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Gene: Cela1 (chymotrypsin like elastase 1) Rattus norvegicus

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Symbol:

Cela1

Name:

chymotrypsin like elastase 1

RGD ID:

2547

Description:

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within several processes, including elastin catabolic process; exocrine pancreas development; and regulation of transcription by RNA polymerase II. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CELA1 (chymotrypsin like elastase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; 4,4'-diaminodiphenylmethane.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

chymotrypsin-like elastase family member 1; chymotrypsin-like elastase family, member 1; Ela1; ELAI1; elastase 1; elastase 1, pancreatic; elastase-1; RATELAI1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CELA1 (chymotrypsin like elastase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Cela1 (chymotrypsin-like elastase family, member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cela1 (chymotrypsin like elastase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CELA1 (chymotrypsin like elastase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CELA1 (chymotrypsin like elastase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cela1 (chymotrypsin like elastase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CELA1 (chymotrypsin like elastase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CELA1 (chymotrypsin like elastase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cela1 (chymotrypsin like elastase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Cela1 (chymotrypsin like elastase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	BIN2 (bridging integrator 2)	HGNC	Ensembl, Inparanoid, OrthoDB, PhylomeDB
Homo sapiens (human):	SLC35D3 (solute carrier family 35 member D3)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Cela1 (chymotrypsin-like elastase family, member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CELA1 (chymotrypsin like elastase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cela1.5 (chymotrypsin like elastase family member 1, tandem duplicate 5)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	cela1.5 (chymotrypsin like elastase family member 1, tandem duplicate 5)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	cela1.2 (chymotrypsin like elastase family member 1, tandem duplicate 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cela1.2 (chymotrypsin like elastase family member 1, tandem duplicate 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	cela1.4 (chymotrypsin like elastase family member 1, tandem duplicate 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cela1.1 (chymotrypsin like elastase family member 1, tandem duplicate 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	cela1.3 (chymotrypsin like elastase family member 1, tandem duplicate 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cela1.3 (chymotrypsin like elastase family member 1, tandem duplicate 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	cela1.6 (chymotrypsin like elastase family member 1, tandem duplicate 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cela1.6 (chymotrypsin like elastase family member 1, tandem duplicate 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Jon74E	Alliance	DIOPT (Hieranoid\|InParanoid)
Drosophila melanogaster (fruit fly):	CG6592	Alliance	DIOPT (Hieranoid\|InParanoid)
Xenopus tropicalis (tropical clawed frog):	cela1.6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cela1.6	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	cela1.4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cela1.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cela1.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cela1.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cela1.5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG7542	Alliance	DIOPT (InParanoid\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	133,651,939 - 133,665,136 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	133,651,941 - 133,665,061 (-)	Ensembl				GRCr8
mRatBN7.2	7	131,773,161 - 131,786,300 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	131,742,002 - 131,786,285 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	133,575,294 - 133,588,426 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	135,800,881 - 135,814,013 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	135,714,422 - 135,727,635 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	142,305,337 - 142,318,621 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	142,305,338 - 142,318,620 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	140,110,478 - 140,123,423 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	139,439,589 - 139,452,717 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	128,249,427 - 128,262,461 (-)	NCBI		Celera
RGSC_v3.1	7	139,515,742 - 139,529,176 (-)	NCBI
Cytogenetic Map	7	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

3,7-dihydropurine-6-thione (EXP)

3H-1,2-dithiole-3-thione (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

ammonium chloride (EXP)

amphetamine (EXP)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

carnosic acid (ISO)

choline (ISO)

ciguatoxin CTX1B (ISO)

clofibrate (ISO)

cobalt dichloride (EXP)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dichloroacetic acid (ISO)

diethylstilbestrol (ISO)

disodium selenite (ISO)

epoxiconazole (ISO)

fenvalerate (EXP)

flutamide (EXP)

folic acid (ISO)

genistein (ISO)

L-methionine (ISO)

mercaptopurine (EXP)

methamphetamine (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

nefazodone (EXP)

oxaliplatin (EXP)

p-toluidine (EXP)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (EXP,ISO)

permethrin (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

purine-6-thiol (EXP)

sodium arsenite (ISO)

streptozocin (ISO)

testosterone (ISO)

tetrachloroethene (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

topotecan (EXP)

triphenyl phosphate (EXP)

valdecoxib (EXP)

valproic acid (ISO)

vancomycin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell chemotaxis (IEA)

digestive system development (ISO)

elastin catabolic process (ISO)

exocrine pancreas development (ISO)

inflammatory response (IBA,ISO)

multicellular organism growth (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

pancreas morphogenesis (ISO)

phagocytosis, engulfment (IEA)

plasma membrane tubulation (IEA)

podosome assembly (IEA)

positive regulation of angiogenesis (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

post-embryonic development (ISO)

proteolysis (IBA,IEA)

regulation of cell differentiation (ISO)

regulation of cell population proliferation (ISO)

tissue remodeling (ISO)

