Ggh (gamma-glutamyl hydrolase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Ggh (gamma-glutamyl hydrolase) Rattus norvegicus
Analyze
Symbol: Ggh
Name: gamma-glutamyl hydrolase
RGD ID: 2682
Description: Enables gamma-glutamyl-peptidase activity. Involved in several processes, including response to ethanol; response to insulin; and response to zinc ion. Located in extracellular space. Orthologous to human GGH (gamma-glutamyl hydrolase); PARTICIPATES IN folate metabolic pathway; hereditary folate malabsorption pathway; methotrexate pharmacodynamics pathway; INTERACTS WITH 3H-1,2-dithiole-3-thione; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: conjugase; gamma-Glu-X carboxypeptidase; gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); gamma-glutamyl hydrolase-like; GH; LOC102549738; MGC105496
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8538,326,747 - 38,349,655 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl538,326,594 - 38,349,647 (+)EnsemblGRCr8
mRatBN7.2533,529,880 - 33,552,790 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl533,529,880 - 33,552,787 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx535,643,220 - 35,666,193 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0537,235,432 - 37,258,403 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0537,174,941 - 37,197,912 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0534,040,258 - 34,063,369 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl534,040,258 - 34,063,361 (+)Ensemblrn6Rnor6.0
Rnor_5.0538,693,591 - 38,716,702 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4534,670,883 - 34,693,791 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera532,605,342 - 32,628,233 (+)NCBICelera
RGSC_v3.1534,671,061 - 34,693,969 (+)NCBI
Cytogenetic Map5q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7-Hydroxymethotrexate  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carnosic acid  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
diuron  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
Evodiamine  (ISO)
folic acid  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
omeprazole  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pemetrexed  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
platinum  (ISO)
platinum(0)  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
Soman  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The effect of dietary zinc depletion and repletion on rats: Zn concentration in various tissues and activity of pancreatic gamma-glutamyl hydrolase (EC 3.4.22.12) as indices of Zn status. Canton MC and Cremin FM, Br J Nutr. 1990 Jul;64(1):201-9.
2. Insulin-dependent suppression in glutamyl hydrolase activity and elevated cellular methotrexate polyglutamates. Galivan J and Rhee MS, Biochem Pharmacol. 1995 Nov 9;50(10):1659-63.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Effect of chronic ethanol consumption on the cellular and subcellular distribution of gamma-glutamyltransferase in rat liver. Halsall S and Peters TJ, Enzyme. 1984;31(4):221-8.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Subcellular fractionation of liver organelles from phenobarbital-treated rats by counter-current partition and sucrose gradient centrifugation. Morris WB, etal., Biochem Pharmacol. 1986 Jul 1;35(13):2187-91.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Gamma-glutamyl hydrolase and drug resistance. Schneider E and Ryan TJ, Clin Chim Acta. 2006 Dec;374(1-2):25-32. Epub 2006 Jun 10.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells. Wang Y, etal., Biochim Biophys Acta 1993 Aug 7;1164(3):227-35.
17. Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase. Yao R, etal., J Biol Chem 1996 Apr 12;271(15):8525-8.
Additional References at PubMed
PMID:11005824   PMID:12477932   PMID:15489334   PMID:19056867   PMID:21630459   PMID:23376485   PMID:23533145   PMID:24006456   PMID:25645918   PMID:26432773  


Genomics

Comparative Map Data
Ggh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8538,326,747 - 38,349,655 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl538,326,594 - 38,349,647 (+)EnsemblGRCr8
mRatBN7.2533,529,880 - 33,552,790 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl533,529,880 - 33,552,787 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx535,643,220 - 35,666,193 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0537,235,432 - 37,258,403 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0537,174,941 - 37,197,912 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0534,040,258 - 34,063,369 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl534,040,258 - 34,063,361 (+)Ensemblrn6Rnor6.0
Rnor_5.0538,693,591 - 38,716,702 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4534,670,883 - 34,693,791 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera532,605,342 - 32,628,233 (+)NCBICelera
RGSC_v3.1534,671,061 - 34,693,969 (+)NCBI
Cytogenetic Map5q13NCBI
GGH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38863,015,079 - 63,038,806 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl863,014,881 - 63,039,407 (-)Ensemblhg38GRCh38
GRCh37863,927,638 - 63,951,365 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36864,090,192 - 64,113,940 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34864,090,194 - 64,113,940NCBI
Celera859,917,838 - 59,941,813 (-)NCBICelera
Cytogenetic Map8q12.3NCBI
HuRef859,415,504 - 59,439,479 (-)NCBIHuRef
CHM1_1863,980,633 - 64,004,623 (-)NCBICHM1_1
T2T-CHM13v2.0863,439,652 - 63,463,378 (-)NCBIT2T-CHM13v2.0
Ggh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39420,041,963 - 20,066,111 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl420,042,052 - 20,066,750 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38420,041,997 - 20,066,111 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl420,042,052 - 20,066,750 (+)Ensemblmm10GRCm38
MGSCv37419,969,199 - 19,993,258 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36420,164,971 - 20,188,858 (+)NCBIMGSCv36mm8
Celera419,800,007 - 19,824,562 (+)NCBICelera
Cytogenetic Map4A3NCBI
cM Map47.79NCBI
Ggh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544415,900,485 - 15,931,338 (+)Ensembl
ChiLan1.0NW_00495544415,901,225 - 15,930,358 (+)NCBIChiLan1.0ChiLan1.0
