RGD Reference Report - Large-scale investigation of genomic markers for severe periodontitis. - Rat Genome Database

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Large-scale investigation of genomic markers for severe periodontitis.

Authors: Suzuki, A  Ji, G  Numabe, Y  Ishii, K  Muramatsu, M  Kamoi, K 
Citation: Suzuki A, etal., Odontology. 2004 Sep;92(1):43-7.
RGD ID: 9685136
Pubmed: PMID:15490304   (View Abstract at PubMed)
DOI: DOI:10.1007/s10266-004-0035-4   (Journal Full-text)

The purpose of the present study was to investigate the genomic markers for periodontitis, using large-scale single-nucleotide polymorphism (SNP) association studies comparing healthy volunteers and patients with periodontitis. Genomic DNA was obtained from 19 healthy volunteers and 22 patients with severe periodontitis, all of whom were Japanese. The subjects were genotyped at 637 SNPs in 244 genes on a large scale, using the TaqMan polymerase chain reaction (PCR) system. Statistically significant differences in allele and genotype frequencies were analyzed with Fisher's exact test. We found statistically significant differences (P < 0.01) between the healthy volunteers and patients with severe periodontitis in the following genes; gonadotropin-releasing hormone 1 (GNRH1), phosphatidylinositol 3-kinase regulatory 1 (PIK3R1), dipeptidylpeptidase 4 (DPP4), fibrinogen-like 2 (FGL2), and calcitonin receptor (CALCR). These results suggest that SNPs in the GNRH1, PIK3R1, DPP4, FGL2, and CALCR genes are genomic markers for severe periodontitis. Our findings indicate the necessity of analyzing SNPs in genes on a large scale (i.e., genome-wide approach), to identify genomic markers for periodontitis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
periodontitis  IAGP 9685136DNA:snp:exon:c.59C>G (human)RGD 
periodontitis  ISOGNRH1 (Homo sapiens)9685136; 9685136DNA:snp:exon:c.59C>G (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Gingival bleeding  IAGP 9685136DNA:snp:exon:c.59C>G RGD 
Periapical bone loss  IAGP 9685136DNA:snp:exon:c.59C>G RGD 
Objects Annotated

Genes (Rattus norvegicus)
Gnrh1  (gonadotropin releasing hormone 1)

Genes (Mus musculus)
Gnrh1  (gonadotropin releasing hormone 1)

Genes (Homo sapiens)
GNRH1  (gonadotropin releasing hormone 1)


Additional Information