Fst (follistatin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Fst (follistatin) Rattus norvegicus
Analyze
Symbol: Fst
Name: follistatin
RGD ID: 2633
Description: Enables heparan sulfate proteoglycan binding activity. Involved in cellular response to growth factor stimulus. Predicted to be located in cytoplasm and nucleus. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (follistatin); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activin-binding protein; FOL1; follistatin-A; FS; Fst-288; LOC686745; RATFOL1; similar to follistatin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc ; WKY.SHRSP-(Fst-Pklr)/Gcrc ; SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc
QTLs:   Bp132  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8247,856,345 - 47,863,670 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl247,856,345 - 47,863,491 (-)EnsemblGRCr8
mRatBN7.2246,123,260 - 46,130,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,123,439 - 46,130,571 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx253,226,536 - 53,233,459 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0251,284,901 - 51,291,822 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0246,164,805 - 46,171,742 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0246,537,589 - 46,544,813 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl246,538,700 - 46,544,457 (-)Ensemblrn6Rnor6.0
Rnor_5.0265,576,721 - 65,583,918 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4246,542,246 - 46,550,678 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera241,883,386 - 41,889,989 (-)NCBICelera
RGSC_v3.1246,470,478 - 46,478,911 (-)NCBI
Cytogenetic Map2q14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-Hydroxybenzo[a]pyrene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Archazolid B  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethyl malate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
isobutanol  (ISO)
isoflavones  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
methamphetamine  (EXP)
Methandrostenolone  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
Monobutylphthalate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxybenzone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentobarbital  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium iodide  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
extracellular region  (IBA,IEA)
extracellular space  (IBA)
nucleolus  (IEA)
nucleus  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Dynamics of messenger RNAs encoding inhibin/activin subunits and follistatin in the ovary during the rat estrous cycle. Arai KY, etal., Biol Reprod. 2002 Apr;66(4):1119-26.
2. Rat anterior pituitary folliculostellate cells are targets of interleukin-1beta and a major source of intrapituitary follistatin. Bilezikjian LM, etal., Endocrinology 2003 Feb;144(2):732-40.
3. GnRH pulse frequency modulation of gonadotropin subunit gene transcription in normal gonadotropes-assessment by primary transcript assay provides evidence for roles of GnRH and follistatin. Burger LL, etal., Endocrinology 2002 Sep;143(9):3243-9.
4. Mapping of rat chromosome 2 markers generated from chromosome-sorted DNA. Deng AY, etal., Mamm Genome 1997 Oct;8(10):731-5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. betaA- and betaC-activin, follistatin, activin receptor mRNA and betaC-activin peptide expression during rat liver regeneration. Gold EJ, etal., J Mol Endocrinol. 2005 Apr;34(2):505-15.
8. Structural basis for the inhibition of activin signalling by follistatin. Harrington AE, etal., EMBO J. 2006 Mar 8;25(5):1035-45. Epub 2006 Feb 16.
9. Crystal structures of the heparan sulfate-binding domain of follistatin. Insights into ligand binding. Innis CA and Hyvonen M, J Biol Chem. 2003 Oct 10;278(41):39969-77. Epub 2003 Jul 16.
10. Multiple defects and perinatal death in mice deficient in follistatin. Matzuk MM, etal., Nature 1995 Mar 23;374(6520):360-3.
11. Granulosa cell tumor mutant FOXL2C134W suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cells. McTavish KJ, etal., Mol Cell Endocrinol. 2013 Jun 15;372(1-2):57-64. doi: 10.1016/j.mce.2013.03.021. Epub 2013 Apr 6.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Differential expression of the pituitary gonadotropin subunit genes during male rat sexual maturation: reciprocal relationship between hypothalamic pituitary adenylate cyclase-activating polypeptide and follicle-stimulating hormone beta expression. Moore JP Jr, etal., Biol Reprod. 2003 Jul;69(1):234-41. Epub 2003 Mar 19.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Pituitary follistatin gene expression in female rats: evidence that inhibin regulates transcription. Prendergast KA, etal., Biol Reprod. 2004 Feb;70(2):364-70. Epub 2003 Oct 15.
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Follistatin overexpression in rodent liver tumors: a possible mechanism to overcome activin growth control. Rossmanith W, etal., Mol Carcinog 2002 Sep;35(1):1-5.
22. The UV filter benzophenone 3, alters early follicular assembly in rat whole ovary cultures. Santamaría CG, etal., Toxicol Lett. 2019 Mar 15;303:48-54. doi: 10.1016/j.toxlet.2018.12.016. Epub 2018 Dec 30.
23. Follistatin gene expression in the ovary and extragonadal tissues. Shimasaki S, etal., Mol Endocrinol 1989 Apr;3(4):651-9.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. Urbanek M, etal., Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8573-8.
26. Expression of the activin axis and neuronal rescue effects of recombinant activin A following hypoxic-ischemic brain injury in the infant rat. Wu DD, etal., Brain Res. 1999 Jul 24;835(2):369-78. doi: 10.1016/s0006-8993(99)01638-8.
