethanol (EXP,ISO)

fenpyroximate (ISO)

folic acid (ISO)

furan (EXP)

gentamycin (EXP)

glycidol (EXP)

ketamine (EXP)

ketoconazole (EXP)

L-methionine (ISO)

lead diacetate (EXP,ISO)

lipopolysaccharide (ISO)

methapyrilene (ISO)

methoxyacetic acid (EXP)

Nor-9-carboxy-delta9-THC (ISO)

paracetamol (EXP)

pentanal (ISO)

phenobarbital (EXP)

PhIP (ISO)

picoxystrobin (ISO)

pioglitazone (ISO)

propanal (ISO)

pyrimidifen (ISO)

resveratrol (ISO)

rotenone (EXP,ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

scopolamine (ISO)

sodium arsenite (ISO)

T-2 toxin (EXP)

tebufenpyrad (ISO)

thallium atom (ISO)

thifluzamide (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate (ISO)

Tropicamide (ISO)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway (IEA,ISO,ISS)

cell communication (IEA)

chemical synaptic transmission (ISO)

G protein-coupled glutamate receptor signaling pathway (IBA,IEA,ISO)

G protein-coupled receptor signaling pathway (IEA)

gamma-aminobutyric acid secretion (TAS)

learning (ISO)

negative regulation of apoptotic process (TAS)

negative regulation of cell population proliferation (TAS)

negative regulation of synaptic transmission (TAS)

neuron projection development (TAS)

positive regulation of MAPK cascade (IEA,ISO)

presynaptic modulation of chemical synaptic transmission (ISO)

regulation of neuron apoptotic process (NAS)

regulation of synaptic transmission, glutamatergic (IBA)

signal transduction (IEA)

signaling (IEA)

synaptic transmission, GABAergic (TAS)

synaptic transmission, glutamatergic (TAS)

Cellular Component

cerebellar granule cell to Purkinje cell synapse (ISO)

cytoplasmic vesicle (IEA,ISO)

dendritic shaft (IDA)

glutamatergic synapse (ISO)

membrane (IEA)

neuron projection (ISO)

parallel fiber to Purkinje cell synapse (ISO)

plasma membrane (IBA,IEA,ISO,TAS)

presynaptic active zone membrane (IDA,ISO)

terminal bouton (IDA)

Molecular Function

adenylate cyclase inhibiting G protein-coupled glutamate receptor activity (IBA)

calcium-dependent protein binding (IPI)

calmodulin binding (IPI)

G protein-coupled receptor activity (IEA,ISO,ISS)

glutamate receptor activity (IEA,ISO,ISS)

protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

glutamate signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS.	Corti C, etal., Neuroscience. 2002;110(3):403-20.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Expression of metabotropic glutamate receptors in rat meningeal and brain microvasculature and choroid plexus.	Gillard SE, etal., J Comp Neurol 2003 Jun 30;461(3):317-32.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Targeting the metabotropic glutamate receptor mGluR4 for the treatment of diseases of the central nervous system.	Marino MJ, etal., Curr Top Med Chem. 2005;5(9):885-95.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Ca2+-dependent binding of calcium-binding protein 1 to presynaptic group III metabotropic glutamate receptors and blockage by phosphorylation of the receptors.	Nakajima Y Biochem Biophys Res Commun. 2011 Sep 9;412(4):602-5. doi: 10.1016/j.bbrc.2011.08.006. Epub 2011 Aug 10.
8.	Ca2+-dependent release of Munc18-1 from presynaptic mGluRs in short-term facilitation.	Nakajima Y, etal., Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18385-9. doi: 10.1073/pnas.0910088106. Epub 2009 Oct 12.
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins.	O'Hara PJ, etal., Neuron 1993 Jul;11(1):41-52.
11.	Online Mendelian Inheritance in Man, OMIM (TM).	Online Mendelian Inheritance in Man, OMIM (TM).
12.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
13.	GOA pipeline	RGD automated data pipeline
14.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	A family of metabotropic glutamate receptors.	Tanabe Y, etal., Neuron 1992 Jan;8(1):169-79.

