Glra1 (glycine receptor, alpha 1) - Rat Genome Database

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Gene: Glra1 (glycine receptor, alpha 1) Rattus norvegicus
Analyze
Symbol: Glra1
Name: glycine receptor, alpha 1
RGD ID: 2704
Description: Enables extracellularly glycine-gated chloride channel activity; glycine binding activity; and identical protein binding activity. Involved in chloride transport and glycinergic synaptic transmission. Located in endoplasmic reticulum and external side of plasma membrane. Is active in calyx of Held; glycinergic synapse; and synaptic membrane. Human ortholog(s) of this gene implicated in hyperekplexia 1. Orthologous to human GLRA1 (glycine receptor alpha 1); PARTICIPATES IN Inhibitory synaptic transmission pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glycine receptor 48 kDa subunit; glycine receptor strychnine-binding subunit; glycine receptor subunit alpha-1; glycine receptor, alpha 1 subunit; GLYRA1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81040,128,284 - 40,228,612 (-)NCBIGRCr8
mRatBN7.21039,625,853 - 39,727,897 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,629,459 - 39,727,162 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1044,313,228 - 44,411,116 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,803,339 - 43,901,228 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01039,307,010 - 39,404,890 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,851,955 - 40,954,364 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,855,559 - 40,953,651 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,687,069 - 40,785,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,922,867 - 41,021,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,936,489 - 41,035,390 (-)NCBI
Celera1038,958,969 - 39,055,009 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional properties of strychnine-sensitive glycine receptors expressed in Xenopus oocytes injected with a single mRNA. Akagi H, etal., Neurosci Res 1991 Jun;11(1):28-40.
2. Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules bound. Beato M, etal., J Gen Physiol 2002 May;119(5):443-66.
3. The activation mechanism of alpha1 homomeric glycine receptors. Beato M, etal., J Neurosci. 2004 Jan 28;24(4):895-906.
4. Single-channel behavior of heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens. Burzomato V, etal., J Neurosci. 2004 Dec 1;24(48):10924-40.
5. Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes. Froh M, etal., Am J Physiol Gastrointest Liver Physiol 2002 Oct;283(4):G856-63.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes. Grenningloh G, etal., EMBO J. 1990 Mar;9(3):771-6.
9. The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Grenningloh G, etal., Nature 1987 Jul 16-22;328(6127):215-20.
10. Differential distribution of glycine receptor subtypes at the rat calyx of Held synapse. Hruskova B, etal., J Neurosci. 2012 Nov 21;32(47):17012-24. doi: 10.1523/JNEUROSCI.1547-12.2012.
11. Alternative splicing generates two variants of the alpha 1 subunit of the inhibitory glycine receptor. Malosio ML, etal., J Biol Chem 1991 Feb 5;266(4):2048-53.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. A novel glycine receptor beta subunit splice variant predicts an unorthodox transmembrane topology. Assembly into heteromeric receptor complexes. Oertel J, etal., J Biol Chem. 2007 Feb 2;282(5):2798-807. Epub 2006 Dec 4.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Distribution of glycine receptors on the surface of the mature calyx of Held nerve terminal. Trojanova J, etal., Front Neural Circuits. 2014 Oct 6;8:120. doi: 10.3389/fncir.2014.00120. eCollection 2014.
Additional References at PubMed
PMID:1371219   PMID:2171639   PMID:2483325   PMID:7506679   PMID:7874121   PMID:7920629   PMID:8062927   PMID:8137830   PMID:8298642   PMID:8406478   PMID:8717357   PMID:8733750  
PMID:9087981   PMID:9145798   PMID:9812897   PMID:11076688   PMID:11275284   PMID:11742725   PMID:11751269   PMID:11973623   PMID:12380014   PMID:12457249   PMID:12837931   PMID:14698963  
PMID:15629462   PMID:15748848   PMID:16144831   PMID:16672662   PMID:16800867   PMID:16964444   PMID:17114051   PMID:17331994   PMID:21917927   PMID:22006921   PMID:22018691   PMID:23994010  
PMID:24198360   PMID:24801766   PMID:25236484   PMID:25339760   PMID:25973519   PMID:27226610   PMID:28026001   PMID:28724750   PMID:34802146  


