Hbegf (heparin-binding EGF-like growth factor) - Rat Genome Database

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Gene: Hbegf (heparin-binding EGF-like growth factor) Rattus norvegicus
Analyze
Symbol: Hbegf
Name: heparin-binding EGF-like growth factor
RGD ID: 2526
Description: Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in epidermal growth factor receptor signaling pathway; negative regulation of elastin biosynthetic process; and positive regulation of cell growth. Predicted to be located in cell surface. Predicted to be active in extracellular space and plasma membrane. Biomarker of acute kidney failure. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,2,4-trimethylbenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: diphtheria toxin receptor; Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor); Dtr; GFHB; Hb-egf; Hegfl; heparin binding epidermal growth factor-like growth factor; heparin-binding epidermal -growth - like growth factor; heparin-binding epidermal -growth factor; proheparin-binding EGF-like growth factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81828,380,337 - 28,390,220 (-)NCBIGRCr8
mRatBN7.21828,106,284 - 28,116,167 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1828,105,760 - 28,116,441 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1828,233,442 - 28,243,328 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01828,995,528 - 29,005,411 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01828,330,776 - 28,340,662 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01829,330,302 - 29,340,185 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1829,329,764 - 29,340,403 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01829,036,863 - 29,046,746 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41829,143,567 - 29,153,944 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11829,170,212 - 29,180,590 (-)NCBI
Celera1827,834,537 - 27,844,179 (-)NCBICelera
Cytogenetic Map18p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
HbegfRatacute kidney failure  IEP 10395241mRNA:increased expression:kidneyRGD 
HbegfRatglomerulosclerosis inducedISOHBEGF (Homo sapiens)1556472 RGD 
HbegfRatperinatal necrotizing enterocolitis treatmentISOHBEGF (Homo sapiens)10395236 RGD 
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Original Reference(s)
HbegfRatautosomal dominant intellectual developmental disorder 31  ISOHBEGF (Homo sapiens)8554872ClinVar Annotator: match by term: NEURODEVELOPMENTAL DISORDER WITH NEONATAL RESPIRATORY INSUFFICIENCY more ...ClinVarPMID:28492532
HbegfRatfamilial adenomatous polyposis 1  ISOHBEGF (Homo sapiens)8554872ClinVar Annotator: match by term: Familial adenomatous polyposis 1ClinVarPMID:17963004 more ...
HbegfRatHereditary Neoplastic Syndromes  ISOHBEGF (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary cancer-predisposing syndromeClinVarPMID:17963004 more ...
HbegfRatNeurodevelopmental Disorders  ISOHBEGF (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
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Original Reference(s)
HbegfRatacute kidney failure  ISOHBEGF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7635938
HbegfRatAnimal Disease Models  ISOHBEGF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21937979
HbegfRatCardiotoxicity  ISOHBEGF (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:29305325
HbegfRatend stage renal disease  ISOHBEGF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21937979
HbegfRatendometriosis  ISOHBEGF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20864642
HbegfRatepilepsy with generalized tonic-clonic seizures  ISOHBEGF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16023256
HbegfRatjuvenile rheumatoid arthritis  ISOHBEGF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504
HbegfRatLeft Ventricular Hypertrophy  ISOHBEGF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9709397
HbegfRatperinatal necrotizing enterocolitis  ISOHBEGF (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:16567187
HbegfRatReperfusion Injury  ISOHBEGF (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7635938