Additional References at PubMed

PMID:8738157	PMID:8815915	PMID:9473604	PMID:11122333	PMID:11891216	PMID:14592619	PMID:14593202	PMID:15047615	PMID:15102938	PMID:15494036	PMID:15730868	PMID:17177262
PMID:17401670	PMID:18593581	PMID:20824730	PMID:21288202	PMID:21358553	PMID:21795692	PMID:22528491	PMID:22570379	PMID:22653971	PMID:23374450	PMID:26176363	PMID:28487067
PMID:28661401	PMID:28829739	PMID:32052426	PMID:34244459

Genomics

Comparative Map Data

Grm4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	5,486,024 - 5,574,668 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	5,482,977 - 5,574,668 (-)	Ensembl				GRCr8
mRatBN7.2	20	5,484,172 - 5,572,821 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	5,481,124 - 5,572,821 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	6,196,275 - 6,284,979 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	5,558,028 - 5,646,733 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	6,038,439 - 6,126,915 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	6,745,682 - 6,791,521 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	6,745,682 - 6,791,519 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	8,986,551 - 9,064,972 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	5,627,733 - 5,727,274 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	7,048,565 - 7,156,973 (-)	NCBI		Celera
RGSC_v3.1	20	5,627,959 - 5,727,501 (-)	NCBI
Cytogenetic Map	20	p12	NCBI

GRM4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	34,018,643 - 34,155,622 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	34,018,643 - 34,155,622 (-)	Ensembl			hg38	GRCh38
GRCh37	6	33,986,420 - 34,123,399 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	34,097,606 - 34,209,421 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	34,097,606 - 34,209,421	NCBI
Celera	6	35,543,989 - 35,655,835 (-)	NCBI		Celera
Cytogenetic Map	6	p21.31	NCBI
HuRef	6	33,731,329 - 33,846,092 (-)	NCBI		HuRef
CHM1_1	6	33,991,696 - 34,125,948 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	33,839,943 - 33,979,214 (-)	NCBI		T2T-CHM13v2.0

Grm4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	27,641,361 - 27,732,800 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	27,641,361 - 27,740,377 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	27,422,387 - 27,513,826 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	27,422,387 - 27,521,403 (-)	Ensembl			mm10	GRCm38
MGSCv37	17	27,559,332 - 27,640,249 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	27,149,976 - 27,230,893 (-)	NCBI		MGSCv36	mm8
Celera	17	27,978,671 - 28,055,379 (-)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	14.05	NCBI

Grm4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	2,358,795 - 2,430,260 (-)	Ensembl
ChiLan1.0	NW_004955437	2,358,839 - 2,449,145 (-)	NCBI	ChiLan1.0	ChiLan1.0

GRM4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	48,497,758 - 48,623,190 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	44,364,920 - 44,490,422 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	33,592,030 - 33,718,712 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	34,696,058 - 34,822,328 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	34,696,058 - 34,830,868 (-)	Ensembl			panPan2	panpan1.1

GRM4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	3,346,395 - 3,459,722 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	3,346,395 - 3,459,878 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	3,362,032 - 3,477,778 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	3,679,385 - 3,795,489 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	3,679,675 - 3,783,992 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	3,344,448 - 3,461,207 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	3,426,828 - 3,542,627 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	3,523,998 - 3,640,232 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Grm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	38,991,868 - 39,095,441 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	24,876,688 - 24,967,473 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	24,866,356 - 24,968,362 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GRM4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	30,179,002 - 30,279,119 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	30,179,723 - 30,278,579 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	34,838,381 - 34,928,232 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GRM4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	37,944,462 - 38,070,105 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	38,001,325 - 38,069,461 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666044	33,902,368 - 34,062,062 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Grm4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	22,932,967 - 22,999,735 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624754	22,931,964 - 23,000,003 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Grm4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	18	6,334,291 - 6,422,553 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Grm4
873 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	144
Count of miRNA genes:	99
Interacting mature miRNAs:	121
Transcripts:	ENSRNOT00000066115
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	4189476	49189476	Rat
61474	Eae1	Experimental allergic encephalomyelitis QTL 1	3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	20	1	6693431	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	1	26925056	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1	33724594	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	26128279	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600300	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24164241	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	1	34066551	Rat
1331772	Cdexp2	CD45RC expression in CD8 T cells QTL 2	5.7		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	20	3626323	10078622	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29193376	Rat
70154	Insul2	Insulin level QTL 2	3.75		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	6693431	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	1	27341128	Rat
1300152	Bp195	Blood pressure QTL 195	3.46		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	3626323	9244918	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29193376	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29193376	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29193376	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29193376	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1	14100378	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578510	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600300	Rat

