Dyrk1a (dual specificity tyrosine phosphorylation regulated kinase 1A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Dyrk1a (dual specificity tyrosine phosphorylation regulated kinase 1A) Rattus norvegicus
Analyze
Symbol: Dyrk1a
Name: dual specificity tyrosine phosphorylation regulated kinase 1A
RGD ID: 2528
Description: Enables protein serine/threonine kinase activity; protein tyrosine kinase activity; and splicing factor binding activity. Involved in several processes, including protein phosphorylation; regulation of RNA splicing; and regulation of cardiac muscle tissue growth. Located in nuclear speck. Used to study congestive heart failure and dilated cardiomyopathy. Biomarker of hyperhomocysteinemia; myocardial infarction; and renovascular hypertension. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A); INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual Specificity Yak1-related kinase; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; Dyrk; MNBH; protein kinase minibrain homolog; PSK47; RP86
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81147,360,824 - 47,479,033 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1147,360,850 - 47,479,033 (+)EnsemblGRCr8
mRatBN7.21133,890,706 - 34,009,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,890,490 - 34,009,420 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1142,573,541 - 42,666,554 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01135,244,902 - 35,337,921 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01134,390,728 - 34,483,971 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01134,858,339 - 34,958,733 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1134,865,532 - 34,956,536 (+)Ensemblrn6Rnor6.0
Rnor_5.01138,453,019 - 38,550,512 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41134,879,733 - 34,970,998 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1134,444,072 - 34,535,020 (-)NCBICelera
RGSC_v3.11134,935,975 - 35,027,241 (+)NCBI
Cytogenetic Map11q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-iodotubercidin  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
ageladine A  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calyculin A  (ISO)
cannabidiol  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
choline  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
enzyme inhibitor  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glycyrin  (ISO)
harmine  (EXP,ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
Licochalcone A  (ISO)
licocoumarone  (ISO)
methionine  (EXP)
nitroglycerin  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
resveratrol  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
SU6656  (ISO)
sunitinib  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin filament  (ISO)
axon  (IEA,ISO)
cytoplasm  (IEA,ISO,ISS)
cytoskeleton  (IEA,ISO)
dendrite  (IEA,ISO)
microtubule  (ISO)
neurofilament  (ISO)
nuclear speck  (IDA,IEA,ISO)
nucleolus  (IDA)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)
ribonucleoprotein complex  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome. Altafaj X, etal., Neurobiol Dis. 2013 Apr;52:117-27. doi: 10.1016/j.nbd.2012.11.017. Epub 2012 Dec 5.
2. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. Becker W, etal., J Biol Chem. 1998 Oct 2;273(40):25893-902.
3. Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE. Birling MC, etal., Sci Rep. 2017 Mar 7;7:43331. doi: 10.1038/srep43331.
4. Ten new cases further delineate the syndromic intellectual disability phenotype caused by mutations in DYRK1A. Bronicki LM, etal., Eur J Hum Genet. 2015 Nov;23(11):1482-7. doi: 10.1038/ejhg.2015.29. Epub 2015 Apr 29.id: 24774285 Error occurred: The following PMID is not available: 24774285
5. Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate. Chen-Hwang MC, etal., J Biol Chem 2002 May 17;277(20):17597-604.
6. A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro. Coutadeur S, etal., J Neurochem. 2015 May;133(3):440-51. doi: 10.1111/jnc.13018. Epub 2015 Jan 26.
7. Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A. Ding S, etal., Neurobiol Aging. 2012 Jul;33(7):1389-99. doi: 10.1016/j.neurobiolaging.2010.11.021. Epub 2011 Jan 6.
8. Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes. García-Cerro S, etal., Neurobiol Dis. 2017 Oct;106:76-88. doi: 10.1016/j.nbd.2017.06.010. Epub 2017 Jun 21.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo. Grebe C, etal., Cardiovasc Res. 2011 Jun 1;90(3):521-8. doi: 10.1093/cvr/cvr023. Epub 2011 Jan 27.
12. Involvement of the dual-specificity tyrosine phosphorylation-regulated kinase 1A-alternative splicing factor-calcium/calmodulin-dependent protein kinase IIdelta signaling pathway in myocardial infarction-induced heart failure of rats. He J, etal., J Card Fail. 2015 Sep;21(9):751-60. doi: 10.1016/j.cardfail.2015.05.015. Epub 2015 Jun 9.
