ANAPC5 (anaphase promoting complex subunit 5) - Rat Genome Database

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Gene: ANAPC5 (anaphase promoting complex subunit 5) Homo sapiens
Analyze
Symbol: ANAPC5
Name: anaphase promoting complex subunit 5
RGD ID: 1314558
HGNC Page HGNC:15713
Description: Enables protein phosphatase binding activity. Involved in protein K11-linked ubiquitination. Located in nucleus and spindle. Part of anaphase-promoting complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: anaphase-promoting complex subunit 5; APC5; cyclosome subunit 5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812121,308,245 - 121,354,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12121,308,245 - 121,399,896 (-)EnsemblGRCh38hg38GRCh38
GRCh3712121,746,048 - 121,792,012 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612120,230,543 - 120,274,585 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412120,208,880 - 120,252,922NCBI
Celera12121,383,688 - 121,428,561 (-)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12118,756,205 - 118,801,940 (-)NCBIHuRef
CHM1_112121,714,488 - 121,760,457 (-)NCBICHM1_1
T2T-CHM13v2.012121,299,648 - 121,345,630 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
anaphase-promoting complex  (IBA,IDA,IEA,IPI,NAS)
cytoplasm  (IEA)
cytoskeleton  (IEA)
cytosol  (TAS)
nucleoplasm  (TAS)
nucleus  (IDA,IEA)
spindle  (IDA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7566098   PMID:9469815   PMID:10318877   PMID:10500174   PMID:10548110   PMID:10793135   PMID:10922056   PMID:11076961   PMID:11285280   PMID:11340163   PMID:11401522   PMID:11535616  
PMID:11742988   PMID:12070128   PMID:12477932   PMID:12956947   PMID:14593737   PMID:14657031   PMID:14702039   PMID:15029244   PMID:15082755   PMID:15302935   PMID:15489334   PMID:15678131  
PMID:15761153   PMID:16169070   PMID:16319895   PMID:16364912   PMID:16861917   PMID:16921029   PMID:17827148   PMID:18162579   PMID:18445686   PMID:18485873   PMID:19531213   PMID:19826416  
PMID:20360068   PMID:20686030   PMID:21043528   PMID:21145461   PMID:21241890   PMID:21549307   PMID:21596315   PMID:21873635   PMID:21900206   PMID:21988832   PMID:22193957   PMID:22580462  
PMID:22792066   PMID:22939629   PMID:22990118   PMID:23007861   PMID:23022380   PMID:23078409   PMID:23160376   PMID:23667531   PMID:23979597   PMID:24163370   PMID:24255178   PMID:24981860  
PMID:25043029   PMID:25306918   PMID:25306923   PMID:25368385   PMID:25490258   PMID:25544563   PMID:26083744   PMID:26186194   PMID:26299517   PMID:26344197   PMID:26496610   PMID:26638075  
PMID:26673895   PMID:26811472   PMID:26972000   PMID:27114510   PMID:27120157   PMID:27248496   PMID:28514442   PMID:28731177   PMID:28786561   PMID:28813667   PMID:28986522   PMID:29033132  
PMID:29183995   PMID:29229926   PMID:29509190   PMID:29549242   PMID:29568061   PMID:29863498   PMID:30554943   PMID:30804502   PMID:31024071   PMID:31073040   PMID:31091453   PMID:31527615  
PMID:31586073   PMID:31753913   PMID:32076268   PMID:32129710   PMID:32152539   PMID:32572027   PMID:32707033   PMID:33306668   PMID:33705438   PMID:33961781   PMID:34011540   PMID:34079125  
PMID:34244565   PMID:34373451   PMID:34831298   PMID:35241646   PMID:35271311   PMID:35439318   PMID:35440621   PMID:35563538   PMID:35831314   PMID:35952650   PMID:36114006   PMID:36215168  
PMID:36520528   PMID:36736316   PMID:37689310   PMID:37827155  


Genomics

Comparative Map Data
ANAPC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812121,308,245 - 121,354,209 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12121,308,245 - 121,399,896 (-)EnsemblGRCh38hg38GRCh38
GRCh3712121,746,048 - 121,792,012 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612120,230,543 - 120,274,585 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412120,208,880 - 120,252,922NCBI