27. Lipopolysaccharide induced activin A-follistatin imbalance affects cardiac fibrosis. Zhang WQ, etal., Chin Med J (Engl). 2012 Jun;125(12):2205-12.
Additional References at PubMed
PMID:8472873   PMID:11948405   PMID:12088867   PMID:12514121   PMID:12697670   PMID:12702211   PMID:15162500   PMID:15305290   PMID:15451575   PMID:15525533   PMID:16123203   PMID:16935389  
PMID:17344471   PMID:18184649   PMID:18781389   PMID:19103603   PMID:20002838   PMID:20032047   PMID:20801187   PMID:21826650   PMID:22033906   PMID:22206666   PMID:22332899   PMID:22464481  
PMID:24006456   PMID:24019467   PMID:27128567   PMID:28277126   PMID:29113826   PMID:32014555   PMID:36899937  


Genomics

Comparative Map Data
Fst
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8247,856,345 - 47,863,670 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl247,856,345 - 47,863,491 (-)EnsemblGRCr8
mRatBN7.2246,123,260 - 46,130,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,123,439 - 46,130,571 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx253,226,536 - 53,233,459 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0251,284,901 - 51,291,822 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0246,164,805 - 46,171,742 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0246,537,589 - 46,544,813 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl246,538,700 - 46,544,457 (-)Ensemblrn6Rnor6.0
Rnor_5.0265,576,721 - 65,583,918 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4246,542,246 - 46,550,678 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera241,883,386 - 41,889,989 (-)NCBICelera
RGSC_v3.1246,470,478 - 46,478,911 (-)NCBI
Cytogenetic Map2q14NCBI
FST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38553,480,629 - 53,487,134 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl553,480,210 - 53,487,134 (+)Ensemblhg38GRCh38
GRCh37552,776,459 - 52,782,964 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,812,352 - 52,817,680 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34552,812,351 - 52,817,659NCBI
Celera549,730,217 - 49,735,545 (+)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef549,748,385 - 49,754,428 (+)NCBIHuRef
CHM1_1552,779,193 - 52,785,231 (+)NCBICHM1_1
T2T-CHM13v2.0554,308,436 - 54,314,946 (+)NCBIT2T-CHM13v2.0
Fst
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913114,588,798 - 114,595,522 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13114,588,826 - 114,595,487 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3813114,452,262 - 114,458,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,452,290 - 114,458,951 (-)Ensemblmm10GRCm38
MGSCv3713115,242,470 - 115,248,938 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3613115,574,219 - 115,579,464 (-)NCBIMGSCv36mm8
Celera13118,786,092 - 118,792,681 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.15NCBI
Fst
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544613,925,776 - 13,932,104 (-)Ensembl
ChiLan1.0NW_00495544613,925,833 - 13,932,104 (-)NCBIChiLan1.0ChiLan1.0
FST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2460,454,897 - 60,462,481 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1558,608,522 - 58,616,019 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0560,544,495 - 60,550,516 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1562,163,655 - 62,168,218 (-)NCBIPanPan1.1PanPan1.1panPan2
FST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1461,779,252 - 61,785,666 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl461,779,259 - 61,783,260 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha461,544,683 - 61,551,112 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0462,270,843 - 62,277,297 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl462,271,936 - 62,277,253 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1462,049,664 - 62,056,089 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0462,178,184 - 62,184,600 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0462,695,162 - 62,701,588 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fst
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213205,054,434 - 205,060,754 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648013,990,929 - 13,997,248 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648013,990,967 - 13,997,248 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,805,932 - 32,811,421 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11632,806,341 - 32,811,382 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21634,779,040 - 34,784,066 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,773,646 - 49,780,343 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl449,773,980 - 49,780,333 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660821,343,148 - 1,349,927 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fst
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247595,798,067 - 5,805,254 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247595,799,127 - 5,804,802 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fst
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13182,255,109 - 182,261,254 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fst
26 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:46
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000015680