Wnt signaling pathway (ISO)

Cellular Component

cell cortex (IEA)

cell projection (IEA)

cytoplasm (IEA)

extracellular region (IEA)

extracellular space (IBA)

phagocytic cup (IEA)

plasma membrane (IEA)

podosome (IEA)

Molecular Function

hydrolase activity (IEA)

metal ion binding (IEA)

peptidase activity (IEA)

phospholipid binding (IEA)

protein binding (ISO)

serine hydrolase activity (IEA)

serine-type endopeptidase activity (IBA,IEA,ISO,ISS)

serine-type peptidase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes.	Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
3.	Primary structure of two distinct rat pancreatic preproelastases determined by sequence analysis of the complete cloned messenger ribonucleic acid sequences.	MacDonald RJ, etal., Biochemistry 1982 Mar 16;21(6):1453-63.
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Structure of the two related elastase genes expressed in the rat pancreas.	Swift GH, etal., J Biol Chem 1984 Nov 25;259(22):14271-8.

Additional References at PubMed

PMID:6555050	PMID:14631510	PMID:14631512	PMID:17222338	PMID:24793170

Genomics

Comparative Map Data

Cela1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	133,651,939 - 133,665,136 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	133,651,941 - 133,665,061 (-)	Ensembl				GRCr8
mRatBN7.2	7	131,773,161 - 131,786,300 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	131,742,002 - 131,786,285 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	133,575,294 - 133,588,426 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	135,800,881 - 135,814,013 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	135,714,422 - 135,727,635 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	142,305,337 - 142,318,621 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	142,305,338 - 142,318,620 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	140,110,478 - 140,123,423 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	139,439,589 - 139,452,717 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	128,249,427 - 128,262,461 (-)	NCBI		Celera
RGSC_v3.1	7	139,515,742 - 139,529,176 (-)	NCBI
Cytogenetic Map	7	q36	NCBI

CELA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	51,328,442 - 51,346,679 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	51,328,442 - 51,346,679 (-)	Ensembl			hg38	GRCh38
GRCh37	12	51,722,226 - 51,740,463 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	50,008,494 - 50,026,730 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	50,008,493 - 50,026,730	NCBI
Celera	12	50,523,712 - 50,541,944 (-)	NCBI		Celera
Cytogenetic Map	12	q13.13	NCBI
HuRef	12	48,755,149 - 48,773,386 (-)	NCBI		HuRef
CHM1_1	12	51,688,462 - 51,705,900 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	51,291,249 - 51,309,485 (-)	NCBI		T2T-CHM13v2.0

Cela1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	100,572,303 - 100,585,801 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	100,572,302 - 100,585,802 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	100,674,422 - 100,687,920 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	100,674,421 - 100,687,921 (-)	Ensembl			mm10	GRCm38
MGSCv37	15	100,504,853 - 100,518,351 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	100,502,459 - 100,515,952 (-)	NCBI		MGSCv36	mm8
Celera	15	102,827,643 - 102,841,149 (-)	NCBI		Celera
Cytogenetic Map	15	F1	NCBI
cM Map	15	56.38	NCBI

Cela1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955547	1,810,670 - 1,824,409 (-)	Ensembl
ChiLan1.0	NW_004955547	1,810,680 - 1,823,938 (-)	NCBI	ChiLan1.0	ChiLan1.0

CELA1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	42,839,742 - 42,859,679 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	42,836,504 - 42,856,441 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	37,407,189 - 37,425,684 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	38,291,831 - 38,310,331 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	38,292,562 - 38,310,197 (+)	Ensembl			panPan2	panpan1.1