Celera12121,383,688 - 121,428,561 (-)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12118,756,205 - 118,801,940 (-)NCBIHuRef
CHM1_112121,714,488 - 121,760,457 (-)NCBICHM1_1
T2T-CHM13v2.012121,299,648 - 121,345,630 (-)NCBIT2T-CHM13v2.0
Anapc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395122,925,522 - 122,960,402 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5122,925,522 - 122,959,402 (-)EnsemblGRCm39 Ensembl
GRCm385122,787,459 - 122,822,339 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5122,787,459 - 122,821,339 (-)EnsemblGRCm38mm10GRCm38
MGSCv375123,237,468 - 123,271,348 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365123,048,344 - 123,081,902 (-)NCBIMGSCv36mm8
Celera5119,865,864 - 119,899,724 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map562.58NCBI
Anapc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81239,409,519 - 39,442,518 (+)NCBIGRCr8
mRatBN7.21233,748,709 - 33,781,709 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,748,735 - 33,781,781 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1234,926,486 - 34,959,417 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01235,537,850 - 35,570,849 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,590,672 - 34,622,963 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,209,134 - 39,242,696 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,209,129 - 39,242,690 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01241,102,262 - 41,134,473 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,850,485 - 34,884,726 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11234,713,850 - 34,748,179 (+)NCBI
Celera1235,427,503 - 35,460,318 (+)NCBICelera
Cytogenetic Map12q16NCBI
Anapc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554826,951,228 - 6,980,382 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554826,951,496 - 6,980,498 (+)NCBIChiLan1.0ChiLan1.0
ANAPC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210129,393,247 - 129,437,781 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112129,389,621 - 129,434,155 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012118,906,482 - 118,950,913 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112122,279,227 - 122,324,428 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12122,279,227 - 122,324,428 (-)Ensemblpanpan1.1panPan2
ANAPC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1267,796,736 - 7,840,726 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl267,796,736 - 7,840,719 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha267,961,641 - 8,005,497 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0268,053,818 - 8,097,709 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,053,749 - 8,097,699 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1267,985,134 - 8,057,509 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0268,072,184 - 8,116,052 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,028,346 - 8,072,402 (+)NCBIUU_Cfam_GSD_1.0
Anapc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118156,472,593 - 156,511,752 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365582,967,817 - 3,006,718 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365582,967,684 - 3,006,833 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANAPC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1431,259,727 - 31,306,441 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11431,259,695 - 31,306,434 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21433,121,481 - 33,169,470 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANAPC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111116,680,799 - 116,728,065 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11116,680,587 - 116,728,122 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037128,358,871 - 128,399,715 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Anapc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474721,844,453 - 21,881,847 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474721,847,948 - 21,881,501 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ANAPC5