13. Dyrk1a regulates the cardiomyocyte cell cycle via D-cyclin-dependent Rb/E2f-signalling. Hille S, etal., Cardiovasc Res. 2016 Jun 1;110(3):381-94. doi: 10.1093/cvr/cvw074. Epub 2016 Apr 7.
14. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
15. Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII. Kentrup H, etal., J Biol Chem 1996 Feb 16;271(7):3488-95.
16. Mapping the in vitro interactome of cardiac sodium (Na+ )-calcium (Ca2+ ) exchanger 1 (NCX1). Lubelwana Hafver T, etal., Proteomics. 2017 Sep;17(17-18). doi: 10.1002/pmic.201600417.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Hyperhomocysteinemia-induced Dyrk1a downregulation results in cardiomyocyte hypertrophy in rats. Raaf L, etal., Int J Cardiol. 2010 Nov 19;145(2):306-307. doi: 10.1016/j.ijcard.2009.10.043. Epub 2009 Nov 10.
20. DYRK1A-haploinsufficiency in mice causes autistic-like features and febrile seizures. Raveau M, etal., Neurobiol Dis. 2018 Feb;110:180-191. doi: 10.1016/j.nbd.2017.12.003. Epub 2017 Dec 6.
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome. Shi J, etal., J Biol Chem. 2008 Oct 17;283(42):28660-9. doi: 10.1074/jbc.M802645200. Epub 2008 Jul 24.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Disruptive de novo mutations of DYRK1A lead to a syndromic form of autism and ID. van Bon BW, etal., Mol Psychiatry. 2016 Jan;21(1):126-32. doi: 10.1038/mp.2015.5. Epub 2015 Feb 24.
26. The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome. Wegiel J, etal., Acta Neuropathol. 2008 Oct;116(4):391-407. doi: 10.1007/s00401-008-0419-6. Epub 2008 Aug 12.
27. Dyrk1A-ASF-CaMKIIδ Signaling Is Involved in Valsartan Inhibition of Cardiac Hypertrophy in Renovascular Hypertensive Rats. Yao J, etal., Cardiology. 2016;133(3):198-204. doi: 10.1159/000441695. Epub 2015 Dec 1.
28. [Metoprolol attenuates pressure overload-induced myocardial hypertrophy through modulating Dryk1A-ASF-CaMKIIδ signaling pathways]. Yao J, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Dec;41(12):1029-33.
29. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion. Yin X, etal., J Biol Chem. 2012 Aug 31;287(36):30497-506. doi: 10.1074/jbc.M112.355412. Epub 2012 Jul 5.
30. Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice. Yin X, etal., Sci Rep. 2017 Apr 4;7(1):619. doi: 10.1038/s41598-017-00682-y.
Additional References at PubMed
PMID:9070862   PMID:15287745   PMID:15694837   PMID:15906374   PMID:17906291   PMID:19372220   PMID:19383720   PMID:19549690   PMID:19722700   PMID:20123978   PMID:20696760   PMID:20736167  
PMID:21252229   PMID:21470964   PMID:21709260   PMID:21878370   PMID:21965663   PMID:22110360   PMID:22250195   PMID:23415227   PMID:23665168   PMID:23809146   PMID:23825664   PMID:24327345  
PMID:27307198   PMID:37501148   PMID:37702441  


Genomics

Comparative Map Data
Dyrk1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81147,360,824 - 47,479,033 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1147,360,850 - 47,479,033 (+)EnsemblGRCr8
mRatBN7.21133,890,706 - 34,009,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,890,490 - 34,009,420 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1142,573,541 - 42,666,554 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01135,244,902 - 35,337,921 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01134,390,728 - 34,483,971 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01134,858,339 - 34,958,733 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1134,865,532 - 34,956,536 (+)Ensemblrn6Rnor6.0
Rnor_5.01138,453,019 - 38,550,512 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41134,879,733 - 34,970,998 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1134,444,072 - 34,535,020 (-)NCBICelera
RGSC_v3.11134,935,975 - 35,027,241 (+)NCBI
Cytogenetic Map11q11NCBI
DYRK1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382137,365,573 - 37,526,358 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2137,365,573 - 37,526,358 (+)Ensemblhg38GRCh38
GRCh372138,737,875 - 38,898,660 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362137,661,729 - 37,809,549 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342137,714,470 - 37,809,347NCBI
Celera2123,938,247 - 24,086,068 (+)NCBICelera
Cytogenetic Map21q22.13NCBI
HuRef2124,215,875 - 24,363,782 (+)NCBIHuRef
CHM1_12138,301,002 - 38,448,854 (+)NCBICHM1_1
T2T-CHM13v2.02135,747,888 - 35,908,739 (+)NCBIT2T-CHM13v2.0
Dyrk1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391694,370,770 - 94,496,378 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1694,370,869 - 94,496,376 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381694,569,947 - 94,695,519 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1694,570,010 - 94,695,517 (+)Ensemblmm10GRCm38
MGSCv371694,791,813 - 94,917,126 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361694,720,258 - 94,801,189 (+)NCBIMGSCv36mm8
Celera1695,699,096 - 95,783,175 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1655.3NCBI