Markers in Region

D20Got103

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	5,587,972 - 5,588,116 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	6,846,191 - 6,846,334	NCBI	Rnor6.0
Rnor_6.0	20	7,109,783 - 7,109,926	NCBI	Rnor6.0
Rnor_5.0	20	9,085,931 - 9,086,074	UniSTS	Rnor5.0
Celera	20	7,151,743 - 7,151,886	UniSTS
Cytogenetic Map	20	p12	UniSTS

RH138230

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	5,487,325 - 5,487,446 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	6,748,835 - 6,748,955	NCBI	Rnor6.0
Rnor_5.0	20	8,989,704 - 8,989,824	UniSTS	Rnor5.0
RGSC_v3.4	20	5,630,889 - 5,631,009	UniSTS	RGSC3.4
Celera	20	7,051,718 - 7,051,838	UniSTS
RH 3.4 Map	20	55.53	UniSTS
Cytogenetic Map	20	p12	UniSTS

BF401962

Rat Assembly	Chr	Position (strand)	Source
Celera	20	7,127,654 - 7,127,777	UniSTS
RH 3.4 Map	20	55.43	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	3	51	138	38	33	23	47	23	6	224	115	10	117	68	67	10	13	13

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063278955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063278956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC095263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M90518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M92077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U47331	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000066115

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	5,490,242 - 5,574,668 (-)	Ensembl
mRatBN7.2 Ensembl	20	5,488,390 - 5,572,821 (-)	Ensembl
Rnor_6.0 Ensembl	20	6,746,577 - 6,791,519 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083426

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	5,486,025 - 5,574,668 (-)	Ensembl
mRatBN7.2 Ensembl	20	5,484,172 - 5,572,821 (-)	Ensembl
Rnor_6.0 Ensembl	20	6,745,744 - 6,791,519 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093374

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	6,791,320 - 6,791,516 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093633

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	5,486,025 - 5,574,668 (-)	Ensembl
mRatBN7.2 Ensembl	20	5,484,172 - 5,572,821 (-)	Ensembl
Rnor_6.0 Ensembl	20	6,745,682 - 6,772,903 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000115661 ⟹ ENSRNOP00000094691

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	5,482,977 - 5,574,668 (-)	Ensembl
mRatBN7.2 Ensembl	20	5,481,124 - 5,572,821 (-)	Ensembl

RefSeq Acc Id:

NM_022666 ⟹ NP_073157

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	5,486,025 - 5,574,668 (-)	NCBI
mRatBN7.2	20	5,484,172 - 5,572,821 (-)	NCBI
Rnor_6.0	20	6,745,682 - 6,791,521 (-)	NCBI
Rnor_5.0	20	8,986,551 - 9,064,972 (-)	NCBI
RGSC_v3.4	20	5,627,733 - 5,727,274 (-)	RGD
Celera	20	7,048,565 - 7,156,973 (-)	RGD

Sequence:

show sequence

TGGGCCTTTTATTATTATCAGGACTTTATTCATGTCCGGGGTGGGTTCCTATCAGAGAAAGTCA
AGCTGGTCCATCTGTGTTCCAGCGAGTGGTCCTCCTTAAACATCCACTTCATGGCGGCGGGAAG
CGACGGAGCCGGCTCTTTGAGGCGCAGACTTCGGCGAAGCGACCACAACAACAACGGCGGCGGC
GGCGGCAGCGGCAGCAGCATCAGCAGCACGGGCACCGTGGCCGCCGCTCCCAGCTCCAGCTTCC
CGGGAGCAGCCGCCGAGCGCCGCTCGCTGCTCCGAGACTCCGGCCGCTTGGCCGCCAGCTCCTC
CCCGCCGCGCCCGGGACCGCCGGCGGCTCGGCGCCCCGCTTGGTCCGCAGCGTCAGCGCCGCCC
GCCGCGGCCCGGGCTCCCGGCAGTGCGAGCAGCTAAGGGCTGGCCGCCGCCTCCCTGAGCTCCC
CCGGAGCAGCCGACCCCTGGTCGCGGCGTTCACCTCGCCGATGCGCGGTTGGTAGGAGTGACCG
GAGCCATTCTCTCCTCGTTGATAAGATTCCCTACCAGGATAGGAGCCTATCTCCCTTTCCACAG
CAGGACACAGAAATCTGGCCTTCAGTACTTTGGGAAAAGGATCTGAGACCTCCTGGAGCTCTGA
CCACTGGCTGTCATCTGTGGCTCTGGCCTGTGTGGGCCACTGAGCTCTACTCAAACATTAAAGA
GGAGGAGGGGAGATCTGTGGAATGGGCCACCCCGTTGGCCTGCTGCATTACTGAACCTGCGCTG
TCCACACGTGCCCAGATCATGGGACCCAGGGCCTGCTAGGGCTAGGAGCGGGGCCCAGTATTCA
TGGGTCTCTAGGCCTTTCCGAAATGTCCGGGAAGGGAGGCTGGGCCTGGTGGTGGGCCCGGCTG
CCCCTCTGCCTACTCCTCAGCCTTTATGCCCCCTGGGTGCCTTCATCCTTGGGAAAGCCCAAGG
GTCACCCCCACATGAACTCTATCCGAATTGACGGGGACATCACACTGGGAGGCCTGTTTCCCGT
CCACGGCCGTGGCTCTGAGGGTAAGGCCTGCGGGGAGCTGAAGAAGGAGAAAGGCATCCACCGC
CTGGAGGCCATGCTGTTTGCCCTGGACCGCATCAACAATGACCCGGACCTACTGCCCAACATCA
CGTTGGGCGCCCGCATTCTGGACACCTGCTCGAGGGACACCCACGCCCTGGAGCAGTCACTGAC
CTTTGTGCGGGCGCTCATCGAGAAGGACGGCACGGAGGTCCGCTGCGGCAGCGGGGGCCCGCCC
ATCATCACCAAGCCCGAACGAGTGGTGGGTGTCATTGGAGCTTCGGGGAGCTCCGTCTCGATCA
TGGTGGCCAACATCCTCCGCCTCTTCAAGATCCCTCAGATCAGCTATGCCTCCACGGCCCCTGA
CTTGAGTGACAACAGCCGCTATGACTTCTTCTCCCGGGTGGTGCCCTCAGACACATACCAGGCC
CAGGCCATGGTGGATATTGTCCGAGCCCTCAAGTGGAACTATGTGTCCACACTGGCCTCAGAGG
GCAGCTACGGTGAGAGTGGTGTGGAGGCCTTTATCCAGAAGTCCCGAGAGAACGGAGGTGTGTG
CATTGCCCAGTCGGTGAAGATTCCACGGGAACCCAAGACGGGGGAGTTCGACAAGATCATCAAA
CGCCTACTGGAAACATCCAATGCCAGGGGTATCATCATCTTTGCCAACGAGGATGACATCAGGA
GGGTGTTGGAGGCAGCTCGCAGGGCCAACCAGACCGGCCACTTCTTTTGGATGGGTTCTGATAG
CTGGGGCTCCAAGAGTGCCCCTGTGCTGCGCCTTGAGGAGGTGGCCGAGGGCGCAGTCACCATT
CTCCCCAAGAGGATGTCTGTTCGAGGGTTCGACCGATACTTCTCCAGCCGCACGCTGGACAACA
ACAGGCGCAACATCTGGTTTGCCGAGTTCTGGGAGGACAACTTCCATTGCAAGTTGAGCCGCCA
CGCGCTCAAGAAGGGAAGCCACATCAAGAAGTGCACCAACCGAGAGCGCATCGGGCAGGACTCG
GCCTATGAGCAGGAGGGGAAGGTGCAGTTCGTGATTGACGCTGTGTACGCCATGGGCCACGCGC
TGCACGCCATGCACCGTGACCTGTGTCCCGGCCGCGTAGGACTCTGCCCTCGCATGGACCCCGT
GGATGGCACCCAGCTGCTTAAGTACATCAGGAACGTCAACTTCTCAGGCATTGCGGGGAACCCT