18 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q24.23-24.33(chr12:118165459-133182322)x3 copy number gain See cases [RCV000050866] Chr12:118165459..133182322 [GRCh38]
Chr12:118603264..133758908 [GRCh37]
Chr12:117087647..132268981 [NCBI36]
Chr12:12q24.23-24.33		 pathogenic
GRCh38/hg38 12q24.31(chr12:120504068-122459718)x1 copy number loss See cases [RCV000051342] Chr12:120504068..122459718 [GRCh38]
Chr12:120941871..122944265 [GRCh37]
Chr12:119426254..121510218 [NCBI36]
Chr12:12q24.31		 pathogenic
GRCh38/hg38 12q24.31(chr12:121325874-122505529)x1 copy number loss See cases [RCV000051343] Chr12:121325874..122505529 [GRCh38]
Chr12:121956483..122990076 [GRCh37]
Chr12:120248060..121556029 [NCBI36]
Chr12:12q24.31		 pathogenic
GRCh38/hg38 12q24.23-24.31(chr12:119286893-122638552)x3 copy number gain See cases [RCV000051981] Chr12:119286893..122638552 [GRCh38]
Chr12:119724698..123123099 [GRCh37]
Chr12:118209081..121689052 [NCBI36]
Chr12:12q24.23-24.31		 uncertain significance
GRCh38/hg38 12q24.21-24.33(chr12:115131583-133166920)x3 copy number gain See cases [RCV000053689] Chr12:115131583..133166920 [GRCh38]
Chr12:115569388..133743506 [GRCh37]
Chr12:114053771..132253579 [NCBI36]
Chr12:12q24.21-24.33		 pathogenic
GRCh38/hg38 12q24.23-24.33(chr12:119417382-133191400)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053691]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053691]|See cases [RCV000053691] Chr12:119417382..133191400 [GRCh38]
Chr12:119855187..133767986 [GRCh37]
Chr12:118339570..132278059 [NCBI36]
Chr12:12q24.23-24.33		 pathogenic
GRCh38/hg38 12q24.31(chr12:121110993-121325874)x3 copy number gain See cases [RCV000135179] Chr12:121110993..121325874 [GRCh38]
Chr12:121548796..121763677 [GRCh37]
Chr12:120033179..120248060 [NCBI36]
Chr12:12q24.31		 likely benign
GRCh38/hg38 12q24.31-24.33(chr12:120697672-133202490)x3 copy number gain See cases [RCV000137651] Chr12:120697672..133202490 [GRCh38]
Chr12:121135475..133779076 [GRCh37]
Chr12:119619858..132289149 [NCBI36]
Chr12:12q24.31-24.33		 pathogenic
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33		 pathogenic
GRCh38/hg38 12q24.31-24.32(chr12:120718786-127500215)x1 copy number loss See cases [RCV000142454] Chr12:120718786..127500215 [GRCh38]
Chr12:121156589..127984760 [GRCh37]
Chr12:119640972..126550713 [NCBI36]
Chr12:12q24.31-24.32		 pathogenic
GRCh38/hg38 12q24.21-24.33(chr12:114268403-133201316)x3 copy number gain See cases [RCV000143656] Chr12:114268403..133201316 [GRCh38]
Chr12:114706208..133777902 [GRCh37]
Chr12:113190591..132287975 [NCBI36]
Chr12:12q24.21-24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic|likely pathogenic
GRCh37/hg19 12q24.31(chr12:121441298-122107345)x3 copy number gain See cases [RCV000447978] Chr12:121441298..122107345 [GRCh37]
Chr12:12q24.31		 uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
NM_016237.5(ANAPC5):c.544G>A (p.Glu182Lys) single nucleotide variant not specified [RCV004329105] Chr12:121345885 [GRCh38]
Chr12:121783688 [GRCh37]
Chr12:12q24.31		 uncertain significance
GRCh37/hg19 12q24.23-24.33(chr12:120367241-133777645)x3 copy number gain not provided [RCV000738070] Chr12:120367241..133777645 [GRCh37]
Chr12:12q24.23-24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33		 pathogenic
NM_016237.5(ANAPC5):c.1727A>T (p.Asn576Ile) single nucleotide variant not specified [RCV004311627] Chr12:121318519 [GRCh38]
