Fgfr4 (fibroblast growth factor receptor 4) - Rat Genome Database

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Gene: Fgfr4 (fibroblast growth factor receptor 4) Rattus norvegicus
Analyze
Symbol: Fgfr4
Name: fibroblast growth factor receptor 4
RGD ID: 2612
Description: Enables fibroblast growth factor receptor activity. Acts upstream of or within fibroblast growth factor receptor signaling pathway. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and transport vesicle. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Predicted to colocalize with cell-cell junction. Human ortholog(s) of this gene implicated in carcinoma (multiple); liver cirrhosis; prostate cancer; and stomach cancer. Orthologous to human FGFR4 (fibroblast growth factor receptor 4); PARTICIPATES IN fibroblast growth factor signaling pathway; endocytosis pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FGFR-4; MGC116290
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,466,686 - 9,481,423 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl179,466,692 - 9,481,389 (-)EnsemblGRCr8
mRatBN7.2179,461,541 - 9,476,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,461,547 - 9,476,242 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx179,477,854 - 9,492,597 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01711,007,466 - 11,022,178 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,474,258 - 9,489,006 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,990,072 - 10,004,339 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,990,078 - 10,004,321 (-)Ensemblrn6Rnor6.0
Rnor_5.01712,099,383 - 12,113,637 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41715,512,144 - 15,527,348 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera179,540,006 - 9,554,750 (-)NCBICelera
RGSC_v3.11715,512,146 - 15,523,432 (-)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylfuran  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benomyl  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
cholesterol  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP,ISO)
DDE  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
flusilazole  (EXP)
flutamide  (EXP)
furosemide  (EXP)
gossypol  (ISO)
GW 4064  (ISO)
heparan sulfate  (ISO)
heparin  (EXP,ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (EXP)
niclosamide  (ISO)
nitrofen  (EXP)
obeticholic acid  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
PD173074  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pirinixic acid  (EXP,ISO)
ponatinib  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulindac sulfide  (ISO)
taurocholic acid  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell-cell junction  (IEA,ISO,ISS)
endoplasmic reticulum  (IEA,ISO,ISS)
endosome  (IEA)
Golgi apparatus  (IEA,ISO)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)
receptor complex  (IBA)
transport vesicle  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The fibroblast growth factor receptor 4 (FGFR4) Arg388 allele correlates with survival in head and neck squamous cell carcinoma. da Costa Andrade VC, etal., Exp Mol Pathol. 2007 Feb;82(1):53-7. doi: 10.1016/j.yexmp.2006.05.003. Epub 2006 Nov 3.
2. Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. Desnoyers LR, etal., Oncogene. 2008 Jan 3;27(1):85-97. doi: 10.1038/sj.onc.1210623. Epub 2007 Jun 25.
3. FGFR4 Gly388Arg polymorphism may affect the clinical stage of patients with lung cancer by modulating the transcriptional profile of normal lung. Falvella FS, etal., Int J Cancer. 2009 Jun 15;124(12):2880-5. doi: 10.1002/ijc.24302.
4. FGFR4 genetic polymorphisms determine the chemotherapy response of Chinese patients with non-small cell lung cancer. Fang HM, etal., Acta Pharmacol Sin. 2013 Apr;34(4):549-54. doi: 10.1038/aps.2012.206. Epub 2013 Mar 25.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Cloning, expression and tissue distribution of the gene encoding rat fibroblast growth factor receptor subtype 4. Horlick RA, etal., Gene 1992 Oct 21;120(2):291-5.
8. The prognostic significance of fibroblast growth factor receptor 4 in non-small-cell lung cancer. Huang HP, etal., Onco Targets Ther. 2015 May 22;8:1157-64. doi: 10.2147/OTT.S81659. eCollection 2015.
9. Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes. Konishi M, etal., J Biol Chem. 2000 Apr 21;275(16):12119-22.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. The FGFR4-388arg Variant Promotes Lung Cancer Progression by N-Cadherin Induction. Quintanal-Villalonga Á, etal., Sci Rep. 2018 Feb 5;8(1):2394. doi: 10.1038/s41598-018-20570-3.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Fibroblast growth factor receptor 4 polymorphism is associated with liver cirrhosis in hepatocarcinoma. Sheu MJ, etal., PLoS One. 2015 Apr 10;10(4):e0122961. doi: 10.1371/journal.pone.0122961. eCollection 2015.
18. High Expression of FGFR4 Enhances Tumor Growth and Metastasis in Nasopharyngeal Carcinoma. Shi S, etal., J Cancer. 2015 Oct 20;6(12):1245-54. doi: 10.7150/jca.12825. eCollection 2015.
19. The Prognostic Significance of FGFR4 Gly388 Polymorphism in Esophageal Squamous Cell Carcinoma after Concurrent Chemoradiotherapy. Shim HJ, etal., Cancer Res Treat. 2016 Jan;48(1):71-9. doi: 10.4143/crt.2015.018. Epub 2015 May 14.
