Gnrh1 (gonadotropin releasing hormone 1) - Rat Genome Database

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Gene: Gnrh1 (gonadotropin releasing hormone 1) Rattus norvegicus
Analyze
Symbol: Gnrh1
Name: gonadotropin releasing hormone 1
RGD ID: 2720
Description: Enables gonadotropin hormone-releasing hormone activity. Involved in several processes, including estrous cycle; negative regulation of immature T cell proliferation; and response to prostaglandin E. Located in several cellular components, including cytoplasmic side of rough endoplasmic reticulum membrane; cytoplasmic vesicle; and perikaryon. Used to study prostatic hypertrophy. Human ortholog(s) of this gene implicated in breast cancer; hypogonadotropic hypogonadism 12 with or without anosmia; and periodontitis. Orthologous to human GNRH1 (gonadotropin releasing hormone 1); PARTICIPATES IN gonadotropin-releasing hormone signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gnrh; GNRHA; Gonadotropin releasing hormone; gonadotropin-releasing hormone 1; gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Lhrh; luteinizing hormone-releasing hormone; progonadoliberin I; progonadoliberin-1; Putative protein SH; RGNRHG1; SH-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   W-Tg(Gnrh1-EGFP)Nphy
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81546,147,878 - 46,152,086 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1546,147,878 - 46,152,086 (+)EnsemblGRCr8
GRCr8 Ensembl1546,148,301 - 46,148,977 (-)EnsemblGRCr8
mRatBN7.21541,972,482 - 41,976,690 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1541,942,339 - 41,976,690 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1541,972,905 - 41,973,581 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1543,837,145 - 43,841,353 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01544,987,366 - 44,991,574 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01543,432,699 - 43,436,907 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01544,441,856 - 44,446,064 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1544,441,856 - 44,446,064 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1544,442,555 - 44,442,875 (-)Ensemblrn6Rnor6.0
Rnor_5.01547,151,131 - 47,155,339 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41547,303,309 - 47,307,517 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1541,636,731 - 41,640,939 (+)NCBICelera
RGSC_v3.11547,319,088 - 47,323,286 (+)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic GMP  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aldehydo-D-glucose  (ISO)
alfuzosin  (EXP)
allethrin  (EXP)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
atrazine  (EXP,ISO)
benzo[a]pyrene  (EXP)
beta-hexachlorocyclohexane  (ISO)
bicuculline  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
BMS-754807  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcium dichloride  (EXP)
carvone  (ISO)
chlormequat chloride  (EXP)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (EXP)
cisplatin  (ISO)
clomiphene  (ISO)
cocaine  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
D-glucose  (ISO)
DDE  (ISO)
DDT  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dopamine  (EXP)
emamectin benzoate  (EXP)
Estradiol 17beta-cyclopentylpropionate  (EXP)
fenvalerate  (EXP)
flavonoids  (EXP,ISO)
flutamide  (EXP)
fulvestrant  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
ketoconazole  (EXP)
KT 5823  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
melatonin  (EXP)
melittin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methoxychlor  (EXP,ISO)
methylene blue  (EXP)
methylmercury chloride  (EXP)
Moniliformin  (ISO)
muscimol  (EXP)
ochratoxin A  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
Phenoxybenzamine  (EXP)
phenylephrine  (EXP)
potassium chloride  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
procymidone  (EXP)
progesterone  (ISO)
propofol  (ISO)
pyrethrins  (EXP)
raloxifene  (ISO)
S-nitrosoglutathione  (ISO)
sevoflurane  (ISO)
sirolimus  (EXP)
T-2 toxin  (EXP)
tamoxifen  (ISO)
testosterone  (EXP)
Tetrachlorobisphenol A  (EXP,ISO)
tetrodotoxin  (ISO)
thioacetamide  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
wortmannin  (ISO)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Two mammalian genes transcribed from opposite strands of the same DNA locus. Adelman JP, etal., Science 1987 Mar 20;235(4795):1514-7.
2. Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathway. Allen MP, etal., J Biol Chem 2002 Oct 11;277(41):38133-40.
3. The role of gonadectomy and testosterone replacement on thymic luteinizing hormone-releasing hormone production. Azad N, etal., J Endocrinol. 1998 Aug;158(2):229-35.
4. Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation. Bouligand J, etal., N Engl J Med. 2009 Jun 25;360(26):2742-8. doi: 10.1056/NEJMoa0900136. Epub 2009 Jun 17.
5. GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism. Chan YM, etal., Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11703-8. doi: 10.1073/pnas.0903449106. Epub 2009 Jun 30.
6. Regulation of gonadotropin subunit gene transcription by gonadotropin-releasing hormone: measurement of primary transcript ribonucleic acids by quantitative reverse transcription-polymerase chain reaction assays. Dalkin AC, etal., Endocrinology 2001 Jan;142(1):139-46.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Age-related changes in hypothalamic gonadotropin-releasing hormone and N-methyl-D-aspartate receptor gene expression, and their regulation by oestrogen, in the female rat. Gore AC, etal., J Neuroendocrinol 2002 Apr;14(4):300-9.
10. Glucocorticoid repression of the reproductive axis: effects on GnRH and gonadotropin subunit mRNA levels. Gore AC, etal., Mol Cell Endocrinol. 2006 Aug 15;256(1-2):40-8. Epub 2006 Jul 12.
11. Gonadotropin-releasing hormone neurons in the preoptic-hypothalamic region of the rat contain lamprey gonadotropin-releasing hormone III, mammalian luteinizing hormone-releasing hormone, or both peptides. Hiney JK, etal., Proc Natl Acad Sci U S A 2002 Feb 19;99(4):2386-91.
12. Bisexual behavior in male rats treated neonatally with antibodies to luteinizing hormone-releasing hormone. Kalcheim C, etal., J Comp Physiol Psychol. 1981 Feb;95(1):36-44.
13. Immunocytochemical localization of luteinizing hormone-releasing hormone in neurons in the medial basal hypothalamus of the female rat. Kelly MJ, etal., Exp Brain Res. 1982;48(1):97-106.
14. Hypothalamic molecular changes underlying natural reproductive senescence in the female rat. Kermath BA, etal., Endocrinology. 2014 Sep;155(9):3597-609. doi: 10.1210/en.2014-1017. Epub 2014 Jun 10.
15. R31C GNRH1 mutation and congenital hypogonadotropic hypogonadism. Maione L, etal., PLoS One. 2013 Jul 25;8(7):e69616. doi: 10.1371/journal.pone.0069616. Print 2013.
16. The hypogonadal mouse: reproductive functions restored by gene therapy. Mason AJ, etal., Science. 1986 Dec 12;234(4782):1372-8.
17. The Pro-LHRH system of the rat brain. Effects of changes in the endocrine background. Merchenthaler I, etal., Brain Res Bull. 1988 Jun;20(6):713-20.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Effect of immune and metabolic challenges on the luteinizing hormone-releasing hormone neuronal system in cycling female rats: an evaluation at the transcriptional level. Nappi RE and Rivest S, Endocrinology. 1997 Apr;138(4):1374-84.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
23. Phosphodiesterase expression targeted to gonadotropin-releasing hormone neurons inhibits luteinizing hormone pulses in transgenic rats. Paruthiyil S, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):17191-6.
24. GnRH and LHR gene variants predict adverse outcome in premenopausal breast cancer patients. Piersma D, etal., Breast Cancer Res. 2007;9(4):R51.
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Comprehensive gene review and curation RGD comprehensive gene curation
30. Combining growth hormone-releasing hormone antagonist with luteinizing hormone-releasing hormone antagonist greatly augments benign prostatic hyperplasia shrinkage. Rick FG, etal., J Urol. 2012 Apr;187(4):1498-504. doi: 10.1016/j.juro.2011.11.081. Epub 2012 Feb 17.
31. Daily GnRH and GnRH-receptor mRNA expression in the ovariectomized and intact rat. Schirman-Hildesheim TD, etal., Mol Cell Endocrinol. 2006 Jun 27;252(1-2):120-5. Epub 2006 May 2.
32. Localization of Immunoreactive Gonadotropin Releasing Hormone (GnRH) and Relative Expression of Its mRNA in the Oviduct During Pregnancy in Rats. Sengupta A, etal., J Histochem Cytochem. 2007 Feb 5;.
33. Large-scale investigation of genomic markers for severe periodontitis. Suzuki A, etal., Odontology. 2004 Sep;92(1):43-7.
34. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
35. Morphological evidence for neuronal regulation of luteinizing hormone-releasing hormone-containing neurons by neuropeptide Y in the rat septo-preoptic area. Tsuruo Y, etal., Neurosci Lett. 1990 Mar 14;110(3):261-6.