HbegfRatStomach Neoplasms  ISOHBEGF (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:15723263
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Original Reference(s)
HbegfRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of HBEGF mRNA]CTDPMID:31150632
HbegfRat(-)-epigallocatechin 3-gallate multiple interactionsISOHBEGF (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of HBEGF mRNA and epigallocatechin gallate affects the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]CTDPMID:22079256 and PMID:26800359
HbegfRat1,10-phenanthroline increases expressionISOHBEGF (Homo sapiens)64804641 and 10-phenanthroline results in increased expression of HBEGF mRNACTDPMID:26800359
HbegfRat1,2,4-trimethylbenzene increases expressionEXP 6480464pseudocumene results in increased expression of HBEGF proteinCTDPMID:17337753
HbegfRat1,2-dimethylhydrazine increases expressionISOHbegf (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of HBEGF mRNACTDPMID:22206623
HbegfRat1-nitropyrene increases expressionISOHBEGF (Homo sapiens)64804641-nitropyrene results in increased expression of HBEGF mRNACTDPMID:19041380
HbegfRat17beta-estradiol increases expressionISOHbegf (Mus musculus)6480464Estradiol results in increased expression of HBEGF mRNACTDPMID:25210133
HbegfRat17beta-estradiol increases expressionISOHBEGF (Homo sapiens)6480464Estradiol results in increased expression of HBEGF mRNACTDPMID:31614463
HbegfRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of HBEGF mRNACTDPMID:32145629
HbegfRat17beta-estradiol multiple interactionsISOHBEGF (Homo sapiens)6480464[Estradiol co-treated with EGF protein] results in increased expression of HBEGF mRNA and [Estradiol results in increased abundance of Cadmium] which results in increased expression of HBEGF proteinCTDPMID:24758408 and PMID:31468104
HbegfRat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:27291303
HbegfRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of HBEGF mRNACTDPMID:22298810
HbegfRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOHbegf (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of HBEGF mRNACTDPMID:21570461 and PMID:26377647
HbegfRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of HBEGF mRNACTDPMID:23196670 and PMID:33387578
HbegfRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 64804642-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of HBEGF mRNA]CTDPMID:23196670
HbegfRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOHBEGF (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of HBEGF mRNACTDPMID:20106945 and PMID:21632981
HbegfRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOHbegf (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of HBEGF mRNACTDPMID:19770486 more ...
HbegfRat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
HbegfRat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOHbegf (Mus musculus)64804642 more ...CTDPMID:38648751
HbegfRat2-amino-2-deoxy-D-galactopyranose multiple interactionsISOHbegf (Mus musculus)6480464[Galactosamine co-treated with lipopolysaccharide more ...CTDPMID:28887131

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Biological Process
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Original Reference(s)
HbegfRatcell chemotaxis involved_inISOHBEGF (Homo sapiens)1624291 PMID:24008408RGDPMID:24008408
HbegfRatcell chemotaxis involved_inIEAUniProtKB:Q99075 and ensembl:ENSP000002309901600115GO_REF:0000107EnsemblGO_REF:0000107
HbegfRatcell migration involved_inIEAUniProtKB:Q06186 and ensembl:ENSMUSP000000253631600115GO_REF:0000107EnsemblGO_REF:0000107
HbegfRatcell migration involved_inISOHbegf (Mus musculus)1624291 PMID:15923649RGDPMID:15923649
HbegfRatepidermal growth factor receptor signaling pathway  TAS 728846 RGD 
HbegfRatepidermal growth factor receptor signaling pathway acts_upstream_of_or_withinIEAUniProtKB:Q06186 and ensembl:ENSMUSP000000253631600115GO_REF:0000107EnsemblGO_REF:0000107
HbegfRatepidermal growth factor receptor signaling pathway acts_upstream_of_or_withinISOHbegf (Mus musculus)1624291 PMID:12621152RGDPMID:12621152