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)23561408353462005Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9685065Swd6Spike wave discharge measurement QTL 65.80.01brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge rate (CMO:0001739)24095742350526673Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat

Markers in Region
D2Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8247,863,756 - 47,863,910 (+)Marker Load Pipeline
mRatBN7.2246,130,672 - 46,130,826 (+)MAPPERmRatBN7.2
Rnor_6.0246,544,917 - 46,545,070NCBIRnor6.0
Rnor_5.0265,584,009 - 65,584,162UniSTSRnor5.0
RGSC_v3.4246,551,143 - 46,551,296UniSTSRGSC3.4
RGSC_v3.4246,551,142 - 46,551,296RGDRGSC3.4
RGSC_v3.1246,479,375 - 46,479,529RGD
RH 3.4 Map2297.6UniSTS
RH 3.4 Map2297.6RGD
RH 2.0 Map2267.2RGD
Cytogenetic Map2q16UniSTS
D2Arb3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2246,130,674 - 46,130,822 (+)MAPPERmRatBN7.2
Rnor_6.0246,544,919 - 46,545,066NCBIRnor6.0
Rnor_5.0265,584,011 - 65,584,158UniSTSRnor5.0
RGSC_v3.4246,551,144 - 46,551,292RGDRGSC3.4
RGSC_v3.4246,551,145 - 46,551,292UniSTSRGSC3.4
RGSC_v3.1246,479,377 - 46,479,525RGD
Cytogenetic Map2q16UniSTS
AA858520  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map2293.1UniSTS
Cytogenetic Map2q16UniSTS
Fst  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0246,539,696 - 46,541,189NCBIRnor6.0
Rnor_5.0265,578,828 - 65,580,216UniSTSRnor5.0
RGSC_v3.4246,543,186 - 46,544,783UniSTSRGSC3.4
Cytogenetic Map2q16UniSTS




Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 140 89 88 57 84 57 6 346 184 11 119 81 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000015680   ⟹   ENSRNOP00000015680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl247,856,345 - 47,863,491 (-)Ensembl
mRatBN7.2 Ensembl246,123,439 - 46,130,571 (-)Ensembl
Rnor_6.0 Ensembl246,538,700 - 46,544,457 (-)Ensembl
RefSeq Acc Id: NM_012561   ⟹   NP_036693
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8247,856,345 - 47,863,292 (-)NCBI
mRatBN7.2246,123,260 - 46,130,208 (-)NCBI
Rnor_6.0246,537,589 - 46,544,452 (-)NCBI
Rnor_5.0265,576,721 - 65,583,918 (-)NCBI
RGSC_v3.4246,542,246 - 46,550,678 (-)RGD
Celera241,883,386 - 41,889,989 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231953   ⟹   XP_006232015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8247,856,345 - 47,863,670 (-)NCBI
mRatBN7.2246,123,260 - 46,130,583 (-)NCBI
Rnor_6.0246,537,589 - 46,544,813 (-)NCBI
Rnor_5.0265,576,721 - 65,583,918 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231954   ⟹   XP_006232016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8247,856,345 - 47,863,669 (-)NCBI
mRatBN7.2246,123,260 - 46,130,582 (-)NCBI
Rnor_6.0246,538,745 - 46,544,813 (-)NCBI
Rnor_5.0265,576,721 - 65,583,918 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_036693 (Get FASTA)   NCBI Sequence Viewer  
  XP_006232015 (Get FASTA)   NCBI Sequence Viewer  
  XP_006232016 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB60704 (Get FASTA)   NCBI Sequence Viewer  
  AAP34393 (Get FASTA)   NCBI Sequence Viewer  
  EDM10382 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015680
  ENSRNOP00000015680.1
GenBank Protein P21674 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036693   ⟸   NM_012561
- Peptide Label: precursor
- UniProtKB: Q80XW7 (UniProtKB/Swiss-Prot),   P21674 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006232015   ⟸   XM_006231953
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006232016   ⟸   XM_006231954
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000015680   ⟸   ENSRNOT00000015680
Protein Domains
Follistatin-like   Kazal-like   TB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21674-F1-model_v2 AlphaFold P21674 1-344 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2633 AgrOrtholog
BioCyc Gene G2FUF-54336 BioCyc
Ensembl Genes ENSRNOG00000011631 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015680 ENTREZGENE
  ENSRNOT00000015680.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot
  3.90.290.10 UniProtKB/Swiss-Prot
InterPro Fol_N UniProtKB/Swiss-Prot
  Follistatin/Osteonectin_EGF UniProtKB/Swiss-Prot
  Kazal_dom UniProtKB/Swiss-Prot
  Kazal_dom_sf UniProtKB/Swiss-Prot
  Prot_Inhib_GrowthFact_Antg UniProtKB/Swiss-Prot
  TB_dom UniProtKB/Swiss-Prot
  TB_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:24373 UniProtKB/Swiss-Prot
NCBI Gene 24373 ENTREZGENE
PANTHER AGRIN UniProtKB/Swiss-Prot
  FOLLISTATIN-RELATED UniProtKB/Swiss-Prot
Pfam FOLN UniProtKB/Swiss-Prot
  FST_N UniProtKB/Swiss-Prot
  Kazal_2 UniProtKB/Swiss-Prot
PhenoGen Fst PhenoGen
PROSITE KAZAL_2 UniProtKB/Swiss-Prot
  PS51364 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011631 RatGTEx
SMART FOLN UniProtKB/Swiss-Prot
  KAZAL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot
  SSF57581 UniProtKB/Swiss-Prot
TIGR TC201576
UniProt A6I5S4_RAT UniProtKB/TrEMBL
  FST_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q80XW7 ENTREZGENE
UniProt Secondary Q80XW7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Fst  follistatin  LOC686745  similar to follistatin  Data merged from RGD:1593716 737654 PROVISIONAL
2006-11-20 LOC686745  similar to follistatin      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Fst  follistatin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mRNA is overexpressed in some hepatocellular carcinomas 728764