GTAACCTTCAATGAGAACGGAGACGCACCGGGGCGCTACGACATCTACCAGTACCAACTGCGCA
ATGGCTCGGCCGAGTACAAGGTCATCGGCTCGTGGACAGACCACCTGCACCTCAGAATAGAGCG
GATGCAGTGGCCAGGGAGTGGCCAGCAGCTGCCGCGCTCCATCTGCAGTCTGCCCTGCCAGCCC
GGGGAGCGAAAGAAGACTGTGAAGGGCATGGCTTGCTGCTGGCACTGCGAGCCCTGCACCGGGT
ACCAGTACCAAGTGGACCGCTACACCTGTAAGACCTGCCCCTACGACATGCGGCCCACAGAGAA
CCGCACGAGCTGCCAGCCCATCCCCATCGTCAAGTTGGAGTGGGACTCGCCGTGGGCCGTGCTG
CCCCTCTTCCTGGCCGTGGTGGGCATCGCCGCCACGCTGTTCGTGGTGGTCACGTTTGTGCGCT
ACAACGATACCCCCATCGTCAAGGCCTCGGGCCGGGAGCTGAGCTACGTGCTGCTGGCGGGCAT
CTTTCTGTGCTACGCCACTACCTTCCTCATGATCGCAGAGCCGGACCTGGGGACCTGTTCGCTC
CGCCGCATCTTCCTAGGGCTCGGCATGAGCATCAGCTACGCGGCCCTGCTGACCAAGACCAACC
GCATTTACCGCATCTTTGAGCAGGGCAAACGGTCGGTCAGTGCCCCGCGTTTCATCAGCCCGGC
CTCGCAGCTGGCCATCACCTTCATCCTCATCTCCCTGCAGCTGCTCGGCATCTGCGTGTGGTTC
GTGGTGGACCCCTCCCACTCGGTGGTGGACTTCCAGGACCAACGGACACTTGACCCCCGCTTTG
CCAGGGGCGTGCTCAAGTGCGACATCTCGGACCTGTCCCTCATCTGCCTGCTGGGCTACAGCAT
GCTGCTGATGGTCACGTGTACTGTGTACGCCATCAAGACCCGAGGCGTGCCCGAGACCTTCAAC
GAGGCCAAGCCCATCGGCTTCACCATGTACACCACCTGCATTGTCTGGCTGGCCTTCATCCCCA
TCTTTTTTGGCACCTCACAGTCAGCCGACAAGCTGTACATCCAGACAACCACACTGACGGTCTC
CGTGAGTCTGAGCGCTTCAGTGTCCCTGGGGATGCTCTACATGCCCAAAGTCTACATCATCCTC
TTCCACCCGGAGCAGAACGTGCCCAAGCGCAAGCGCAGTCTCAAAGCCGTGGTCACCGCCGCCA
CCATGTCCAACAAGTTCACACAGAAGGGCAACTTCAGGCCCAATGGGGAAGCCAAATCAGAGCT
GTGTGAGAACCTGGAGACCCCAGCGCTGGCTACCAAACAGACCTACGTCACCTACACCAACCAT
GCCATCTAGCCGGGCCGCGGAGCCAAGCAGGCTAAGGAGCCACAACCTCTGAGGATGGCACATT
GGGCCAGGGCCGTTCCCGAGGGCCCTGCCGATGTCTGCCCGCCTCCCGGGCATCCACGAATGTG
GCTTGGTGCTGAGGACAGTAGAGACCCCGGCCATCACTGCTGGGCAAGCCGTGGTGGGCAACCA
GAGGAGGCCGAGTGGCTGGGGCAGTTCCAGGTTATGCCACACACAGGTCTTCCTTCTGGACCAC
TGTTGGGCCCAGCCCCAAAGCACAGGGGCTCGGTCTCCAGAGCCCAGCCCTGGCTTCCTCTCCT
TCCTCCTGCCTCCGTCTGTCCTGTGGGTGACCCCGGTTGGTCCCTGCCCCGTCTTTACGTTTCT
CTTCCGTCTTTGCTCTGCATGTGTTGTCTGTTTGGGCCCTCTGCTTCCATATTTTTCCATTCTG
CTCCTGGCCTTCCCCTGCCATCTGCCCTGCCCCCTGCCCCTCCTCCCTGAGCTGCCCCATCCCC
GCCATCATTTTCTCTTCTGTTCCCCCTCGATCTCATTTCCTACCAGCCTTCCCCCTACTTGGCT
TCATCCACCAACTCTTTCACCACGTTGCAAAAGAGAAAAAAAAAGGGGGGGGGGAATCACCCCC
TACAAAAAAGCCCAAACAAAAACTAATCTTGAGTGTGTTTCGAAGTGCTGCGTCCTCCTGGTGG
CCTGTGTGTCCCTGTGGCCTGCAGCCTGCTCGCCCGCCCTACCCGTCTGCCGTGTGTCCTGCCC
GCCCGCCTGCCCGCCTTGCCCTTCCTGCTAACGACACGGAGTTCAGTGCCTGGGTGTTTGGTGA
TGGTCTCTGATGTGTAGCATGTCTGTTTTTATACCGAGAACATTTCTAATAAAGATAAACACAT
GGTTTTGC