Chr12:121756322 [GRCh37]
Chr12:12q24.31		 uncertain significance
GRCh37/hg19 12q24.22-24.33(chr12:117461902-133841395)x3 copy number gain Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures [RCV001801213] Chr12:117461902..133841395 [GRCh37]
Chr12:12q24.22-24.33		 likely pathogenic
NM_016237.5(ANAPC5):c.2042C>T (p.Pro681Leu) single nucleotide variant not specified [RCV004159104] Chr12:121309715 [GRCh38]
Chr12:121747518 [GRCh37]
Chr12:12q24.31		 likely benign
GRCh37/hg19 12q24.31(chr12:121551496-121771295)x3 copy number gain not provided [RCV002473864] Chr12:121551496..121771295 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.1108C>T (p.His370Tyr) single nucleotide variant not specified [RCV004163677] Chr12:121330597 [GRCh38]
Chr12:121768400 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.158G>A (p.Ser53Asn) single nucleotide variant not specified [RCV004164132] Chr12:121352183 [GRCh38]
Chr12:121789986 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.1799C>T (p.Ala600Val) single nucleotide variant not specified [RCV004118432] Chr12:121318371 [GRCh38]
Chr12:121756174 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.1006G>A (p.Asp336Asn) single nucleotide variant not specified [RCV004139224] Chr12:121331373 [GRCh38]
Chr12:121769176 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.508G>A (p.Val170Met) single nucleotide variant not specified [RCV004100505] Chr12:121345921 [GRCh38]
Chr12:121783724 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.1778G>A (p.Arg593Gln) single nucleotide variant not specified [RCV004101444] Chr12:121318392 [GRCh38]
Chr12:121756195 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.2198G>A (p.Cys733Tyr) single nucleotide variant not specified [RCV004103895] Chr12:121308550 [GRCh38]
Chr12:121746353 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.244A>G (p.Ile82Val) single nucleotide variant not specified [RCV004182734] Chr12:121347845 [GRCh38]
Chr12:121785648 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.1004A>G (p.Asn335Ser) single nucleotide variant not specified [RCV004075003] Chr12:121331375 [GRCh38]
Chr12:121769178 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.1493C>T (p.Pro498Leu) single nucleotide variant not specified [RCV004252284] Chr12:121320407 [GRCh38]
Chr12:121758210 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.1459T>C (p.Ser487Pro) single nucleotide variant not specified [RCV004299337] Chr12:121320441 [GRCh38]
Chr12:121758244 [GRCh37]
Chr12:12q24.31		 uncertain significance
GRCh37/hg19 12q24.31(chr12:121341598-124103434)x3 copy number gain See cases [RCV003329531] Chr12:121341598..124103434 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.2263C>G (p.Leu755Val) single nucleotide variant not specified [RCV004356410] Chr12:121308485 [GRCh38]
Chr12:121746288 [GRCh37]
Chr12:12q24.31		 uncertain significance
GRCh37/hg19 12q24.31-24.33(chr12:121551496-133777902)x3 copy number gain not provided [RCV003484881] Chr12:121551496..133777902 [GRCh37]
Chr12:12q24.31-24.33		 pathogenic
GRCh37/hg19 12q24.31-24.33(chr12:120880079-133777902)x3 copy number gain not provided [RCV003484880] Chr12:120880079..133777902 [GRCh37]
Chr12:12q24.31-24.33		 pathogenic
NM_016237.5(ANAPC5):c.657+1G>A single nucleotide variant not provided [RCV003991782] Chr12:121342002 [GRCh38]
Chr12:121779805 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.1097A>G (p.Lys366Arg) single nucleotide variant ANAPC5-related condition [RCV003951375] Chr12:121330608 [GRCh38]
Chr12:121768411 [GRCh37]
Chr12:12q24.31		 likely benign
NM_016237.5(ANAPC5):c.1351C>G (p.Leu451Val) single nucleotide variant not specified [RCV004410279] Chr12:121327185 [GRCh38]
Chr12:121764988 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.1352T>C (p.Leu451Pro) single nucleotide variant not specified [RCV004410282] Chr12:121327184 [GRCh38]