HbegfRatepidermal growth factor receptor signaling pathway involved_inIEAUniProtKB:Q99075 and ensembl:ENSP000002309901600115GO_REF:0000107EnsemblGO_REF:0000107
HbegfRatepidermal growth factor receptor signaling pathway involved_inISOHBEGF (Homo sapiens)1624291 PMID:17655843 and PMID:8702723RGDPMID:17655843 and PMID:8702723
HbegfRatepidermal growth factor receptor signaling pathway involved_inIBAMGI:107508 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
HbegfRatepidermal growth factor receptor signaling pathway  IMP 1581908 RGD 
HbegfRatERBB2-EGFR signaling pathway involved_inISOHbegf (Mus musculus)1624291MGI:2665039 PMID:21946538RGDPMID:21946538
HbegfRatERBB2-EGFR signaling pathway involved_inIEAUniProtKB:Q06186 and ensembl:ENSMUSP000000253631600115GO_REF:0000107EnsemblGO_REF:0000107
HbegfRatERBB2-ERBB4 signaling pathway involved_inISOHbegf (Mus musculus)1624291MGI:2655703 PMID:12621152RGDPMID:12621152
HbegfRatERBB2-ERBB4 signaling pathway involved_inIEAUniProtKB:Q06186 and ensembl:ENSMUSP000000253631600115GO_REF:0000107EnsemblGO_REF:0000107
HbegfRatnegative regulation of glycoprotein biosynthetic process involved_inIDA 8554842PMID:12882762UniProt 
HbegfRatnervous system development  TAS 728846 RGD 
HbegfRatpositive regulation of cell growth  IDA 728846 RGD 
HbegfRatpositive regulation of cell migration involved_inISOHBEGF (Homo sapiens)1624291 PMID:17655843RGDPMID:17655843
HbegfRatpositive regulation of cell migration involved_inIEAUniProtKB:Q99075 and ensembl:ENSP000002309901600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
HbegfRatcell surface located_inISOHBEGF (Homo sapiens)1624291 PMID:12743035RGDPMID:12743035
HbegfRatcell surface located_inIEAUniProtKB:Q99075 and ensembl:ENSP000002309901600115GO_REF:0000107EnsemblGO_REF:0000107
HbegfRatextracellular region located_inIEAUniProtKB-SubCell:SL-01121600115GO_REF:0000044UniProtGO_REF:0000044
HbegfRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
HbegfRatextracellular space located_inISOHBEGF (Homo sapiens)1624291 PMID:12743035RGDPMID:12743035
HbegfRatextracellular space located_inIEAUniProtKB:Q06186 and ensembl:ENSMUSP000000253631600115GO_REF:0000107EnsemblGO_REF:0000107
HbegfRatextracellular space located_inIEAUniProtKB:Q99075 and ensembl:ENSP000002309901600115GO_REF:0000107EnsemblGO_REF:0000107
HbegfRatextracellular space is_active_inIBAMGI:107508 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
HbegfRatextracellular space is_active_inISOHbegf (Mus musculus)1624291 PMID:12621152 and PMID:21946538RGDPMID:12621152 and PMID:21946538
HbegfRatextracellular space located_inISOHbegf (Mus musculus)1624291 PMID:9857183RGDPMID:9857183
HbegfRatextracellular space is_active_inISOHBEGF (Homo sapiens)1624291 PMID:8702723RGDPMID:8702723
HbegfRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
HbegfRatplasma membrane is_active_inIBAMGI:96070 and PANTHER:PTN0000777391600115GO_REF:0000033GO_CentralGO_REF:0000033
HbegfRatplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
HbegfRatplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
HbegfRatplasma membrane located_inIEAUniProtKB:Q06186 and ensembl:ENSMUSP000000253631600115GO_REF:0000107EnsemblGO_REF:0000107
HbegfRatplasma membrane located_inISOHbegf (Mus musculus)1624291 PMID:9857183RGDPMID:9857183
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Molecular Function
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Original Reference(s)
HbegfRatepidermal growth factor receptor binding  IMP 1581908 RGD 
HbegfRatepidermal growth factor receptor binding enablesIEAUniProtKB:Q06186 and ensembl:ENSMUSP000000253631600115GO_REF:0000107EnsemblGO_REF:0000107
HbegfRatepidermal growth factor receptor binding enablesIBAMGI:107508 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
HbegfRatepidermal growth factor receptor binding enablesISOHbegf (Mus musculus)1624291 PMID:1840698RGDPMID:1840698
HbegfRatgrowth factor activity  IMP 1581908 RGD 
HbegfRatgrowth factor activity enablesIEAUniProtKB-KW:KW-03391600115GO_REF:0000043UniProtGO_REF:0000043
HbegfRatgrowth factor activity enablesIEAUniProtKB:Q99075 and ensembl:ENSP000002309901600115GO_REF:0000107EnsemblGO_REF:0000107