Genomics

Comparative Map Data
Glra1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81040,128,284 - 40,228,612 (-)NCBIGRCr8
mRatBN7.21039,625,853 - 39,727,897 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,629,459 - 39,727,162 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1044,313,228 - 44,411,116 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,803,339 - 43,901,228 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01039,307,010 - 39,404,890 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,851,955 - 40,954,364 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,855,559 - 40,953,651 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,687,069 - 40,785,100 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,922,867 - 41,021,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,936,489 - 41,035,390 (-)NCBI
Celera1038,958,969 - 39,055,009 (-)NCBICelera
Cytogenetic Map10q22NCBI
GLRA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,822,513 - 151,924,851 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5151,822,513 - 151,924,851 (-)EnsemblGRCh38hg38GRCh38
GRCh375151,202,074 - 151,304,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365151,182,361 - 151,284,596 (-)NCBINCBI36Build 36hg18NCBI36
Build 345151,182,360 - 151,284,596NCBI
Celera5147,283,467 - 147,385,844 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5146,347,483 - 146,449,349 (-)NCBIHuRef
CHM1_15150,634,496 - 150,736,836 (-)NCBICHM1_1
T2T-CHM13v2.05152,361,497 - 152,463,867 (-)NCBIT2T-CHM13v2.0
Glra1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391155,405,065 - 55,499,024 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1155,405,064 - 55,499,024 (-)EnsemblGRCm39 Ensembl
GRCm381155,514,239 - 55,608,198 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1155,514,238 - 55,608,198 (-)EnsemblGRCm38mm10GRCm38
MGSCv371155,328,315 - 55,421,292 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361155,358,236 - 55,451,213 (-)NCBIMGSCv36mm8
Celera1160,300,816 - 60,360,053 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1133.12NCBI
Glra1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554086,236,092 - 6,333,166 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554086,236,092 - 6,333,166 (-)NCBIChiLan1.0ChiLan1.0
GLRA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24147,050,625 - 147,153,444 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15145,190,265 - 145,292,989 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05147,245,741 - 147,348,555 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15153,248,488 - 153,350,573 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5153,248,488 - 153,350,567 (-)Ensemblpanpan1.1panPan2
GLRA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1457,443,094 - 57,541,494 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl457,443,999 - 57,528,376 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha457,296,776 - 57,348,297 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0457,919,593 - 57,971,180 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl457,885,421 - 57,971,013 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1457,735,798 - 57,787,335 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0457,834,258 - 57,885,784 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0458,337,576 - 58,389,066 (+)NCBIUU_Cfam_GSD_1.0
Glra1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213112,367,383 - 112,460,891 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651510,817,422 - 10,896,958 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651510,816,712 - 10,896,958 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLRA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,142,198 - 71,230,344 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11671,140,751 - 71,236,867 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21677,317,685 - 77,407,159 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLRA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12354,384,452 - 54,485,957 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2354,387,229 - 54,484,372 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603423,216,388 - 23,318,088 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glra1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473337,153,863 - 37,235,485 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473337,153,348 - 37,238,201 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Glra1
757 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:137
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000063889
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system nervous system reproductive system respiratory system
High
Medium 8
Low 36 11 11
Below cutoff 3 7 12 16

Sequence


RefSeq Acc Id: ENSRNOT00000063889   ⟹   ENSRNOP00000063384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,629,459 - 39,727,162 (-)Ensembl
Rnor_6.0 Ensembl1040,855,559 - 40,953,651 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092189   ⟹   ENSRNOP00000073440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,630,050 - 39,726,978 (-)Ensembl
Rnor_6.0 Ensembl1040,856,150 - 40,953,467 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113718   ⟹   ENSRNOP00000088166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,630,050 - 39,694,990 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119787   ⟹   ENSRNOP00000087752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,630,050 - 39,695,038 (-)Ensembl
RefSeq Acc Id: NM_013133   ⟹   NP_037265
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81040,130,121 - 40,227,815 (-)NCBI
mRatBN7.21039,629,459 - 39,727,162 (-)NCBI
Rnor_6.01040,855,559 - 40,953,651 (-)NCBI
Rnor_5.01040,687,069 - 40,785,100 (-)NCBI
RGSC_v3.41040,922,867 - 41,021,767 (-)RGD
Celera1038,958,969 - 39,055,009 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246378   ⟹   XP_006246440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81040,128,284 - 40,228,612 (-)NCBI
mRatBN7.21039,625,853 - 39,727,897 (-)NCBI
Rnor_6.01040,851,955 - 40,954,364 (-)NCBI
Rnor_5.01040,687,069 - 40,785,100 (-)NCBI
Sequence:
RefSeq Acc Id: NP_037265   ⟸   NM_013133
- Peptide Label: precursor
- UniProtKB: Q546L7 (UniProtKB/TrEMBL),   A0A096MIV2 (UniProtKB/TrEMBL),   A0A8I6GGT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246440   ⟸   XM_006246378
- Peptide Label: isoform X1
- UniProtKB: Q546L6 (UniProtKB/Swiss-Prot),   P07727 (UniProtKB/Swiss-Prot),   A6HEN3 (UniProtKB/TrEMBL),   A0A8I6GGT5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073440   ⟸   ENSRNOT00000092189
RefSeq Acc Id: ENSRNOP00000063384   ⟸   ENSRNOT00000063889
RefSeq Acc Id: ENSRNOP00000088166   ⟸   ENSRNOT00000113718
RefSeq Acc Id: ENSRNOP00000087752   ⟸   ENSRNOT00000119787
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07727-F1-model_v2 AlphaFold P07727 1-457 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2704 AgrOrtholog
BioCyc Gene G2FUF-25074 BioCyc
Ensembl Genes ENSRNOG00000013588 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000063889 ENTREZGENE
  ENSRNOT00000063889.4 UniProtKB/Swiss-Prot
  ENSRNOT00000092189.2 UniProtKB/TrEMBL
  ENSRNOT00000113718.1 UniProtKB/TrEMBL
  ENSRNOT00000119787.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycine_rcpt_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycine_rcpt_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25674 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25674 ENTREZGENE
PANTHER GLYCINE RECEPTOR SUBUNIT ALPHA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Glra1 PhenoGen
PRINTS GABAARECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLYRALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLYRALPHA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013588 RatGTEx
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MIV2 ENTREZGENE
  A0A8I6A8K2_RAT UniProtKB/TrEMBL
  A0A8I6GGT5 ENTREZGENE, UniProtKB/TrEMBL
  A6HEN3 ENTREZGENE, UniProtKB/TrEMBL
  A6HEN4_RAT UniProtKB/TrEMBL
  GLRA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q546L6 ENTREZGENE
  Q546L7 ENTREZGENE, UniProtKB/TrEMBL
  Q99JD0_RAT UniProtKB/TrEMBL
UniProt Secondary A0A096MIV2 UniProtKB/TrEMBL
  Q546L6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-14 Glra1  glycine receptor, alpha 1  Glra1  glycine receptor, alpha 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Glra1  Glycine receptor, alpha 1 subunit      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA and protein expressed in Kupffer cells, other macrophages and leukocytes 625689
gene_protein 48 kDa 625689