Chr12:121764987 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.1433C>T (p.Ala478Val) single nucleotide variant not specified [RCV004410287] Chr12:121327103 [GRCh38]
Chr12:121764906 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.517G>A (p.Ala173Thr) single nucleotide variant not specified [RCV004410320] Chr12:121345912 [GRCh38]
Chr12:121783715 [GRCh37]
Chr12:12q24.31		 uncertain significance
NM_016237.5(ANAPC5):c.986G>A (p.Arg329Lys) single nucleotide variant not specified [RCV004410323] Chr12:121331393 [GRCh38]
Chr12:121769196 [GRCh37]
Chr12:12q24.31		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3587
Count of miRNA genes:1055
Interacting mature miRNAs:1272
Transcripts:ENST00000261819, ENST00000344395, ENST00000366333, ENST00000422342, ENST00000441917, ENST00000534976, ENST00000535463, ENST00000535472, ENST00000535482, ENST00000535641, ENST00000536366, ENST00000536416, ENST00000536837, ENST00000538223, ENST00000538334, ENST00000539079, ENST00000539612, ENST00000539871, ENST00000541652, ENST00000541887, ENST00000544314, ENST00000544442, ENST00000545218, ENST00000545801
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
HSC2OG072  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712121,746,167 - 121,746,376UniSTSGRCh37
Build 3612120,230,550 - 120,230,759RGDNCBI36
Celera12121,383,807 - 121,384,016RGD
Cytogenetic Map12q24.2UniSTS
Cytogenetic Map12q24.31UniSTS
HuRef12118,756,324 - 118,756,533UniSTS
GeneMap99-GB4 RH Map12470.84UniSTS
Whitehead-RH Map12597.9UniSTS
SHGC-82223  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712121,783,491 - 121,783,833UniSTSGRCh37
Build 3612120,267,874 - 120,268,216RGDNCBI36
Celera12121,420,029 - 121,420,371RGD
Cytogenetic Map12q24.31UniSTS
HuRef12118,793,402 - 118,793,744UniSTS
TNG Radiation Hybrid Map1259445.0UniSTS
G64617  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712121,761,439 - 121,761,723UniSTSGRCh37
Build 3612120,245,822 - 120,246,106RGDNCBI36
Celera12121,397,824 - 121,398,108RGD
Cytogenetic Map12q24.31UniSTS
HuRef12118,770,969 - 118,771,253UniSTS
G64569  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712121,783,131 - 121,783,331UniSTSGRCh37
Build 3612120,267,514 - 120,267,714RGDNCBI36
Celera12121,419,669 - 121,419,869RGD
Cytogenetic Map12q24.31UniSTS
HuRef12118,793,042 - 118,793,242UniSTS
G19833  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712121,746,133 - 121,746,252UniSTSGRCh37
Build 3612120,230,516 - 120,230,635RGDNCBI36
Celera12121,383,773 - 121,383,892RGD
Cytogenetic Map12q24.2UniSTS
Cytogenetic Map12q24.31UniSTS
HuRef12118,756,290 - 118,756,409UniSTS
A001Z45  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712121,746,133 - 121,746,252UniSTSGRCh37
Build 3612120,230,516 - 120,230,635RGDNCBI36
Celera12121,383,773 - 121,383,892RGD
Cytogenetic Map12q24.2UniSTS
Cytogenetic Map12q24.31UniSTS
HuRef12118,756,290 - 118,756,409UniSTS
GeneMap99-GB4 RH Map12469.33UniSTS
NCBI RH Map12751.0UniSTS
SHGC-34758  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q24.31UniSTS
TNG Radiation Hybrid Map1259437.0UniSTS
GeneMap99-GB4 RH Map12464.49UniSTS
Whitehead-RH Map12580.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2428 2840 1678 581 1879 421 4355 2123 3652 406 1446 1605 171 1204 2788 4 2
Low 11 151 48 43 72 44 2 74 82 13 14 8 4 1 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001137559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001330489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017019424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA349724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC048337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC069209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF191339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI879332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK025614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC045686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX381618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX537687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR980654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000261819   ⟹   ENSP00000261819