Dyrk1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540736,453,098 - 36,589,382 (+)Ensembl
ChiLan1.0NW_00495540736,456,628 - 36,588,940 (+)NCBIChiLan1.0ChiLan1.0
DYRK1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22233,475,597 - 33,629,787 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12128,339,782 - 28,489,307 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02123,729,204 - 23,878,820 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12137,092,172 - 37,231,916 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2137,137,253 - 37,231,987 (+)EnsemblpanPan2panpan1.1
DYRK1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13132,564,970 - 32,655,232 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3132,511,502 - 32,652,572 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3131,572,154 - 31,719,378 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03131,812,898 - 31,959,979 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3131,811,351 - 31,960,042 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13131,682,502 - 31,829,001 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03131,695,751 - 31,842,602 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03132,186,102 - 32,332,696 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dyrk1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497132,044,360 - 32,150,716 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365005,316,164 - 5,404,353 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365005,317,109 - 5,423,593 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYRK1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13201,009,480 - 201,159,948 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113201,008,506 - 201,159,946 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213211,096,538 - 211,247,962 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DYRK1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1281,318,509 - 81,467,227 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl281,425,902 - 81,467,677 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660549,164,197 - 9,315,412 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dyrk1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474526,180,864 - 26,315,234 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474526,180,858 - 26,316,848 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dyrk1a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1449,950,807 - 50,070,077 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dyrk1a
544 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:359
Count of miRNA genes:210
Interacting mature miRNAs:254
Transcripts:ENSRNOT00000050342
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11381815448818154Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)111080612555806125Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)113532319955805892Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)112995899657754989Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)112631803155806125Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat

Markers in Region
D11Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,006,281 - 34,006,459 (+)MAPPERmRatBN7.2
Rnor_6.01134,955,595 - 34,955,772NCBIRnor6.0
Rnor_5.01138,547,374 - 38,547,551UniSTSRnor5.0
RGSC_v3.41134,970,059 - 34,970,236UniSTSRGSC3.4
Celera1134,444,834 - 34,445,011UniSTS
Cytogenetic Map11q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 171 91 90 59 92 59 6 357 192 11 150 82 92 31 22 22

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC106913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC131528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X79769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000050342   ⟹   ENSRNOP00000042446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1147,415,711 - 47,479,033 (+)Ensembl
mRatBN7.2 Ensembl1133,916,184 - 34,009,420 (+)Ensembl
Rnor_6.0 Ensembl1134,865,532 - 34,956,536 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103651   ⟹   ENSRNOP00000095263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1133,971,575 - 34,009,415 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114109   ⟹   ENSRNOP00000096172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1147,360,850 - 47,479,030 (+)Ensembl
mRatBN7.2 Ensembl1133,890,490 - 34,009,415 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117746   ⟹   ENSRNOP00000083937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1147,441,977 - 47,479,033 (+)Ensembl
mRatBN7.2 Ensembl1133,972,363 - 34,009,420 (+)Ensembl
RefSeq Acc Id: NM_012791   ⟹   NP_036923
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,385,802 - 47,479,033 (+)NCBI
mRatBN7.21133,916,184 - 34,009,420 (+)NCBI
Rnor_6.01134,865,532 - 34,956,534 (+)NCBI
Rnor_5.01138,453,019 - 38,550,512 (+)NCBI
RGSC_v3.41134,879,733 - 34,970,998 (+)RGD