20. Futibatinib Is a Novel Irreversible FGFR 1-4 Inhibitor That Shows Selective Antitumor Activity against FGFR-Deregulated Tumors. Sootome H, etal., Cancer Res. 2020 Nov 15;80(22):4986-4997. doi: 10.1158/0008-5472.CAN-19-2568. Epub 2020 Sep 24.
21. Functional FGFR4 Gly388Arg polymorphism predicts prognosis in lung adenocarcinoma patients. Spinola M, etal., J Clin Oncol. 2005 Oct 10;23(29):7307-11. doi: 10.1200/JCO.2005.17.350. Epub 2005 Aug 1.
22. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
23. FGFR4 polymorphism, TP53 mutation, and their combinations are prognostic factors for oral squamous cell carcinoma. Tanuma J, etal., Oncol Rep. 2010 Mar;23(3):739-44.
24. The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression. Wang J, etal., Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6169-78. doi: 10.1158/1078-0432.CCR-04-0408.
25. Tumor Fibroblast Growth Factor Receptor 4 Level Predicts the Efficacy of Lenvatinib in Patients With Advanced Hepatocellular Carcinoma. Yamauchi M, etal., Clin Transl Gastroenterol. 2020 May;11(5):e00179. doi: 10.14309/ctg.0000000000000179.
26. The fibroblast growth factor receptor-4 Arg388 allele is associated with gastric cancer progression. Ye Y, etal., Ann Surg Oncol. 2010 Dec;17(12):3354-61. doi: 10.1245/s10434-010-1323-6. Epub 2010 Sep 16.
27. Silencing of FGFR4 could influence the biological features of gastric cancer cells and its therapeutic value in gastric cancer. Ye Y, etal., Tumour Biol. 2016 Mar;37(3):3185-95. doi: 10.1007/s13277-015-4100-0. Epub 2015 Oct 2.
28. Fibroblast growth factor receptor 4 regulates proliferation and antiapoptosis during gastric cancer progression. Ye YW, etal., Cancer. 2011 Dec 1;117(23):5304-13. doi: 10.1002/cncr.26207. Epub 2011 May 12.
Additional References at PubMed
PMID:8663044   PMID:9716527   PMID:10525310   PMID:10809780   PMID:12477932   PMID:15489334   PMID:15576401   PMID:17623664   PMID:17627937   PMID:17664243   PMID:18061161   PMID:18187602  
PMID:18480409   PMID:19085950   PMID:20683963   PMID:20798051   PMID:20876804   PMID:21561999   PMID:21653700   PMID:24259513   PMID:28339837  


Genomics

Comparative Map Data
Fgfr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,466,686 - 9,481,423 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl179,466,692 - 9,481,389 (-)EnsemblGRCr8
mRatBN7.2179,461,541 - 9,476,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,461,547 - 9,476,242 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx179,477,854 - 9,492,597 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01711,007,466 - 11,022,178 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,474,258 - 9,489,006 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,990,072 - 10,004,339 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,990,078 - 10,004,321 (-)Ensemblrn6Rnor6.0
Rnor_5.01712,099,383 - 12,113,637 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41715,512,144 - 15,527,348 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera179,540,006 - 9,554,750 (-)NCBICelera
RGSC_v3.11715,512,146 - 15,523,432 (-)NCBI
Cytogenetic Map17p14NCBI
FGFR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385177,086,915 - 177,098,144 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5177,086,456 - 177,098,151 (+)Ensemblhg38GRCh38
GRCh375176,513,916 - 176,525,145 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365176,446,527 - 176,457,733 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345176,446,526 - 176,457,730NCBI
Celera5171,976,184 - 171,987,401 (-)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5171,435,609 - 171,446,679 (+)NCBIHuRef
CHM1_15175,946,753 - 175,957,892 (+)NCBICHM1_1
T2T-CHM13v2.05177,630,123 - 177,641,352 (+)NCBIT2T-CHM13v2.0
Fgfr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,300,631 - 55,316,572 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,300,453 - 55,316,572 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381355,152,818 - 55,168,759 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,152,640 - 55,168,759 (+)Ensemblmm10GRCm38
MGSCv371355,254,179 - 55,270,120 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361355,162,497 - 55,178,362 (+)NCBIMGSCv36mm8
Celera1356,213,486 - 56,229,296 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1329.8NCBI
Fgfr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,370,468 - 29,383,971 (+)Ensembl
ChiLan1.0NW_00495540829,370,480 - 29,383,531 (+)NCBIChiLan1.0ChiLan1.0
FGFR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24172,169,490 - 172,181,379 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15170,308,253 - 170,320,916 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05172,386,443 - 172,400,271 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15179,454,995 - 179,466,114 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,454,995 - 179,467,605 (+)EnsemblpanPan2panpan1.1
FGFR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1436,243,689 - 36,254,636 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl436,244,220 - 36,252,035 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha436,209,722 - 36,220,671 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0436,607,886 - 36,618,835 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl436,607,906 - 36,618,801 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,434,871 - 36,445,815 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0436,622,022 - 36,632,969 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0437,130,265 - 37,141,210 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fgfr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213122,360,727 - 122,372,869 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365971,385,624 - 1,397,758 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365971,388,394 - 1,397,731 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGFR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl280,841,536 - 80,853,796 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1280,841,536 - 80,853,791 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2282,414,997 - 82,427,239 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGFR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,095,031 - 79,106,018 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,097,429 - 79,105,456 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607510,259,717 - 10,291,447 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgfr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473312,964,746 - 12,976,732 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473312,964,893 - 12,979,198 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fgfr4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11473,480,630 - 73,495,762 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fgfr4
159 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:50
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000042394
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920650523859062Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920650523859062Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17798524316523460Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920650523859062Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 142 91 90 59 35 59 6 299 135 10 119 81 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000042394   ⟹   ENSRNOP00000050988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl179,466,692 - 9,481,389 (-)Ensembl
mRatBN7.2 Ensembl179,461,547 - 9,476,242 (-)Ensembl
Rnor_6.0 Ensembl179,990,078 - 10,004,321 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082836   ⟹   ENSRNOP00000069871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl179,461,547 - 9,473,596 (-)Ensembl
Rnor_6.0 Ensembl179,990,078 - 10,001,901 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118916   ⟹   ENSRNOP00000094461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl179,466,692 - 9,481,389 (-)Ensembl
mRatBN7.2 Ensembl179,461,547 - 9,476,242 (-)Ensembl
RefSeq Acc Id: NM_001109904   ⟹   NP_001103374
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,466,686 - 9,481,389 (-)NCBI
mRatBN7.2179,461,541 - 9,476,242 (-)NCBI
Rnor_6.0179,990,072 - 10,004,321 (-)NCBI
Rnor_5.01712,099,383 - 12,113,637 (-)NCBI
RGSC_v3.41715,512,144 - 15,527,348 (-)RGD
Celera179,540,006 - 9,554,750 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253606   ⟹   XP_006253668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,466,686 - 9,481,423 (-)NCBI
mRatBN7.2179,461,541 - 9,476,268 (-)NCBI
Rnor_6.0179,990,072 - 10,004,339 (-)NCBI
Rnor_5.01712,099,383 - 12,113,637 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095374   ⟹   XP_038951302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,466,686 - 9,475,463 (-)NCBI
mRatBN7.2179,461,541 - 9,470,316 (-)NCBI
RefSeq Acc Id: XM_063276076   ⟹   XP_063132146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,466,686 - 9,481,415 (-)NCBI
RefSeq Acc Id: NP_001103374   ⟸   NM_001109904
- Peptide Label: precursor
- UniProtKB: Q498D6 (UniProtKB/Swiss-Prot),   A0A8L2UPP9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253668   ⟸   XM_006253606
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QQB7 (UniProtKB/TrEMBL),   A0A8L2UPP9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069871   ⟸   ENSRNOT00000082836
Ensembl Acc Id: ENSRNOP00000050988   ⟸   ENSRNOT00000042394
RefSeq Acc Id: XP_038951302   ⟸   XM_039095374
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000094461   ⟸   ENSRNOT00000118916
RefSeq Acc Id: XP_063132146   ⟸   XM_063276076
- Peptide Label: isoform X2
- UniProtKB: A0A8L2UPP9 (UniProtKB/TrEMBL),   A6KAU9 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Ig-like C2-type   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q498D6-F1-model_v2 AlphaFold Q498D6 1-800 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700313
Promoter ID:EPDNEW_R10837
Type:multiple initiation site
Name:Fgfr4_1
Description:fibroblast growth factor receptor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01710,004,305 - 10,004,365EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2612 AgrOrtholog
BioCyc Gene G2FUF-10193 BioCyc
Ensembl Genes ENSRNOG00000016763 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000042394 ENTREZGENE
  ENSRNOT00000118916 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7096119 IMAGE-MGC_LOAD
  IMAGE:7100540 IMAGE-MGC_LOAD
InterPro FGF_rcpt_fam UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RTK UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:25114 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116290 IMAGE-MGC_LOAD
  MGC:93687 IMAGE-MGC_LOAD
NCBI Gene 25114 ENTREZGENE
PANTHER FIBROBLAST GROWTH FACTOR RECEPTOR 4 UniProtKB/Swiss-Prot
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot
Pfam I-set UniProtKB/Swiss-Prot
  Ig_3 UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
PhenoGen Fgfr4 PhenoGen
PIRSF FGFR UniProtKB/Swiss-Prot
PRINTS TYRKINASE UniProtKB/Swiss-Prot
PROSITE IG_LIKE UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016763 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6ANB5_RAT UniProtKB/TrEMBL
  A0A8L2QQB7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UPP9 ENTREZGENE
  A6KAU9 ENTREZGENE, UniProtKB/TrEMBL
  FGFR4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Fgfr4  fibroblast growth factor receptor 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may have a role in breast and ovarian tumorigenesis 69837
gene_expression overexpressed in gynecological tumor samples 69837
gene_function receptor for acidic fibroblast growth factor 69837