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,308,245 - 121,352,411 (-)Ensembl
RefSeq Acc Id: ENST00000366333
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,318,535 - 121,321,111 (-)Ensembl
RefSeq Acc Id: ENST00000422342
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,308,245 - 121,310,394 (-)Ensembl
RefSeq Acc Id: ENST00000441917   ⟹   ENSP00000415061
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,308,357 - 121,347,883 (-)Ensembl
RefSeq Acc Id: ENST00000534976
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,308,357 - 121,352,304 (-)Ensembl
RefSeq Acc Id: ENST00000535463
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,328,257 - 121,328,835 (-)Ensembl
RefSeq Acc Id: ENST00000535472
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,326,353 - 121,337,367 (-)Ensembl
RefSeq Acc Id: ENST00000535482   ⟹   ENSP00000438754
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,308,358 - 121,331,391 (-)Ensembl
RefSeq Acc Id: ENST00000535641
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,308,332 - 121,335,609 (-)Ensembl
RefSeq Acc Id: ENST00000536416
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,345,840 - 121,352,417 (-)Ensembl
RefSeq Acc Id: ENST00000536837   ⟹   ENSP00000441508
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,345,999 - 121,399,896 (-)Ensembl
RefSeq Acc Id: ENST00000538223
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,328,999 - 121,337,395 (-)Ensembl
RefSeq Acc Id: ENST00000538334
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,326,486 - 121,335,172 (-)Ensembl
RefSeq Acc Id: ENST00000539079   ⟹   ENSP00000437857
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,308,357 - 121,337,393 (-)Ensembl
RefSeq Acc Id: ENST00000539612
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,330,583 - 121,342,071 (-)Ensembl
RefSeq Acc Id: ENST00000539871   ⟹   ENSP00000445191
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,345,924 - 121,352,395 (-)Ensembl
RefSeq Acc Id: ENST00000541652
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,335,517 - 121,347,875 (-)Ensembl
RefSeq Acc Id: ENST00000541887   ⟹   ENSP00000439875
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,308,357 - 121,352,388 (-)Ensembl
RefSeq Acc Id: ENST00000544314
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,308,358 - 121,335,682 (-)Ensembl
RefSeq Acc Id: ENST00000544442   ⟹   ENSP00000440800
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,335,533 - 121,352,385 (-)Ensembl
RefSeq Acc Id: ENST00000545218
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,317,890 - 121,337,331 (-)Ensembl
RefSeq Acc Id: ENST00000545801
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl12121,346,795 - 121,352,327 (-)Ensembl
RefSeq Acc Id: NM_001137559   ⟹   NP_001131031
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812121,308,245 - 121,354,209 (-)NCBI
GRCh3712121,746,048 - 121,792,012 (-)ENTREZGENE
HuRef12118,756,205 - 118,801,940 (-)ENTREZGENE
CHM1_112121,714,488 - 121,760,457 (-)NCBI
T2T-CHM13v2.012121,299,648 - 121,345,630 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001330489   ⟹   NP_001317418
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812121,308,245 - 121,352,411 (-)NCBI
T2T-CHM13v2.012121,299,648 - 121,343,818 (-)NCBI
Sequence:
RefSeq Acc Id: NM_016237   ⟹   NP_057321