36. Differential secretion of proLHRH fragments in response to [K+], prostaglandin E2 and C kinase activation. Valenca MM, etal., Mol Cell Endocrinol. 1988 Jan;55(1):95-100.
37. Coordinate gene expression of luteinizing hormone-releasing hormone (LHRH) and the LHRH-receptor after prolactin stimulation in the rat Nb2 T-cell line: implications for a role in immunomodulation and cell cycle gene expression. Wilson TM, etal., Mol Endocrinol. 1995 Jan;9(1):44-53.
38. Proestrous surge of gonadotropin-releasing hormone secretion inhibits apoptosis of anterior pituitary cells in cycling female rats. Yin P and Arita J, Neuroendocrinology 2002 Nov;76(5):272-82.
39. A hypothalamic follicle-stimulating hormone-releasing decapeptide in the rat. Yu WH, etal., Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9499-503.
40. Luteinizing hormone-releasing hormone in thymus and hypothalamus of rat fetuses: suppressing effect of antagonist and of antibodies on concanavalin A-induced proliferation of thymocytes. Zakharova LA, etal., Biochemistry (Mosc). 2000 Oct;65(10):1135-9.
Additional References at PubMed
PMID:1468115   PMID:2476669   PMID:2867548   PMID:7771642   PMID:10803590   PMID:11738808   PMID:11897697   PMID:12198245   PMID:12403831   PMID:12433965   PMID:12598657   PMID:12639934  
PMID:12639939   PMID:12697272   PMID:12810529   PMID:12810551   PMID:12838577   PMID:12865345   PMID:14670985   PMID:14715715   PMID:15138251   PMID:15824321   PMID:15908340   PMID:15919747  
PMID:15964850   PMID:15994198   PMID:16337733   PMID:16405927   PMID:16469806   PMID:17241740   PMID:17280591   PMID:17332066   PMID:17557168   PMID:17935160   PMID:18032409   PMID:18063679  
PMID:18227283   PMID:18467526   PMID:18550775   PMID:18603625   PMID:18701637   PMID:18716286   PMID:18775461   PMID:19179437   PMID:19200975   PMID:19228890   PMID:19253008   PMID:19524128  
PMID:19757493   PMID:19819960   PMID:19856133   PMID:19889867   PMID:20016824   PMID:20380165   PMID:20680515   PMID:20814074   PMID:20937356   PMID:20970475   PMID:21074602   PMID:22039515  
PMID:22147011   PMID:22684563   PMID:23090753   PMID:23197165   PMID:23321696   PMID:23452939   PMID:23518222   PMID:23668015   PMID:23736294   PMID:24216131   PMID:24374911   PMID:24668712  
PMID:24708241   PMID:25048263   PMID:25177948   PMID:25794706   PMID:26248220   PMID:27349532   PMID:30130567   PMID:30218420   PMID:31272713   PMID:31430847   PMID:34268716   PMID:37797313  
PMID:38129517  


Genomics

Comparative Map Data
Gnrh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81546,147,878 - 46,152,086 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1546,147,878 - 46,152,086 (+)EnsemblGRCr8
GRCr8 Ensembl1546,148,301 - 46,148,977 (-)EnsemblGRCr8
mRatBN7.21541,972,482 - 41,976,690 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1541,942,339 - 41,976,690 (+)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1541,972,905 - 41,973,581 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1543,837,145 - 43,841,353 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01544,987,366 - 44,991,574 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01543,432,699 - 43,436,907 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01544,441,856 - 44,446,064 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1544,441,856 - 44,446,064 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1544,442,555 - 44,442,875 (-)Ensemblrn6Rnor6.0
Rnor_5.01547,151,131 - 47,155,339 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41547,303,309 - 47,307,517 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1541,636,731 - 41,640,939 (+)NCBICelera
RGSC_v3.11547,319,088 - 47,323,286 (+)NCBI
Cytogenetic Map15p12NCBI
GNRH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38825,419,258 - 25,425,040 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl825,419,258 - 25,424,654 (-)Ensemblhg38GRCh38
GRCh37825,276,774 - 25,282,556 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36825,332,691 - 25,338,473 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34825,332,692 - 25,337,836NCBI
Celera824,237,655 - 24,243,437 (-)NCBICelera
Cytogenetic Map8p21.2NCBI
HuRef823,821,751 - 23,827,534 (-)NCBIHuRef
CHM1_1825,478,220 - 25,484,032 (-)NCBICHM1_1
T2T-CHM13v2.0825,694,484 - 25,700,266 (-)NCBIT2T-CHM13v2.0