hide sequence

RefSeq Acc Id:

XM_063278955 ⟹ XP_063135025

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	5,486,024 - 5,574,495 (-)	NCBI

RefSeq Acc Id:

XM_063278956 ⟹ XP_063135026

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	5,486,024 - 5,570,583 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_073157	(Get FASTA)	NCBI Sequence Viewer
	XP_063135025	(Get FASTA)	NCBI Sequence Viewer
	XP_063135026	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA88788	(Get FASTA)	NCBI Sequence Viewer
	AAA93190	(Get FASTA)	NCBI Sequence Viewer
	EDL96884	(Get FASTA)	NCBI Sequence Viewer
	EDL96885	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000082873
	ENSRNOP00000082873.1
GenBank Protein	P31423	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_073157 ⟸ NM_022666
- Peptide Label:	precursor
- UniProtKB:	P31423 (UniProtKB/Swiss-Prot), A6JJL9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEG KACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVRALIE KDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRY DFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKI PREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAP VLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSH IKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLK YIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYKVIGSWTDHLHLRIERMQWPGSG QQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPI PIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATT FLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITF ILISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCT VYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASV SLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETP ALATKQTYVTYTNHAI hide sequence

Ensembl Acc Id:

ENSRNOP00000094691 ⟸ ENSRNOT00000115661

RefSeq Acc Id:	XP_063135025 ⟸ XM_063278955
- Peptide Label:	isoform X1
- UniProtKB:	P31423 (UniProtKB/Swiss-Prot), A6JJL9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063135026 ⟸ XM_063278956
- Peptide Label:	isoform X2
- UniProtKB:	Q62916 (UniProtKB/TrEMBL)

Protein Domains

G-protein coupled receptors family 3 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P31423-F1-model_v2	AlphaFold	P31423	1-912	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2745	AgrOrtholog
BioCyc Gene	G2FUF-4473	BioCyc
Ensembl Genes	ENSRNOG00000000487	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000093633	ENTREZGENE
	ENSRNOT00000093633.2	UniProtKB/Swiss-Prot
Gene3D-CATH	2.10.50.30	UniProtKB/Swiss-Prot
	3.40.50.2300	UniProtKB/Swiss-Prot
InterPro	ANF_lig-bd_rcpt	UniProtKB/Swiss-Prot
	GPCR_3	UniProtKB/Swiss-Prot
	GPCR_3_9-Cys_dom	UniProtKB/Swiss-Prot
	GPCR_3_9-Cys_sf	UniProtKB/Swiss-Prot
	GPCR_3_C	UniProtKB/Swiss-Prot
	GPCR_3_CS	UniProtKB/Swiss-Prot
	GPCR_3_mtglu_rcpt	UniProtKB/Swiss-Prot
	GPCR_3_mtglu_rcpt_4	UniProtKB/Swiss-Prot
	mGluR	UniProtKB/Swiss-Prot
	Peripla_BP_I	UniProtKB/Swiss-Prot
KEGG Report	rno:24417	UniProtKB/Swiss-Prot
NCBI Gene	24417	ENTREZGENE
PANTHER	METABOTROPIC GLUTAMATE RECEPTOR	UniProtKB/Swiss-Prot
Pfam	7tm_3	UniProtKB/Swiss-Prot
	ANF_receptor	UniProtKB/Swiss-Prot
	NCD3G	UniProtKB/Swiss-Prot
PhenoGen	Grm4	PhenoGen
PRINTS	GPCRMGR	UniProtKB/Swiss-Prot
	MTABOTROPC4R	UniProtKB/Swiss-Prot
	MTABOTROPICR	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F3_1	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F3_2	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F3_3	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F3_4	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000000487	RatGTEx
Superfamily-SCOP	SSF53822	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZVP4_RAT	UniProtKB/TrEMBL
	A0A8I6A4M8_RAT	UniProtKB/TrEMBL
	A0A8I6AI99_RAT	UniProtKB/TrEMBL
	A6JJL8_RAT	UniProtKB/TrEMBL
	A6JJL9	ENTREZGENE, UniProtKB/TrEMBL
	GRM4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q62916	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-05-11	Grm4	glutamate metabotropic receptor 4	Grm4	glutamate receptor, metabotropic 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-11-06	Grm4	glutamate receptor, metabotropic 4		Glutamate receptor, metabotropic 4	Name updated	625702	APPROVED
2002-06-10	Grm4	Glutamate receptor, metabotropic 4			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)