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812121,308,245 - 121,352,411 (-)NCBI
GRCh3712121,746,048 - 121,792,012 (-)ENTREZGENE
Build 3612120,230,543 - 120,274,585 (-)NCBI Archive
HuRef12118,756,205 - 118,801,940 (-)ENTREZGENE
CHM1_112121,714,488 - 121,758,710 (-)NCBI
T2T-CHM13v2.012121,299,648 - 121,343,818 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001131031   ⟸   NM_001137559
- Peptide Label: isoform b
- UniProtKB: Q9UJX4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_057321   ⟸   NM_016237
- Peptide Label: isoform a
- UniProtKB: Q8N4H7 (UniProtKB/Swiss-Prot),   E9PFB2 (UniProtKB/Swiss-Prot),   Q9BQD4 (UniProtKB/Swiss-Prot),   Q9UJX4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001317418   ⟸   NM_001330489
- Peptide Label: isoform c
- UniProtKB: F5H0F9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000439875   ⟸   ENST00000541887
RefSeq Acc Id: ENSP00000440800   ⟸   ENST00000544442
RefSeq Acc Id: ENSP00000415061   ⟸   ENST00000441917
RefSeq Acc Id: ENSP00000438754   ⟸   ENST00000535482
RefSeq Acc Id: ENSP00000441508   ⟸   ENST00000536837
RefSeq Acc Id: ENSP00000437857   ⟸   ENST00000539079
RefSeq Acc Id: ENSP00000261819   ⟸   ENST00000261819
RefSeq Acc Id: ENSP00000445191   ⟸   ENST00000539871
Protein Domains
Anaphase-promoting complex subunit   Anaphase-promoting complex subunit 5 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UJX4-F1-model_v2 AlphaFold Q9UJX4 1-755 view protein structure

Promoters
RGD ID:6789671
Promoter ID:HG_KWN:16861
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:UC001UAF.1,   UC001UAI.1,   UC001UAJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 3612120,259,556 - 120,260,056 (-)MPROMDB
RGD ID:6789646
Promoter ID:HG_KWN:16863
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_016237,   UC009ZXD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 3612120,274,284 - 120,274,784 (-)MPROMDB
RGD ID:7225651
Promoter ID:EPDNEW_H18571
Type:initiation region
Name:ANAPC5_1
Description:anaphase promoting complex subunit 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812121,352,408 - 121,352,468EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:15713 AgrOrtholog
COSMIC ANAPC5 COSMIC
Ensembl Genes ENSG00000089053 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000261819 ENTREZGENE
  ENST00000261819.8 UniProtKB/Swiss-Prot
  ENST00000441917 ENTREZGENE
  ENST00000441917.6 UniProtKB/Swiss-Prot
  ENST00000535482.1 UniProtKB/TrEMBL
  ENST00000536837.1 UniProtKB/TrEMBL
  ENST00000539079.5 UniProtKB/TrEMBL
  ENST00000539871.1 UniProtKB/TrEMBL
  ENST00000541887 ENTREZGENE
  ENST00000541887.5 UniProtKB/TrEMBL
  ENST00000544442.5 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000089053 GTEx
HGNC ID HGNC:15713 ENTREZGENE
Human Proteome Map ANAPC5 Human Proteome Map
InterPro Apc5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Apc5_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Apc5_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:51433 UniProtKB/Swiss-Prot
NCBI Gene 51433 ENTREZGENE
OMIM 606948 OMIM
PANTHER ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12830 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANAPC5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Apc5_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA24788 PharmGKB
SMART TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt APC5_HUMAN UniProtKB/Swiss-Prot
  E9PFB2 ENTREZGENE
  F5GY68_HUMAN UniProtKB/TrEMBL
  F5GZ05_HUMAN UniProtKB/TrEMBL
  F5H0F9 ENTREZGENE, UniProtKB/TrEMBL
  F5H0N1_HUMAN UniProtKB/TrEMBL
  F5H3S5_HUMAN UniProtKB/TrEMBL
  H0YFB5_HUMAN UniProtKB/TrEMBL
  Q49A41_HUMAN UniProtKB/TrEMBL
  Q8N4H7 ENTREZGENE
  Q9BQD4 ENTREZGENE
  Q9UJX4 ENTREZGENE
UniProt Secondary E9PFB2 UniProtKB/Swiss-Prot
  Q8N4H7 UniProtKB/Swiss-Prot
  Q9BQD4 UniProtKB/Swiss-Prot