Gnrh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391467,982,717 - 67,986,889 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1467,982,630 - 67,986,888 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381467,745,181 - 67,749,440 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1467,745,181 - 67,749,439 (+)Ensemblmm10GRCm38
MGSCv371468,363,286 - 68,367,493 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361466,699,676 - 66,702,621 (+)NCBIMGSCv36mm8
Celera1465,502,860 - 65,507,056 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.66NCBI
Gnrh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540348,343,597 - 48,346,595 (-)Ensembl
ChiLan1.0NW_00495540348,341,731 - 48,346,595 (-)NCBIChiLan1.0ChiLan1.0
GNRH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2743,960,415 - 43,967,332 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1819,674,806 - 19,680,584 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0824,700,268 - 24,707,332 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1821,609,407 - 21,616,521 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl821,609,407 - 21,615,936 (-)EnsemblpanPan2panpan1.1
GNRH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12532,038,631 - 32,043,192 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2532,039,613 - 32,043,028 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2532,623,319 - 32,627,816 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02532,237,978 - 32,242,489 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2532,238,905 - 32,242,478 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12532,193,651 - 32,198,162 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02532,043,144 - 32,047,652 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02532,208,954 - 32,213,456 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gnrh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494310,029,435 - 10,033,174 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367571,282,185 - 1,285,832 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367571,282,185 - 1,285,804 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNRH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl149,442,971 - 9,453,035 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1149,442,971 - 9,447,521 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21410,597,132 - 10,607,824 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GNRH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1823,543,717 - 23,550,728 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl823,542,806 - 23,547,771 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605218,616,776 - 18,623,795 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnrh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475820,447,583 - 20,450,968 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475820,447,413 - 20,451,059 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gnrh1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11256,728,147 - 56,732,756 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gnrh1
7 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:281
Count of miRNA genes:183
Interacting mature miRNAs:214
Transcripts:ENSRNOT00000017939, ENSRNOT00000018006
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154480677352597086Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154446544756583797Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat

Markers in Region
D15Mgh12  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81546,147,000 - 46,147,098 (+)Marker Load Pipeline
mRatBN7.21541,971,604 - 41,971,702 (+)MAPPERmRatBN7.2
Rnor_6.01544,440,979 - 44,441,076NCBIRnor6.0
Rnor_5.01547,156,119 - 47,156,216UniSTSRnor5.0
RGSC_v3.41547,302,432 - 47,302,529UniSTSRGSC3.4
RGSC_v3.41547,302,431 - 47,302,529RGDRGSC3.4
Celera1541,635,854 - 41,635,951UniSTS
RGSC_v3.11547,318,211 - 47,318,309RGD
Cytogenetic Map15p12UniSTS
D15Arb6  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81546,146,956 - 46,147,197 (+)Marker Load Pipeline
mRatBN7.21541,971,560 - 41,971,801 (+)MAPPERmRatBN7.2
Rnor_6.01544,440,935 - 44,441,175NCBIRnor6.0
Rnor_5.01547,156,020 - 47,156,260UniSTSRnor5.0
RGSC_v3.41547,302,387 - 47,302,628RGDRGSC3.4
RGSC_v3.41547,302,388 - 47,302,628UniSTSRGSC3.4
Celera1541,635,810 - 41,636,050UniSTS
RGSC_v3.11547,318,167 - 47,318,408RGD
FHH x ACI Map1546.36RGD
FHH x ACI Map1546.36UniSTS
Cytogenetic Map15p12UniSTS
RH94423  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21541,973,792 - 41,973,984 (+)MAPPERmRatBN7.2
Rnor_6.01544,443,167 - 44,443,358NCBIRnor6.0
Rnor_5.01547,153,837 - 47,154,028UniSTSRnor5.0