CELA1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	3,542,327 - 3,560,777 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	3,542,309 - 3,560,777 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	42,697,240 - 42,715,697 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	3,587,196 - 3,605,707 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	3,536,169 - 3,605,707 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	3,554,804 - 3,573,236 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	3,541,322 - 3,559,772 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	43,094,493 - 43,113,139 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Cela1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	64,244,890 - 64,263,156 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936512	8,905,339 - 8,919,819 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936512	8,901,674 - 8,919,819 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CELA1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa10.2	5	17,250,142 - 17,279,128 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CELA1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	47,526,354 - 47,545,390 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	47,526,365 - 47,544,726 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	198,550,809 - 198,569,559 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cela1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624816	906,121 - 939,696 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624816	906,103 - 939,252 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cela1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	262,423,025 - 262,436,240 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Cela1
48 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	50
Count of miRNA genes:	47
Interacting mature miRNAs:	49
Transcripts:	ENSRNOT00000006351
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	110725024	135371468	Rat
1354582	Stl11	Serum triglyceride level QTL 11	3.42		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	121393075	137014596	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	132099939	137014596	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	98549867	137014596	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	119280025	135560836	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	100548246	137014596	Rat
61397	Bw17	Body weight QTL 17	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	7	95485047	137014596	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	82111245	134948181	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	115313999	136544683	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	104186212	135371468	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	92362341	137014596	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	71827901	136544683	Rat

Markers in Region

D7Wox23

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	131,786,627 - 131,786,744 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	142,318,964 - 142,319,080	NCBI	Rnor6.0
Rnor_5.0	7	140,123,788 - 140,123,904	UniSTS	Rnor5.0
RGSC_v3.4	7	139,453,082 - 139,453,198	UniSTS	RGSC3.4
RGSC_v3.4	7	139,453,081 - 139,453,198	RGD	RGSC3.4
Celera	7	128,262,804 - 128,262,920	UniSTS
RGSC_v3.1	7	139,529,518 - 139,529,635	RGD
RH 3.4 Map	7	1066.9	UniSTS
RH 3.4 Map	7	1066.9	RGD
RH 2.0 Map	7	793.1	RGD
Cytogenetic Map	7	q36	UniSTS

D7Mit26

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	7	133,665,376 - 133,665,591 (+)	Marker Load Pipeline
mRatBN7.2	7	131,786,600 - 131,786,815 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	142,318,937 - 142,319,151	NCBI	Rnor6.0
Rnor_5.0	7	140,123,761 - 140,123,975	UniSTS	Rnor5.0
RGSC_v3.4	7	139,453,055 - 139,453,269	UniSTS	RGSC3.4
RGSC_v3.4	7	139,453,054 - 139,453,269	RGD	RGSC3.4
Celera	7	128,262,777 - 128,262,991	UniSTS
RGSC_v3.1	7	139,529,491 - 139,529,706	RGD
RH 3.4 Map	7	1065.9	RGD
RH 3.4 Map	7	1065.9	UniSTS
RH 2.0 Map	7	790.8	RGD
Cytogenetic Map	7	q36	UniSTS

D7Arb6

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	131,786,607 - 131,786,854 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	142,318,944 - 142,319,190	NCBI	Rnor6.0
Rnor_5.0	7	140,123,768 - 140,124,014	UniSTS	Rnor5.0
RGSC_v3.4	7	139,453,062 - 139,453,308	UniSTS	RGSC3.4
RGSC_v3.4	7	139,453,061 - 139,453,308	RGD	RGSC3.4
Celera	7	128,262,784 - 128,263,030	UniSTS
RGSC_v3.1	7	139,529,498 - 139,529,745	RGD
RH 3.4 Map	7	1070.6	UniSTS
RH 3.4 Map	7	1070.6	RGD
RH 2.0 Map	7	794.8	RGD
SHRSP x BN Map	7	88.4599	RGD
FHH x ACI Map	7	73.51	RGD
Cytogenetic Map	7	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	10	32	145	91	90	59	89	59	6	313	149	10	125	81	92	31	7	7

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012552	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063262977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063262978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063262979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AH003519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227752	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	V01234	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006351 ⟹ ENSRNOP00000006351

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	133,651,941 - 133,665,061 (-)	Ensembl
mRatBN7.2 Ensembl	7	131,773,163 - 131,786,285 (-)	Ensembl
Rnor_6.0 Ensembl	7	142,305,338 - 142,318,620 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000048262 ⟹ ENSRNOP00000039630

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	133,620,783 - 133,646,986 (-)	Ensembl
mRatBN7.2 Ensembl	7	131,742,002 - 131,768,308 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097496 ⟹ ENSRNOP00000079003