HbegfRatgrowth factor activity enablesIEAUniProtKB:Q06186 and ensembl:ENSMUSP000000253631600115GO_REF:0000107EnsemblGO_REF:0000107
HbegfRatgrowth factor activity enablesISOHbegf (Mus musculus)1624291 PMID:1840698RGDPMID:1840698
HbegfRatgrowth factor activity enablesIBAMGI:1919170 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
HbegfRatgrowth factor activity enablesISOHBEGF (Homo sapiens)1624291 PMID:12070119RGDPMID:12070119
HbegfRatheparin binding enablesISOHBEGF (Homo sapiens)1624291 PMID:8300582RGDPMID:8300582
HbegfRatheparin binding enablesIEAUniProtKB:Q06186 and ensembl:ENSMUSP000000253631600115GO_REF:0000107EnsemblGO_REF:0000107
HbegfRatheparin binding enablesIEAUniProtKB:Q99075 and ensembl:ENSP000002309901600115GO_REF:0000107EnsemblGO_REF:0000107
HbegfRatheparin binding enablesISOHbegf (Mus musculus)1624291 PMID:1840698RGDPMID:1840698
HbegfRatheparin binding enablesIBAMGI:96070 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
HbegfRatheparin binding enablesIEAUniProtKB-KW:KW-03581600115GO_REF:0000043UniProtGO_REF:0000043
HbegfRatprotein binding enablesISOHBEGF (Homo sapiens)1624291UniProtKB:P00533 more ...RGDPMID:28988771 more ...
HbegfRatreceptor ligand activity enablesISOHBEGF (Homo sapiens)1624291 PMID:8702723RGDPMID:8702723
HbegfRatreceptor ligand activity enablesIEAUniProtKB:Q06186 and ensembl:ENSMUSP000000253631600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  
Object Symbol
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Original Reference(s)
HbegfRatepidermal growth factor/neuregulin signaling pathway   ISOHBEGF (Homo sapiens)2317963 RGD 
HbegfRatepidermal growth factor/neuregulin signaling pathway   IMP 1581908 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
HbegfRatepidermal growth factor/neuregulin signaling pathway   IEA 6907045 KEGGrno:04012
HbegfRatgonadotropin-releasing hormone signaling pathway  IEA 6907045 KEGGrno:04912

Imported Annotations - PID (archival)

Object Symbol
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Original Reference(s)
HbegfRatepidermal growth factor/neuregulin signaling pathway   ISOHBEGF (Homo sapiens)6484113 PIDPID:200159

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#
Reference Title
Reference Citation
1. Heparin-binding EGF-like growth factor: characterization of rat and mouse cDNA clones, protein domain conservation across species, and transcript expression in tissues. Abraham JA, etal., Biochem Biophys Res Commun 1993 Jan 15;190(1):125-33.
2. Comparison of epidermal growth factor and heparin-binding epidermal growth factor-like growth factor for prevention of experimental necrotizing enterocolitis. Dvorak B, etal., J Pediatr Gastroenterol Nutr. 2008 Jul;47(1):11-8. doi: 10.1097/MPG.0b013e3181788618.
3. Heparin-binding epidermal-growth-factor-like growth factor gene expression is induced by scrape-wounding epithelial cell monolayers: involvement of mitogen-activated protein kinase cascades. Ellis PD, etal., Biochem J 2001 Feb 15;354(Pt 1):99-106.
4. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) regulates survival of midbrain dopaminergic neurons. Farkas LM and Krieglstein K, J Neural Transm 2002 Mar;109(3):267-77.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Control of the epidermal growth factor receptor and its ligands during renal injury. Hise MK, etal., Nephron. 2001 May;88(1):71-9.
7. Heparin-binding EGF-like growth factor regulates elastin and FGF-2 expression in pulmonary fibroblasts. Liu J, etal., Am J Physiol Lung Cell Mol Physiol. 2003 Nov;285(5):L1106-15. Epub 2003 Jul 25.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93.
15. A role of heparin-binding epidermal growth factor-like growth factor in cardiac remodeling after myocardial infarction. Tanaka N, etal., Biochem Biophys Res Commun 2002 Sep 20;297(2):375-81.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Heparin-binding EGF-like growth factor gene transcription regulated by Cdx2 in the intestinal epithelium. Uesaka T, etal., Am J Physiol Gastrointest Liver Physiol 2002 Oct;283(4):G840-7.
18. Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. Wharram BL, etal., J Am Soc Nephrol 2005 Oct;16(10):2941-52. Epub 2005 Aug 17.
19. Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle. Zhang H, etal., Circ Res. 2004 Nov 12;95(10):989-97. Epub 2004 Oct 14.
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PMID:1840698   PMID:8300582   PMID:8702723   PMID:9857183   PMID:11882602   PMID:12070119   PMID:12621152   PMID:12743035   PMID:12746188   PMID:15490481   PMID:15923649   PMID:16364500  
PMID:16737974   PMID:16753836   PMID:16806064   PMID:17655843   PMID:17855771   PMID:18299347   PMID:18929421   PMID:19193634   PMID:19225541   PMID:19237431   PMID:19389413   PMID:20696782  
PMID:21244855   PMID:23534509   PMID:24008408   PMID:24303948   PMID:24703506   PMID:25759388   PMID:31882563   PMID:35281434   PMID:36655849   PMID:37868978   PMID:38262115  



Hbegf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81828,380,337 - 28,390,220 (-)NCBIGRCr8
mRatBN7.21828,106,284 - 28,116,167 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1828,105,760 - 28,116,441 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1828,233,442 - 28,243,328 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01828,995,528 - 29,005,411 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01828,330,776 - 28,340,662 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01829,330,302 - 29,340,185 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1829,329,764 - 29,340,403 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01829,036,863 - 29,046,746 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41829,143,567 - 29,153,944 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11829,170,212 - 29,180,590 (-)NCBI
Celera1827,834,537 - 27,844,179 (-)NCBICelera
Cytogenetic Map18p11NCBI
HBEGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385140,332,843 - 140,346,603 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5140,332,843 - 140,346,603 (-)EnsemblGRCh38hg38GRCh38
GRCh375139,712,428 - 139,726,188 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365139,692,612 - 139,706,358 (-)NCBINCBI36Build 36hg18NCBI36
Celera5135,789,059 - 135,802,819 (-)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5134,857,589 - 134,871,349 (-)NCBIHuRef
CHM1_15139,145,572 - 139,159,324 (-)NCBICHM1_1
T2T-CHM13v2.05140,858,275 - 140,872,035 (-)NCBIT2T-CHM13v2.0
Hbegf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391836,637,980 - 36,648,858 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1836,637,980 - 36,648,858 (-)EnsemblGRCm39 Ensembl
GRCm381836,504,927 - 36,515,805 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1836,504,927 - 36,515,805 (-)EnsemblGRCm38mm10GRCm38
MGSCv371836,664,581 - 36,675,459 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361836,630,906 - 36,641,748 (-)NCBIMGSCv36mm8
Celera1836,954,561 - 36,965,476 (-)NCBICelera
Cytogenetic Map18B2NCBI
cM Map1819.46NCBI
Hbegf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955418309,096 - 321,387 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955418259,860 - 321,340 (+)NCBIChiLan1.0ChiLan1.0
HBEGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24135,592,663 - 135,606,509 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15133,732,214 - 133,746,060 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05135,699,553 - 135,713,366 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15141,816,402 - 141,830,531 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5141,816,402 - 141,830,531 (-)Ensemblpanpan1.1panPan2
HBEGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1235,551,248 - 35,563,310 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl235,551,250 - 35,563,043 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha232,590,448 - 32,601,580 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0236,006,883 - 36,018,938 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl236,006,888 - 36,018,924 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1233,058,605 - 33,070,652 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0233,926,053 - 33,938,108 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0234,678,980 - 34,691,039 (-)NCBIUU_Cfam_GSD_1.0