GGH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2778,741,363 - 78,769,505 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1854,380,324 - 54,408,566 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0859,547,821 - 59,571,523 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1861,222,194 - 61,246,096 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl861,222,194 - 61,246,252 (-)EnsemblpanPan2panpan1.1
GGH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12913,143,881 - 13,165,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2913,134,232 - 13,165,028 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2913,471,573 - 13,492,163 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02913,246,558 - 13,267,739 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2913,245,957 - 13,267,728 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12913,258,091 - 13,279,415 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02913,375,202 - 13,396,822 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02913,641,119 - 13,662,465 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ggh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530364,282,077 - 64,299,958 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649610,485,504 - 10,505,842 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649610,485,528 - 10,505,506 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GGH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl470,996,755 - 71,021,838 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1470,996,730 - 71,020,513 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2477,279,213 - 77,303,313 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GGH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1858,908,524 - 58,932,885 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl858,908,417 - 58,932,685 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603982,649,447 - 82,674,608 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ggh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474428,752,909 - 28,785,661 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474428,752,785 - 28,786,293 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ggh
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11122,963,764 - 122,987,103 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ggh
154 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:136
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000009758
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)51373115343590997Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)53113042148841739Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51460607859606078Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009758   ⟹   ENSRNOP00000009758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl538,326,594 - 38,349,647 (+)Ensembl
mRatBN7.2 Ensembl533,529,880 - 33,552,787 (+)Ensembl
Rnor_6.0 Ensembl534,040,258 - 34,063,361 (+)Ensembl
RefSeq Acc Id: NM_012960   ⟹   NP_037092
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8538,326,747 - 38,349,655 (+)NCBI
mRatBN7.2533,529,880 - 33,552,790 (+)NCBI
Rnor_6.0534,040,258 - 34,063,369 (+)NCBI
Rnor_5.0538,693,591 - 38,716,702 (+)NCBI
RGSC_v3.4534,670,883 - 34,693,791 (+)RGD
Celera532,605,342 - 32,628,233 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037092 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52506 (Get FASTA)   NCBI Sequence Viewer  
  AAH87602 (Get FASTA)   NCBI Sequence Viewer  
  EDL98506 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009758
  ENSRNOP00000009758.3
GenBank Protein Q62867 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037092   ⟸   NM_012960
- Peptide Label: precursor
- UniProtKB: Q62867 (UniProtKB/Swiss-Prot),   A6IID6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009758   ⟸   ENSRNOT00000009758
Protein Domains
Gamma-glutamyl hydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62867-F1-model_v2 AlphaFold Q62867 1-317 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693592
Promoter ID:EPDNEW_R4117
Type:initiation region
Name:Ggh_2
Description:gamma-glutamyl hydrolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4118  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0534,040,260 - 34,040,320EPDNEW
RGD ID:13693593
Promoter ID:EPDNEW_R4118
Type:initiation region
Name:Ggh_1
Description:gamma-glutamyl hydrolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4117  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0534,040,362 - 34,040,422EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2682 AgrOrtholog
BioCyc Gene G2FUF-41832 BioCyc
BioCyc Pathway PWY-2161B [glutamate removal from folates] BioCyc
BioCyc Pathway Image PWY-2161B BioCyc
Ensembl Genes ENSRNOG00000007351 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009758 ENTREZGENE
  ENSRNOT00000009758.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.880 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7312627 IMAGE-MGC_LOAD
InterPro Class_I_gatase-like UniProtKB/Swiss-Prot
  Pept_C26_g-glut_hydrolase UniProtKB/Swiss-Prot
  Peptidase_C26 UniProtKB/Swiss-Prot
KEGG Report rno:25455 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105496 IMAGE-MGC_LOAD
NCBI Gene 25455 ENTREZGENE
PANTHER GAMMA-GLUTAMYL HYDROLASE UniProtKB/Swiss-Prot
  PTHR11315 UniProtKB/Swiss-Prot
Pfam Peptidase_C26 UniProtKB/Swiss-Prot
PharmGKB GGH RGD
PhenoGen Ggh PhenoGen
PROSITE PEPTIDASE_C26_GGH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007351 RatGTEx
Superfamily-SCOP SSF52317 UniProtKB/Swiss-Prot
TIGR TC234330
UniProt A6IID6 ENTREZGENE, UniProtKB/TrEMBL
  GGH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ggh  gamma-glutamyl hydrolase  LOC102549738  gamma-glutamyl hydrolase-like  Data merged from RGD:7676232 737654 PROVISIONAL
2016-01-27 Ggh  gamma-glutamyl hydrolase  Ggh  gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102549738  gamma-glutamyl hydrolase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-03-09 Ggh  gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)  Ggh  gamma-glutamyl hydrolase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ggh  gamma-glutamyl hydrolase      Name updated 70584 APPROVED