RGSC_v3.41547,304,620 - 47,304,811UniSTSRGSC3.4
Celera1541,638,042 - 41,638,233UniSTS
Cytogenetic Map15p12UniSTS


Related Rat Strains
The following Strains have been annotated to Gnrh1
W-Tg(Gnrh1-EGFP)Nphy    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 20 96 186 132 132 74 96 74 12 437 239 8 152 87 111 58 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000017939   ⟹   ENSRNOP00000017939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1546,148,301 - 46,148,977 (-)Ensembl
mRatBN7.2 Ensembl1541,972,905 - 41,973,581 (-)Ensembl
Rnor_6.0 Ensembl1544,442,555 - 44,442,875 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000018006   ⟹   ENSRNOP00000018006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1546,147,878 - 46,151,576 (+)Ensembl
mRatBN7.2 Ensembl1541,972,482 - 41,975,781 (+)Ensembl
Rnor_6.0 Ensembl1544,441,856 - 44,446,064 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110456   ⟹   ENSRNOP00000079319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1541,942,339 - 41,976,690 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000139957   ⟹   ENSRNOP00000100068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1546,147,878 - 46,152,086 (+)Ensembl
RefSeq Acc Id: NM_012767   ⟹   NP_036899
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81546,147,878 - 46,152,086 (+)NCBI
mRatBN7.21541,972,482 - 41,976,690 (+)NCBI
Rnor_6.01544,441,856 - 44,446,064 (+)NCBI
Rnor_5.01547,151,131 - 47,155,339 (-)NCBI
RGSC_v3.41547,303,309 - 47,307,517 (+)RGD
Celera1541,636,731 - 41,640,939 (+)RGD
Sequence:
RefSeq Acc Id: XM_006252096   ⟹   XP_006252158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81546,148,697 - 46,152,079 (+)NCBI
mRatBN7.21541,973,270 - 41,976,683 (+)NCBI
Rnor_6.01544,442,651 - 44,446,057 (+)NCBI
Rnor_5.01547,151,131 - 47,155,339 (-)NCBI
Sequence:
RefSeq Acc Id: NP_036899   ⟸   NM_012767
- Peptide Label: precursor
- UniProtKB: P07490 (UniProtKB/Swiss-Prot),   A6K6Q6 (UniProtKB/TrEMBL),   A0A8L2UJ58 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252158   ⟸   XM_006252096
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G553 (UniProtKB/TrEMBL),   A0A8L2UJ58 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018006   ⟸   ENSRNOT00000018006
Ensembl Acc Id: ENSRNOP00000017939   ⟸   ENSRNOT00000017939
Ensembl Acc Id: ENSRNOP00000079319   ⟸   ENSRNOT00000110456
Ensembl Acc Id: ENSRNOP00000100068   ⟸   ENSRNOT00000139957

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07490-F1-model_v2 AlphaFold P07490 1-92 view protein structure
AF-P55248-F1-model_v2 AlphaFold P55248 1-106 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2720 AgrOrtholog
BioCyc Gene G2FUF-13302 BioCyc
Ensembl Genes ENSRNOG00000013433 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000013441 Ensembl
  ENSRNOG00000066847 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017939.5 UniProtKB/Swiss-Prot
  ENSRNOT00000139957 ENTREZGENE
InterPro GnRH UniProtKB/Swiss-Prot
  Gonadoliberin UniProtKB/Swiss-Prot
  Gonadoliberin_I_precursor UniProtKB/Swiss-Prot
KEGG Report rno:25194 UniProtKB/Swiss-Prot
NCBI Gene 25194 ENTREZGENE
PANTHER PROGONADOLIBERIN-1 UniProtKB/Swiss-Prot
  PTHR10522 UniProtKB/Swiss-Prot
Pfam GnRH UniProtKB/Swiss-Prot
PhenoGen Gnrh1 PhenoGen
PRINTS GONADOLIBRNI UniProtKB/Swiss-Prot
PROSITE GNRH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013433 RatGTEx
  ENSRNOG00000013441 RatGTEx
  ENSRNOG00000066847 RatGTEx
TIGR TC231726
UniProt A0A8I6G553 ENTREZGENE
  A0A8L2UJ58 ENTREZGENE, UniProtKB/TrEMBL
  A6K6Q6 ENTREZGENE, UniProtKB/TrEMBL
  GON1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P55248 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Gnrh1  gonadotropin releasing hormone 1  Gnrh1  gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Gnrh1  gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)  Gnrh1  gonadotropin-releasing hormone 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gnrh1  gonadotropin-releasing hormone 1      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Gnrh1  gonadotropin-releasing hormone 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in neurons and hypothalamus 628509
gene_process regulates synthesis and secretion of the pituitary gonadotropins LH and FSH 61523
gene_regulation secretion increases after gonadectomy in both sexes and during the proestrus LH surge in females 61523
gene_regulation hormone release in hypothalamus is mediated by the cAMP levels 628509