Hbegf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213152,266,443 - 152,278,566 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365319,332,898 - 9,345,067 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365319,332,939 - 9,345,039 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HBEGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2142,102,458 - 142,115,174 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12142,102,455 - 142,115,192 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22148,047,629 - 148,058,091 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HBEGF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12342,981,640 - 42,995,116 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2342,981,640 - 42,994,995 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603434,887,898 - 34,902,819 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hbegf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474333,112,036 - 33,124,169 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474333,112,105 - 33,124,145 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Hbegf
25 total Variants

Predicted Target Of
Summary Value
Count of predictions:721
Count of miRNA genes:298
Interacting mature miRNAs:373
Transcripts:ENSRNOT00000025157
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 33 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat

1 to 10 of 33 rows
RH127462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21828,105,863 - 28,106,082 (+)MAPPERmRatBN7.2
Rnor_6.01829,329,882 - 29,330,100NCBIRnor6.0
Rnor_5.01829,036,443 - 29,036,661UniSTSRnor5.0
RGSC_v3.41829,143,147 - 29,143,365UniSTSRGSC3.4
Celera1827,834,117 - 27,834,335UniSTS
RH 3.4 Map18416.8UniSTS
Cytogenetic Map18p11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000025157   ⟹   ENSRNOP00000025157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1828,105,760 - 28,116,441 (-)Ensembl
Rnor_6.0 Ensembl1829,329,764 - 29,340,403 (-)Ensembl
RefSeq Acc Id: NM_012945   ⟹   NP_037077
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81828,380,337 - 28,390,220 (-)NCBI
mRatBN7.21828,106,284 - 28,116,167 (-)NCBI
Rnor_6.01829,330,302 - 29,340,185 (-)NCBI
Rnor_5.01829,036,863 - 29,046,746 (-)NCBI
RGSC_v3.41829,143,567 - 29,153,944 (-)RGD
Celera1827,834,537 - 27,844,179 (-)RGD
Sequence:
Protein RefSeqs NP_037077 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA81780 (Get FASTA)   NCBI Sequence Viewer  
  EDL76294 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025157
  ENSRNOP00000025157.5
GenBank Protein Q06175 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037077   ⟸   NM_012945
- Peptide Label: precursor
- UniProtKB: Q06175 (UniProtKB/Swiss-Prot),   A6J312 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025157   ⟸   ENSRNOT00000025157
EGF-like

Name Modeler Protein Id AA Range Protein Structure
AF-Q06175-F1-model_v2 AlphaFold Q06175 1-208 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700720
Promoter ID:EPDNEW_R11243
Type:multiple initiation site
Name:Hbegf_1
Description:heparin-binding EGF-like growth factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01829,340,413 - 29,340,473EPDNEW


1 to 19 of 19 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-7875 BioCyc
Ensembl Genes ENSRNOG00000018646 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025157 ENTREZGENE
  ENSRNOT00000025157.7 UniProtKB/Swiss-Prot
Gene3D-CATH Laminin UniProtKB/Swiss-Prot
InterPro EGF-like_dom UniProtKB/Swiss-Prot
KEGG Report rno:25433 UniProtKB/Swiss-Prot
NCBI Gene 25433 ENTREZGENE
PANTHER PROHEPARIN-BINDING EGF-LIKE GROWTH FACTOR UniProtKB/Swiss-Prot
  PTHR10740 UniProtKB/Swiss-Prot
PhenoGen Hbegf PhenoGen
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018646 RatGTEx
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
TIGR TC230854
UniProt A6J312 ENTREZGENE, UniProtKB/TrEMBL
  HBEGF_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 19 of 19 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Hbegf  heparin-binding EGF-like growth factor  Dtr  diphtheria toxin receptor  Symbol and Name updated 1299863 APPROVED
2004-02-26 Dtr  diphtheria toxin receptor      Symbol and Name status set to approved 625702 APPROVED
2003-05-08 Dtr  diphtheria toxin receptor  Hb-egf  heparin-binding epidermal -growth factor  Data merged from RGD:70330 628472 PROVISIONAL
2003-04-09 Dtr  diphtheria toxin receptor  Hegfl  heparin binding epidermal growth factor-like growth factor  Symbol and Name updated 629477 APPROVED
2002-11-06 Hegfl  heparin binding epidermal growth factor-like growth factor  Dtr  Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor)  Symbol and Name updated 625702 APPROVED
2002-06-10 Dtr  Diphtheria toxin receptor (heparin binding epidermal growth factor - like growth factor)      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Hb-egf  heparin-binding epidermal -growth factor      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_disease may play a role in cardiac fibroblast proliferation and remodeling after myocardial infarction 728765