Celera1134,444,072 - 34,535,020 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088026   ⟹   XP_038943954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,360,824 - 47,479,023 (+)NCBI
mRatBN7.21133,891,213 - 34,009,420 (+)NCBI
RefSeq Acc Id: XM_039088027   ⟹   XP_038943955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,360,826 - 47,479,023 (+)NCBI
mRatBN7.21133,891,210 - 34,009,414 (+)NCBI
RefSeq Acc Id: XM_039088028   ⟹   XP_038943956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,360,826 - 47,479,023 (+)NCBI
mRatBN7.21133,891,210 - 34,009,420 (+)NCBI
RefSeq Acc Id: XM_039088031   ⟹   XP_038943959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,360,824 - 47,479,023 (+)NCBI
mRatBN7.21133,891,213 - 34,009,420 (+)NCBI
RefSeq Acc Id: XM_039088032   ⟹   XP_038943960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,360,829 - 47,479,023 (+)NCBI
mRatBN7.21133,891,223 - 34,009,420 (+)NCBI
RefSeq Acc Id: XM_063270304   ⟹   XP_063126374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,360,826 - 47,479,023 (+)NCBI
RefSeq Acc Id: XM_063270305   ⟹   XP_063126375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81147,360,826 - 47,479,023 (+)NCBI
RefSeq Acc Id: NP_036923   ⟸   NM_012791
- UniProtKB: Q63470 (UniProtKB/Swiss-Prot),   A6KPV9 (UniProtKB/TrEMBL),   A0A8I5ZY45 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000042446   ⟸   ENSRNOT00000050342
RefSeq Acc Id: XP_038943956   ⟸   XM_039088028
- Peptide Label: isoform X1
- UniProtKB: Q63470 (UniProtKB/Swiss-Prot),   A6KPV9 (UniProtKB/TrEMBL),   A0A8I5ZY45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943955   ⟸   XM_039088027
- Peptide Label: isoform X1
- UniProtKB: Q63470 (UniProtKB/Swiss-Prot),   A6KPV9 (UniProtKB/TrEMBL),   A0A8I5ZY45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943954   ⟸   XM_039088026
- Peptide Label: isoform X1
- UniProtKB: Q63470 (UniProtKB/Swiss-Prot),   A6KPV9 (UniProtKB/TrEMBL),   A0A8I5ZY45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943959   ⟸   XM_039088031
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZY45 (UniProtKB/TrEMBL),   A0A8I6GL29 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943960   ⟸   XM_039088032
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZY45 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095263   ⟸   ENSRNOT00000103651
Ensembl Acc Id: ENSRNOP00000083937   ⟸   ENSRNOT00000117746
Ensembl Acc Id: ENSRNOP00000096172   ⟸   ENSRNOT00000114109
RefSeq Acc Id: XP_063126374   ⟸   XM_063270304
- Peptide Label: isoform X1
- UniProtKB: Q63470 (UniProtKB/Swiss-Prot),   A0A8I5ZY45 (UniProtKB/TrEMBL),   A6KPV9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126375   ⟸   XM_063270305
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZY45 (UniProtKB/TrEMBL),   A0A8I6GL29 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63470-F1-model_v2 AlphaFold Q63470 1-763 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2528 AgrOrtholog
BIND 119589
  134466
BioCyc Gene G2FUF-21759 BioCyc
Ensembl Genes ENSRNOG00000001662 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000050342 ENTREZGENE
  ENSRNOT00000050342.6 UniProtKB/Swiss-Prot
  ENSRNOT00000114109 ENTREZGENE
  ENSRNOT00000114109.1 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PKc_DYR1A/1B UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  Ser_Thr_dual-spec_kinase UniProtKB/Swiss-Prot
KEGG Report rno:25255 UniProtKB/Swiss-Prot
NCBI Gene 25255 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN KINASE UniProtKB/Swiss-Prot
  PTHR24058:SF121 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Dyrk1a PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001662 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
TIGR TC218329
UniProt A0A8I5ZY45 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GL29 ENTREZGENE
  A6KPV9 ENTREZGENE, UniProtKB/TrEMBL
  A6KPW0_RAT UniProtKB/TrEMBL
  DYR1A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Dyrk1a  dual specificity tyrosine phosphorylation regulated kinase 1A  Dyrk1a  dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Dyrk1a  dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A  Dyrk  Dual Specificity Yak1-related kinase  Symbol and Name updated 625702 APPROVED
2002-06-10 Dyrk  Dual Specificity Yak1-related kinase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease plays a role in the mental retardation associated with Downs syndrome 625468
gene_domains contains a kinase domain, a bipartite nuclear target sequence, a PEST (proline, glutamate, serine, and threonine) region, a 13-residue histidine repeat, and a serine/threonine repeat near the C-terminal end 625468
gene_function proline-directed serine/threonine kinase 625468
gene_process plays a dual role in regulating the interaction of dynamin 1 with amphiphysin 1 625468
gene_process may mediate the assembly of endocytic apparatus 625468
gene_product member of Dyrk-related genes family 625468
gene_product either 763 or 754 amino acids as a result of alternative splicing 625468