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	133,624,594 - 133,640,015 (-)	Ensembl
mRatBN7.2 Ensembl	7	131,745,813 - 131,761,236 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103654 ⟹ ENSRNOP00000084036

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	133,620,140 - 133,647,218 (-)	Ensembl
mRatBN7.2 Ensembl	7	131,742,002 - 131,786,285 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000140130 ⟹ ENSRNOP00000101583

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	133,651,941 - 133,665,061 (-)	Ensembl

RefSeq Acc Id:

NM_012552 ⟹ NP_036684

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	133,651,941 - 133,665,061 (-)	NCBI
mRatBN7.2	7	131,773,163 - 131,786,285 (-)	NCBI
Rnor_6.0	7	142,305,337 - 142,318,621 (-)	NCBI
Rnor_5.0	7	140,110,478 - 140,123,423 (-)	NCBI
RGSC_v3.4	7	139,439,589 - 139,452,717 (-)	RGD
Celera	7	128,249,427 - 128,262,461 (-)	NCBI

Sequence:

show sequence

AGTGGTCTACTCTCTCCACAACATGCTGCGCTTCCTGGTGTTCGCTTCCCTGGTCCTGTATGGA
CACAGTACCCAGGACTTTCCGGAAACTAATGCCCGCGTGGTTGGAGGGGCTGAAGCCCGGAGGA
ACTCCTGGCCATCTCAGATTTCCCTCCAGTACCTGTCCGGAGGATCATGGTACCACACCTGTGG
AGGGACCCTCATCCGACGCAACTGGGTGATGACCGCTGCCCACTGTGTGAGCAGCCAGATGACT
TTCCGAGTGGTCGTCGGAGACCACAACCTGAGTCAGAATGACGGCACGGAGCAGTACGTGAGCG
TGCAGAAGATCGTGGTGCACCCCAACTGGAACAGCAACAATGTGGCTGCAGGCTATGACATCGC
CCTATTGCGCTTGGCCCAGAGTGTCACACTCAATAACTACGTCCAGCTGGCTGTTTTGCCCCAG
GAGGGAACCATCCTGGCTAACAACAATCCCTGCTATATCACAGGCTGGGGGAGAACCAGAACCA
ATGGGCAGCTGTCTCAGACCCTGCAGCAGGCGTACCTGCCCAGCGTGGACTACAGCATCTGCTC
CAGCTCCTCTTACTGGGGCTCCACGGTGAAGACGACCATGGTGTGTGCTGGTGGAGACGGAGTC
CGCTCTGGGTGCCAGGGTGATTCTGGGGGACCCCTCCATTGCTTGGTGAACGGCCAGTATTCTG
TCCACGGAGTGACCAGCTTTGTGTCCAGTATGGGCTGTAATGTCTCCAGGAAGCCCACAGTCTT
CACCCGAGTCTCTGCTTACATTTCCTGGATGAACAATGTCATTGCCTACAACTGAACGTCTTCC
TGAGTCCAGTGGCCTCCCCAAGATGGTGCTTAGCTCTGCAATAAGATCTGAAGTAAGCGAGAAG
GAGTTAGGGCTGGGGTTATCGCTCAGCGGCAGAACACTTTCTAATATGTGCGAAGCCCTGGGTT
CCATCCCTAATACTGCAGCGGGGGCAGGGGAGTGCTGCTGGTGTCTCTCTGCTCTTTCTCCAGT
ATCTGGGGCAAAGGTGGTTAATGAAAAACAGCTCTGAGACTGAGCCAGATACAGAAAGGCAAAT
AAAACTCAATGTGTTATCA

hide sequence

RefSeq Acc Id:

XM_063262977 ⟹ XP_063119047

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	133,652,838 - 133,665,136 (-)	NCBI

RefSeq Acc Id:

XM_063262978 ⟹ XP_063119048

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	133,651,939 - 133,665,027 (-)	NCBI

RefSeq Acc Id:

XM_063262979 ⟹ XP_063119049

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	133,652,838 - 133,665,134 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_036684	(Get FASTA)	NCBI Sequence Viewer
	XP_063119047	(Get FASTA)	NCBI Sequence Viewer
	XP_063119048	(Get FASTA)	NCBI Sequence Viewer
	XP_063119049	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA98811	(Get FASTA)	NCBI Sequence Viewer
	CAA24544	(Get FASTA)	NCBI Sequence Viewer
	EDL86926	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006351
GenBank Protein	P00773	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_036684 ⟸ NM_012552
- Peptide Label:	precursor
- UniProtKB:	P00773 (UniProtKB/Swiss-Prot), A0A0G2JSI5 (UniProtKB/TrEMBL), A6KCL6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLRFLVFASLVLYGHSTQDFPETNARVVGGAEARRNSWPSQISLQYLSGGSWYHTCGGTLIRRN WVMTAAHCVSSQMTFRVVVGDHNLSQNDGTEQYVSVQKIVVHPNWNSNNVAAGYDIALLRLAQS VTLNNYVQLAVLPQEGTILANNNPCYITGWGRTRTNGQLSQTLQQAYLPSVDYSICSSSSYWGS TVKTTMVCAGGDGVRSGCQGDSGGPLHCLVNGQYSVHGVTSFVSSMGCNVSRKPTVFTRVSAYI SWMNNVIAYN hide sequence

Ensembl Acc Id:

ENSRNOP00000006351 ⟸ ENSRNOT00000006351

Ensembl Acc Id:

ENSRNOP00000039630 ⟸ ENSRNOT00000048262

Ensembl Acc Id:

ENSRNOP00000084036 ⟸ ENSRNOT00000103654

Ensembl Acc Id:

ENSRNOP00000079003 ⟸ ENSRNOT00000097496

RefSeq Acc Id:	XP_063119048 ⟸ XM_063262978
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063119047 ⟸ XM_063262977
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063119049 ⟸ XM_063262979
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSRNOP00000101583 ⟸ ENSRNOT00000140130

Protein Domains

BAR Peptidase S1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P00773-F1-model_v2	AlphaFold	P00773	1-266	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695664

Promoter ID:

EPDNEW_R6188

Type:

single initiation site

Name:

Cela1_1

Description:

chymotrypsin-like elastase family, member 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	142,318,621 - 142,318,681	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2547	AgrOrtholog
BioCyc Gene	G2FUF-32011	BioCyc
Ensembl Genes	ENSRNOG00000004725	Ensembl
	ENSRNOG00000031930	Ensembl
	ENSRNOG00000080453	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000006351	ENTREZGENE
Gene3D-CATH	2.40.10.10	UniProtKB/Swiss-Prot
InterPro	Peptidase_S1_Elastase_sf	UniProtKB/Swiss-Prot
	Peptidase_S1_PA	UniProtKB/Swiss-Prot
	Peptidase_S1_PA_chymotrypsin	UniProtKB/Swiss-Prot
	Peptidase_S1A	UniProtKB/Swiss-Prot
	Trypsin_dom	UniProtKB/Swiss-Prot
	TRYPSIN_HIS	UniProtKB/Swiss-Prot
	TRYPSIN_SER	UniProtKB/Swiss-Prot
KEGG Report	rno:24331	UniProtKB/Swiss-Prot
NCBI Gene	24331	ENTREZGENE
PANTHER	CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER	UniProtKB/Swiss-Prot
	CHYMOTRYPSIN-LIKE ELASTASE FAMILY MEMBER 1	UniProtKB/Swiss-Prot
Pfam	Trypsin	UniProtKB/Swiss-Prot
PhenoGen	Cela1	PhenoGen
PRINTS	CHYMOTRYPSIN	UniProtKB/Swiss-Prot
PROSITE	TRYPSIN_DOM	UniProtKB/Swiss-Prot
	TRYPSIN_HIS	UniProtKB/Swiss-Prot
	TRYPSIN_SER	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000004725	RatGTEx
	ENSRNOG00000031930	RatGTEx
	ENSRNOG00000080453	RatGTEx
SMART	Tryp_SPc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF50494	UniProtKB/Swiss-Prot
UniProt	A0A0G2JSI5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZM51_RAT	UniProtKB/TrEMBL
	A0A8I5ZY98_RAT	UniProtKB/TrEMBL
	A0ABK0LKT9_RAT	UniProtKB/TrEMBL
	A6KCL6	ENTREZGENE, UniProtKB/TrEMBL
	CELA1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-04-10	Cela1	chymotrypsin like elastase 1	Cela1	chymotrypsin-like elastase family, member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-05-18	Cela1	chymotrypsin-like elastase family, member 1	Ela1	elastase 1, pancreatic	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Ela1	elastase 1, pancreatic		elastase 1	Name updated	1299863	APPROVED
2002-06-10	Ela1	Elastase 1			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expression is decreased 4.2 fold in SHR compared with WKY rats	1357414

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD